suppression of the accumulation of body and liver fat
Báo cáo khoa học: Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs potx
... at 37 °C for h and further incubated for h, the cellular levels of Hsp105a and Hsc70 (a constitutive isoform of Hsp70) increased, and the expression of Hsp70 (an inducible isoform of Hsp70) was ... according to the manufacturer’s instructions Results Induction of hsp promoter activity, activation of HSF and accumulation of hsps by IND and NDGA We first examined the effect of IND and NDGA on the hsp105 ... markedly induced (Fig 2B) On the other hand, the increase in the levels of Hsp105a and Hsc70 and the induction of Hsp70 expression were observed at low levels in the cells treated with 0.2 mM...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... oncogenic potential of loss of Rb is likely to be decided by the expression of each of the Rb family members and the role these family members play in the differentiation of the cell type involved ... RasV12 , even in the absence of p16Ink4a and p19Arf Inactivation of either p21CIP1 or inactivation of the pocket protein family by expression of HPV-E7 restored the immortalization and RasV12 -mediated ... that in this assay loss of the Rb gene family is sufficient to allow oncogenic transformation On the other hand, in view of the lack of anchorage-independent growth of these cells, it remains...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... disease, the primary pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis ... ‘relapse’ of Gb3 accumulation monitored ERT primarily affects serum and liver Gb3 accumulation [9] and these tissues were therefore the primary focus of our study, although the location of Gb3 accumulated ... v) per 100 lL of plasma and then partitioned against ⁄ volume of water The lower phase was dried under a stream of nitrogen gas and then the residue was dissolved in chloroform The sample was...
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Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... location of the aromatic ring of the position and amino acid residues seem to be critical for the stimulation of the [35S] GTPcS binding and the activation of the downstream effector systems PP-76 The ... higher in the N–C+ group than in the N+C– group, and the frequency of metastasis and number of cases with stage D were lower in the N+ group than in the N- group Furthermore, the number of cases ... increased the activation of CREB and decreased the activation of ERK1/2, p38 and caspase-3 These results demonstrate that the degenerative effect of hyperosmotic medium and the protective effect of...
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Báo cáo khoa học: Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA pdf
... shows the results of analysis of 8-oxoG in the control and KD-1 cells In the KD-1 cells, the concentration of endogenous 8-oxoG was significantly increased, indicating that PRDX5 contributed to the ... Therefore, knockdown of the PRDX5 gene stimulated transcription of some families of human satellite DNA, which may be caused by direct involvement of PRDX5 in silencing of the transcription of ... using two different dilutions (1 : and : 729) of template cDNA from the control clone (lanes and 3) and the same dilutions of cDNA from the KD-1 clone (lanes and 4) Control reactions with b-actin...
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Báo cáo khoa học: Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space pptx
... underneath the inner nuclear membrane and function to maintain the nuclear architecture [3] The majority of vimentin may be bound to the nuclear lamina from the outside the nucleus [18] The presence of ... in The eluate was fractionated as indicated (B) ⁄ 100 volumes of the fractions were analyzed by 8.5% SDS ⁄ PAGE, and the gel was stained with silver The positions of the molecular mass standards ... found by proteome analyses, and some of these are thought to be linked to a variety of dystrophies [15] These findings strongly suggest that the structure and functions of the nuclear envelope are...
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Báo cáo sinh học: " Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA" pdf
... intriguing, because of the central role that ppUL44 plays in the synthesis of viral DNA [9,20,21] These data taken together with the observed defects in the onset and expansion of viral DNA synthesis suggest ... probe the unique function of mammalian UNG2 homologs in DNA synthesis In HSV, the deletion of the UNG homolog (UL2) affects the ability of the virus to replicate in mice, particularly the CNS The ... depicts the 1.2 kb insertion containing the E coli gpt gene (white arrow) that replaces most of the UL114 ORF The final three lines represent the same region in Towne and depict the placement of the...
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báo cáo hóa học:" Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA" potx
... intriguing, because of the central role that ppUL44 plays in the synthesis of viral DNA [9,20,21] These data taken together with the observed defects in the onset and expansion of viral DNA synthesis suggest ... probe the unique function of mammalian UNG2 homologs in DNA synthesis In HSV, the deletion of the UNG homolog (UL2) affects the ability of the virus to replicate in mice, particularly the CNS The ... depicts the 1.2 kb insertion containing the E coli gpt gene (white arrow) that replaces most of the UL114 ORF The final three lines represent the same region in Towne and depict the placement of the...
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báo cáo hóa học:" In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA" doc
... including degradation of type II collagen, the most important type of collagen in the ECM This research also focuses on the effect of the suppression of the MMP-3 gene on mRNA and proteoglycan production ... With the aim of investigating the specificity of MMP-3 siRNA in the suppression of the target mRNA, five functionally related transcripts were analyzed for their relative abundance at 48 and 72 ... expression of the MMP-3 gene, and led to decreased cell apoptosis, and increased cell viability and mitotis Moreover, a suppression of MMP-3 can increase production of GAG and HA For further study,...
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Báo cáo khoa học: "Advancing parity is associated with high milk production at the cost of body condition and increased periparturient disorders in dairy herds" pot
... ecnecseroulf eht rof Co08 fo pets lanoitidda nA Co27 ta ces 01 rof noitagnole dna ,Co95 ta ces 01 rof gnilaenna ,Co59 ta ces rof noitarutaned fo gnitsisnoc hcae selcyc noitacifilpma 05 yb dewollof Co59 ... VASI hcae rof snoitcartxe ANR ehT demrofrep erew elpmas hcae rof snoitcartxe ANR etacilpirT snoisnepsus erutluc eussit )detcefninu ro( detcefni-suriv fo lµ 003 saw noitcartxe ANR lla rof emulov ... etartsnomed ot )1 :dlofowt saw yduts tneserp eht fo esoprup ehT nim 08 nihtiw detelpmoc eb dluoc dna VASI rof RCP-TR lanoitnevnoc eht naht evitisnes erom semit 001 eb ot dnuof saw yassa ehT seulav...
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báo cáo khoa học: "Synchronous double primary malignant tumor of the gallbladder and liver: a case report" potx
... and showed wall thickening There was a palpable mass felt on the surface of the gallbladder neck portion The patient underwent surgical resection of the gallbladder and the left lobe of the liver ... tumor of the gallbladder and liver: a case report World Journal of Surgical Oncology 2011 9:84 Conclusions We report the first case of synchronous double primary malignancies of gallbladder and liver ... Young Jung and Jeong Won Kim made up the surgical and pathological team involved in the case Jae Pil Jung and Ji Won Kim wrote and edited the manuscript All authors read and approved the final...
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Báo cáo khoa học: "Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellular Carcinoma" pps
... 0.001) (Table 2) The tumor size & site, the presence of underlying liver cirrhosis and the sur- Using the univariate analysis method, there was no difference between the groups in terms of recurrence ... recurrence is considered one of the most important factors that impact the prognosis of HCC patients [25] The present study attempts to determine the impact of the type of liver resection (anatomical ... In-hospital mortality, morbidity and length of hospital stay 2- The detection of early disease recurrence through the year follow-up period The impact of the type of resection (anatomic vs non-anatomic)...
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Báo cáo khoa học: "The combined effect of erythropoietin and granulocyte macrophage colony stimulating factor on liver regeneration after major hepatectomy in rats" pot
... conceived of the study, and participated in its design and coordination and helped to draft the manuscript NC, TA and DN conducted the experiments TT and FG participated in the design of the study and ... with the extent of regeneration [18] In addition, they are have already been widely used for the study of liver regeneration and in particular for the study of the effects of EPO on liver regeneration ... relationship between the two factors [15,16] Aim of the present study is to compare the effect of the administration of EPO and GM-CSF alone or in combination on the acceleration of liver regeneration...
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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx
... defined the upper lobe in the right lung and the segment 1+2 and in the left lung as the upper lung field, and the rest of the lung as the lower lung field The tumor movement in the lower lung field ... the gantry not to collide with the patient and the BodyFix system We avoided the interference of the thick carbon bars that lie on the right and left sides of the couch Dry run was performed ... to be satisfactory Therefore, the use of the BodyFix system appeared to have limited influence on the ITV size Covering the patient's lower body up to the abdomen and up to the thorax with a clear...
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Báo cáo khoa hoc:" Estimation of the genetic parameters of sexual dimorphism of body weight in ’label’ chickens and Muscovy ducks" potx
... a the direct genetic effect of the jth animal, m! the maternal j genetic effect from the kth dam, ez!! the residual of the jth animal from the kth dam, reared in the ith hatch and cov(a, m) the ... increased body weight at weeks (BW6) and weight gain between weeks and slaughter (WG) (12 weeks for males and 10 weeks for females) as well as for the weight of the fatty liver of males after 13 d of ... f the subscripts ’m’ and ‘f’ stand for male and female, respectively model 2.2 Analysis The analysis model was: where yZ!k is the performance of the jth animal from the kth dam, reared in the...
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Báo cáo khoa hoc:"Effect of the slow (K) or rapid (k +) feathering gene on body and feather growth and fatness according to ambient temperature in a Leghorn × brown egg type cross" ppsx
... body and feathers of the chick at weeks of age are in competition for arginin and cystein, of which the requirement is more important during the synthesis of feathers Feathering genes and growth ... feathers (absolute and per cent of body weight) and an effect of sex on per cent of feathers On the contrary, the age × genotype interaction in both sexes for the two same traits showed that the ... remiges and rectrices At one day of age, the primary and secondary feathers are like coverts in a slow feathering chick, and at eight days they not have tails Owing to the considerable power of thermal...
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Báo cáo sinh học: " Genetic parameters of body weight, egg production and shell quality traits in the Brown Tsaiya laying duck" potx
... logarithm of the likelihood function; W (X!Z); * b° is the solution vector of the MME; C is the inverse of the coefficient matrix of the number of observations The the number of animals; and n the ... close and the maximum difference is = = only 3% The estimates of the heritabilities of the 12 traits and their genetic correlations could provide a basic knowledge of the genetic parameters in the ... ix are the random additive genetic effects of the ijkth and ikth animals respectively, and e2!xl and e are the residual effects iki Sires from the origins were considered to belong to the same...
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báo cáo khoa học: " Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis" potx
... 200 mg of the anterior edge of the liver were sampled and kept at -80° C until the platinum assay The comparison of groups and should assess the effect of hyperthermia; that of groups and should ... and should assess the effect of adrenaline; and that of groups and should assess the effect of the duration of IPC A 2- Page of hour HIPEC was impossible due to intolerance of the animals Atomic ... This underlines the interest of adrenaline to increase the tissue concentration of chemotherapy and the fact that the best method to deliver of IPC remains to be defined [10,17,21] The rats treated...
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báo cáo khoa học: " Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma" potx
... 72 h after the administration of 10 and 20 μM simvastatin On the basis of these results, 5, 5, and 10 μM were determined to be the cytotoxic concentrations of mevastatin, fluvastatin, and simvastatin, ... decrease the activation of ERK1/2 Akt [4] These findings are in agreement with the results of the present study and indicate that statins induce apoptosis via suppression of Ras/ERK and Ras/Akt ... the functions of Ras by inhibiting prenylation through the inhibition of GGPP synthesis; this enables localization of Ras at the plasma membrane [14,15] Ras is involved in the activation of the...
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Báo cáo y học: "Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver" ppt
... differences in expression levels of each gene existed between the spleen and liver These organs contain macrophages and other cell types capable of responding to LPS and other inflammatory stimuli Methods ... parthenolide control animals (Fig 5) The level of IL-1β mRNA in spleen and liver of vehicle and parthenolide control animals was negligible In the spleens of co-treated animals, there was a significant (p ... compared to the liver Figure mRNA expression levels in parthenolide and LPS co-treatment spleen and liver following COX-2 COX-2 mRNA expression levels in spleen and liver following parthenolide and LPS...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008