symptomatic therapy in pediatric multiple sclerosis

... and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment and remission maintenance in adult ... favorable maintenance of clinical remission Since CD may progress from intestinal inflammation to strictures and penetrating disease, including fistulas and abscess formation, mucosal healing has ... weeks for maintenance of remission After 54 weeks, the initial clinical response was maintained in only 17% of patients in the single dose group compared to 43% of patients maintained on 5 mg/kg...

Ngày tải lên: 22/03/2014, 10:20

... W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, et al: Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis Multiple Sclerosis Collaborative ... progression in multiple sclerosis Mult Scler 1999, 5:287-290 Bagnato F, Durastanti V, Finamore L, Volante G, Millefiorini E: Beta-2 microglobulin and neopterin as markers of disease activity in multiple ... biological activity Initially, IFNb-1a administration may result in a sharp increase in the neopterin levels owing to the acute, proinflammatory actions of IFNb-1a [35,36] However, in the long term...

Ngày tải lên: 18/06/2014, 19:20

... W, Coats ME, Goodkin DE, Weinstock-Guttman B, Herndon RM, et al: Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis Multiple Sclerosis Collaborative ... progression in multiple sclerosis Mult Scler 1999, 5:287-290 Bagnato F, Durastanti V, Finamore L, Volante G, Millefiorini E: Beta-2 microglobulin and neopterin as markers of disease activity in multiple ... biological activity Initially, IFNb-1a administration may result in a sharp increase in the neopterin levels owing to the acute, proinflammatory actions of IFNb-1a [35,36] However, in the long term...

Ngày tải lên: 20/06/2014, 03:20

... implying that the items in each scale contain a similar proportion of information concerning the construct being measured, except for one item in the 11-item Coordination of Care scale These findings ... grouped into clinically meaningful themes, and examined for redundancy At this stage we were over inclusive in developing items from patients’ statements This qualitative work generated a preliminary ... friends were not closely involved in their care experiences Two domains (attitude of health care professionals; interpersonal care) were combined to form a single domain (interpersonal care) because...

Ngày tải lên: 20/06/2014, 15:20

... with POTS Initial therapy consisted of an increase in salt and fluid intake as well as aerobic reconditioning with resistance training to increase lower extremity strength Pharmacotherapy was ... or in combination in the following order: fludrocortisone 0.1mg po bid, midodrine 5-10 mg po tid, propanolol10 mg po tid, pyrodostigmine 60 mg po bid, serotonin reuptake inhibitor or modafinil ... by cerebrospinal fluid analysis and Magnetic Resonance Imaging of the brain in each case Two patients with POTS, who were followed at our clinic, developed multiple sclerosis after being diagnosed...

Ngày tải lên: 26/10/2012, 09:39

... Background Information for Nursing Practice in Multiple Sclerosis The History of Multiple Sclerosis Care Domains of Multiple Sclerosis Nursing Practice Change Theory and Its Application in Multiple Sclerosis ... Chain in Multiple Sclerosis 51 iii iv CONTENTS 12 The Multiple Sclerosis Care Team 13 Bladder Dysfunction 65 69 14 Bowel Elimination and Continence 75 15 The Nurse’s Role in Advanced Multiple Sclerosis ... attacks in the brain, including many that did not manifest symptoms In 1993, FDA approved Betaseron® (IFN-beta 1b) for relapsing remitting MS (R-R MS) 4 NURSING PRACTICE IN MULTIPLE SCLEROSIS: ...

Ngày tải lên: 15/03/2014, 19:20

... with relapsing-remitting MS in 1993, presenting symptoms were noticeable tingling and burning sensation in the right leg, followed by paraplegia lasting almost three weeks Neurological investigations ... allows homing toward injured/hypoxic tissue after intravenous administration Indeed this has allowed for numerous studies demonstrating positive effects of intravenously administered MSC causing regeneration ... cells responsible for creating and maintaining the myelin sheath, which helps the neurons carry electrical signals MS results in a thinning or complete loss of myelin and, less frequently, transection...

Ngày tải lên: 18/06/2014, 15:20

... physical stress in multiple sclerosis Brain Behav Immun 2003, 17(6):473-481 White LJ, Castellano V, Mc Coy SC: Cytokine responses to resistance training in people with multiple sclerosis J Sports ... Impact Scale Competing interests The authors declare that they have no competing interests Authors' contributions NS was involved in all aspects of this study She was involved in the concept and ... 13(8):1038-1045 Multiple Sclerosis Council for Clinical Practice Guidelines: Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis Paralyzed Veterans...

Ngày tải lên: 18/06/2014, 19:20

... self-esteem and because, in certain countries such as the USA, remaining in full-time employment is an important determinant of obtaining insurance for reimbursement of treatment costs Again, the impact ... Falini A, Comi G, Filippi M: fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection Human brain mapping 2007, 28(5):373-382 Khan O, Mackenzie ... Brain (1)H-MRS Study in Multiple Sclerosis: Effect of Glatiramer Acetate Therapy on Axonal Metabolic Function and Feasibility of Long-Term (1)H-MRS Monitoring in Multiple Sclerosis J Neuroimaging...

Ngày tải lên: 18/06/2014, 19:20

... fatigue in multiple sclerosis In Multiple sclerosis clinical practice guideline Washington, DC: Paralyzed Veterans Association; 1998 Freal JE, Kraft GH, Coryell JK: Symptomatic fatigue in multiple sclerosis ... Psychosocial correlates of fatigue in multiple sclerosis Arch Phys Med Rehabil 1996, 77:165-170 Krupp LB, Elkins LE: Fatigue and declines in cognitive functioning in multiple sclerosis Neurology 2000, ... IFN Change in IMA B Percent (%) 50 40 30 20 10 1.0-3.0 4.0 5.0-6.0 Fatigue Score Figure Changes 2in fatigue rating following a change in IMA Changes in fatigue rating following a change in IMA NARCOMS...

Ngày tải lên: 18/06/2014, 19:20

... training mode As regards changes within one session, to distinguish between the changes in performance occurring during the Robot Training phase from those occurring during the Subject Training ... (d = 3): Figure Training protocol and study design Top: Phases of the training protocol: Baseline (B1), Robot Training, Baseline (B2), Subject Training, Wash-out The phases in which the robot ... changes in movement kinematics We found no significant effects of Robot Training (baseline vs baseline 2) As regards the effect of Subject Training (baseline vs wash-out), we found a decrease in the...

Ngày tải lên: 19/06/2014, 08:20

... time of the unilateral activities (i.e grasping and moving a jar, pouring water from a jug into a cup, inserting coins in a slot, pinching and moving small objects) was registered The maximal ... Sanguineti V: Adaptive robot training for the treatment of incoordination in Multiple Sclerosis J Neuroeng Rehabil 2010, 7:37 McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, ... could hold promise for complementing traditional MS therapy, as therapy time dedicated to arm and hand function training is often limited, principally being indicated in highly disabled MS patients...

Ngày tải lên: 19/06/2014, 08:20

... fatigue in multiple sclerosis Multiple Sclerosis Council for Clinical Practice Guidelines; 1998 35 Iyengar V, Santos MJ, Ko M, Aruin AS: Grip force control in individuals with multiple sclerosis Neurorehabilitation ... evaluate fatigue in multiple sclerosis Multiple Sclerosis 1999, 5(1):10-16 28 Kos D, Nagels G, D’Hooghe MB, Duportail M, Kerckhofs E: A rapid screening tool for fatigue impact in multiple sclerosis ... assess multiple sclerosis- related fatigue Multiple Sclerosis 2009, 15(12):1509-1517 34 Guidelines MSCfCP: Fatigue and Multiple Sclerosis: evidence based management strategies for fatigue in multiple...

Ngày tải lên: 19/06/2014, 08:20

... Defining the clinical course of multiple sclerosis: results of an international survey National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis ... yr, per Lublin and Reingold [4] During the next 15 years she had documented relapses which resolved with intravenous glucocorticoid therapy The relapses decreased in frequency during this time, ... diabetes and act by improving insulin resistance without causing hypoglycemia, even in euglycemic individuals They were later found to activate PPARγ and shown to promote antiinflammatory and immunosuppressive...

Ngày tải lên: 19/06/2014, 22:20

... activity in multiple sclerosis (MS) Clinical and brain magnetic resonance imaging (MRI) disease activity in MS is associated with fluctuations in sHLA-I and sHLA-II levels in the serum and cerebrospinal ... of interferon-beta 1b treatment in patients with relapsingremitting multiple sclerosis is associated with an increase in serum levels of soluble HLA-I molecules during the first months of therapy ... an increase in serum sHLAI, but not in serum HLA-II levels, in MS has been reported [14] Fainardi et al [15] reported a decrease in sHLA-I concentrations during exacerbations in MS, but an increase...

Ngày tải lên: 19/06/2014, 22:20

... nostaining was found in normal-appearing white matter of brain and spinal cord IL-16 immunoreactivity was readily observed in CD3+ T cells in perivenular infiltrates (Fig 6A) Within the pool of infiltrating ... was undetectable in control brain (Fig 1A), and was very low in control spinal cord white matter (Fig 1B), but was abundantly present in MS lesions in brain and spinal cord In brain, levels of proIL-16 ... not detected in control brain (A) or spinal cord (B) In MS lesions, relatively high levels T-bet were measured in acute lesions (AL) and chronic lesions (CL) in brain, and in AL in spinal cord Compared...

Ngày tải lên: 19/06/2014, 22:20

... role in cell adhesion, i.e slowing and initiating cell rolling, they have been shown to have a dominant role in allowing non-specifically activated cells to gain access to the CNS [5], independent ... to inward trafficking of various molecules and cells in the intravascular compartment.2 Inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) induce opening ... independent from the integrin VLA-4 and VCAM-1 interaction Elevated plasma levels of plasma EMPs have been reported in MS, with values in stable patients in the normal range and elevations during exacerbations...

Ngày tải lên: 19/06/2014, 22:20

... Hematoxylin & eosin together with cyanin R staining in alternate sections of the spinal cord revealed pathology consistent with the clinical score The most conspicuous changes appeared in rats showing ... mimetics, including CHEC-9, have been used previously to increase cell survival and inhibit inflammation in a variety of experimental paradigms In the present study, we used a non-invasive urinary ... Neuroinflammation 2006, 3:26 Background The pathophysiology of multiple sclerosis (MS) involves both antigen specific mechanisms and the innate immune system, including elements of the acute inflammatory...

Ngày tải lên: 19/06/2014, 22:20

... Danish Multiple Sclerosis Study Group: Clinical importance of neutralizing antibodies against interferon beta in relapsing-remitting multiple sclerosis Lancet 2003, 362:1184-1191 Chadha K, Winstock-Guttman ... of interferon-beta1b treatment in patients with relapsingremitting multiple sclerosis is associated with an increase in serum levels of soluble HLA-I molecules during the first months of therapy ... brain scan results Of particular interest, the increase in sHLA-II values was associated with a decline on brain MRI activity as demonstrated by post-contrast T1-weighted axial brain images Initially,...

Ngày tải lên: 19/06/2014, 22:20

... cholesterol was associated with increases in the number of contrast-enhancing lesions on brain MRI in clinically isolated syndrome patients following a first clinical demyelinating event [21] MS patients ... Cholesterol is a major component of myelin and statins may hinder remyelination by inhibiting cholesterol synthesis in the brain [36,37] The studies of statin treatment in MS have likewise also yielded ... disease-modifying agents and brain volume changes in multiple sclerosis Neurology 2008, 71:136-144 25 Zivadinov R, Weinstock-Guttman B, Zorzon M, Uxa L, Serafin M, Bosco A, Bratina A, Maggiore...

Ngày tải lên: 19/06/2014, 22:20