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Báo cáo khoa hoc:" Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects" ppsx
... flocks using the full model to its value calculated under the reduced model The full model involved both a fixed flock effect and a random sire effect The reduced model, obtained by excluding the ... mating represented 100% of the mating Model adequacy and data structure 383 In the link sires design, males per flock contributed to connectedness by between-flock mating, the other mating being ... varied according to the mating system The withinfamily genetic variance (due to meiosis) depends on the gene pool to which it is possible to refer in the base population [15,46] For a fully connected...
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Báo cáo sinh học: "A comparison between Poisson and zero-inflated Poisson regression models with an application to number of black spots in Corriedale sheep" doc
... models involves fixing or adding a single parameter Preliminary analysis indicated that flock and year effects (and their interaction) had minor importance, so these factors were not included in ... to envisage management measures aiming to reduce incidence of dark fibres If an intrinsic 392 H Naya et al ageing process is the main factor, reducing the age at shearing could be a practice to ... the error term in the regression Dashed lines connect models that need to incorporate one parameter while fixing the other parameter to zero 2.4 End points for model comparison Models were contrasted...
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Introduction to Financial Econometrics Hypothesis Testing in the Market Model
... are in support of the null hypothesis1 To determine how big | tα=0 | needs to be to reject the null, we use the fact that under the statistical assumptions of the market model and assuming the ... b 1.3 Testing Hypotheses about β In the market model regression β measures the contribution of an asset to the variability of the market index portfolio One hypothesis of interest is to test if ... this hypothesis 1.4 Testing Joint Hypotheses about α and β Often it is of interest to formulate hypothesis tests that involve both α and β For example, consider the joint hypothesis that α =...
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Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc
... codon 72 in TP53, resulting in either a proline (Pro72) or an arginine (Arg72) This occurs in the region of the gene encoding the polyproline domain, which is important for the apoptotic functions ... certain environmental carcinogens, such as PAHs, preferentially bind to guanines in methylated CpG sites, and UV irradiation often modifies methylated cytosines [31– 33] Thus, in cells exposed to ... methylation at CpG sites may increase the potential for planar carcinogen compounds to intercalate prior to covalent binding, although the precise mechanism still remains to be determined Furthermore, the...
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Database Guide: International Index to Black Periodicals Full Text docx
... Guide: International Index to Black Periodicals Full Text Truncation Truncation searching in the International Index to Black Periodicals Full Text allows you to retrieve records containing variations ... executing a phrase truncation search, only the final word in the phrase can be truncated Operators The International Index to Black Periodicals Full Text allows you to combine search terms using ... proximity operators Search Fields To conduct a search in the International Index to Black Periodicals Full Text, type the required search terms (individual words or phrases) into the relevant...
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Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt
... translocates into the nucleus to bind to the DNA complex to relieve repression; (b) Gal3p sequesters Gal80p from the nucleus into the cytoplasm to relieve repression There is further ambiguity regarding ... Gal3p, respectively Model I includes sequential binding of activated Gal3p to DNA-Gal4p–Gal80p Parameter m represents cooperativity during binding of Gal4p to the second binding site All other ... both in the nucleus and in the cytoplasm [11,23] The above two studies indicate the existence of following two contrasting in vivo mechanisms for GAL protein expression: (a) regulatory protein...
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Boom and Bust in Australian Screen Policy: 10BA, the Film Finance Corporation and Hollywood‘s ‗Race to the Bottom‘ ppt
... approach to film financing was modelled on an investment prospectus, which although inefficient, led to the growth of film management companies, and investment banks that specialised in investor prospectuses ... declining share of cinema attendance in Australia, compared to the 10BA boom‘s glory days The FFC‘s uncertain ‗recoupment‘ record also bears witness to the high risks for the investor inherent in ... altered the screen industry‘s institutional ‗balance of power‘ According to Screen Australia, ―direct funding from government agencies, principally the Film Finance Corporation Australia, again became...
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Báo cáo khoa học: "What’s There to Talk About? A Multi-Modal Model of Referring Behavior in the Presence of Shared Visual Information" potx
... in providing the shared visual information, and various asymmetries in the interlocutors’ visual information In addition to this we plan to extend our model to a wider range of task domains in ... modeling plans Motivation There are several motivating factors for developing a computational model of referring behavior in shared visual contexts First, a model of referring behavior that integrates ... Xu, T (2005b) Utilizing visual attention for cross-modal coreference interpretation In Proceedings of Fifth International and Interdisciplinary Conference on Modeling and Using Context (CONTEXT-05),...
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Báo cáo khoa học: Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization pot
... p27Kip, a cyclin kinase inhibitor Thus, the increased expression of cyclin E and cyclin E ⁄ CDK2 appeared to be the result of increased production and not decreased cyclin kinase inhibition Studies ... immunoperoxidase staining kit (Vector, Burlingame, CA) according to the manufacturer’s instructions The sections were treated with DAB for 10 min, counterstained with Mayer’s hematoxylin for 10 min, washed ... alcohol-associated increase in CNV size we measured the levels of 1406 cyclin E and cyclin E ⁄ CDK2 by western blot in alcohol-fed rats We found a 3.0-fold increase in cyclin E and cyclin E ⁄ CDK2 levels in...
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báo cáo hóa học: " Adalimumab improves health-related quality of life in patients with moderate to severe plaque psoriasis compared with the United States general population norms: Results from a randomized, controlled Phase III study" pdf
... baseline and at Week 16 To be eligible for the study, patients were required to meet the following disease severity indices at the baseline visit: moderate to severe plaque psoriasis defined ... can be used as guidelines to interpret clinically meaningful differences; differences of to points for the summary scores are considered the minimum important difference in the general US population ... observed in patients with moderate to severe psoriasis The difference in MCS scores between the REVEAL and the MEPS samples were 3.1 to 3.4 points, which exceeded the MCID of 3.0 points This finding...
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Báo cáo nghiên cứu khoa học: " AN APPROACH TO THREE CLASSICAL TESTS OF THE GENERAL THEORY OF RELATIVITY IN THE VECTOR MODEL FOR GRAVITATIONAL FIELD" docx
... of University of Natural Sciences, Ho Chi Minh city in Vietnamese, (1999) [8] A.Einstein, The Meaning of Relativity, Princeton University Press, Princeton, N.J., (1946) Trang 11 ... any other coordinate system x , which can be a Cartesian coordinate system at rest in the laboratory, but also may be curvilinear, accelerated, rotating , The freely falling coordinates are functions ... linear and angular momentum not hold in noninertial reference frames due to the non-uniformity and anisotropy of space in these frames Finally, it can also be shown that time is non-uniform in...
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Báo cáo lâm nghiệp: "Using past growth to improve individual-tree diameter growth models for uneven-aged mixtures of Pinus sylvestris L. and Pinus nigra Arn. in Catalonia, north-east Spain" doc
... changes in the stand basal area (G) of the living pines in the inventory plots using the initial version of the diameter growth models (A), using the new version of the diameter growth models (B) In ... changes in the tree basal area (g) of living P nigra in the inventory plots: using the initial version of the diameter growth models (A), using the new version of the diameter growth models (B) In ... descriptors (Eqs (3) and (4)) In the new model versions, site effects were incorporated into the growth index (GI) included in the fixed part of the models However, the remaining between-plot variability...
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Báo cáo y học: "CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model" pdf
... extracellular IgV domain of CD47/IAP may interact with the integrin, inducing change to a high-affinity state presumably by modulating a structural change in the integrin extracellular domain In the present ... act to stabilise associations of CD47/ IAP with integrins, whereas the cytoplasmic tail may be involved in regulation of the cytoskeleton through PLICs (proteins linking IAP to cytoskeleton) ... appears to be dependent on α5β1 integrin signalling, stretch-activated ion channels, the actin cytoskeleton, and subsequent secretion of interleukin-4, which (via a paracrine/autocrine signalling...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... evidence of and insights into epitope spreading in CIA (Figure 2) Our results indicate that epitope spreading in CIA includes development of autoantibody responses targeting citrullinated epitopes at ... contributes to the development of RA [13] Alterations in the citrullination of myelin proteins and autoimmune targeting of citrullinated myelin proteins have been observed in MS Myelin basic protein (MBP) ... generated in inflamed joint tissue but also with citrullinated filaggrin, a protein expressed in stratified epithelium but not in joints [4,6] It is interesting that many of the citrullinated proteins...
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Báo cáo khoa hoc:" The chicken as a model to study microchromosomes in birds: a review" potx
... used to define microchromosomes are mainly their size (which varies according to authors between 0.5 and 1.5 u.m (44!), the impossibility of distinguishing them from each other and of defining ... and lower degree of chromatin compaction possible to obtain characteristic banding patterns for each pair (68], it is im- However, by using DAPI or chromomycin A3 staining, it has been suggested ... also present in lower numbers in a few other vertebrates (fish, batracians, reptiles) and tend to disappear completely in mammals [68] According to Rodionov [68], it might be tempting to consider...
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Báo cáo y học: "Systematic mapping of two component response regulators to gene targets in a model sulfate reducing bacterium" ppt
... HK in this operon appears to be split into two orfs, with DVU3336 having the K+ sensor domain and an UspA domain, and DVU3335 having the HK dimerization and phosphoacceptor domain Interestingly, ... with in vitro DNA protein binding assays, we undertook several preliminary experiments to provide the adequate controls to assess false positives and to set the threshold for cut off (outlined in ... demonstrated for RRs Determination of binding site motifs Binding sites for the RRs were determined using two methods The first method used MEME [18] to find a motif using the upstream regions...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... pCX-shh-IG injection (arrowheadindicated in (c) and (d), also magnified in the inlets) (C) The pCX-shh-IG-injected prostate tissue sections were stained strongly for Hedgehog protein in PIN and CaP, in ... arrowhead-indicated in (a)) In the pCX-shh-IG-injected prostates, as the prostates were induced into PIN and progressed into CaP status, these P63 + /CK14(low or -) cells appeared to be differentiated ... localization in the normal (Figure 3A; arrowheadindicated in (a)) and hyperplasic basal cells (Figure 3A; arrow-indicated in (b)), P63 was detected in the cytoplasm of cells in the HGPIN (high grade PIN)...
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báo cáo khoa học: " Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis" potx
... platinum in peritoneal nodules and in peritoneum lining muscle when adrenaline was used in combination with cisplatin, as compared to HIPEC This underlines the interest of adrenaline to increase ... non-heated intraperitoneal cisplatin in ovarian carcinoma In previous papers, we reported that intraperitoneal adrenaline increased platinum uptake in rat peritoneal tumor nodules by a factor of to [17-19] ... of IPC to obtain high local drug concentrations in the abdominal wall, peritoneum and muscle lining, all of which are possibly infiltrated by malignant cells in peritoneal carcinomatosis In previous...
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Báo cáo y học: "Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model" doc
... of proinflammatory cytokines [19] and cytokines [20] Moreover, intracellular inhibitors of apoptosis proteins (IAPs) are important regulators of neutrophil survival time under inflammatory conditions ... -15min 10min 0min 25min 70min 85min 265min Equilibration Baseline 1-3 Hemorrhage Hypotensive shock Resuscitation Therapy 15 10 15 45 15 180 Begin experiment Begin data/sample collection Begin ... samples were fixed in 4% formaldehyde and embedded in paraffin according to standard procedures Sections (5 μm) were stained with hematoxylineosin for pathological examination In addition, chloracetatesterase...
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