systematic review and meta analysis in clinical practice

... ordinal and interval scales is inadequate in relation to meta- analysis Ann Rheum Dis 2001, 60:349-352 Barden J: Meta- analysis to investigate methodological issues in clinical trials using pain ... anti-inflammatory drug Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded ... extraction, analysis, and preparing the manuscript; SD with data extraction, analysis, and writing; GTM with planning, data extraction, analysis, and writing the manuscript; HJM with planning, analysis, ...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... systemic review and meta- analysis to determine IGRA test performance in persons with suspected or confirmed active pulmonary tuberculosis living in low- and middle-income settings modeling, which ... standard guidelines and methods for systematic reviews and meta- analyses of diagnostic tests [18–21] Search Methods We previously published systematic and narrative reviews on the accuracy and ... was performed with blinding to IGRA results Industry involvement was unknown in studies (19%) and acknowledged in (30%), including donation of IGRA kits (6 studies) and work and/ or financial relationships...

Ngày tải lên: 22/03/2014, 18:20

... regimens including pyrazinamide, 31% received drug regimens including a fluoroquinolone, and 17% received drug regimens including streptomycin Induction drug regimens consisted of drugs in 5% of ... fluoroquinolone in 52%, pyrazinamide in 18%, and streptomycin in 14% Most maintenance regimens consisted of 2-drug (46%) or 3-drug (29%) regimens No patients received single-drug MTB therapy during induction ... Tuberculosis Risk Factors and Treatment for LTBI Our review identified 82 cases in which active MTB infection developed in transplanted patients and sufficient accompanying clinical information was available...

Ngày tải lên: 29/03/2014, 03:20

... the original idea for the paper and vouches for the integrity of the analysis DW, UM and MVG extracted and analysed the data All authors collaborated in interpreting the data and writing the ... manufacturing, insulation and cladding work, shipyard, asbestos industries, asbestos cement factory, ceiling tiles and wallboards, railway, ironworker, sheet metal, construction carpenters and millwrights) ... importance of included former workers These biases are probably present in the studies included in our systematic review, since most of them had a cross-sectional design not accounting for changes in lung...

Ngày tải lên: 20/06/2014, 00:20

... Results of an influence analysis in which the metaanalysis is re-estimated omitting each study in turn Rerunning the analysis without the study by Mathias and Kent [32] increased the standardised ... synthesis Meta- analyses were carried out using Stata V 9.1 (Stata, College Station, TX, USA) using the user-contributed commands for meta- analyses: ‘metan’ [19], ‘metainf’ [20], ‘metabias’ [21] and ‘metatrim’ ... overall meta- analysis summary The influence of individual studies on the estimated overall effect size (removing each study and recalculating overall effect) was minor Rerunning the meta- analysis...

Ngày tải lên: 09/08/2014, 01:21

... homogeneity tests in meta- analyses in pain using simulations of individual patient data Pain 2000, 85:415-424 33 L'Abbe KA, Detsky AS, O'Rourke K: Meta- analysis in clinical research Ann Intern Med 1987, ... treatment as defined by the original authors (mainly urine protein excretion, serum creatinine or creatinine clearance, or a combination of these) and subsequent relapse Adverse events sought included ... of clinical or biochemical improvement Reduced protein excretion was mentioned in 10, reduced corticosteroid dose in 7, with each mentioning reduced serum creatinine and disease severity or increased...

Ngày tải lên: 09/08/2014, 08:23

... overall meta- analysis results in the randomized clinical trials Comparison of (a) the forced vital capacity (FVC) and (b) the diffusing overall meta- analysis results in the randomized clinical ... measured by pulmonary function tests by conducting a systematic review and meta- analysis of randomized clinical trials and prospective observational studies in patients with SSc treated with CYC To ... counted in our nine studies included two cases of hemorrhagic cystitis [17] and several cases of hematuria – one case in Valentini and colleagues [18], two cases in Hoyles and colleagues [10] and nine...

Ngày tải lên: 09/08/2014, 13:22

... more frequently in people with schizophrenia than in controls); and state-independence (because they are present whether or not the illness is active) This systematic review and meta- analysis aimed ... adequate blinding is difficult to attain and this bias cannot be fully eliminated); and degree of age matching between comparison groups (see table 2) Data were extracted independently by two reviewers ... combination of offspring, siblings and/ or parents In the first of these studies [14], the ages of all three groups were similar, suggesting that the relatives group were principally siblings and...

Ngày tải lên: 11/08/2014, 15:22

... ethically inappropriate considering the documented symptomatic and functional benefits of many treatments in PAH This illustrates the role of a meta- analysis in determining the improvement in mortality ... This analysis was based on 1404 patients from eleven studies that evaluated prostacyclin or prostacyclin analogues, including intravenous epoprostenol and treprostinil, subcutaneous treprostinil, ... compared trepostinil to placebo [18] The study of intravenous treprostinil and one study of inhaled treprostinil were published in abstract form only, but provided sufficient information for analysis...

Ngày tải lên: 12/08/2014, 11:20

... training protocol was at least (on average) 40% of maxHR or if the training protocol included exercise involving at least one-sixth of the skeletal muscles (for example, walking, running, biking, ... Aerobic exercise combined with education or psychotherapy or pharmacotherapy 35 of studies included in meta- analysis Figure Preferred Reporting Items for Systematic Reviews and Meta- Analyses flow ... post treatment, and on pain, fatigue and sleep at follow-up Continuing exercise is necessary to maintain positive effects on pain Page of 14 The following statements are valid for pain reduction...

Ngày tải lên: 12/08/2014, 12:20

... [5] Methods Systematic review methods The search strategy employed in the original Strachan and Cook systematic review and meta- analysis [3] was repeated in the current study and included a comprehensive ... studies has increased substantially since the original systematic review was published however, and the updated systematic review and meta- analysis described in the present study combines data ... assessing the quality of non randomised studies in meta- analysis [http://www.ohri.ca/programs/ clinical_ epidemiology/oxford.htm] DerSimonian R, Laird N: Meta- analysis in clinical trials Control Clin...

Ngày tải lên: 12/08/2014, 13:22

... patients receiving PDT and ST varies greatly in different practice settings, with ST being performed exclusively in some ICUs, PDT being performed almost exclusively in others and others using a mixture ... critically ill patients remains unanswered To address these shortcomings and provide a comprehensive and contemporary overview, we performed a systematic review and meta- analysis to investigate whether, ... MEDLINE (inception to 2005), EMBASE (inception to 2005), CINAHL (inception to 2005) and the Cochrane Controlled Clinical Trials Register databases (inception to 2005) were searched via OVID MEDLINE...

Ngày tải lên: 12/08/2014, 23:23

... evidence of clinical efficacy into context, it is also important to take into account the costs and difficulties involved in implementing non-invasive ventilation in clinical practice and the logistic ... decreasing need for ETI and mortality without increasing the risk of AMI, from a practical point of view CPAP has been shown to be cheaper and easier to use and implement in clinical practice ... preferred intervention in ACPE patients Finally, we think it is important for researchers in this field to create consensus guidelines over methods for reporting and defining population, interventions...

Ngày tải lên: 12/08/2014, 23:23

... abstraction After pretesting and refining the forms on two trials of surfactant therapy in adults and clarifying definitions based on feedback from the reviewers, two reviewers then independently abstracted ... study Intensive Care Med 2003, 29:437-446 Davison C, Ventre KM, Luchetti M, Randolph AG: Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta- analysis ... enough information to make an assessment Two reviewers independently reviewed all citations meeting criteria for further review and applied the inclusion criteria Disagreements between reviewers...

Ngày tải lên: 13/08/2014, 03:21

... derived from randomised and non-randomised studies Health Technol Assess 2000, 4:1-154 Shapiro S: Meta- analysis/ Shmeta -analysis Am J Epidemiol 1994, 140:771-778 Greenland S: Can meta- analysis be ... Watson RS, Martin LD: Inspiratory work of breathing is not decreased by flow-triggered sensing during spontaneous breathing in children receiving mechanical ventilation: a preliminary report Pediatr ... prevented analysis of pooled data This finding is in contrast with that reported for preterm neonates The systematic reviews and metaanalyses overall provide no evidence that HFO as the initial...

Ngày tải lên: 14/08/2014, 07:21

... technique of drainage, including the use of imaging guidance, the level of training of the operator, and the type of drainage procedure performed; and outcomes Only outcomes reported in mechanically ... participated in data analysis and manuscript preparation NA participated in data analysis and manuscript preparation NF participated in study design and manuscript preparation Competing interests ... differences for analyzing continuous outcome variables in meta- analysis: a simulation study BMC Med Res Methodol 2008, 8:32 29 Higgins JP, Thompson SG: Quantifying heterogeneity in a meta- analysis Stat...

Ngày tải lên: 14/08/2014, 07:21

... Medical (mixed, n = 7) Table Baseline characteristics and outcomes in intervention and control groups in 14 studies included in metaanalysis Author: Year Creatinine* Urea* APACHE II score Early ... (that is, clinical trial vs cohort study), operational definitions for RRT timing (that is, clinical vs biochemical criteria) and the inability to account for heterogeneity in clinical practice ... RIFLE Criteria Risk: Increase in serum Creatinine by 1.5 times or urine output

Ngày tải lên: 14/08/2014, 07:21

... reduce falls in older people with dementia living in the community: A systematic review and meta- analysis Clin Interv Aging 2015;9:421–34 20 Guo J, Tsai Y, Liao J, Tu H, Huang C Interventions ... falls and fractures in hospitals and care homes and effect of cognitive impairment: Systematic review and meta- analyses BMJ 2007;334:82–7 26 Winter H, Watt K, Peel NM Falls prevention interventions ... Delbaere K, Cambier D, et al Characteristics and effectiveness of fall prevention programs in nursing homes: A systematic review and meta- analysis of randomized controlled trials J Am Geriatr Soc...

Ngày tải lên: 25/08/2016, 21:43

... falls in older people Clinical practice guideline Oliver, D., Healey, F., & Haines, T P (2010) Preventing falls and fall-related injuries in hospitals Clinics in Geriatric Medicine, 26, 645–692 Perell, ... Praxis (Bern 1994), 93, 1503–1508, (in German) Leipzig, R M., Cumming, R G., & Tinetti, M E (1999a) Drugs and falls in older people: A systematic review and meta- analysis: I Psychotropic drugs Journal ... Society, 47, 30–39 Leipzig, R M., Cumming, R G., & Tinetti, M E (1999b) Drugs and falls in older people: A systematic review and meta- analysis: II Cardiac and analgesic drugs Journal of the American...

Ngày tải lên: 25/08/2016, 23:00