systems biology approaches to cancer drug development

... al.: A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:2 Abbreviations Frc: fructose; Glc: ... Phytochemistry 68R(6):709–731 (2007) H Schmidt, M Jirstrand, Systems biology toolbox for MATLAB: a computational platform for research in systems biology Bioinformatics 22(4):514–515 (2006) doi:10.1093/bioinformatics/bti799 ... states in such strongly regulated systems are prone to instability, leading to effects as bi-stability or oscillations The model defined by Equations 2, 5, 6, and approaches a stable steady state...

Ngày tải lên: 21/06/2014, 03:20

... inefficient The biology society urges the revolution of methodologies and in recent years have seen more and more research activities in the field of systems biology 1.1 Systems Biology Systems biology ... surprising to apply systems theory to biological systems However, this work is not a routine application of control methods and systems theory to an unconventional plant The most appreciated work of systems ... in systems biology is how to obtain an accurate and predictable computational model for the biomolecular networks under study Therefore, to enhance the reliability, we propose two approaches to...

Ngày tải lên: 10/09/2015, 15:52

... had to devote more time to research than to her Dr Guna, who made it possible for me to this PhD, by first accepting me into the M.Sc in Bioinformatics programme, and then recommending me to A-Star ... -dependent and independent way These rely on Gem’s ability both to be re-localized to the cytosol upon CaM binding, and to effect cytoskeletal remodeling upon 14-3-3 binding These findings reveal ... at a later stage to replenish the internal stores [75] There is also continuous regulation of cytosolic calcium, which is either flushed out of the cell or pumped into internal storage Consequently,...

Ngày tải lên: 11/09/2015, 09:11

... variation To study these topics, scientists need to coordinate different subjects of biology, from molecular biology and biochemistry to cell biology and physiology, further to the system biology, ... major ways to study developmental biology The earliest is anatomical approach, which gave rise to experimental approach Genetic approach was built based on anatomic and experimental approaches ... genetics has begun to integrate these approaches to produce a vigorous and multifaceted science of development biology A multicellular organism before birth is usually refered to as an embryo It...

Ngày tải lên: 14/09/2015, 12:11

Ngày tải lên: 09/11/2015, 08:58

... research teams started to develop laboratory tests in order to predict tumor reaction to cytostatic drugs [5] They used fresh cancer tissue and examined the effect of the drugs on tumor cell growth ... growth factors, i.e their cell receptors as cancer biomarkers to develop new targeted anticancer drugs with better tumor response However, tumor concentrations of growth factor receptors not reliably ... laboratory techniques were still in their infancy Short term cell cultures of cancer tissues were difficult to perform and procedures varied from laboratory to laboratory However, the cancer...

Ngày tải lên: 25/10/2012, 11:10

... 7.6.0.324, R2008a) with the software packages systems biology toolbox2 and the sbpd Extension Package as described in [34] Both matlab and systems biology toolbox2 are necessary for the performance ... Glob Optim 39, 197–219 34 Schmidt H & Jirstrand M (2006) Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology Bioinformatics 22, 514– 515 35 Tang X, Ruffner ... (n = 7) Systems biology of cold acclimation in A thaliana T Nagele et al ¨ FEBS Journal 278 (2011) 506–518 ª 2010 The Authors Journal compilation ª 2010 FEBS T Nagele et al ¨ Systems biology...

Ngày tải lên: 14/02/2014, 22:20

... Contributors Yerramilli V B K Subrahmanyam, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA E-mail: subu.yerramilli@qiagen.com Asako Sugimoto, Ph.D Laboratory Head Laboratory for Developmental ... University of Bristol The School of Medical Sciences University Walk, Bristol BS8 1TD UK E-mail: p.kuwabara@bristol.ac.uk Eric Lader, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA ... The University of Tokyo Hongo, Tokyo 113-8656 Japan Marc Gentzel European Molecular Biology Organization Meyerhofstr.1 69117 Heidelberg Germany Contributors Bob Goldstein, PhD Biology Department...

Ngày tải lên: 06/03/2014, 09:21

... acid Drugs near the top of the list are more effective and less toxic while drugs placed near the bottom of the list are less effective or more toxic, or more difficult to obtain Resistance to ... rifabutin-resistance and the laboratory should be asked to test for it It is only possible to use one drug within each drug class and if it is difficult to find five drugs to use then the clinician can ... more akin to that for cancer than to that for infection It has a mortality rate of up to 80%, which depends on a number of factors, including: (1) How many drugs the organism is resistant to (the...

Ngày tải lên: 23/03/2014, 17:20

... prostate cancer cells Selective androgen receptor modulators (SARMs) are drugs that block the binding of testosterone to these cancer cells, inhibiting their growth and possibly preventing prostate cancer ... tumors in cancer patients A drug called Gleevec® inhibits cancer cell growth and causes cancer cells to undergo apoptosis, or programmed cell death It binds to abnormal proteins in cancer cells, ... resistant to the therapeutic drugs One of the characteristics of cancer cells is a high frequency of mutation In the presence of toxic drugs, cancer cells that mutate and become resistant to the drug...

Ngày tải lên: 29/03/2014, 01:20

... Functional genomics and systems biology S Ivakhno Table Overview of the topics covered in the meeting report according to systems biology applications, types of high-throughput ... regulatory elements that are active only in a particular cellular state, developmental stage or cell type Functional genomics approaches to diagnosis of diseases One of the goals of systems biology ... leukaemia From systems to networks biology Talks related to networks biology covered a large portion of the meeting Among many different types of biological networks discussed were gene regulatory networks,...

Ngày tải lên: 30/03/2014, 09:20

... gathered to discuss whether it is time to move into a more integrated molecular biology (and if so, how) As it was at the workshop, the challenge of this book is to show that different approaches to ... irrelevant to their use and maintenance My car mechanic does not need to know the history of the internal combustion engine or to possess the plans of the automobile assembly line to know how to fix ... is not a book devoted to computational approaches to molecular biology In fact, a sizable number of computational approaches currently applied to molecular biology are not represented in this book...

Ngày tải lên: 11/04/2014, 09:48

... CONCLUSIONS In this paper, we consider practical approaches to the problem of optimal resource allocation in OFDM-based systems We study both single- and multiuser systems and show that the single-user ... defined by the relative length of the information part of the symbol with respect to its total length: BERaver = K subject to 2.1 OFDM-OFDMA basics η= E K Aiming at low complexity of implementation, ... has been allocated to another user, the next ordered vacated subcarrier of the user k is assigned to it Algorithm “B” (starting with the “best” user) The algorithm is similar to the previous one...

Ngày tải lên: 22/06/2014, 19:20

... Journal of Biology 2009, 8:65 65.3 Larva Adult Figure Exploring the effects of changes in life history on development The lineages in red show two independent shifts to lecithotrophic development ... beginning to provide insights into the action of selection across development, the approach faces several challenges One is that expression levels of many regulatory genes rise during development, ... of development at a genetic level was stronger for genes expressed early in development, suggesting that changes in gene expression levels may disproportionately affect early development (a topic...

Ngày tải lên: 06/08/2014, 19:20

... positive or negative hormonal receptors, and Her2 overexpression However, none of these classical prognostic factors is able to predict the response to treatment of breast cancers The advent of genomic ... Biological tools: To determine breast cancer patients at high risk of local relapse The current locoregional management of early breast cancer consists of breast conserving surgery (i.e., lumpectomy ... Biological tools: To a personalized radiosensitivity of normal tissues Different parameters could be involved in the development of late radiation-induced toxicity, such as genetic factors (DNA...

Ngày tải lên: 09/08/2014, 10:20

... Scheiber et al [15] to relate chemical substructures to side-effects and by Campillos et al [16] to combine drug chemical similarity to side effect similarity to predict shared drug targets Recent ... predicted binding affinities to activators and inhibitors of Tatonetti et al.: Genome Biology 2009, 10:238 238.3 the renin-angiotensin-aldosterone system (RAAS), they showed that torcetrapib caused more ... the work by Apsel et al [14], who have integrated chemical biology and systems biology techniques to design drugs that act as dual inhibitors of two families of oncogenes The recent work of Xie...

Ngày tải lên: 09/08/2014, 20:20

... Genome Biology 2011, 12:R32 http://genomebiology.com/2011/12/3/R32 Page of 12 DrugProperties (a) PCA DRUGS DRUGS DRUGS CCA/Biclustering PROTEINS Drug- Properties Drug- Properties DRUGS DRUGS (c) ... the total number of proteins sensitive to either property (upper triangle, union) The diagonal is the total number of proteins that were sensitive to the particular drug property descriptor (Methods; ... connector matrices and thus be amenable to the CRIT framework The derivation of the connector matrix can be trivial such as mapping transcription factors to their binding sites or splice sites to...

Ngày tải lên: 09/08/2014, 22:24

... differ according to various combinations of biophysical and other factors Well-functioning soil systems have the following requirements according to Ana Primavesi, another contributor to this volume: ... management of weeds into cropping systems to take advantage of what such plants can contribute, such as q 2006 by Taylor & Francis Group, LLC Biological Approaches to Sustainable Soil Systems 10 Shadow ... volume is intended to communicate the scope and substance of biological approaches to managing soil systems (a) to scientists who have an interest in innovation and practice, and (b) to practitioners...

Ngày tải lên: 11/08/2014, 17:21

... cell C: photoautotrophs, photoheterotrophs, chemoautotrophs, and chemoheterotrophs (Atlas and Bartha, 1998) Photoautotrophs, as noted above, include plants, cyanobacteria, and other photosynthetic ... it into energy-rich organic molecules are called autotrophs They are considered to be “producers.” If this energy comes from light, these organisms are photosynthetic autotrophs (or photoautotrophs), ... more likely to immobilize mineral nutrients, q 2006 by Taylor & Francis Group, LLC Biological Approaches to Sustainable Soil Systems 76 whereas the activities of fungi, protozoa, nematodes, and...

Ngày tải lên: 11/08/2014, 17:21