systems biology tool development and application to cancer

... drugs labeled as high and low, and the denominator is simply the difference between the standard error for high and low Welch’s t-statistic was used to compute P values, and proteins with P < ... immunohistochemical staining Activation of this receptor results in strikingly different cancer phenotype due to extensive downstream remodeling of transcriptional programs, and the genes and molecular ... networks: protein-protein interactions and gene regulatory [21] (genetic interaction and phosphorylome [22] had too few nodes to determine significance) All topological statistics (degree, clustering...

Ngày tải lên: 09/08/2014, 22:24

... the development of gradient smoothing operations in the weak and strong forms and the application of these methods to model biological systems The work comprises three parts: the first is to apply ... Velocity history at μ=0.4 Figure 6.10 Pressure and vertical velocity contours at the steady state ( μ=0.4 ) Figure 6.11 Velocity history at μ=0.5 Figure 6.12 Pressure and vertical velocity contours ... the development of gradient smoothing operations in the weak and strong form to overcome the shortcomings of the FEM, FVM and FDM, and combines the gradient smoothing operation in the weak and...

Ngày tải lên: 09/09/2015, 18:58

... shopping, and psychographic portrait of customers A number of drawbacks and benefits pertaining to the tools have been pointed out and discussed Both the research models and the tools, while diverse to ... with it Table Some attributes for tool library Product Significant range of tools Access to professional tools Availability of tools Ergonomic, silent, amortisation Tools are well ma intained (e.g ... included into this study 12 The overview of tools for measuring customer satisfaction excluded practical advice on how to develop these tools and how to analyse collected data, due to the general...

Ngày tải lên: 04/11/2013, 10:15

... cell and the presence of other co-stimulators and immune modulators [19,20] Previous studies have shown that IL21 activates both IFNγ and IL2RA in purified NK and purified T cells [21] CD19 and ... effector function was chosen for development because the therapeutic goal is to block the interaction of IL21 with IL21R, and therefore minimization of effector function is desirable Endotoxin ... directed towards blockade of inflammatory pathways, is often a healthy volunteer population To develop biomarkers for drugs targeting inflammatory pathways, previous investigators have turned to ex...

Ngày tải lên: 18/06/2014, 16:20

... simulation and comparison tool for tree and stand growth, silvicultural treatments and timber assortment, in: Proc Connection between silviculture and wood quality through modelling approaches and simulation ... according to relations (1) and (2) Incremental state vector at the origin and the extremity of the beam are denoted by ∆ n S O and ∆ nS E respectively, according to the definition (A.3) These ˆ vectors ... by INRA-FMN and Région Aquitaine We wish to thank Alexia Stokes and Neal Harries for their corrections and language review We also thank two anonymous reviewers for their comments and suggestions...

Ngày tải lên: 08/08/2014, 01:22

... Database [62], and KEGG [26] To store these imported data into the Reactome database, the original Reactome schema was extended by adding one new class, Interaction, as a subclass to Event, and a new ... 2:125-132 Donovan J, Slingerland J: Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer Breast Cancer Res 2000, 2:116-124 ... factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer Breast Cancer Res 2000, 2:107-115 Wakefield LM, Yang YA, Dukhanina O: Transforming growth factor-beta...

Ngày tải lên: 09/08/2014, 20:22

... different amount of BSA picomol, 500 femtomol, 100 femtomol, 50 femtomol, 10 femtomol, femtomol to femtomol BSA (From left to right)were loaded and run by SDS-PAGE and then stained by sliver 19 preparation ... down to femtomole were also run by SDS-PAGE and stained by silver staining Gel bands with less than 100 femtomole BSA are too week to be seen by eyes (Figure 2.1) So they were cut according to ... (Sigma) were prepared and run in different lanes of 7.5% polyacrylamide gel from 10 picomol, picomol, 500 femtomol, 100 femtomol, 50 femtomol, 10 femtomol, femtomol to femtomol with a Mini protein...

Ngày tải lên: 04/10/2015, 15:46

... 3, and 10 kPa and annealed at 600 8C (b) WO3 nanoparticles deposited at kPa and annealed at 400 and 600 8C results for the sensors made of WO3 nanoparticles deposited at 1, 3, and 10 kPa and ... nanoparticles deposited at kPa and annealed at 400, 600, and 800 8C, respectively Please cite this article in press as: D Meng, et al., Preparation of WO3 nanoparticles and application to NO2 sensor, Appl ... where Ra and Rg were the electrical resistances in air and in air including NO2, respectively Results and discussion Fig 2(a) shows XRD patterns for WO3 nanoparticles deposited at 1–10 kPa and annealed...

Ngày tải lên: 20/03/2014, 13:06

... monitoring of phenanthrene (a 3-ring PAH) concentrations during a laboratory toxicological dosing study, and 4) monitoring PAH concentrations in stormwater runoff into both a retention pond and ... to the toxicity of the WAF Similarly, heterocycles are expected to follow the same trends as PAHs with regard to increased toxicity with increased alkylation and a tendency to bioaccumulate and ... problematic to environmental and human health Petroleum is comprised of thousands of compounds, including polycyclic aromatic hydrocarbons (PAHs) and heterocycles, some of which are toxic and/ or carcinogenic...

Ngày tải lên: 13/05/2014, 14:01

... collected all data and built up the database, designed and performed the statistical analysis and wrote the manuscript HW and WW contributed to the development of the study design and advised about ... measures ADL for stoke patients We successfully developed a VBA-Excel CAT module and demonstrated how CAT can be used to reduce patient and proxy burdens, and improve data collection and quality measurement ... exposure and a less cost consumption on item development in medical and healthcare professions Purposes The aim of this study is to verify how CAT can save time and reduce burden for patients and...

Ngày tải lên: 18/06/2014, 18:20

... to convolve the signal x with a random waveform and randomly under-sample the result in time-domain The random convolution is performed through a random pre-modulation in the Fourier domain and ... signal x by a wide-band signal c = (cl )1 l N ∈ CN , with |cl | = and random phases, before projecting the resulting signal onto m vectors of the basis Φ The measurement vector y thus satisfies ... Universal and efficient compressed sensing by spread spectrum and application to realistic Fourier imaging techniques Gilles Puy∗1,2 , Pierre Vandergheynst1 , R´mi Gribonval3 and Yves Wiaux1,4,5...

Ngày tải lên: 20/06/2014, 20:20

... is studied to achieve very low range sidelobes for potential application to spaceborne rain radar In the paper [11], timedomain weighting of the transmitted pulse is used and is able to achieve ... zero autocorrelation sidelobe zero mutual cross-correlation peaks during Zero Correlation Zone We also present and analyze a method to construct such ternary codes and subsequently apply them to ... definitions and properties of ZCZPS In Section 3, the optimized punctured ZCZPS is introduced, and a method using optimized punctured sequence-pair and Hadamard matrix to construct such codes is given and...

Ngày tải lên: 21/06/2014, 17:20

... to convolve the signal x with a random waveform and randomly under-sample the result in time-domain The random convolution is performed through a random pre-modulation in the Fourier domain and ... signal x by a wide-band signal c = (cl )1 l N ∈ CN , with |cl | = and random phases, before projecting the resulting signal onto m vectors of the basis Φ The measurement vector y thus satisfies ... Universal and efficient compressed sensing by spread spectrum and application to realistic Fourier imaging techniques Gilles Puy∗1,2 , Pierre Vandergheynst1 , R´mi Gribonval3 and Yves Wiaux1,4,5...

Ngày tải lên: 21/06/2014, 17:20

... guidelines and consists in the following three steps: to improve the Lipschitz constant of the level sets of u far from F(u), to carry this interior gain to the free boundary, to rescale and iterate ... the vectors Vi , i = 1, ,n − 1, involves only the Lipschitz continuity of A Construction of the family of subsolutions and application to the free boundary problem For the application to our ... The following two lemmas are similar to [5, Lemmas and 3], respectively Lemma 2.3 Let η0 > be fixed and w and z as in Lemma 2.2 Then there exist r0 = r0 (η0 ) and t0 = t0 (λ,Λ,n) > such that, if...

Ngày tải lên: 22/06/2014, 22:20

... (xm ) converges to x with respect to | · |n if and only if (xm ) converges to x with respect to · n Consequently the condition (ii) is satisfied with respect to · n On the other hand, we also have ... Fr´chet space and let C,D : X → X be two operators Suppose that the following hypotheses are fulfilled: (a) C is a compact operator; (b) D is a contraction operator with respect to a family of ... theorem and application and it follows that b(t) = t (1 − L)2 ω2 (t,s)ds − 0, → as t − ∞ → (4.24) Furthermore, it follows from (4.23) and (H3 )(iii) that +∞ b(s)ds < +∞ (4.25) On the other hand,...

Ngày tải lên: 22/06/2014, 22:20

... distortion after signal reconstruction DK again contains two components, the distortion due to the signal a approximation DK , and the distortion due to quantization q DK The distortion due to ... and the number of descriptions varies We fix the total number of atoms to 600 and vary the number of descriptions between and 4, as well as the number of atoms per description We use 11 bits to ... approximation, and yet correlated to provide robustness to channel erasures We propose to achieve this construction by partitioning the dictionary into blocks of similar atoms Each atom of a block...

Ngày tải lên: 22/06/2014, 22:20

... for him or her to appreciate the advantages of the J -matrix method, and to encourage its use and development into a viable method for theoretical calculation of nuclear and atomic systems Riyadh ... facts enabled the group to calculate Dapprox (E + i ε) and obtain accurate scattering results This development added some analytical tools to the predominant numerical tools available for use ... · Hashim A Yamani · Mohamed S Abdelmonem Editors The J-Matrix Method Developments and Applications Foreword by Hashim A Yamani and Eric J Heller Editors Abdulaziz D Alhaidari Shura Council Riyadh...

Ngày tải lên: 27/06/2014, 05:20

... a future focal point of systems biology If modern systems biology is only a short leap from classical biochemistry and genetics, how will future experiments in systems biology continue the trend ... host-bacterium symbiosis Such systems will have the power to detect genetic interactions relevant to paracrine signaling in eukaryotic cells, and to quorum sensing and other intraspecies signaling ... signaling in response to an extracellular growth factor - and so another form of higher-dimension systems biology will be the study of how cellular modules change over space and time Another area...

Ngày tải lên: 09/08/2014, 20:21

... stages Application to other organisms The models described above provide a useful tool to integrate gene expression and chromatin data Currently, the C elegans dataset is the best one to demonstrate ... used to predict to which class each transcript in the testing set belongs We repeated the procedure for all 160 bins, and 100 different random splitting of the transcripts into training and testing ... may be instructive to build a simpler linear regression model to explore to what extent the chromatin features are redundant, and to what extent they are interacting in a combinatorial fashion Specifically,...

Ngày tải lên: 09/08/2014, 22:23

... methods able to detect and quantify the BCR-ABL fusion transcripts, which is of paramount relevance when monitoring minimal residual disease and genetic recurrence in patients known to harbor the ... recognition and quantification of BCRABL b3a2 (e14a2) fusion for the early diagnosis of CML, which is inexpensive very easy to perform and uses total human RNA as target without reverse transcription and/ or ... NaCl, recentrifuged and redispersed in ml of the same buffer to a final concentration in AuNPs of 8.5 nM The resulting Aunanoprobe was stored in the dark at 4°C Cell culture and total RNA isolation...

Ngày tải lên: 11/08/2014, 00:22