... with glycine alone was performed and no binding was observed. In our hands, as others [54], the most reproducible data was obtained from injections of the metal into a solution of the protein. Typically ... research is that understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders. Experimental ... high affinity copper binding protein, and (b) that amyloid fibril formation of this protein is diminished in presence of Cu 2+ ions. Another interesting finding is that copper binding gets less strong...
Ngày tải lên: 19/02/2014, 06:20
Impact of chronic disease on quality of life among the elderly in the state of São Paulo, Brazil: a population-based study pptx
... nº 88/14099 and the São Paulo State Secretary of Health for financing the fieldwork; to the Secre- tary of Health Surveillance of the Minis- try of Health for financial support in the data analysis ... ISA-SP: the cities of Botucatu and Campinas; an area encompassing the cities of Itapecerica da Serra, Embu, and Taboão da Serra; and the District of Bu- tantã, in the city of São Paulo (13). The state ... up. The total scores for each of the eight scales were then converted to points from 0 to 100, with 0 denoting the worst state of health and 100 denoting the best (10, 11). The following were the...
Ngày tải lên: 05/03/2014, 21:20
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For active n-Src in which the C-tail tyrosine was ... demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and ⁄ or binding of the SH2 kinase linker to the SH3 ... studies of inactive and active Src, the SH2 and SH3 domains are believed to form a ‘regulatory apparatus’. Binding of the phos- phorylated C-terminus to the SH2 domain and ⁄ or binding of the SH2-kinase...
Ngày tải lên: 06/03/2014, 01:20
AN ACCOUNT OF TIMBUCTOO AND HOUSA, TERRITORIES IN THE INTERIOR OF Africa docx
... unanimous, and if no person of the royal line be the object of their choice, they may elect one of their own body. The members of the council are appointed by the king; he chooses them for their ... Great Britain to attend to the Intercourse with Africa Danger of the French colonizing Senegal, and supplanting us, and thereby depreciating the Value of our West-India Islands. Interest of Money237 ... Description of the Country and Produce Dangerous Defile in the Mountains through which the Author passed Chasm in the Mountain Security of Suse from Marocco, originating in the narrow Defile in the...
Ngày tải lên: 06/03/2014, 03:21
Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... of RNase-A in the presence of these amino acids and amino acid derivatives, and values of DG D °, measured in triplicate, are given in Table 1. The effect of polyols on the kinetic parameters (K m and ... advances in understanding the effect of osmolytes on protein stability, folding and the activity of proteins and enzymes, the relationship between protein stabilization by osmolytes and its con- sequent ... values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl- glycine have not been published elsewhere. We have therefore measured the thermodynamic parameters of RNase-A...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e. inhibiting ... possibly increased. In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, this was directly measured using [ 32 P]ATP in the absence of Ca 2ỵ (Fig. ... 3A) and ATP (Fig. 3B) in the absence and presence of curcumin, using the coupled enzyme assay. In Fig. 3A, the half-maximal activation of the ATPase by Ca 2ỵ was measured in the absence of and in the...
Ngày tải lên: 08/03/2014, 23:20
corporate social responsibility strategies for sustainable development for small and medium enterprises in the village of bac ninh province, vietnam
... represents a unique Kinh Bac region (Northern of Vietnam). The businesses in the village have been promoting their intellectual inheritance of the essence of his father left, forming the well-known ... replace the above product set small and medium enterprises interested in maintaining and promoting the expansion of products of wood handicrafts, wood industry, paper, writing paper, packaging, ... maintain the traditional products in the marketplace. - To maintain the prestige of the business to the customer. - To develop business through marketing on strong market - Protect the investment...
Ngày tải lên: 13/03/2014, 14:20
Postal Savings and the Provision of Financial Services: Policy Issues and Asian Experiences in the Use of the Postal Infrastructure for Savings Mobilization pdf
... however, and in India the Ministry of Finance estimates that the overall cost of tax incentives amounts to 16 per cent of the value of the funds collected under the programme. In China, any number of ... Provision of Financial Services 19 Claims relating to the use of home Internet and telephone banking services in place of postal counter services in Finland and other countries invite further scrutiny. ... network. In 1987, in addition to the post offices, it had 50 branch offices in 33 cities and towns, 13 of them in the Helsinki area alone. Following Finland’s commercial banking crisis in the early...
Ngày tải lên: 15/03/2014, 09:20
Surfing the waves of globalization - Asia and financial lobalization in the context of the trilemma
... ĐẠI HỌC KINH TẾ TP HCM KHOA SAU ĐẠI HỌC TIỂU LUẬN TÀI CHÍNH QUỐC TẾ ĐỀ TÀI: SURFING THE WAVES OF GLOBALIZATION: ASIA AND FINANCIAL LOBALIZATION IN THE CONTEXT OF THE TRILEMMA ... đặc sắc nhất được minh chứng bằng kinh nghiệm của các nền kinh tế euro. Mặt khác, nền kinh tế thị trường mới nổi xuất hiện hội tụ theo hướng giữa cái hiện đang áp dụng với sự linh hoạt quản lý ... Diamond cho nền kinh tế tư nhân ( B ) nền kinh tế châu á ( C) nến kinh tá châu mỹ la tinh ( d) khác. Mặc dầu các dự án được tóm tắt trong bảng 5 thì không khớp với thực tế cảu nền kinh tế tư nhân,...
Ngày tải lên: 15/03/2014, 11:21
Water pollution and habitat degradation in the Gulf of Thailand ppt
... Jringjit, K., 1987a. Heavy metals in seawater and sediments of the eastern coast of the Inner Gulf of Thailand. In: Proceedings the 5th Seminar on Research in Water Quality and Quality of Living ... 1984. Total mercury in bivalves of the east coast of the inner Gulf of Thailand. In: Proceedings the 3rd Seminar on Research in Water Quality and Quality of Living Resources in Thai Waters, 26–28 ... is evident that the increasingly deteriorating conditions in the marine environment of the inner Gulf of Thailand have threatened the existence of several economically important organisms in the area....
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice doc
... molar extinction coefficient of the protein, and thus the increase in absorbance in the aromatic region. Shortly thereafter, a gradual unfolding of the protein occurs that results in the increase of ... con- stant, and the spectra were taken in several time intervals (indicated on the right). (D) FTIR spectrum of CD69 protein in the region of the amide I and II bands (the full line). The dash–dot line ... After the initial dilution caused by binding and retaining in the tissues, the blood level of these proteins stabilized within 4 h, and then remained nearly unchanged for up to 24 h after injection...
Ngày tải lên: 16/03/2014, 04:20
Making the Poor Pay for Public Goods via Microfinance Economic and Political Pitfalls in the Case of Water and Sanitation docx
... causes bone and joint disease (expert interview, 25 May 2010), and the other lies in the driest region of southern India, which has been highly rain-deficient in recent years. Especially in the smaller ... role of the state in the 2000s has coincided with the rising acknowl- edgement of water and sanitation as unconditional entitlements, placing the onus on governments and international institutions ... decades; the estimated population of the Hyderabad 15 The names and identity markers of the organisations and people involved have been left out since some of the involved parties prefer to remain...
Ngày tải lên: 16/03/2014, 09:20
Consumer market study on the functioning of e-commerce and Internet marketing and selling techniques in the retail of goods potx
... online and offline; ã Chapter 3 presents the use and the functioning of price comparison websites; ã Chapter 4 provides findings of a comparison of online and offline price levels and pricing ... S hopping process online and offline In order to assess the entire shopping process as a whole and the impact of e-commerce on the retail market as a whole (including online and offline purchases), ... study on the functioning of e-commerce and Internet marketing and selling techniques in the retail of goods Civic Consulting The online shoppers in this survey were asked whether they also...
Ngày tải lên: 23/03/2014, 08:21
Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS-1, PTS-2 and I-PTS proteins to the glycosome. To further analyse the effect of the destruction ... the peroxin PEX14 is a component of a docking complex at the peroxisomal membrane, where it is involved in the import of matrix proteins into the organelle after their synthesis in the cytosol and ... a binding constant K d of 2.75 l M , and that the amino-terminal domains of the two peroxins were respon- sible for this interaction. The role of TbPEX14 in glycosome biogenesis received further...
Ngày tải lên: 23/03/2014, 17:21
Báo cáo khoa học: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth* potx
... neurotrans- mitter in the insect CNS [1], and octopaminergic neurons [31] and several octopamine receptors [2,32] have been identified in the fly and other insects. At the cellular level, TrnDAT and TrnOAT ... dopamine- selective transporter is found. Keywords: insect; neurotransmitter; transporter; dopamine; octopamine; cocaine. The catecholamine dopamine (DA), the phenolamine octopamine (OA) and the indolamine ... does the moth OAT substitute for DAT in dopami- nergic signaling pathways in the moth CNS, and what is the nature of the mechanism that substitutes for OAT in the octopaminergic pathways in the...
Ngày tải lên: 23/03/2014, 20:22
towards a just monetary system a discussion of money, banking and monetary policy in the light of islamic teachings
Ngày tải lên: 31/05/2014, 01:31
bodies of difference experiences of disability and institutional advocacy in the making of modern china
Ngày tải lên: 01/06/2014, 01:00
byrn - 1852 - the complete practical brewer or, plain accurate , and thorough instructions in the brewing of ale, beer, and porter
Ngày tải lên: 12/06/2014, 11:32
byrn - 1860 - the complete practical brewer or, plain accurate , and thorough instructions in the brewing of ale, beer, and porter
Ngày tải lên: 12/06/2014, 11:32