targeted cytostatic or anti angiogenic agents
báo cáo khoa học: "Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma" docx
Ngày tải lên :
10/08/2014, 22:21
... reported efficiency in refractory MCL resistant to conventional cytotoxic drugs On the long term, this supports the evaluation of antiangiogenic drugs in refractory MCL Consent Written informed ... investigator’s choice therapy for the treatment of relapsed or refractory mantle cell lymphoma J Clin Oncol 2009, 27:3822-3829 Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, ... thus reduce tumor burden through a direct cytostatic effect on the tumor cells, but also through an associated effect on tumor angiogenesis This dual effect of temsirolimus on tumor tissue could...
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báo cáo hóa học:" Anti-angiogenic effect of high doses of ascorbic acid" pptx
Ngày tải lên :
18/06/2014, 15:20
... also an important modulator for the expression of endogenous angiogenic factors such as VEGF and basic FGF [40] Further, NO has been shown to be involved in tumor angiogenesis [41-44] Tumors that ... ranged from 16% for 0.2 mM of reagent to 45% for 0.5–3 mM L-NAME These data strongly suggest that NO formation is an important regulator of the angiogenic process Use of a NOS inhibitor (LNAME) markedly ... either: inhibitors, stimulators, or ascorbic acid For endothelial nitric oxide synthase inhibition, a derivative of L-arginine N-nitro-Larginine methyl ester (L-NAME) was used, and for stimulation...
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Báo cáo hóa học: "Evaluation of the anti-angiogenic properties of the new selective aVb3 integrin antagonist RGDechiHCit" potx
Ngày tải lên :
18/06/2014, 16:20
... v b antagonist reported in literature [18,19] and is in phase III clinical trials as antiangiogenic drug for glioblastoma therapy [15] The development of more selective antiangiogenic molecule ... c57BL/6 mice (Charles River Laboratories, Milan, Italy; n = 13) All animal procedures were performed in accordance with the Guide for Page of 10 the Care and Use of Laboratory Animals published by ... work All authors read and approved the final manuscript Page of 10 Competing interests We have no financial or personal relationships with other people or organizations that would bias our work...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
Ngày tải lên :
19/06/2014, 22:20
... secondary antibodies (1:200, Vector Laboratories, Burlingame, CA) for 30 at room temperature The staining was visualized by the biotin-avidin-peroxidase method (Elite Kit, Vector Laboratories, Burlingame, ... 80% formic acid for before blocking with BSA The primary antibodies used were: rabbit antimouse GFAP (1: 1000, Sigma), rat anti- mouse Mac-1 (1: 250, Serotec, Oxford, United Kingdom), rabbit anti- ... for the quantification of microglia activation DG: dentate gyrus; HiF: hippocampal fissure secondary antibodies were purchased from Vector Labs For quantitative assessment of bands, the autoradiographs...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
Ngày tải lên :
10/08/2014, 22:20
... [92] I Refractory solid tumors and lymphoid(22) Once weekly for weeks of a week cycle mg/m2 [90] I Refractory solid tumors and lymphoid(27) Once weekly for weeks of a week cycle or once every ... monotherapy or combination with other antitumor drugs in CTCL and other malignancies At least 80 clinical trials are underway, testing more than eleven different HDAC inhibitory agents including ... approved by FDA for treating cutaneous T-cell lymphoma (CTCL) for patients with progressive, persistent, or recurrent disease on or following two systemic therapies Other inhibitors, for example,...
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Báo cáo y học: "Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein" pptx
Ngày tải lên :
11/08/2014, 03:20
... mechanism of anti- inflammatory action from Page of 11 corticosteroids and nonsteroidal anti- inflammatory drugs (NSAIDs) NSAIDs and corticosteroids have become the mainstay of anti- inflammatory agents ... class of anti- inflammatory agents which act on immune cells, the central regulators of all inflammation The term “Immune Selective Anti- Inflammatory Derivatives” (ImSAIDs) is proposed for salivary-derived ... potentially therapeutically useful anti- inflammatory agents The Neuroendocrine Axis The existence of salivary-derived, systemically acting, anti- inflammatory factors and the regulation of salivary...
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Báo cáo y học: "RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies" potx
Ngày tải lên :
12/08/2014, 11:22
... Effect of anti- TNFα, anti- IL-1, or anti- RANKL therapy on bone resorption markers Effects of PEGylated soluble TNF receptor type I (TNFRI), IL-1 markers receptor antagonist (IL-1Ra) or osteoprotegerin ... CIA Effect of anti- TNFα, anti- IL-1, or anti- RANKL therapy on bone mineral density Effects of PEGylated soluble TNF receptor type I (TNFRI), IL-1 recepdensity tor antagonist (IL-1Ra) or osteoprotegerin ... CIA Effect of anti- TNFα, anti- IL-1, or anti- RANKL therapy on hind paw swelling Effect of PEGylated soluble TNF receptor type I (TNFRI), IL-1 receptor swelling antagonist (IL-1Ra) or osteoprotegerin...
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Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
Ngày tải lên :
10/09/2015, 08:38
... of my research work I am very grateful to her for accepting me into UROPS in 2005 when I was a life science undergraduate My passion for medicinal chemistry has grown enormously for the past years ... Suresh Kumar Gorla and Dr Yang Tianming for their enlightening discussions and scientific advice rendered Special thanks go to my FYP mentors Dr Kong Kah Hoe and senior Dr Lee Chong Yew for their ... benzylated or acetylated in order to display kinase inhibitory activity (ii) Analogs with benzylated OH groups on the sugar are generally strong kinase inhibitors (at 10 µM) but devoid of antiproliferative...
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Isolation and identification of components from ixeris sonchifolia hance as potential anti stroke agents
Ngày tải lên :
11/09/2015, 10:06
... intracerebral haemorrhage, and subarachnoid haemorrhage, but excludes transient ischemic attacks (TIA, which last for less than 24 hours), subdural or extradural haemorrhage, and infarction or haemorrhage ... efforts would be mainly directed towards the isolation of compounds that could exhibit either antioxidant, anti- apoptotic or anti- inflammatory activities As Ixeris sonchifolia Hance is known for ... potential anti- stroke effects, which at least in part were attributed to their antioxidant and anti- inflammatory activities IX List of tables Table Title Page 1.1.3.1 Summary of anti- stroke agents...
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5 SUBSTITUTED BENZIMIDAZOLE DERIAVATIVES AS ANTI STROKE AGENTS
Ngày tải lên :
12/10/2015, 17:35
... Tsun Hon, for being my co-supervisor during my course of study Thank you for allowing me to perform animal work in your laboratory, as well as the guidance, support and helpful suggestions during ... thrombolytic agents, antiplatelet agents or fibrinogen depleting agents that aim to allow the return of blood flow to the ischemic region An example is the recombinant tissue plasminogen activator (tPA), ... The Glutamate Receptor Superfamily The glutamate receptor superfamily is divided into two major categories, namely the metabotropic receptor family and the ionotropic receptor family (Figure 1-2)...
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Isothiocyanate derivatives as anti cancer agents
Ngày tải lên :
08/11/2015, 17:15
... Antiproliferatives Retinoids/carolcnoids Antihormones Anliinflammatories G6PDH inhibitors ODC inhibitors Other: Calcium Antioxidants Anliinflammalories: See under "Antiproliferatives" Anlioxidants Phase ... chemopreventive agents1 Antimutagens/carcinogen blocking agents Phase II metabolic enzyme inducers Polyphenols α Other: Curcumin DHEA, fluasterone (16-fluoro-DHEA) Antiproliferatives Retinoids/carolcnoids Antihormones ... and drink, or, to a lesser extent, to exposure to radiation or cancer-causing agents (carcinogens) in the environment and the workplace Some people are more sensitive than others to factors that...
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báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
Ngày tải lên :
18/06/2014, 15:20
... including 95°C for 30 seconds, 55°C for 45 seconds, 72°C for 30 seconds For GAPDH amplification: 95°C for five minutes, 32 cycles including 95°C for 30 seconds, 53°C for 45 seconds, 72°C for 30 seconds ... were as follows: For PTEN amplification: 95°C for two minutes, 30 cycles including 95°C for 30 seconds, 57°C for 45 seconds, 72°C for 30 seconds For EGFR amplification: 95°C for two minutes, 32 ... homozygous or hemizygous deletion of PTEN by differential PCR using genomic primers for PTEN exon (forward 5'-AAACAGTAGAGGAG CCG TCA-3' and reverse 5'-GACTTTTGTAATTTGTGTATGCT-3') or EGFR exon 22 (forward...
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Báo cáo y học: "The anti-inflammatory effects of levocetirizine - are they clinically relevant or just an interesting additional effect" pptx
Ngày tải lên :
08/08/2014, 21:20
... the effect of anti- inflammatory drugs on the pro-inflammatory processes responsible for the manifestations of allergic disease Antiinflammatory effects independent of H1-receptor blockade have ... Levocetirizine had the lowest proportional impairment ratio of all the antihistamines reviewed, followed by fexofenadine and desloratadine respectively [16] Anti- inflammatory effects - In vitro There ... blockade have been described for the majority of anti- histamines while the parent compound of levocetirizine, cetirizine has extensive well documented anti- inflammatory properties both in vivo...
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Báo cáo y học: "α Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification" pps
Ngày tải lên :
09/08/2014, 06:23
... Damme N, Cuvelier C, De Vos M, Mielants H, Veys EM, De Keyser F: Immunomodulatory effects of anti- tumor necrosis factor alpha therapy on synovium in spondyloarthropathy: histological findings in ... modification or prevention of structural damage and ankylosis Although the data certainly cannot be extrapolated, preliminary evidence suggests that continuous therapy with non-steroidal anti- inflammatory ... disease, whereas in the first years inflammation might be the driving force Invariably, a major improvement in the BASFI has been reported in all studies with infliximab Imaging data, especially by...
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Báo cáo y học: "Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies" ppt
Ngày tải lên :
09/08/2014, 14:21
... longitudinal study showed no abnormality in EBV viral load or EBV-specific T-cell response in patients with RA or SpA at baseline or after treatment with MTX or anti- TNF drugs In contrast to other ... of MTX and anti- TNF drug on EBV-specific T-cell effector functions in patients with RA or SpA At 3month follow-up, neither MTX treatment in RA patients nor anti- TNF therapy in RA and /or SpA patients ... W12, week 12 Conclusions Authors' contributions In patients with RA or SpA, short-term (3-month) exposure to MTX or anti- TNF therapy does not alter the EBV viral load or the EBV-specific T-cell...
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báo cáo khoa học: "More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells" docx
Ngày tải lên :
10/08/2014, 10:21
... of 0, 1, 2, or 4, and the tumors were finally Page of determined as negative: score 0; lower expression: score ≤ 2; or higher expression: score The percentage of TrkB positive tumor cells was ... incubator with 5% CO at 37°C To neutralize secretory BDNF in culture supernatant for subsequent studies, cells (80-90% confluence) were treated with antiBDNF antibody (20 μg/ml, Santa Cruz, USA) for ... with receptor tyrosine kinase signaling, cells were also treated by Trk tyrosine receptor kinase inhibitor K252a (0.1 μM, Sigma, USA) for 24 h Cells treated were used for apoptosis or invasion...
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báo cáo khoa học: "First-in-class, first-in-human phase I results of targeted agents: Highlights of the 2008 American Society of Clinical Oncology meeting" pot
Ngày tải lên :
10/08/2014, 22:20
... chemotherapeutic and targeted agents [24] PI3K, AKT, and mTOR have been targeted individually by various drugs, but XL765 is the first oral dual PI3K and mTOR inhibitor with Phase I trial results, reported ... trials of targeted agents represent the culmination of years of laboratory work and preclinical animal evaluations Therefore the results are met with excitement and trepidation: excitement for possible ... typical for phase I clinical trials-all patients had good performance status (ECOG or better), and most patients were heavily pre-treated with standard drug regimens before enrollment The anti- angiogenic...
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Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf
Ngày tải lên :
11/08/2014, 08:22
... Richmond A, Graham GJ, Segerer S, Nibbs RJ, Rot A: The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity Nat Immunol 2009, 10:101-8 Nibbs RJ, Wylie ... system namely D6, DARC (Duffy antigen/receptor for chemokines) and CCX-CKR (chemocentryx chemokine receptor) Both D6 and DARC clear chemokines that bind signalling receptors CCR1, CCR2, CCR3, CCR4 ... In addition, DARC targets chemokines for receptors CXCR1 and CXCR2 CCX-CKR seems to have a more narrow spec- Table 1: Human chemokines and their receptors targeted by early HHV-6A infection HHV-6A...
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Báo cáo y học: "Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study" doc
Ngày tải lên :
12/08/2014, 14:22
... smoking OR and 95% CI for smoking versus non-smoking were adjusted for age, sex, GTG carriage and SE alleles RA, rheumatoid arthritis; anti- CCP, anti- cyclic citrullinated peptide autoantibody; OR, ... (RA), 1,288 were evaluated for ever smokers, and 967 were evaluated for anti cyclic citrullinated peptide antibodies (anti- CCP) Among control subjects, 991 were evaluated for ever smokers Out of these ... with susceptibility to anti- CCP-positive and negative RA* Controls, No Subgroup All RA cases No OR (95% CI) anti- CCP-positive RA No OR (95% CI) anti- CCP-negative RA No OR (95% CI) GTG-negative†...
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