tcns enhance anti inflammatory effects of theophylline

... effects of theophylline were significantly enhanced when the drug was delivered by TCNs. Conclusion: Intranasal delivery of theophylline complexed with TCNs augmented the anti- inflammatory effects ... thiolation enhances the capacity of chitosan nanoparticles to effectively deliver theophylline to bronchial epithelium. It is likely that the enhanced anti- inflammatory effects of theophylline ... anti- inflammatory effects of theophylline were markedly enhanced when the drug was delivered by TCNs compared to unmodified chitosan or theophylline alone. The increased mucoadhesiveness of TCNs...

Ngày tải lên: 12/08/2014, 16:20

... http://www.translational-medicine.com/content/9/1/129 Page 4 of 10 in the macrophage infiltration of WAT and an improve- ment of the inflammatory profile of gene expression. The cholinergic anti- inflammatory pathway has been ... induction of lethal peritonitis in mice indicating that the cholinergic anti- inflammatory pathway can modulate theinflammatoryresponseeveninestablishedsepsis [26]. The cholinergic anti- inflammatory ... a7nAChR is essential in mediating the anti- inflammatory effect of ACh [16]. The cholinergic anti- inflammatory pathway is a brain- to-immune mechanism that regulates inflammatory responses via a7-nAChR-dependent,...

Ngày tải lên: 18/06/2014, 22:20

... http://www.translational-medicine.com/content/9/1/129 Page 4 of 10 in the macrophage infiltration of WAT and an improve- ment of the inflammatory profile of gene expression. The cholinergic anti- inflammatory pathway has been ... induction of lethal peritonitis in mice indicating that the cholinergic anti- inflammatory pathway can modulate theinflammatoryresponseeveninestablishedsepsis [26]. The cholinergic anti- inflammatory ... a7nAChR is essential in mediating the anti- inflammatory effect of ACh [16]. The cholinergic anti- inflammatory pathway is a brain- to-immune mechanism that regulates inflammatory responses via a7-nAChR-dependent,...

Ngày tải lên: 20/06/2014, 04:20

... of 10 (page number not for citation purposes) Journal of Inflammation Open Access Research Anti- inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of ... period of 3 days prior to dona- tion. Informed consent was obtained from all partici- pants. Topical anti- inflammatory activity Topical anti- inflammatory activity of the extracts and frac- tions of ... mental model of acute inflammation which allows evalu- ating the anti- inflammatory properties of extracts, fractions and pure compounds, as well studying the pres- ence of several anti- inflammatory...

Ngày tải lên: 11/08/2014, 08:22

... chronic, allergic inflammatory skin disorder, and we investigated both the anti- allergic and anti- inflammatory effects of ALBE We examined the anti- allergic effects by checking the release of b-hexosaminidase ... butanol extract of A lappa (ALBE) had previously unreported antiallergic or anti- inflammatory effects Methods: This study examined the effect of ALBE on the release of b-hexosaminidase in antigen-stimulated-RBL2H3 ... phosphorylation of MAPKs, which are activated during inflammation, in ConA-treated primary murine splenocytes to validate the anti- inflammatory effects of ALBE Methods Preparation of extract Roots of Arctium...

Ngày tải lên: 13/08/2014, 13:22

... coordinated and sustained activation of inflammatory cells including mast cells, T-helper cells, B cells, macrophages and eosinophils, and synthesis of a variety of proinflammatory mediators (Maddox ... Wong WSF Effects of mitogenactivated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro Brit J Pharmacol 1998;125:61 Tsang F, Wong WSF Inhibitors of tyrosine ... in immunopharmacology of asthma Biochem Pharmacol 2000;59:1323 166 Wong WSF, Koh DSK, Koh AHM, Ting WL, Wong PTH Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in...

Ngày tải lên: 15/09/2015, 22:09

... no studies on the effects of the intervention of these signaling pathways in animal models of asthma The purpose of my thesis was to investigate the antiinflammatory effects of genistein, a broad-spectrum ... 5.5A-D, I 97 Effects of U0126 on lung tissue eosinophilia 99 ix 5.5E-H, J Effects of U0126 on mucus production 100 5.6 Effects of U0126 on cytokine levels in BAL fluid 101 5.7 Effects of U0126 on ... ANTI- INFLAMMATORY EFFECTS OF INHIBITORS OF THE TYROSINE KINASE SIGNALING CASCADE IN ANIMAL MODELS OF ASTHMA Duan Wei (B.Med.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 16/09/2015, 17:11

... anti- inflammatory effects of VY ethanol extract (VYE) on macrophages and attempted to identify the bioactive components of VYE Methods: We assessed the effects of VYE on secretion of nitric oxide (NO) and inflammatory ... revealed to exert anti- inflammatory effects through decrease the expression of pro -inflammatory mediators including NO, PGE2 and cytokines [19, 20] Thus, enhanced the production of HO-1 expression ... anti- coagulant activities, and protective effects against LPS-induced acute lung injury in mice [2–4] However, the detailed molecular mechanism of the antiinflammatory effects of VY is not well-characterized...

Ngày tải lên: 19/11/2022, 11:37

... other species and its antinociceptive and anti- inflammatory activities have been already demonstrated [24-28] It is accepted that the anti- inflammatory property of lupeol often accompany its immune ... Federal University of Ceará, Brazil 2Department of Pharmacy, Federal University of Ceará, Brazil Department of Morphology, Federal University of Ceará, Brazil 4Faculty of Medicine of Juazeiro Norte, ... V: Anti- inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models J Ethnopharmacol 2005, 98:267-273 Ferrándiz ML, Alcaraz MJ: Anti- inflammatory...

Ngày tải lên: 11/08/2014, 03:20

... ties of antibiotics used in sepsis treatment through their anti- PAF or anti- thrombin activities. This is the first study to report the anti- inflammatory and anti- thrombo- tic activities of a ... bring in surface putative anti- inflammatory and anti- thrombotic activities of some antibiotics used in sepsis, through their in vitro studied anti- PAF and anti- thrombin effects in rabbit platelets. ... order of magnitude lower than those of all the other antibiotics, with the exception of that of amikacin in the case of Lyso-PAF-AT inhibition, which in turn was also much lower than those of all...

Ngày tải lên: 11/08/2014, 03:20

... ties of antibiotics used in sepsis treatment through their anti- PAF or anti- thrombin activities. This is the first study to report the anti- inflammatory and anti- thrombo- tic activities of a ... bring in surface putative anti- inflammatory and anti- thrombotic activities of some antibiotics used in sepsis, through their in vitro studied anti- PAF and anti- thrombin effects in rabbit platelets. ... order of magnitude lower than those of all the other antibiotics, with the exception of that of amikacin in the case of Lyso-PAF-AT inhibition, which in turn was also much lower than those of all...

Ngày tải lên: 11/08/2014, 06:23

... nsPEFs have a duration of 60–300 ns, with a rise time of 4–30 ns18–21 Owing to its Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and ... upregulation of the proapoptotic factor Bax and downregulation of the anti- apoptotic factor Bcl-2 Everolimus and nsPEFs synergistically inhibited angiogenesis by decreasing the expression of vascular ... However, a phase II trial of single-agent everolimus for the treatment of advanced melanoma failed, with a disease control rate of 29% and a progression-free survival (PFS) of months15 Everolimus...

Ngày tải lên: 04/12/2022, 15:31

... anti- inflammatory action of statins in RA The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal attack complex has the potential to exert antiinflammatory ... clinically Page of 12 (page number not for citation purposes) apparent anti- inflammatory effects of statins in rodent models of inflammatory arthritis and in one model in patients with RA [23-26] ... conditions (Figure 7a) The use of C5-deficient serum prevented the generation of the C5b-9 MAC, therefore facilitating investigation of the effects of DAF Treatment of HUVEC Available online http://arthritis-research.com/content/8/4/R130...

Ngày tải lên: 09/08/2014, 08:22

... increased expression of A3AR, rendering inflammatory cells more susceptible to CF101 Combined treatment of AIA rats with MTX and CF101 enhanced the anti- inflammatory effect of each drug In addition, ... the anti- inflammatory effect of MTX is attributed more to adenosine than to tetrahydrolate MTX increases the extracellular concentration of adenosine, where it is known to exert its antiinflammatory ... that the anti- inflammatory effect of MTX is due to adenosine, which is known to exert potent anti- inflammatory effect [3,4] More specifically, MTX polyglutamates inhibit the activity of the enzyme...

Ngày tải lên: 09/08/2014, 08:23

... receptor (PPAR)-γ agonists with potent anti- diabetic properties and potential antiinflammatory effects We compared the ability of a range of oral doses of these thiazolidinediones, including ... entered the clinics [14,18] and to the suppression of the release of cytokines, resulting in antiinflammatory effects [19] The anti- arthritic potency of PPAR agonists has been demonstrated only rarely ... control of inflammation [13,14] PPAR-β/δ is expressed ubiquitously and takes part in the reverse transport of cholesterol and the oxidation of fatty acids [15] It has profound anti- obesity and anti- diabetic...

Ngày tải lên: 09/08/2014, 10:22

... a strong anti- inflammatory effect compa- rable to hydrocortisone when examined in the ACD model. The anti- inflammatory effects of consumption of MPM occur without the undesirable side effects ... bition of development of inflammation following an inflammatory stimulus. The anti- inflammatory potential of MPM has been con- firmed in these studies with the murine ACD model. This model of inflammation ... also exhibit anti- inflammatory properties when placed in the context of inflammation. The objective of this present study was to evaluate the sys- temic anti- inflammatory potential of MPM and...

Ngày tải lên: 11/08/2014, 08:21

... expression of IL-4, an anti- inflammatory cytokine which induces apoptosis of neutrophils and macrophages, and downregulates the effects of IL-1,... be involved in the anti- inflammatory ... are anti- inflammato ry. Nanocrystalline silver-derived solutions show promise for a variety of anti- inflammatory treatment applications. * Correspondence: rburrell@ualberta.ca 1 Department of ... nanocrystalline silver has anti- inflam- matory activity independent of its antimicrobial activity in a porcine model of contact dermatitis[6]. Visual and histological signs of inflammation were reduced,...

Ngày tải lên: 11/08/2014, 08:22

... therapeutic effects of antidepressants could be at least partly exerted by attenuating brain expression or action of inflammatory cytokines [3,4]. In this line, administration of the tricyclic antidepressant ... molecules could become prototypes for new anti- inflammatory drugs. Molecular targets of antidepressants The few previous reports investigating the effects of anti- depressants on AP-1 and NF-κB were ... vitro assays, antidepressants produced antiin- flammatory effects in the complete absence of glucocorti- coid. Moreover, A549 cells do not express P-glycoprotein [29]. The effects of antidepressants...

Ngày tải lên: 12/08/2014, 15:20

... -prostaglandin J 2 (15ΔPGJ 2 ), anti- COX-2 polyclonal antiserum and anti- mPGES-1 antibodies were from Cayman Chemical (Ann Arbor, MI, USA). Anti- IL-6, anti- IL-8 and anti- actin antibo- dies were purchased ... some anti- inflammatory action of the thermal mud was described also in patients by monitoring the level of inflammatory cytokines in their serum [10], but studies on a possible specific anti- inflammatory ... activities, including anti- viral [3], anti- tumor and anti- proliferative activity [4,5], this class of compounds revealed an anti- inflammatory activity in vitro by inhi- biting the generation of a superoxide...

Ngày tải lên: 12/08/2014, 17:21

... Besides being anti- neoplastic, HDAC inhibitors are promising antiinflammatory... mechanisms of action of HDAC inhibitors Inhibition of RASF proliferation, suppression of proinflammatory ... of HDAC inhibitors on VEGF inhibition in E11 cells 147 7.2 HDAC inhibitors totally abrogated VEGF-induced... effects of HDAC inhibitors 44 2.1 Possible anti- inflammatory and anti- ... their anti- rheumatic mechanisms of action are not well elucidated The work that was carried out for this thesis aimed to elucidate the anti- inflammatory and anti- rheumatic... values of...

Ngày tải lên: 11/09/2015, 09:16