targeting viral antigens for the treatment of cancer

... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of cancer, ... altering the rate of internalization of the receptor or influencing the intracellular trafficking The proteome of the target cell also influences the pathway We have observed large differences in the...

Ngày tải lên: 22/03/2014, 15:21

... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... beyond the confines of the lymph nodes to other parts of the body, is generally defined as stage IV of the American Joint Committee on Cancer (AJCC) tumour node metastases (TNM) system or stage D of ... represents 12% of all new cancer cases in women and 14% of all new cancer cases in men The incidence of colorectal cancer increases with age In people between the ages of 45 and 49 years the incidence...

Ngày tải lên: 14/02/2014, 22:20

... Board of Directors of the AUA Funding of the Panel and of the PGC was provided by the AUA, although Panel members received no remuneration for their work Each member of the PGC and of the Panel ... Cryosurgery for the Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized ... addressed Placement of a thermosensor to monitor the temperature of the external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal...

Ngày tải lên: 28/03/2014, 23:20

... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account for the vast majority of tumorassociated host hematopoietic cells, thus the majority of the ... against murine antigens, and therefore not directly translatable to humans The therapeutic effect seen with anti-CD52 therapy of ovarian tumors in mice is consistent with the aforementioned murine...

Ngày tải lên: 18/06/2014, 15:20

... demonstrated by further clinical study Additional studies appear warranted for the use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in the treatment of late stage prostate cancer Acknowledgements ... seen before treatment once treatment ended (Fig 1a and 1b) Thirteen of the 17 patients had a successful outcome; a decrease in PSAV and a lengthening of PSDT (Table 2) The probability of 13/17 ... compensate for their elevated BMI values Both patients subsequently became “responders” In addition, 15 of 17 patients opted to continue Apatone therapy following the 12 week trial The PSA values of these...

Ngày tải lên: 08/08/2014, 17:20

... guidelines for the screening and selection of patients for Page of 10 APBI [22,23], and these guidelines formed the basis for patient selection in the EBT multicenter study [20] Of the 65 patients ... during the 5-day treatment period Patient compliance with the treatment regimen was excellent Patients expressed satisfaction with the conduct of the study as well as the delivery of the radiotherapy ... maintain the distance from the balloon to the skin surface The greater the volume of the balloon, with the attendant compression of adjacent breast tissue, the more fully the target breast tissue...

Ngày tải lên: 09/08/2014, 01:24

... date of diagnosis of metastases was 3.4 years the median survival time from the start of TACE treatment was 1.34 years The median survival time of the palliative group was 1.4 years, of the symptomatic ... device to be safe in the treatment of metastatic colorectal cancer[ 14] The goals of this analysis was to: 1) gain a better understanding of the value of drug eluting bead therapy when administered ... toxicity, and, if the data allowed, the response to therapy Follow-up assessments included a tri-phase CT scan of the liver within at least one to two months from the treatment Evaluation of the enhancement...

Ngày tải lên: 09/08/2014, 04:21

... tomotherapy for locally advanced pancreatic cancer [35] To the best of our knowledge, this is first comprehensive analysis of the clinical application of helical tomotherapy for a group of inoperable ... prematurely stopping radiotherapy There was no direct treatment- related grade 3/4 toxicity or death Therefore helical tomotherapy is a safe option in the treatment of advanced pancreatic cancer This study ... lung), the metastatic lesions were also targeted as another PTV The distribution of isodoses in the helical tomotherpy treatment planning is shown in Figure The dose and volume constraints for the...

Ngày tải lên: 09/08/2014, 09:20

... clinical trial of vaginal EBT for the treatment of endometrial cancer EBT treatment was delivered successfully for all 48 fractions of treatment in this study The EBT device performed as expected ... given the option of treating with an EBT prescription dose of 6.0 Gy x to the vaginal surface or 8.0 Gy x to the vaginal surface Treatment planning was performed according to the standard of care ... Rotmensch J, Wazer DE: A dosimetric comparison of xoft axxent electronic brachytherapy and Ir192 hdr brachytherapy in the treatment of endometrial cancer Brachytherapy 2008, 7(4):351-4 Rivard MJ, Davis...

Ngày tải lên: 09/08/2014, 09:20

... digital photo, illustrating the method of immobilization of the treatment area and a simulation of the set-up of the system prior to the first fraction, was taken A typical treatment area definition ... responsible for the development of the protocol and case report form; recording of the clinical data from the patient records; analysis of the data; and writing, final review, and approval of this ... radiation of epithelial skin cancer Int J Radiat Oncol Biol Phys 1990, 19:235-242 Silva JJ, Tsang RW, Panzarella P, Levin W, Wells W: Results of radiotherapy for epithelial skin cancer of the pinna: the...

Ngày tải lên: 09/08/2014, 09:20

... to the cytoplasmic domain of the receptor [10] Subsequently, TRAF6 interacts with UBC13/UEV1A, a heterodimer that catalyzes the synthesis of polyubiquitin chains assembled through linkage of the ... interferes more strongly with NF-κB signaling Therefore, the proteasome is likely a better target for anti-NF-κB intervention than the IKK cascade for treatment of septic shock Clinically, our findings ... including the NF-κB pathway Interestingly, many of the genes in these pathways are regulated by the proteasome [18] Therefore, combined with our results, this may also help explain why targeting...

Ngày tải lên: 13/08/2014, 16:21

... around the world to search for new therapeutic options [5]; one of these options involves the use of Dendritic Cell (DCs) immunotherapy Clinical trails based on DCs have been conducted for the treatment ... one-third of these patients progress to incurable metastatic disease, for which there are few treatment options The chemotherapy currently used has limited efficacy [3,4] This lack of treatment ... molecules should be used instead of small peptides because of the diversity of the HLA molecules found in these populations Furthermore, vaccines for at least the first two doses should be prepared...

Ngày tải lên: 14/08/2014, 19:22

... analogues 115 4.15 Methology suitable for the radiosynthesis of the E isomer of CA-1 121 4.16 Radiosynthesis of the E isomer of CA-1 123 4.17 Scale-up synthesis of OXi8007 124 4.18 Proposed nitrogen ... among the most important of which is the formation of the mitotic spindle, involved in the alignment of replicated chromosomes to the equatorial plane to promote further segregation of the chromosomes ... targets for cancer therapy are identified, and several drugs enter clinical trials, the emergence of resistance to targeted cancer therapeutics, the different toxicity profiles, the efficacy and the...

Ngày tải lên: 14/11/2014, 11:32

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...

Ngày tải lên: 26/10/2012, 09:32

... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results of the study All twelve patients (10 males, females) completed the surgery without...

Ngày tải lên: 26/10/2012, 09:57

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...

Ngày tải lên: 05/09/2013, 09:38

... with the increased HRT of the adsorption tank From an engineering application point of view, the appropriate operational parameters of the recycle ratio, HRT of the regeneration tank, HRT of the ... in the PO43 P removal These results revealed that the selection of the operational parameters of the CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated The removal efficiency...

Ngày tải lên: 05/09/2013, 09:38

... reported on the efficacy and/or effectiveness of hydroxyurea treatment of hematologic diseases, the toxicity of hydroxyurea in the treatment of any disease, and the barriers to the treatment of sickle ... reviewer reconciled the results of the first two reviewers in the case of the randomized trials 29 For the other study designs, the results of the two reviewers were averaged The quality assessment ... reliability of the instruments used A pair of reviewers each performed the quality assessment independently In the case of the RCTs, a third reviewer reconciled the results of the first two reviewers; for...

Ngày tải lên: 05/03/2014, 10:20

... (COX) In these enzymes, the redox potential of the metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential of the metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...

Ngày tải lên: 07/03/2014, 10:20

... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy for SUI Some ... effective for the treatment of SUI The other studies in the review were considered for the generalisability of their findings to clinical practice by identifying the patient populations from which the...

Ngày tải lên: 28/03/2014, 14:20