the affective response to attachment and separation

... autophagy in a population of cells Autophagic response to nutrient deprivation Autophagy is strongly upregulated in response to nutrient deprivation [19,29] To examine the autophagic response to ... lysosomal activity to quantify autophagic flux During the initiation of autophagy, cytosolic LC3 (LC3-I) is cleaved and lipidated to form LC3-II [16,20] LC3-II is then recruited to the autophagosomal ... of the autophagosomes and cargo by lysosomal proteases [2,3] The autophagic pathway is crucial for maintaining cell homeostasis and disruption to the pathway can be a contributing factor to many...

Ngày tải lên: 07/03/2014, 09:20

... TRAIL-mediated apoptosis in HCT116 human colon carcinoma cells by inhibiting the translocation of Bax from the cytosol to the mitochondria, thereby preventing the release of cytochrome c and progression ... signaling, leading to the activation of two distinct pathways One pathway might lead to increased nuclear localization of BRCA1 and the other to apoptosis Hypoxia could block the apoptotic arm (Fig ... of chemotherapeutic drugs and tumor necrosis factor-related apoptosisinducing ligand ⁄ Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo Cancer Res 63, 5390–5400 Tomlinson...

Ngày tải lên: 30/03/2014, 03:20

... questions needed to be answered to allow these tools to handle longitudinal data and dynamic network simulations, as well as to use sampled and incomplete data to parameterize, model and simulate ... research aiming to expand on the work they had done Attempts to extend the compartmental modelling frame to handle relational concurrency yielded novel theoretical approaches, but these were generally ... amounts of concurrency led to the extinction of the HIV epidemic The final work [27] is the first to include a model in which both the partnership timing and networks and the biology are fully driven...

Ngày tải lên: 20/06/2014, 08:20

... from the same stand, which was selected according to the law on forest reproductive material The seeds were sown into a permeable pot of 2000 cm3 in size and the seedlings stayed there to the ... respectively)) and the dry mass of the main stem (DMshoot) at the end of the experiment, the dry mass of the main stem at the start of the experiment and after 50 days was estimated using the following ... the reduced light quantity On the one hand accelerated height growth is the most frequent response of light demanding species to a reduced R/FR-ratio [23, 45] On the other hand, in contrast to...

Ngày tải lên: 08/08/2014, 01:21

... attributed to wind-borne surfactants from the sea (Gellini et al, 1983, 1985) The present study seeks to assess the effect of natural and artificial exposure to ABS on the leaf waxes of oak species and ... abscission and destruction, and the collapse of the secreting heads of glandular hairs (fig 1A-D) Damage decreased in the following order: Q pubescens, Q frainetto, Q ilex and Q robur The same ... of the leaf waxes similar to that of the year before, but the relative tolerance among the species was unchanged In the culture ABS, pollen damaged trees than in the healthy-looking tree, and...

Ngày tải lên: 08/08/2014, 19:21

... TGF1 [29-32] The aim of the present study was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposus cells The study was designed to (1) analyze the effect of ... through G1 into S phase requires cyclin D-CDK4/6 and cyclin E-CDK2, which phosphorylate the retinoblastoma protein [26] CDK inhibitors (CKIs) are the negative regulators and are grouped into two families ... At the same time, these investigators suggested that TGF is a bifunctional regulator of cellular growth [19,20] Considering these findings, we hypothesized that the cells that show mitogenic response...

Ngày tải lên: 09/08/2014, 01:22

... related to the grape protein accession ACF21938 than to the other members of the subgroup (AtMYB30, 31, 94 and 96) On the other hand, the grape accession protein ABK59040 was closely related to AtMYB30 ... in the first intron and the third exon, which were longer in the grape genes compared to AtMYB60 Expression of VvMYB30 and VvMYB60 in grape tissues and in response to hormonal and stress factors ... AtMYB30 and AtMYB31 and to a lesser extent to AtMYB94 and AtMYB96 (Figure 1A) Hereafter, we will refer to ACF21938 and ABK59040 as VvMYB60 and VvMYB30, respectively Based on these results, we further...

Ngày tải lên: 11/08/2014, 11:21

... Acknowledgements The authors thank all the subjects and doctors for their cooperation in the study Authors’ contributions SA and MI conceived of the study participated in its design and coordination and gave ... treatment response Hepatology 2000, 31(6):1360-1370 Lo S, Lin HH: Variations within hepatitis C virus E2 protein and response to interferon treatment Virus Res 2001, 75(2):107-112 Saito T, Ito T, tto ... WJ, Changchien CS: Mutations in the NS5A and E2-PePHD region of hepatitis C virus type 1b and correlation with the response to combination therapy with interferon and ribavirin J Viral Hepat 2003,...

Ngày tải lên: 11/08/2014, 21:21

... powder and whipping cream was weighed (laboratory grade balance) and measured prior to the mixing of each drink The volume of water added to each drink (in order to bring the total volume to 350 ... Clearly, the population tested, as well as the type and quantity of macronutrient, may influence the postprandial insulin response with regards to both carbohydrate and lipid meals Related to testosterone, ... regards to the postprandial hormonal milieu, data are conflicting with regards to the hormonal response following the ingestion of carbohydrate- and lipid-rich food [4,10-17] Moreover, to our...

Ngày tải lên: 11/08/2014, 23:21

... children and newborns [21,22] To further analyse the specificity and significance of the antibody responses toward the two linear preS1 sequences that have been shown to represent human B cell epitopes ... whereas the N-terminal part is believed to play a major role in mediating virus attachment and entry into hepatocytes [3] Within the preS1 protein, the 21–47 amino acid epitope was shown to mediate ... enhanced response to HBsAg We found that recognition of several preS1 epitopes, and in particular, the epitope contained within the second half of the hepatocyte binding site localised in the hepatitis...

Ngày tải lên: 12/08/2014, 04:21

... tests The reproducibility of the exercise response in relation to the different NAEPPII scores is given in Table There was no relationship between the NAEPII score and the severity of the response ... before the first FEV was measured We excluded those who were symptomatic to the allergens to which they tested positive to a skin test at the time to reduce variability due to environmental factors ... fall FEV1 and AUC0-30 % fall FEV1 per on the two exercise challenges in relation to the average value for the two challenges in adults (a and b) and children (c and d) The interval defines the 95%...

Ngày tải lên: 12/08/2014, 11:22

... linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in Toronto and will be implemented ... fora, and other meetings The recommendations from those consultations – among others, to improve the quality of science, to broaden diversity, to facilitate cross-disciplinary linkages and dialogue, ... culture, language and resources, and to leverage the expertise and knowledge of its members in an effective, sustained global response If there is a lesson to be learned from our history with this...

Ngày tải lên: 13/08/2014, 09:20

... behavior, and reactive aggression [5] Thus, it is important to understand the implications for the individual as they get older and to evaluate medication effects with respect to age We therefore ... (e.g in the Achievement domain) In both age groups, correlations between the ADHD core symptoms and the HR-QoL were small to moderate at endpoint and with regard to the change from baseline There ... baseline to endpoint were small to moderate, suggesting that next to the effect of core symptoms, other factors might play a role in the background of the observed impairments in HR-QoL Further studies...

Ngày tải lên: 13/08/2014, 18:21

... signals There are two components to spectral   33   bleedthrough The first is the direct excitation of the acceptor at the wavelength used to excite the donor (acceptor cross talk) The second is the ... inactive state the autoinhibitor phosphorylation site (Y527) in the Cterminal tail is phosphorylated (Cooper et al., 1986) and the SH2, SH3, and SH1 domains bind to one another to form an autoinhibited ... anabolic bone gene expression Taken together, these data support the hypothesis that “STOP” mechanosomes exist and their activity is simulated in response to fluid shear stress Fredrick M Pavalko,...

Ngày tải lên: 24/08/2014, 11:45

... while other students form teams to brainstorm character traits and motivations for the main characters in the story they are reading that week Data from the various screening and progress monitoring ... monitored regularly using progress monitoring measures to assess whether the program is on course and to determine whether a team of professionals needs to refine the instructional program to ... skills to decrease as they begin to understand letter-sound correspondence In other words, by the time students were post-tested their understanding of the relationship between letters and the sounds...

Ngày tải lên: 27/08/2016, 13:26

... lot of money You have to buy the land You have to pay for the original breeding stock and later you’ll have to pay large stud fees There’s no way you could ever it.” Then the teacher added, “If ... that the owner was servic42 The Value-Play Strategy ing the washers and dryers himself He repaired the machines when they broke down, collected the money from them, and had to deal with the tenants ... maintained them as rentals, but over the past three years had begun selling them off to the individuals who lived in them, or to other investors who rented them out Of his original inventory of...

Ngày tải lên: 07/11/2013, 14:15

... completely from the process Your role is to manage the managers by defining your objectives for the property You provide the leadership, and then get out of the way and let them their jobs Do not ... marketplace There are four crucial factors to consider: The resources available to work with The size of the property The age of the property Your holding period It goes without saying that there is ... developers and builders begin a project, they will perform a feasibility study to determine whether the project makes sense They will estimate all of the costs that go into the project, examine the...

Ngày tải lên: 07/11/2013, 14:15

... Because the law gives creditors the right to force the sale of the assets of the business to meet their claims, your equity is considered to be subordinate to the debt In the event a company declares ... through the use of ratios to the owner’s equity or to the total assets, returns can be calculated and used to assess the company’s level of profitability relative to similar businesses The balance ... was set to zero The next section of the model is Operating Revenues The model reads the Gross Monthly Revenues value from the Cost and Revenues section and 133 THE COMPLETE GUIDE TO BUYING AND SELLING...

Ngày tải lên: 14/12/2013, 19:15

... things to the broker that you would never say 176 Negotiation Strategies and the Due Diligence Process to the seller, and the seller can say things to the broker that the seller should never say to ... with the seller A meeting with both the broker and the seller at the property site for a general tour can be very revealing to the astute investor who is attuned to the seller’s needs Does the ... packaged together and sold to investors who seek to maintain a specific yield or return on their capital Because the loans are pooled together, it is very difficult to pay off a single loan out of the...

Ngày tải lên: 14/12/2013, 19:15