... to the cervical and vaginal mucosa When these are removed, slight oozing occurs There may be both erythema and edema ofthe vulva and vagina The discharge with Candida infection has a pH of 4–5 ... acne, and symptoms are soreness and local swelling, edema, CHAPTER 20 DISORDERSOFTHE VULVA AND VAGINA 581 cellulitis, and suppuration ofthe groin Involvement of apocrine glands establishes the ... in origin Nonetheless, cancer ofthe vulva may arise also from the urethra, glandular elements ofthe vulva, or mucosa ofthe lower third ofthe vagina Vulvar cancers are intraepithelial or invasive...
... 645 Other causes of extrinsic pressure on the common bile duct, 645 37 Tumours ofthe Gallbladder andBile Ducts, 647 Benign lesions ofthe gallbladder, 647 Carcinoma ofthe gallbladder, 647 Other ... to the skin into theliver substance and extracted This is the quick part ofthe procedure The tip ofthe needle is now placed on sterile paper and some ofthe remaining saline flushed through the ... receptor and ligand are transferred to a compartment of uncoupling of receptor and ligand (CURL) The receptor and ligand separate The receptor returns to sinusoidal plasma membrane andthe ligand...
... especially the hypothenar and thenar eminences and pulps ofthe fingers (fig 6.12) Islets of erythema may be found at the bases ofthe fingers The soles ofthe feet may be similarly affected The mottling ... diameter and is not obliterated by pressure Venous stars are seen on the dorsum ofthe foot, legs, back and on the lower border ofthe ribs Palmar erythema (liver palms) The hands are warm andthe ... Microscopically, the leukaemic infiltration involves only theportal tracts — the normal site of lymphoid tissue in theliverTheportal areas are enlarged and contain both mature and immature cells of the...
... Deviation of blood into these channels leads to varicosities in the submucous layer ofthe lower end ofthe oesophagus and fundus ofthe stomach (b) At the anus, the superior haemorrhoidal vein ofthe ... changes depend on the cause oftheportalhypertensionThe height oftheportal venous pressure correlates poorly with the apparent degree of cirrhosis and in particular of fibrosis There is a much ... uncertain whether the hyperdynamic circulation is the cause or the consequence oftheportalhypertension or both It is related to the severity ofliver failure Cardiac output increases and there is...
... one another to form septal bileductsand so on until the two main hepatic ducts emerge from the right and left lobes oftheliver at the porta hepatis Small bileducts distal to the canals of Hering ... passes into the interlobular bile duct which is the rst bile channel to be accompanied by a branch ofthe hepatic artery andportal vein These are also found in theportal triad These channels ... cirrhosis results in portalhypertensionand splenomegaly The intestinal contents are bulky and greasy; the more complete the cholestasis, the paler the stools The kidneys are swollen andbile stained...
... serum IgG anti-HDV is found There may be a window period between the disappearance of one andthe detection ofthe other Loss of IgM anti-HDV confirms the resolution of HDV infection, whereas persistence ... both as monotherapy, and, on the basis of recently completed large trials, in combination with ribavirin The cost and availability makes all these treatments out of reach ofthe millions of sufferers ... introspection by the patient Antiviral therapy The aim is to control infectivity, eradicate the virus and prevent the development of cirrhosis However, permanent loss of HBeAg and HBV DNA are unusual and...
... lipids synthesized in theliver itself The origin depends upon the dose of ethanol ingested andthe lipid content ofthe diet After an acute, isolated ingestion of a large dose of ethanol the fatty ... redox state oftheliverThe hydrogen generated replaces fatty acid as a fuel and is followed by triglyceride accumulation and fatty liverThe redox state oftheliver changes, protein synthesis is ... dilatation and irregularity ofthe pancreatic duct and smooth constriction ofthe common bile duct as it passes behind the inflamed pancreas Alcohol andtheLiver 100 90 80 % Survival sis of complicating...
... throughout the world except in New Zealand, Australia and some parts ofthe west Pacific The Borrelia multiply in the liver, invading liver cells and causing focal necrosis Just before the crisis the ... been found in theliverof man The tissue stage of human malaria is confined to theliver cells Pathology Theliver shows reticulo-endothelial proliferation, both of Kupffer cells and in zone Focal, ... 627 Liver flukes Cysts are consumed and larvae develop in the duodenum and eventually reach thebileductsThe flukes probably invade theliver through its peritoneal coat and are carried via the...
... lesions oftheliverandbileducts are increasingly being diagnosed This can be related to the improved methods of imaging theliverandbile ducts, andofliver biopsy Application of such methods ... mechanism through the amount ofbile salts and cholesterol reaching theliver from the gut Bile acid synthesis is decreased by administration ofbile salts and increased by interruption ofthe entero-hepatic ... between the junction ofthe main right and left hepatic ductsandthe entry ofthe cystic duct Floating gallbladder (fig 35.1c) It may, however, join the cystic duct, the gallbladder or the common bile...
... usually used The left lobe ofthe donor liver is excised andthe right lobe anastomosed to theportal vein, inferior vena cava and aorta ofthe recipient The donor liver hypertrophies andthe recipient’s ... into theliver They cause complete obstruction ofthe extra-hepatic bileducts with intra-hepatic biliary dilatation and enlargement oftheliverThe gallbladder is collapsed and flaccid If the ... pooling in the lower part ofthe body and splanchnic congestion The cannulae are placed in the inferior vena cava (via the femoral vein) andtheportal vein, and run to the subclavian vein The veno-venous...
... infusion The study by Krejci and colleagues therefore raises the question of whether AVP compares favorably with catecholamines In a complementary investigation the same group compared the regional ... Krejci and colleagues confirm that the unrestricted use of even ‘low-dose’ AVP may result in ‘overconstriction’, in particular in the hepato-splanchnic region andthe kidney Furthermore, the authors’ ... activation ofthe inducible isoform of nitric oxide synthase) probably did not assume major importance Finally, as the authors themselves acknowledge, although labelled ‘low dose’, the infusion...
... system The confluence takes place at the right ofthe hilus ofthe liver, anterior to theportal venous bifurcation and overlying the origin ofthe right branch oftheportal vein (Fig 1.5) The biliary ... Anatomy and physiology ofthe biliary tree and gallbladder James Toouli and Mayank Bhandari OBJECTIVES • Describe the anatomy oftheliverand biliary tract • Highlight thesurgical anatomy oftheliver ... surrounds the branches oftheportal vein [7] These ducts increase in caliber and possess smooth muscle fibers within their wall as they reach the hilus oftheliver Furthermore, as they become...
... ductopenia Theportal triads are often small and inconspicuous and lack a significant inflammatory infiltrate The degree ofportal fibrosis is Chapter 2: Pathology ofthe intrahepatic and extrahepatic bile ... extrahepatic bileductsand gallbladder 41 Figure 2.16 Paucity of intrahepatic bileducts Most portal triads are devoid of interlobular bileducts in this example of Alagille’s syndrome Theportal tract ... Tumor confined to thebile duct histologically T2 Tumor invades beyond the wall ofthebile duct T3 Tumor invades the liver, gallbladder, pancreas and/ or unilateral branches oftheportal vein or...
... enhancement and thickening ofthe wall ofthe extrahepatic bile ducts, and increased enhancement ofthe periphery oftheliver during the hepatic arterial phase Cystic dilatation ofthebile duct Congenital ... Involvement ofthe main trunk oftheportal vein Involvement of both branches oftheportal vein or bilateral involvement ofthe hepatic artery andportal vein Vascular involvement on one side oftheliver ... visualize thebileducts at their extremes (i.e the peripheral intrahepatic ducts at one end andthe distal common bile duct at the other), the central intrahepatic ductsand especially the common...
... approaches for the biliary tree and gallbladder by irradiation They further characterized the injury as “vacuolation, swelling, and necrosis ofthe epithelial cells ofthe ducts, and by a slow and atypical ... al The role of radiation therapy in cancer ofthe extra-hepatic biliary system: an analysis of thirteen patients and a review ofthe literature ofthe effectiveness of surgery, chemotherapy and ... of patients have an aberrant common bile duct from the left hemiliver to the right bile duct In another 6% ofthe cases an aberrant bile duct originates from the posterior right side ofthe liver...
... to the anterior surface ofthe sheath ofthe main right portal pedicle Therefore, to find thebile duct within the sheath ofthe right portal pedicle, the cystic plate must be detached from the ... when the portion of occluded liver is small or if the injury was remote andtheliver has atrophied When the injury is recent andthe portion ofliver affected is large (e.g the whole right hemiliver) ... exposing theductsof segment II Careful release ofthe clamp allows identification ofthe vessels, which are selectively ligated The branches oftheportal vein run in close proximity to thebile ducts...
... intravenously and will normally be taken up by theliverand then the gallbladder Uptake by theliverand excretion into the duodenum without filling ofthe gallbladder is indicative for occlusion ofthe ... to 72 hours from the onset of symptoms With the introduction of laparoscopic cholecystectomy at the beginning ofthe 1990s the question of timing arose again At the beginning ofthe decade, acute ... sequestration ofbile acids in the gallbladder, reducing the amount ofbile salts available for cholesterol solubilization [23] usually in excess of 40% Bilirubin is secreted by theliver into the bile...
... nature of cystic diseases ofthe biliary tract • Understand the role ofliver resection for biliary cystadenoma and cystadenocarcinoma Introduction Cystic lesions ofthebileductsandliver can ... Further investigations demonstrate fusiform cystic dilatations ofthe common bile duct with thickening ofthebile duct wall and extension ofthe cystic abnormalities into the left lobe oftheliver ... resection ofthe gallbladder fossa includes which segments ofthe liver? a I and IVb b IVb and V c V and VIII d IVb and VIII The term “extended cholecystectomy” may encompass a resection of all of the...
... confluence ofthe left and right main hepatic bileducts (perihilar: 67% ofthe cases) [11] The tumor has a tendency to spread along thebileductsand perineural sheets Distant metastases are rare and ... segment VI oftheliver b compression ofthe right portal vein c enlargement ofthe perihilar lymph nodes d encasement ofthe main hepatic artery in the hilar mass 5.3 A PTC is placed andthe cholangiography ... demonstrates occlusion ofthebile duct bifurcation with narrowing ofthe right common bile duct The best surgical option for the patient is a resection ofthe extrahepatic bile duct and hepaticojejunostomy...
... atresia ofthe gallbladder and all external bileducts Variants include atresia ofthe proximal hepatic ducts with patency ofthe gallbladder and distal duct, or atresia ofthe distal ductsand patency ... excluding the gallbladder, andthe fundus ofthe gallbladder is approximated to the dissection at the hilum oftheliver In this way, the gallbladder andbile duct act as the conduit through which bile ... atresia) and that the proximal ducts dilate in response to obstruction [32] The operative strategy required will depend on the age ofthe child, the size ofthe ducts, andthe location ofthe perforation...