targeting argininosuccinate synthetase in cancer therapy

... these agents The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination, will better define their activity in cancer Competing interests RY, AK, WJB, and DL ... weekly) in patients with MBC showed that continuous daily administration produced greater tumor shrinkage [55] In 2006, a phase III trial evaluating temsirolimus in combination with endocrine therapy ... patients [52,53] mTOR inhibitors have shown clinical activity in patients with advanced breast cancer [54,55] and are being actively investigated in this setting in combination with other agents...

Ngày tải lên: 10/08/2014, 22:20

... resistance in transfection studies 43 191 ABCC2 Thiopurines ABCC1 Kinase inhibitors Camptothecins ABCB1 Epipodophyllotoxins Taxanes ABCC1 43,196 10,131 Vinblastine 10 43,194 Vincristine 10 43,194 ... failure in adult AML59,60 Although compelling data exist indicating an important role for Pgp in determining efficacy of chemotherapy, the relevance of the other ABC transporters in clinical MDR ... Phase I and II clinical trials began to test the clinical potential of Pgp inhibitors Initial trials used ‘first-generation’ Pgp inhibitors, including verapamil, quinine and cyclosporine (also known...

Ngày tải lên: 15/03/2014, 01:20

... thestateofcurrentknowledgeandlatestresearchfindingsintheareaofcancertherapy. For this purpose research articles, clinical investigations and review papers that are thoughttoimprovethereadersunderstandingofcancertherapydevelopmentsand/or ... like, for example, delineating the killing mechanisms of MCC 18 Advances in Cancer Therapy These conflicting reports might indicate that there seem to be other factors determining the relationship ... marks cargo proteins for endosomal sorting Monoubiquitination appears to mark cargo proteins for protein sorting within the MVBs In yeast, recruitment of ubiquitinated cargo proteins depends on...

Ngày tải lên: 27/06/2014, 17:20

... hIL-12: Human interleukin-12; IL-3: Interleukin-3; IL-4: Interleukin-4; IL4-PE: Interleukin-4Pseudomonas exotoxin; Mab: Monoclonal antibody; mIL-12: Murine interleukin 12; mGM-CSF: Murine granulocyte-macrophage-colony ... modified or recombinant toxins This is achieved by deleting the DNA coding for the toxin binding region and replacing it with various complementary DNA encoding other cellbinding proteins has been ... these toxins need to be targeted to specific sites on the surface of cancer cells This process is accomplished by eliminating binding to toxin receptors by conjugating the toxins to cell-binding proteins...

Ngày tải lên: 10/08/2014, 05:21

... regulator Mdm2 This inhibitor binds selectively to the pocket of Mdm2, resulting in increased p53 levels Nutlin was an effective inhibitor in cell lines and in mice with various types of cancer and was ... an antagonistic interaction Arul Chinnaiyan (University of Michigan, Ann Arbor, USA) presented data characterizing gene fusions in prostate cancer, including his group’s original discovery of ... used for genome-wide mapping using ChIP-chip By correlating the binding profiles of all NRs, they found profile similarities and common binding sites between ER and retinoic acid receptor α; they...

Ngày tải lên: 14/08/2014, 21:20

... S, Kung HJ, Bold RJ: Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase Int J Cancer 2008, 123:1950-1955 doi:10.1186/1423-0127-18-25 ... Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma Drug Target Insights 2007, 2:119-128 17 Lamb J, Wheatley DN: Single amino acid (arginine) deprivation induces ... JH, Park IS, Yoon DK, Min BH: Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase Int J Cancer 2007, 120:897-905...

Ngày tải lên: 10/08/2014, 05:21

... molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed ... key roles in cancer progression However, in most cases, the agents targeting MMPs exhibited poor performance in clinical trials, in contrast to their promising activity in many preclinical models...

Ngày tải lên: 15/03/2014, 00:20

... cancer and independently associated with the increased risk of colorectal cancer in men [14], and overall cancer risk [15] Interleukin-6 (IL-6) has been used for the diagnosis of colorectal cancer ... understanding of this repeating immune cycle might be able to assist the clinician by pinpointing recurring opportunities to selectively enhance Teffectors and/or deplete or inhibit T-reg cells, in ... this in clinical practice at present, we are currently actively exploring some of these exciting avenues of investigation Chemotherapy We have investigated this hypothesis further by examining...

Ngày tải lên: 18/06/2014, 15:20

... dissolved within the NCs' oily core and the PLA shell The drug/polymer interaction has been indeed thermodynamically explained using the Flory-Huggins interaction parameters Doc release kinetic data ... nanocapsules; drug loading Background In cancer therapy, most of the proposed formulations present certain drawbacks related to the formulation properties including low drug loading, toxicity, and unsuitable ... particles and high drug loading with sustained-release characteristics This allows releasing the drug in the target site in its therapeutic concentration and preventing drug inefficiency and side effect...

Ngày tải lên: 18/06/2014, 22:20

... unknown 29-kD amino-terminal and 40-kD carboxy-terminal heparin-binding fragments inhibit EC proliferation Carboxy-terminal hemopexin-like domain of matrix metalloproteinase-2 inhibits EC proliferation ... carboxy-terminal noncollagenous domain of Type XV collagen; 60% homology to murine endostatin Amino-terminal fragment of calreticulin; inhibits EC proliferation and tumor growth in mice Interleukins ... cytokine 8-kD CXC chemokine; inhibits tumor growth in mice 8.6-kD CXC chemokine induced by IFN-γ 42-kD serine protease inhibitor (serpin); inhibits EC migration and tumor growth and vascularity in...

Ngày tải lên: 06/08/2014, 19:21

... patients With ongoing practice some 'rules' evolved, breaking some former "taboos" in radiotherapy of lung cancer: Minimizing the dose to the ipsilateral (i.e tumor bearing) lung In many cases the ... range of up to 10% within a zone of less than ± mm can be neglected Although this error might be increased in principal by connecting two opposing beams (knowing that the machine's isocenter is a ... sparing of the lung while maintaining good sparing of myelon and esophagus, This series is treated to 63,0 Gy; after 45 Gy the elective nodes of the upper mediastinum are withdrawn by setting...

Ngày tải lên: 09/08/2014, 10:20

... following LA administration; supports the overall feasibility of using LA as a dietary supplement [3] In recent years, LA has gained considerable attention in the cancer field as an anticancer ... growth inhibition assay Human HL-60 cells were obtained from American Tissue Culture Collection (Manassas, VA) and maintained in RPMI 1640 supplemented with penicillin, streptomycin and 10% heat inactivated ... nucleus and promoting the caspase-independent induction of apoptosis chrome c in the activation caspase-independent apoptosis, as involving the nucleus accumulation of cytochrome c instead of a more...

Ngày tải lên: 10/08/2014, 22:20

... combined with other keywords including ‘dietary agents’, cancer , ‘prostate cancer , ‘brain cancer , ‘pancreatic cancer , ‘colorectal cancer , cancer stem cells’, cancer prevention’, cancer therapy , ... prostate, pancreatic and colorectal cancers were included in the review Potential applications of curcumin in cancer prevention and therapy Curcumin exhibits in vitro and in vivo chemopreventive and ... sustained delivery of curcumin into cancer cells These strategies include the use of curcumin phospholipid complexes, the inclusion of curcumin in liposomes/lipidic micelles or the curcumin encapsulation...

Ngày tải lên: 13/08/2014, 14:20

... Pathway Proteins in Cancer 19 Inhibition of the DNA Repair Function of Ape1 as a Target in Cancer 22 Existing Ape1 DNA Repair Inhibitors 26 Methoxyamine (MX), an Indirect Inhibitor ... which it interacts with several proteins from different signaling pathways (206) There is a vast amount of data showing that down-regulating or inhibiting Ape1 in cancer cells using RNA interference ... reduction of the critical cysteines in the DNA binding domains of the transcription factors increases their DNA binding ability thereby activating them and resulting in the transcription of several...

Ngày tải lên: 24/08/2014, 13:10

... methacrylate-co-poly(ethylene glycol) methyl ether methacrylate) combined with a targeting ligand, folic acid, to attain high selectivity in targeting cancers with minimal uptake by macrophages All these nanoparticles ... ring-opening reaction with ethylenediamine, different amounts of tumor -targeting ligand, folic acid (FA) are conjugated on the surface to attain high  Chapter selectivity in targeting cancer cells ... gives an alternative method for synthesizing FA-conjugated SPIONs for minimizing uptake by macrophages and enhancing the selectivity in targeting of cancer cells ATRP of GMA and poly(ethylene...

Ngày tải lên: 09/09/2015, 10:14

... Introduction 1.1 Background Brain cancer is caused by uncontrolled cell growth in the brain It can be divided into two categories: the primary brain cancer which is originated within the brain ... fluorescence in rat brain after i.v injection of fluorescent dextran loaded NPs (Sun, et al,2004) significant increase in brain uptake in in vitro cell line experiment & in situ brain perfusion ... tumor startes, not brain cells Like other cancers, effective treatments of brain cancers include surgery, radiotherapy, chemotherapy, hormone therapy, biotherapy, and immunotherapy (Oncology, 2002)...

Ngày tải lên: 26/11/2015, 22:41

... outw ward-facing o orbital ellipso oid 144 increas in size, w ses while the inw ward facing decreases This re esults in a co oupling of th electron sp he pins with the nuclear spin of the rare ... N-1.3.-diamino propane linker substituted glycine with the GdxSc3-xN@C80 The product 11 acts as the dienophile reaction partner with diene tetrazine-NLS-S∩S-CPP conjugate 13 in the final DARinv as pointed ... acetonitrile in water (B) as eluent The conjugate was eluted with a successive linear gradient, increasing from 25% to 60% B-eluent in 49 at a flow rate of 10 ml/min The fractions corresponding to...

Ngày tải lên: 26/10/2012, 09:07