... ENGINEERING AND SURFACE MODIFICATION OF BACULOVIRUS DERIVED VECTORS FOR IMPROVED GENE DELIVERY TO THE CENTRAL NERVOUS SYSTEM YANG YI (B Eng.) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... UNIVERSITY OF SINGAPORE AND INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY July 2006 ACKNOWLEDGMENTS First and foremost, I wish to express my appreciation to my supervisor, Dr Wang Shu, Associate Professor, ... Professor, Department of Biological Science, National University of Singapore; Group Leader, Institute of Bioengineering and Nanotechnology, for his continuous support and patient guidance And to my co-supervisors,...
Ngày tải lên: 14/09/2015, 11:28
... substrate surface Based on both these curves, coercive fields (Hc) of 355.8 and 93.6 Oe, respectively, for NCs and PSC, saturation magnetizations (Ms) of 125.7 and 162.5 emu/g, respectively, for NCs and ... http://www.nanoscalereslett.com/content/6/1/285 Page of published SY and YQ: partly carried out the TEM and HRTEM experiments, as well as drafted the manuscript XL, LS, and HL: conceived of the study, and participated in its design and coordination ... out the experimental and numerical calculations, as well as drafted the manuscript VSM and PPMS: performed an analysis and interpretation of results, and gave final approval of the version to be...
Ngày tải lên: 21/06/2014, 04:20
Synthesis and Physical Properties of Polyester Amides Derived from Lipid-Based Components
... Outline Introduction of polyester amide (PEA) What is polyester amide Applications Advantage of Lipid -based components Previous Examples of Lipid -based PEA Objectives and Results Conclusions ... increased elasticity The increase of ester to amide ratio in PEA structure will diminish the mechanical strength of the polymer Synthesis of the PEA Step 1: Synthesis of different diols from oleic ... Journal of Biomaterials Science-Polymer Edition, 2007 18(6): p 673-685 Guo, K and C.C Chu, Journal of Polymer Science Part a-Polymer Chemistry, 2005 43(17): p 3932-3944 Advantage of Lipid-based...
Ngày tải lên: 02/07/2014, 13:01
Surface modification of ferromagnetic nanoparticles for separation of toxic heavy metals and environmental applications
... 65 3.2.2 Synthesis of phosphonium based silane (PPhSi) 66 3.2.3 Synthesis of phosphonium based silane coated magnetic nanoparticles (PPhSi-MNPs) 67 3.2.4 Synthesis of carboxymethyl-β-cyclodextrin ... 3.2.5 Synthesis of carboxymethyl-β-cyclodextrin polymer (CDpoly) 68 3.2.6 Surface modification of magnetic nanoparticles with CM-β-CD (CMCDMNPs) 69 3.2.7 Surface modification of ... loss of magnetism and dispersibility Therefore, the surface modification of nanoparticles is indispensable and the particle surface can be modified by grafting inorganic or organic coating Surface...
Ngày tải lên: 08/09/2015, 19:41
Design, synthesis and biological studies of coumarin based probes and tetrahydrolipstatin analogs 1
... Romo’s synthesis of THL 53 4.10 Hoffmann-La Roche enantiosynthesis of THL 54 4.11 Kumaraswamy’s synthesis of THL 56 4.12 Synthesis of β-hydroxy aldehyde 4.71 57 4.13 Davies’ synthesis of THL ... synthesis of THL 4.4 Kocienski’s synthesis of THL 48 4.5 Hanessian’s synthesis of THL 49 4.6 Ghosh’s asymmetric synthesis of THL 50 4.7 Mcleod’s synthesis of THL 52 4.8 Laglois’ synhesis of THL ... Synthesis of mono-Boc linker 16 2.5 Synthesis of flurescent RGDC conjugate 19 4.1 Schneider’s synthesis of THL 45 4.2 45 4.3 Hoffmann-La Roche second generation synthesis of THL Uskoković’s synthesis...
Ngày tải lên: 11/09/2015, 09:58
Design, synthesis and biological studies of coumarin based probes and tetrahydrolipstatin analogs
... 125.7577890 MHz DATE_d : DECNUC : off NS 39.9955 39.8279 39.7551 39.6968 39.6603 39.4927 39.3324 39.1648 38.9972 38.8514 38.7057 BF1 : 137 Oct 23 2006 NUCLEUS : off PULPROG : zgpg30 SFO1 : 125.7709936 ... Parameters *** O sg1023~1 : *** Acquisition Parameters *** O 2.19 Oct 23 2006 : off NS O : DECNUC N : 125.7577890 MHz DATE_d : 57 off PULPROG : N H BF1 NUCLEUS : N H (1) N O : PROCNO 34.0345 33.9106 O ... MHz 1.00 Hz 32768 *** 1D NMR Plot Parameters *** O N H (1) 35.0 : SF 60 50 40 30 20 10 60.62 Hz off 220 39.6968 38.8514 38.7057 38.4506 34.0345 33.9106 69.5313 69.4875 68.9774 68.9556 97.4419...
Ngày tải lên: 11/09/2015, 09:58
Surface and molecular modification of polyimides via graft copolymerization and functionalization
... processes of Ar plasma pretreatment and UV-induced graft copolymerization of FPI with VIDz to form the VIDz-g-FPI surface and 4VP to form a 4VP-g-FPI surface, and the activation of the modified FPI surface ... scan and C 1s core-level spectra of (a) the pristine FPI-1 surface, the delaminated (b) Cu surface and (c) FPI-1 surface from a Cu/VIDz-g-FPI-1 assembly; the delaminated (d) Cu surface and (e) ... powers of (b) W and (c) 180 W, and (d) the 4VP homopolymer Figure 4.4 XPS N 1s core-level spectra of (a) the pristine PI surface, (b) the pristine P4VP surface, and (c) the pp-4VP-PI surface...
Ngày tải lên: 17/09/2015, 17:20
Synthesis and photoluminescence property of silicon carbon nanowires synthesized by the thermal evaporation method
... SEM image of the nanoporous AAO template surface Results and discussion A typical SEM image of the nanoporous AAO template surface is shown in Fig The image shows the nanopores on the surface with ... reveals that large quantities of randomly distributed wire-like products have been obtained The nanowires are of uniform diameter of about 50 nm and lengths up to tens of micrometers In addition, ... ratio of Si/C/O of the nanowires is about 3:2:2, which corresponds well to the standard SiC and SiO2 The small quantity of oxygen may come from the resident oxide layer The IR spectrum of the...
Ngày tải lên: 16/03/2014, 15:21
Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx
... the phosphorylated form of hCdc6p However, more importantly in the present context, we note that the synthesis of hCdc6p continues through most of the cell cycle Synthesis of hCdc6p during G1 phase ... with chromatin during the 2-h label period Rates of hCdc6p synthesis To investigate whether the synthesis of hCdc6p was restricted to specific phases of the cell cycle, HeLa cells were arrested by ... well as at the end of mitosis and during the early G1 phase (12–14 h) of the next cycle (Fig 2A) Cytoplasmic and chromatin extracts were immunoprecipitated with specific antibodies and transferred...
Ngày tải lên: 17/03/2014, 23:20
hydrothermal synthesis and crystal structure of a novel one - dimensional tritungstate
... at calculated positions and refined using the riding model of SHELXTL program with a fixed ˚ C–H bond length of 0.97 A and a N–H bond length of ˚ Final refinement was based on 1917 reflections ... 2q cations occupy interstrand regions 4y of the W6 O 20 chains and exhibit strong hydrogen bond network to terminal and bridging oxo groups of the anionic 4y chains of W6 O 20 X Crystal data ... associated with Õ ŽO–W–O modes In addition, absorption bands at 1480 and 1624 cmy1 , and a broad band centred at 3400 cmy1 suggest the presence of en species By replacing en with other organodiamines...
Ngày tải lên: 19/03/2014, 16:48
hydrothermal synthesis and structural characterization of fe2o3sno2 nanoparticles
... evidence of the solubility limits of Sn4þ in the hematite structure and of Fe3þ in SnO2 are discussed the compositional uniformity The determined average values of x; for the analyzed series of mixed ... with coordinates of ð0; 0; zÞ occupy 2/3 of the octahedral holes in successive oxygen layers, and 1/3 of the octahedral holes with coordinates of ð0; 0; 0Þ are empty In the case of our samples, ... shape and the disappearance of magnetic hyperfine structure as tin content in the samples M Sorescu et al / Journal of Physics and Chemistry of Solids 65 (2004) 1021–1029 Fig TEM image (a) and the...
Ngày tải lên: 19/03/2014, 16:48
research on gas - sensing properties of lead sulfide-based sensor for detection
... and responses of the sensors based on PbS was prepared with Na2 S at 80 ◦ C at the optimal operating voltage and in a room temperature that NH3 and NO2 on the surface of PbS absorption ways and ... advantages of being simple to fabricate and having cheaper prices Please cite this article in press as: T Fu, Research on gas-sensing properties of lead sulfide -based sensor for detection of NO2 and ... properties of lead sulfide -based sensor for detection of NO2 and NH3 at room temperature, Sens Actuators B: Chem (2009), doi:10.1016/j.snb.2009.03.075 G Model ARTICLE IN PRESS SNB-11469; No of Pages...
Ngày tải lên: 20/03/2014, 13:06
sol–gel synthesis and morphological control of nanocrystalline tio2 via urea treatment
... ratio) The straight and parallel stripes (referred to Figs 4b and 4c) on the surface of the rods and hollow tubes may result from the aggregates of the smaller and finer nanorods of ∼10 nm in diameter ... rods and hollow tubes, consisting of aggregates of nanorods of ∼10 nm in diameter The nanocrystalline TiO2 thus prepared appears to have an engraved surface morphology and consists mainly of the ... [38] Fig FE-SEM images of nanocrystalline TiO2 rods and hollow tubes (a) and the engraved surface (b) for SDS-90 8.7 25.6 11.5 164 L.-H Kao et al / Journal of Colloid and Interface Science 316...
Ngày tải lên: 20/03/2014, 13:07
synthesis and optical properties of colloidal tungsten oxide nanorods
... and the intensity of this peak increases relative to that of UV emission as the length of nanorods increases A similar PL pattern with two emission maxima, yet at much lower energies of 2.8 and ... band gap due to impurities.22b In light of these assignments, we suggest that the UV emission of nanorod samples in this work might correspond to the band-toband transition The blue emission of ... COMMUNICATIONS Comparing the intensities of the (010) and (014) peaks of the sample with those of the bulk W18O49, it was found that the relative intensity of (010) has been dramatically increased...
Ngày tải lên: 20/03/2014, 13:08
Báo cáo khoa học: Synthesis and structural characterization of a mimetic membrane-anchored prion protein doc
... composed of 35% a helix and a small amount of b sheet, whereas PrPSc appears to have elevated levels of b sheet [7,8] Higher resolution studies of the structure of PrPC have made use of NMR and ... is indeed a cell -surface event, this requires a thorough understanding of the folding and interactions of PrP in its tethered conformation on the plasma membrane The interaction of PrP with different ... a hydrophobic component The composition of the membranes and conformation of PrP affect the strength of the binding and the propensity for aggregation of the protein It was found that membranes...
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is a-D-Gal-(1fi3)-a-D-GalNAc pot
... increments in t1 and spectral widths of 8000 Hz and 17 591 Hz in the 1H and 13C dimensions, respectively A total of 256 summed scans were collected with a relaxation delay of 1.3 s All 1H and 1H-13C ... part of the INSIGHT suite of programs (Accelrys, San Diego, CA, USA) Ó FEBS 2004 Glycopeptide tx5a synthesis and NMR analysis (Eur J Biochem 271) 4943 Results After synthesis and deprotection of ... between GNH3 of GalNAc and GH1 of Gal, which is labeled in bold The amino acids Gly6, Thr10 and Pro13 are represented by 6G, 10T and 13P Ó FEBS 2004 Glycopeptide tx5a synthesis and NMR analysis...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo " Synthesis and thermoelectric properties of La(Fe1-xSix)13 compounds (x = 0.12, 0.14 and 0.15) " pptx
... and 18% for x = 0.12 and 0.14, respectively Finally, the thermal conductivity (κ) of La(Fe1-xSix)13 (x = 0.12, 0.14 and 0.15) compounds is shown in Fig For general, the thermal conductivity of ... diffraction patterns of La(Fe1-xSix)13 compounds Fig shows the XRD patterns of the La(Fe1-xSix)13 (x = 0.12, 0.14 and 0.15) compounds X-ray diffraction confirms that the solid solution of La(Fe1-xSix)13 ... Temperature dependence of the thermopower of La(Fe1-xSix)13 compounds Fig shows the temperature dependence of the thermopower (α) in the La(Fe1-xSix)13 (x = 0.12, 0.14 and 0.15) compounds All...
Ngày tải lên: 28/03/2014, 13:20
DELIVERING HEALTH EDUCATION VIA THE WEB: DESIGN AND FORMATIVE EVALUATION OF A DISCOURSE-BASED LEARNING ENVIRONMENT pot
... students of the Faculty of Education, University of Wollongong; and testing by undergraduate teacher trainees of the Faculty of Education, University of Wollongong The health education and instructional ... list of questions to help guide their review of the Web site The questions covered: structure and navigation, readability of text, appropriateness of graphics and icons, clarity and quality of ... evaluation of the Web site have a varied teaching background in terms of level and content and are focusing their postgraduate studies on the design, development and evaluation of technology-based...
Ngày tải lên: 28/03/2014, 21:20
Báo cáo khoa học: Physical properties and surface activity of surfactant-like membranes containing the cationic and hydrophobic peptide KL4 potx
... of the structural and functional properties of the native proteins and thus may offer a useful basis for the design of agents for therapeutic intervention [7] Studies of different fragments and ... (GUVs), (b) the effect of the lipid composition on KL4 structure, in the absence and presence of Ca2+, using CD and (c) the role of the lipid composition and peptide structure on surface adsorption ... peptide and lipid bilayers, and their dependence on calcium Therefore, the objectives of this study were to analyze (a) the effect of KL4 on the physical properties of membranes, in the absence and...
Ngày tải lên: 30/03/2014, 11:20