... differentiate bacterial from acute viral rhinosinusitis These recommendations are intended to improve the likelihood of separating acute bacterial from viral rhinosinusitis solely based on the duration of ... adults with a presumptive diagnosis of ABRS Lack of Precision in Current Methods of Diagnosis The gold standard for the diagnosis of ABRS is the recovery of bacteria in high density ($104 colony-forming ... established Thus, the diagnosis of ABRS in most randomized controlled trials (RCTs) of antimicrobial therapy is based on the presence of compatible symptoms and signs of acute rhinosinusitis (Table 2)...
Ngày tải lên: 05/03/2014, 10:20
... Berlin, Germany) with a limit of detection of 0.07 mg/ml Treatment and course of illness The efficacy of initial antibiotic treatment was assessed on the basis of in vitro bacterial sensitivity to ... start of treatment showing sterilization in all cases Antibiotic treatment was simplified eight times out of 21 on the basis of the results of microbiological analysis of CSF samples All of the ... the start of treatment in six patients out of 24 on the basis of the results of microbiological analysis of the CSF For the three patients with a CSF culture not showing any evidence of bacteria,...
Ngày tải lên: 12/08/2014, 22:22
Báo cáo y học: "Effect of Acute Administration of an Herbal Preparation on Blood Pressure and Heart Rate in Humans"
... absorption of fats and carbohydrates [5] In spite of their widespread use and the lack of credible reports regarding adverse effects, controversy has existed regarding the safety of bitter orange ... and is not a constituent of C aurantium Because of the known cardiovascular effects of nor-epinephrine and ephedrine, it has generally been assumed that consumption of p-synephrine and bitter ... increases in heart rate and blood pressure [8-11] The purpose of this study was to determine the effects of the acute administration of a product containing caffeine from guarana, p-synephrine...
Ngày tải lên: 25/10/2012, 11:10
Tài liệu Báo cáo khoa học: Intrinsic GTPase activity of a bacterial twin-arginine translocation proofreading chaperone induced by domain swapping ppt
... co-ordination of the two distinct functions of TorD with the folding of TorA and possible interactions of both proteins with the MGD biosynthetic apparatus [12] The concentration of GTP in the cytoplasm of ... proteins as a result of its structural similarity to nucleotide cofactors Specifically-bound proteins are then normally eluted by the application of either an amount of cofactor or by increasing ... an assay measuring the effect of competition of a ten-fold excess of XMP on the GTPase activities of the native protein and the TorDD68N variant The GTPase activity of TorDD68N was found to be...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates pdf
... movement of the cofactor-binding domain of subunit A relative to subunits B and C (not shown) This domain alteration involves a rotation of 5° and translation of ˚ 0.7 A Five segments of polypeptide ... hydrogen bond with the C3-hydroxyl of RU5P, C2-hydroxyl of PEX or the C4-hydroxyl of 6PG (in the modelled ternary complex) Some 84 residues of the cofactor-binding domain of LlPDH are strictly conserved ... occupancies Superposition of subunit A on B and C (468 Ca atoms) in complex II and III of LlPDH gives an rmsd of ˚ 1.6 A in each case, however, superposition of B on C ˚ gives an rmsd of only 0.3 A We...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khóa học: Active-site residues and amino acid specificity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx
... synthesis of PPC occurs in two half reactions starting with the formation of 4¢-phosphopantothenoyl-CMP (activation of the carboxyl group of 4¢-phosphopantothenate) In a second step, the amide bond of ... binding one of the (co)substrates of CoaB, indicating that the provided models of the substrate binding sites of human CoaB not give a complete insight into the active-site architecture of CoaB The ... characterization of Dfp and CoaB proteins Growth of strains E coli M15 (pREP4, pQE8/pQE12) cells were grown in the presence of ampicillin (100 lgÆmL)1) and kanamycin (25 lgÆmL)1) in 0.5 L of B-broth...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Evidence-based Management of Acute Musculoskeletal Pain ppt
... Associated with Acute Low Back Pain Summary of Key Messages: Acute Low Back Pain Alerting Features of Serious Conditions Associated with Acute Thoracic Spinal Pain Summary of Key Messages: Acute Thoracic ... Features of Serious Conditions Associated with Acute Neck Pain Summary of Key Messages: Acute Neck Pain Alerting Features of Serious Conditions Associated with Acute Shoulder Pain Summary of Key ... www.nhmrc.gov.au • The guide covers the management of five regions of acute musculoskeletal pain (acute low back pain, acute thoracic spinal pain, acute neck pain, acute shoulder pain, anterior knee pain)...
Ngày tải lên: 21/02/2014, 11:20
Tài liệu Evidence-Based Guidelines for Migraine Headache in the Primary Care Setting: Pharmacological Management of Acute Attacks doc
... analysis of NSAIDs and other nonopiate analgesics included 33 controlled trials Comparisons with placebo consistently demonstrated the efficacy of this class of agents for pain relief 10 of acute ... Treatment of acute migraine attack: ibuprofen and placebo compared Headache 1989;29(8):507-509 57 Kloster R, Nestvold K, Vilming ST A double-blind study of ibuprofen versus placebo in the treatment of ... treatment of migraine Headache 1975;15(3):211-213 140 Ryan RE A study of Midrin in the symptomatic relief of migraine headache Headache 1974;14(1):33-42 44 141 Ogden HD Controlled studies of a new...
Ngày tải lên: 21/02/2014, 12:20
Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt
... [12,16] The very N-terminal region of PolC and the C-terminal domain of DnaE appear to be specific for each type of polymerase The small a ⁄ b C-terminal domain of DnaE has been shown to be responsible ... first half of the PolC N-terminal region ( 1–100) also detected the PolIIIs-V domain, albeit weakly (hhsearch probability of 16%) The structures of PolIIIs-V and DnaA-I adopt a variant of the so-called ... include Lys36 and Lys41 In addition, species of the class Bacilli often have one to four Lys or Arg residues in variable positions of the N-terminal part of the a1 helix These residues also contribute...
Ngày tải lên: 05/03/2014, 23:20
Báo cáo khoa học: Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes pdf
... cell pellet was resuspended in 15 mL of ice-cold spheroplast buffer (10 mL of m Tris ⁄ HCl, pH 8.0, 17.1 g of sucrose, 100 lL of 0.5 m EDTA, pH 8.0, and 200 lL of phenyl- FEBS Journal 273 (2006) ... PAGE analysis of purified chitinase G (ChiG) Fig S2 Degradation of b-chitin Fig S3 Close-up view of the rA-weighted 2Fo–Fc electron density map in a representative part of the structure of chitinase ... into two subsets of interrelated changes, with each subset affecting one side of the substrate-binding groove of the enzyme (Fig 4B,C) On the side where the nonreducing end of the substrate FEBS...
Ngày tải lên: 07/03/2014, 11:20
Diagnosis of acute maxillary sinusitis and acute otitis media pptx
... Department of Otorhinolaryngology University of Helsinki and Dr Maija Hytönen Department of Otorhinolaryngology University of Helsinki Reviewed by: Professor Emeritus Heikki Puhakka Department of Otorhinolaryngology ... University of Tampere and Docent Jukka Luotonen Department of Otorhinolalaryngology University of Oulu Dissertation opponent Professor Jouko Suonpää Department of Otorhinolaryngology University of Turku ... Journal of Pediatric Otorhinolaryngology 2003;67(7):757–760 list of original publications Blomgren_K 3 21.11.2003, 11:03:58 abstract The number of diagnosed acute otitis media (AOM) and acute maxillary...
Ngày tải lên: 07/03/2014, 13:20
Guidelines on the diagnosis and management of acute pulmonary embolism pot
... presence of an acute clot because of simultaneous activation of coagulation and fibrinolysis Hence, a normal D-dimer level renders acute PE or DVT unlikely, i.e the negative predictive value (NPV) of ... treatment of VTE is supported by three lines of evidence, all from randomized trials One of these studies showed a 20% rate of symptomatic extension and/or recurrence within months in patients with symptomatic ... risk of perioperative VTE The longer the duration of antithrombotic prophylaxis, the lower the incidence of VTE.5,9 Most patients with symptomatic DVT have proximal clots, and in 40–50% of cases...
Ngày tải lên: 08/03/2014, 14:20
Management of suspected bacterial urinary tract infection in adults pdf
... symptoms of urinary tract infection and bacteriuria the main aim of treatment is relief of symptoms Secondary outcomes are adverse effects of treatment or recurrence of symptoms For asymptomatic ... occurrence of ≥104 white blood cells (WBC)/ml in a freshly voided specimen of urine Higher numbers of WBC are often found in healthy asymptomatic women Pyuria is present in 96% of symptomatic ... with symptoms of LUTI A Treat non-pregnant women of any age with Audit of practice against care symptoms or signs of acute LUTI with a three day pathway course of trimethoprim or nitrofurantoin...
Ngày tải lên: 08/03/2014, 14:20
Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
... contribution of AclB, as well as the b subunit of Ec-SCS, in the catalytic process seems to be assistance of the nucleotide binding to and phosphorylation of the a subunit Another function of AclB ... conditions, the majority of Cl-ACL binds to only one molecule of citrate In the presence of sufcient levels of ATP, the low Ks1 value would contribute to the efcient conversion of citrate at low concentrations ... 8.4) in a total volume of mL All RESULTS Purication of Cl-ACL from recombinant E coli Cl-ACL consists of two distinct subunits a (AclA) and b (AclB), with molecular masses of 65 535 Da and 43 657...
Ngày tải lên: 08/03/2014, 22:20
Báo cáo khoa học: Characterization and regulation of a bacterial sugar phosphatase of the haloalkanoate dehalogenase ppt
... Overproduction and purification of recombinant AraL-His6 (A) Analysis of the soluble (S) and insoluble (P) protein fraction (20 lg of total protein) of induced cultures of E coli Bl21(DE3) pLysS harboring ... pLG11 carrying the truncated version of AraL, overproduction was successful (Fig 3) Deletion of the 5¢-end of the araL gene caused an increase of the free energy of the putative mRNA secondary structure ... (Hitachi Software Engineering Co Ltd, Tokyo, Japan), is shown (B) Overproduction of recombinant AraL-His6 Analysis of the soluble (S) and insoluble (P) protein fraction (20 lg of total protein) of induced...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: A mutagenic analysis of the RNase mechanism of the bacterial Kid toxin by mass spectrometry pptx
... semiquantitive assessment of the relative levels of toxicity of the different mutants was derived by comparing the number of colonies and growth of the spots at the different levels of dilution 4984 CD ... vivo inhibition of Analysis of Kid RNase model cell growth, underlining their relevance to our understanding of the basic activities of this toxin Results Selection and isolation of Kid mutants ... causing disruption of the binding pocket [20], loss of the positive charge of R85 and full exposure to the negative charge of E18 [20] This, in turn, may explain the very poor activity of this toxin...
Ngày tải lên: 16/03/2014, 03:20
Báo cáo khoa học: Biochemical and spectroscopic characterization of the bacterial phytochrome of Pseudomonas aeruginosa pdf
... kDa) The yield of purified BphP was typically mg per litre of bacterial culture Analytical gel permeation chromatography revealed that the apo form, as well as the assembled holo form, of BphP is ... properties of holo-BphP (A) Absorbance spectrum changes during h in the dark after assembly of apo-BphP with biliverdin (B) Dark reversion of BphP photoconverted in the Pr form (C) Dark reversion of ... wavelength of 630 nm The emission spectrum was obtained at an excitation wavelength of 570 nm Structure of 15, 16-dihydrobiliverdin is also shown not shown) These results imply that the site of chromophore...
Ngày tải lên: 16/03/2014, 18:20
CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... include these theories [5-8] The theory of Greaves and that of Kinlen have been discussed in one of the chapters in this book One of the limitations of the theory of Greaves is that it has not been ... peak age of onset of ALL reflects the degree of susceptibility with which a child is born and, on the other hand, the degree of proliferation of the cells involved in the development of the disease ... considered mobili‐ zation of children from the records of changes of residence The results showed evidence of space-time clustering based on place of birth and time of diagnosis for the sub-groups...
Ngày tải lên: 17/03/2014, 12:20
Management of acute upper and lower gastrointestinal bleeding potx
... Chair of SIGN; Co-Editor Royal College of Physicians and Surgeons of Glasgow Royal Pharmaceutical Society of Great Britain SIGN Programme Director; Co-Editor Royal College of Physicians of Edinburgh ... a history of previous LGIB from a known diagnosis of diverticular disease (the commonest cause of LGIB accounting for 23-48% of cases) predicts a further episode with a 10% chance of recurrence ... points) The minimum score of is assigned to patients with age
Ngày tải lên: 17/03/2014, 15:20
WHO/UNICEF JOINT STATEMENT CLINICAL MANAGEMENT OF ACUTE DIARRHOEA pot
... SEVERITY AND DURATION OF DIARRHOEA Twelve studies examined the impact of zinc supplements on the management of acute diarrhoea Eleven of these showed a reduction in the duration of the diarrhoeal ... Bahl, R., et al., ‘Effect of zinc supplementation on clinical course of acute diarrhoea‘ – Report of a Meeting, New Delhi, 7-8 May 2001 Journal of Health, Population and Nutrition, ... acceptance of the scientific basis and benefits of these therapies by governments and the medical community It also depends on reinforcing family knowledge of prevention and treatment of diarrhoea,...
Ngày tải lên: 17/03/2014, 20:20