targeted therapeutics in cancer treatment

... only by certain ranges of light Uses in Treatment In another study, pre-clinical trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed ... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... Kanzius RF Machine uses radio waves for dielectric heating Uses in Detection Gold nanoparticles in this image showed 600 percent more affinity to Cancer cells than healthy cells (EGFR binding) White...

Ngày tải lên: 15/02/2014, 05:20

... Trials in Stomach Cancer PSK and Stomach Cancer Stomach cancer continues to inflict major mortality in Japan and has been the object of more clinical trials with PSK than any other cancer Beginning ... predict anticancer efficacy in humans Maitake D-Fraction has been used in a few exploratory studies in cancer patients.17 In 1994, a group from China published in abstract form their findings from ... 1-6 main chains and 1-4 branchings, and the more common 1-3 main chains and 1-6 branchings.18 This fraction also is highly active in vitro and in animal models of cancer, although activity in these...

Ngày tải lên: 06/03/2014, 02:21

... cannot join the trial Common criteria for entering a trial include: ■■ Having a certain type or stage of cancer ■■ Having received a certain kind of therapy in the past ■■ Being in a certain age ... Taking Part in Cancer Treatment Research Studies If you have cancer, you may want to think about taking part in a clinical trial Clinical trials are a treatment option for many people with cancer ... people They are the final step in a long process that begins with research in a lab and animal testing Many treatments used today are the result of past clinical trials In cancer, clinical trials are...

Ngày tải lên: 15/03/2014, 01:20

... females Cisplatin Carboplatin Doxorubicin Specific Regimens: VAMP w/COP Low Risk/No Risk: Cytarabine Vincristine Methotrexate Dactinomycin Bleomycin Mercaptopurine Vinblastine Page Risk of infertility ... years away from having children of his or her own, thinking about his or her fertility before starting cancer treatment can help increase the chances of being able to have children in the future Talk ... the timing in mind when deciding on this treatment option The first pregnancy from a frozen embryo was in 1983, and since then thousands of children have been born following embryo freezing Today,...

Ngày tải lên: 15/03/2014, 01:20

... relapse on imatinib therapy have point mutations in the BCR–ABL kinase domain, including the T315I gatekeeper mutation that impairs imatinib binding [58,59] Accordingly, new therapies are being tested ... ATP-competitive inhibitor, which targets several protein kinases such as cyclindependent kinases (CDKs), checkpoint protein (CHK1), 3¢-phosphoinositide-dependent kinase-1 (PDK1) and protein kinase Cs ... ⁄ inhibitor, PD0325901, and rapamycin was remarkably effective at inhibiting the growth of prostate cancer cell lines and the growth of prostate cancer in vivo in Pten-deficient mice Interestingly,...

Ngày tải lên: 16/03/2014, 00:20

... support (in similar initiative in Latin America involving the Sarajevo, Bosnia and Herzegovina) ARCAL (Regional Co-operative Arrangements for 12 Cancer Treatment in Developing Countries Fighting Cancer ... anticipate a steady increase in the extension of these services in developing countries in the early 21st century Cancer Treatment in Developing Countries units in this facility,” explains Mr H.M.S ... Facilities 11 ■ New Treatment Facilities in Developing Countries ■ Fighting Cancer in Zambia 13 ■ Training Radiotherapy Professionals 15 ■ Quality Assurance in Radiotherapy Treatment ■ Ensuring Accuracy...

Ngày tải lên: 29/03/2014, 01:20

... protein tyrosine kinases Breast cancer src, yes, fgr fps/fes, abl Nonreceptor protein tyrosine kinases Colon cancer raf, pim0-1, mos, cot Cytoplasmic protein-serine kinases Small-cell lung cancer ... THERAPY IN THE TREATMENT OF CANCER now in development Such inhibition results not only in growth inhibition in vitro but also results in growth inhibition of tumors in animal models of carcinogenesis ... administered intradermally In a long-term clinical trial, idiotype vaccination resulted in tumor regression in cancer patients and cancer immunity in patients in remission Thus, idiotype vaccination,...

Ngày tải lên: 10/04/2014, 22:11

... cancer and independently associated with the increased risk of colorectal cancer in men [14], and overall cancer risk [15] Interleukin-6 (IL-6) has been used for the diagnosis of colorectal cancer ... 348(10):891-899 Allin KH, Bojesen SE, Nordestgaard BG: Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer J Clin Oncol 2009, 27(13):2217-24 Ghiringhelli ... able to assist the clinician by pinpointing recurring opportunities to selectively enhance Teffectors and/or deplete or inhibit T-reg cells, in a cycle specific manner, in the near future Further...

Ngày tải lên: 18/06/2014, 15:20

... HDAC inhibition increases the anti -cancer effect of IL-13PE targeting IL-13Ra2 in vitro and in vivo As HDAC inhibition increased IL-13Ra2 expression in IL-13Ra2-negative but not in normal cell lines, ... IL-13Ra2 expressing pancreatic cancer cell lines [28], we investigated the impact of IL-13Ra2 upregulation by HDAC inhibitors by examining IL-13 induced MMPs expression TSA treatment increased mRNA ... HDAC inhibitors can modulate IL-13Ra2 expression in pancreatic cancer cell lines Interestingly, similar to histone acetylation, TSA treatment resulted in increased IL-13Ra2 mRNA expression in pancreatic...

Ngày tải lên: 18/06/2014, 19:20

... HDAC inhibition increases the anti -cancer effect of IL-13PE targeting IL-13Ra2 in vitro and in vivo As HDAC inhibition increased IL-13Ra2 expression in IL-13Ra2-negative but not in normal cell lines, ... IL-13Ra2 expressing pancreatic cancer cell lines [28], we investigated the impact of IL-13Ra2 upregulation by HDAC inhibitors by examining IL-13 induced MMPs expression TSA treatment increased mRNA ... HDAC inhibitors can modulate IL-13Ra2 expression in pancreatic cancer cell lines Interestingly, similar to histone acetylation, TSA treatment resulted in increased IL-13Ra2 mRNA expression in pancreatic...

Ngày tải lên: 20/06/2014, 03:20

... cisplatin had significantly better responses in the cisplatin containing arm [23] A Dutch study reported a better outcome for a cisplatin containing regimen over combination hexamethylmelamine, ... counterparts in several human cancer cell lines, including ovarian cancer [61,62] Repair of platinum-DNA adducts occurs predominantly by nucleotide excision repair (NER) [17] Inhibiting DNA repair ... trioxide induced cytotoxicity in human ovarian cancer cells are promising Clinically achievable concentrations (2 μM) induced apoptosis in the platinum-resistant human ovarian cancer cell line CI80-13S...

Ngày tải lên: 20/06/2014, 07:20

... Poplin EA, Goodin S, Mauro D, Rubin EH: Pharmacokinetics of cetuximab after administration of escalating single dosing and weekly fixed dosing in patients with solid tumors Clin Cancer Res 2006, ... HER -targeted therapeutics effectively inhibited the growth of certain T100 cells For example, erlotinib and lapatinib inhibited proliferation of all four tested cell lines, whereas gefitinib inhibited ... candidate signaling proteins, including receptor tyrosine kinases of the EGFR/ErbB/HER family, are frequently expressed in these tumors The EGFR/ErbB/ HER family of receptor tyrosine kinases (i.e.,...

Ngày tải lên: 20/06/2014, 07:20

... history including past cancer history, b) physical examination, c) recording of medications and recent therapies, including analgesic consumption, d) pain assessment using the Brief Pian Inventory ... 20 21 Cherny N: The management of cancer pain Cancer J Clin 2000, 50:70-116 Hearn J, Higginson IJ: Cancer pain epidemiology: a systematic review In Cancer Pain, Assessment and Management Edited ... aimed at making available to treating physicians, patients and families valid information about pain management in cancer Two main lines of activities were identified as necessary: information...

Ngày tải lên: 20/06/2014, 15:20

... Through the feeding tube, a complete polymeric isotonic enteral nutrient was administered, in a dose of 1.5 grams of protein per kilogram of weight per day, by using an infusion bomb during 20 hours, ... the feeding tube located in the jejunum away from the leak area Each point is indicated by arrows Discussion Gastric cancer is a very common cancer worldwide and surgery is the only treatment ... anastomotic failure following total gastrectomy Acta Chir Scand 1987, 153(4):303-6 Sasako M: Role of surgery in multidisciplinary treatment for solid cancers Int J Clin Oncol 2004, 9:346-351 10...

Ngày tải lên: 09/08/2014, 03:22

... breast is inflated with exactly 40 cc, 50cc, 60 cc, or 70 A CEDandinserted through a small incision in the lateral cc A CED is inserted through a small incision in the lateral breast and inflated ... as, the limited shielding requirements make XB a logical modality to be utilized for IORT in the treatment of early-stage breast cancer Delivering IORT treatment in a single session is not a ... Goldstein NS, Martinez A: Limited-field radiation therapy in the management of early stage breast cancer J Natl Cancer Inst 2003, 95:1205-1210 King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins...

Ngày tải lên: 09/08/2014, 04:21

... administered beginning on day of the treatment, to a total dose of 70 Gy We hypothesized that there were no significant differences in treatment outcomes based on site for patients receiving ... evidence of carcinoma at the local site within months following the completion of treatment (persistent disease), or histological evidence of carcinoma in the local site presenting after months ... glossectomy Patients were followed every week during the treatment protocol Tumor response was determined during therapy by physical examination, and restaging was performed months after radiation by...

Ngày tải lên: 09/08/2014, 07:21

... disparities in adjuvant breast cancer treatment J Clin Oncol 2006, 24(9):1357-1362 Griggs JJ, Sorbero ME, Stark AT, Heininger SE, Dick AW: Racial disparity in the dose and dose intensity of breast cancer ... following breast conservation therapy in African-American women with invasive breast cancer Am J Surg 2000, 179(1):22-26 Cunningham JE, Butler WM: Racial disparities in female breast cancer in South ... differences in time intervals to diagnosis and start of treatment In a previous study from our group that included patients from the present cohort, we examined the time interval between date of initial...

Ngày tải lên: 09/08/2014, 07:21

... parameters of genito-urinary toxicity and ED, including the possible correlation between ED and PB dose-volume parameters In this type of study, involving many Institutes aiming at evaluating the possible ... routine practice for most institutes in Europe, although the use of MRI for prostate planning is increasingly widespread The main result of the current investigation is the quite large contouring ... situation The increased use of MRI, too, will likely help in reducing contouring uncertainty, as demonstrated by evidence that this imaging modality is highly superior to CT in defining PB and other...

Ngày tải lên: 09/08/2014, 09:21

... chemotherapy treatment In group A the treatment was based on anthracycline and in group B the treatment was based on CMF Eighty four percent of the investigated cases (81% in group A and 86.5% in group ... in the combined modality treatment of breast cancer Int J Radiat Oncol Biol Phys 1993, 26:23-35 Greene FL, Page DL, Fleming ID: AJCC cancer staging manual 6th edition New York: Springer-Verglag; ... with early breast carcinoma were selected at the National Institute of Oncology in Rabat, for investigation during treatment and up to now follow up The patients were divided in two groups on the...

Ngày tải lên: 09/08/2014, 09:22

... distributed within both groups, mainly for tumour localization of abdominal wall and extremities Tumours of the trunk include the following localizations: tumours in the breast, intra-thoracic, 12 intra-peritoneal ... randomised clinical trial in a defined patient group, especially as modern three-dimensional radiotherapy treatment planning and the use of functional imaging may give a better indication of the incidence ... fibromatosis or desmoid tumours Cancer 2000, 88:1517-1523 Rare Cancer Network [http://www.rarecancer.net] ICRU Report 50: Prescribing, recording and reporting photon beam therapy In International Commission...

Ngày tải lên: 09/08/2014, 10:21