systemic toxicity caused by absorption of drugs and chemicals through skin

... without fat, of WT and H-PGDS TG mice (n = 6) Continuous dissections of mouse fat and bone in the whole body were quantified by use of a micro-CT scanner and LATHETA software (Aloka) Open and closed ... H-PGDS Bars: 100 lm (D) PGDS activity in liver of WT and S41, S55 and S66 TG mice subcutaneous and visceral adipose tissues, as well as of muscle, of WT and TG (S55) mice were analyzed with a micro-CT ... Fujitani et al and size of adipocytes A major role of adipocytes is to store large amounts of triglycerides during periods of energy excess and to mobilize these depots during periods of nutritional...

Ngày tải lên: 16/02/2014, 09:20

... reduction of signal intensities of The ability of drugs to regulate Bsep gene transcription was assessed by transfection of the full length construct p-1453 into HepG2 cells and subsequent treatment of ... sequence of the first FXRE Ó FEBS 2002 3500 T Gerloff et al (Eur J Biochem 269) Fig Decrease of basal activity and loss of CDCA-mediated stimulation of the minimal Bsep promoter after mutation of the ... altering hepatic bile flow and clearance MATERIALS AND METHODS Genomic cloning and sequence analysis of the 5¢ flanking region We amplified rat genomic DNA and Bsep cDNA by PCR using the oligonucleotide...

Ngày tải lên: 17/03/2014, 23:20

... the initial dose caused further lowering of the absorption of rice starch compared to the standard dose after one and two hours as estimated by the Int J Med Sci 2007, appearance of circulating ... breakdown of rice starch and sucrose The hypothesis tested was that natural starch and sucrose enzyme inhibitors (amylase and sucrase) would diminish and/ or slow the breakdown of starch and sucrose ... and 90 kg at the initiation of study, were deprived of food and water for hours at the time of study Then, they were given challenges of 200 g sucrose (table sugar) and/ or 100 g rice starch individually...

Ngày tải lên: 08/08/2014, 16:23

... MM, Anderson RA Effect of chromium and guar on sugar-induced hypertension in rats Clin Neph 1995; 44:170-177 28 Cori CF The fate of sugar in the animal body I The rate of absorption of hexoses and ... and test [T] groups DISCUSSION Our previous studies show that a formulation composed of inhibitors of the gastrointestinal absorption of starch and sucrose were effective at lessening their absorption ... SEM SBP and BW were examined by 2-way analyses of variance (one factor being group and the second factor being time of examination) Where a significant effect of regimen was detected by repeated...

Ngày tải lên: 08/08/2014, 16:23

... ascending colon and hepatic flexure, into which a large segment of his ileum, appendix, cecum, and part of his ascending colon were invaginated Because of compromised perfusion and swelling of his colonic ... flow, perforation and seeding of infection and tumor cells into the peritoneal cavity, and increased risk of anastomotic complications [26] The advantages of intraoperative reduction of the intussusception ... considerable length of bowel and thereby prevent development of short-bowel syndrome Begos and colleagues [15] are proponents of resection without attempting reduction when the bowel Page of is inflamed,...

Ngày tải lên: 10/08/2014, 23:20

... review of information provided to individual recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information about shipment and storage of drugs, disposition of unused ... development or acquisition of drugs and biologics for CBW defense It also recommends organizational changes in the Office of the Secretary of iii iv The Acquisition of Drugs and Biologics for CBW ... responsibilities have been reordered by the events of September 11, 2001; officials in the Department of Health and Human Services and in the Department of Homeland Security; and the interested public This...

Ngày tải lên: 17/02/2014, 11:20

... of Science, Mathematics - Physics 26 (2010) 43-49 47 Proccessing of the measured results and drawing of graphs are done by software of Origin The fitted equations and saturation thicknesses of ... having outer diameter of 60 mm, inner diameter of 15 mm, thickness of mm, and aluminum incident window with thickness of 0.3 mm, and a photomultiplier working at high voltage of 1300 V; Am-241 source ... activity of 370 MBq (10 mCi) in a disk shape (having overall diameter of mm, overall thickness of mm, active diameter of 4.2 mm, beryllium window with thickness of mm) is placed in well of the...

Ngày tải lên: 22/03/2014, 11:20

... acetone, and 10 lg cell supernatant After incubation at 37 °C (30 min), the reaction was terminated by addition of mL of borate ⁄ carbonate buffer (0.1 m, pH 10.5) followed by mL of chloroform ⁄ ... endothelial cells and macrophages [15,16] Macrophage expression of adipophilin is upregulated by oxLDL [17], acetylated LDL (AcLDL) [18], enzymatically modified LDL [19] and by synthetic agonists of the ... multiplicity of infection values (m.o.i.) of 100 and 500, adipophilin mRNA was increased  14 ± 0.8- and  39 ± 7.8-fold, respectively, and adipophilin protein was increased  6.5 ± 1.7- and  38...

Ngày tải lên: 23/03/2014, 10:21

... because adolescent addictions are different than those of adults He describes the process of counseling, denial and compliance, and surrender and recovery Nowinski stresses the need for family intervention ... dramatic rise in the use of marijuana and more use of stimulants, LSD and inhalants It also describes how this trend was a reversal from the recent downward patterns of drug use among teens D) ... Drug Education program and three times as many as the Adolescent Group Therapy model.V.) Summary and Conclusion: Through the literature and the class it is obvious that drug and alcohol abuse among...

Ngày tải lên: 02/04/2014, 17:48

... 3b) X-ray of forearms, legs, and chest showed ossification of interosseous membranes of the forearm in 18 of 23 patients (78.3%) (Fig 2), of the leg in 14 of 23 patients (60.1%), and of the ribs ... myeloradiculopathy caused by skeletal fluorosis was thought to be a result of compression of the spinal cord by osteophytes and vertebral osteosclerosis [7,23] However, myelopathy caused by OLF in patients ... activation and proliferation of osteoblast-like cells with enhanced expression of messenger ribonucleic acid and proteins of c-fos and c-jun Clinical feature of thoracic ossification of ligamentum...

Ngày tải lên: 20/06/2014, 00:20

Ngày tải lên: 20/06/2014, 00:20

... platform (SB) described in [8] By a reasonable organization of the hardware components and of the bus segments, one can increase the degree of parallelism of data transfers and in this way possibly ... solutions The proposed heuristics start with a random initial deviceto-segments allocation set by: (i) InitRandomly Random initial order of devices, and randomly set segment borders (code not shown) ... inclusion of the processing time and of the packet size in future versions of the algorithm comes as a necessity Impact of Topology A further improvement of performance is represented by a circular...

Ngày tải lên: 21/06/2014, 20:20

... of Science, Mathematics - Physics 26 (2010) 43-49 47 Proccessing of the measured results and drawing of graphs are done by software of Origin The fitted equations and saturation thicknesses of ... having outer diameter of 60 mm, inner diameter of 15 mm, thickness of mm, and aluminum incident window with thickness of 0.3 mm, and a photomultiplier working at high voltage of 1300 V; Am-241 source ... activity of 370 MBq (10 mCi) in a disk shape (having overall diameter of mm, overall thickness of mm, active diameter of 4.2 mm, beryllium window with thickness of mm) is placed in well of the...

Ngày tải lên: 21/07/2014, 16:21

... number of species in the plots (Table 6) On 239 Table Number of Mesostigmata mites species found on the plots with stands non conversed (1, and 7) and with stands during conversion (2, and 8) Stands ... and and and and the other pairs and and and still had a similarity rates quite high and over 50 The lowest rates (less than 40) were among plots and 7, and and and (every three pairs are with ... site 169b pure stand of 111-year-old spruce mixed mountain forest site 169b 4-year-old beech stand in a thinned 111-year-old stand mixed mountain forest site 169g pure stand of 38-year-old spruce...

Ngày tải lên: 07/08/2014, 03:22

... coefficient of 0.88 beginning of the season, the predawn potential was about -0.5 MPa water for both sprouts and standards and it reached minimum values (-2.6, -2.8 MPa for sprouts and standards, ... determined by adding a blue dye to the water and counting with a microscope the number and area of vessels filled by the solution The relationship between the real sap velocity ( Vs) and the heat ... consisted of measuring in the field the water uptake of sampled trees, which represented the averages of the size classes A plastic tank was attached around the stem and filled with water The bark and...

Ngày tải lên: 09/08/2014, 02:21

... evidence of collagen synthesis, evidence of myofibroblasts/ED-A FN and collagen synthesis, no evidence of either myofibroblasts/ED-A FN or collagen synthesis Disease duration, skin score and capillary ... http://arthritis-research.com/content/7/5/R1113 Figure Increased expression of LOX and ED-A FN in dcSSc skin Cryosecskin tions of (a,b) normal skin are compared with (c-f) dcSSc skin In normal skin, immunostaining for LOX was detected ... function and origin remain unknown The objective of our study was to investigate both the origin and biosynthetic profile of myofibroblasts in dcSSc biopsies Double immunofluorescence labelling of...

Ngày tải lên: 09/08/2014, 07:20

... biosynthesis by dual mechanisms: the promoted degradation of MITF protein through the up-regulation of MAPK/ERK signaling pathway, and the suppressed activation of CREB via the down-regulation of p38 ... explore the details of Cpcinduced MITF degradation through MAPK/ERK pathway The existence of Cpc in melanoma cells was evidenced by the analyses of immunoblotting and confocal immunofluorescence localization ... (black) and melanin content (grey) were measured (B) The expression of tyrosinase was determined by immunoblotting analysis (black) and RT-PCR (grey), using b-actin and GAPDH as internal standards,...

Ngày tải lên: 10/08/2014, 10:20

... delivery of vaccines, genes, drugs and other biomolecules in the body They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, ... number of biomolecules, drugs, genes and vaccines to the site of interest in-vivo During the 1980’s and 1990’s several drug delivery systems were developed to improve the efficiency of drugs and ... at the surface of NPs by adsorption of surfactants or by use of block copolymers or branched copolymers [38-40] DRUG LOADING AND ENCAPSULATION One of the most desired qualities of a successful...

Ngày tải lên: 11/08/2014, 08:20

... because of the crater-shaped lesion found, and the indurated and necrotic tissue Primary carcinoma of the vagina is rare It represents only 2% of all gynecological malignancies [5] Most of these ... examination of a patient to exclude the possible non-gynecological origin of vaginal bleeding Page of Consent Written informed consent was obtained from the patient for publication of this case report and ... manuscript Author Details 1Department of Obstetrics and Gynecology, Groene Hart Ziekenhuis, PO Box 1098, 2800 BB Gouda, the Netherlands and 2Department of Pathology, Groene Hart Ziekenhuis, PO...

Ngày tải lên: 11/08/2014, 12:20