submissions from successful phase i applicants

... tissue from testosterone suppression This may lead to false-positive results with ASTRO definition and a recalculation with nadir + definition was performed With this definition no biochemical failure ... multicenter phase III trial could be started comparing conventional fractionation of 74 Gy in Gy fraction with hypofractionation giving 66 Gy in 25 fractions of 2.64 Gy in patients with localized prostate ... the highest probability of toxicity which, if true, implies that the irradiation schedule does not warrant further investigation, in this trial P0 has been taken as 50% incidence of grade II or...

Ngày tải lên: 09/08/2014, 10:21

... aphasic behavior in English speaking patients, specif i c a l l y in agrammatics and Broca's aphasics French neurolinguistic studies have documented a similar degradation in the a b i l i t y ... I t can be INHIBITORY and EXCITATORY in its effect INTERPRETATIONis a result of activation of a pragmatic representation of a disambiguatedword meaning in current l i n g u i s t i c research ... thresholding device with memory I t has an a c t i v i t y value, i n i t i a l l y at a resting state, that is modified over time depending on the input, interconnections to other information, and...

Ngày tải lên: 21/02/2014, 20:20

... proportion of Illiterate women using family planning CPR(illiterate) = ∑w i i CPR i (illiterate) ∑w i i Where, w i = Proportion(illiterate) * Pi (1991) ∑ Proportion(illiterate) * P i (district population) ... corresponding district level indicators For example, I= ∑ I (i, j ) * W (i, j ) i, j I indicator at the national level I (i, j ) is the same indicator for ith district in jth state W (i, j ) is weight ... population) (1991) (district population) i i.e the proportion of population illiterate in ith district to the sum of illiterate population of all districts within the state The estimates at the national...

Ngày tải lên: 05/03/2014, 10:20

... fame difiance from the Priiin as before, moving the Paper either towards the Prifm or from ir, LInti I found the jufi difiancc where the Reailinear Sides of the Image became mofi d&n& For in this ... intermediate $aces; Which agrees with, tkxcfir& ProprAit~oq that: pi: ht$ which differ in CSolour &o di%x in Refi~q.$~ B iry, The length of the kmge iiti &e $&qpitig Ex,pegi.metits 1ne3hred from ... Reflexions fixffcrs nk Alecration in its Modifications and Properties, I IICE here take notice of any R&a&ions made in the Sides af the firT1; Prifm, becaufe the Light enters it perycndiculnrly...

Ngày tải lên: 17/03/2014, 14:57

... We are moving from this whole idea of ownership—It is mine If I own it, I can maintain it, I can control it— to an Internet world where everything is shared That is a relationship issue rather ... Purchasing supplies and materials from a specific vendor; Accessing facilities manuals (e.g., maintenance or training); Publishing static project information; Taking interactive training courses; ... developed by Facility Information Systems, Inc (FIS), a venture-capital-backed firm with offices in Camarillo, California (www.fisinc.com) FIS was unique in that it uses Oracle 8i for its backend...

Ngày tải lên: 29/03/2014, 11:20

... their individual efforts in gathering information and writing sections of the report vii viii ACKNOWLEDGMENTS This report has been reviewed in draft form by individuals chosen for their diverse ... technology-related findings and recommendations identified by the committee They pertain to gasification, gas purification, turbines, and fuel cells Gasification Finding Under current conditions in the United ... University, Pittsburgh, Pennsylvania RAMON L ESPINO, University of Virginia, Charlottesville ENRIQUE IGLESIA, University of California, Berkeley EDWARD S RUBIN, Carnegie Mellon University, Pittsburgh,...

Ngày tải lên: 29/03/2014, 13:20

... http://www.translational-medicine.com/content/7/1/68 administration of equivalent mixtures of antibody and IL2 [6] EMD 273063 was tested in a phase I clinical trial aimed at evaluating its safety, toxicity and in vivo immunological ... were clinical anti-tumor activity, safety, toxicity and pharmacokinetics (PK) of EMD 273063 Toxicity grades were classified according to the NCI Common Toxicity Criteria Version Objective tumor ... patients had received prior therapy for metastatic disease, which included IL2 (4 patients) and/or IFN-α2b (7 patients) in all patients based on the study eligibility of requiring prior cytokine-based...

Ngày tải lên: 18/06/2014, 15:20

... specific lysis of inhibition by isotype control) - (% specific lysis of inhibition by MAb)]/(% specific lysis of inhibition by isotype control) × 100 All mAb was purchased from Dako Japan Inc Immuno-histochemical ... Immunohistochemical analysis of vitiligo Biopsy specimens of the area with vitiligo in P2 were stained with H&E to identify infiltrating cells This focus was a match for vitiligo To characterize ... dermatologic toxicities such as induration, rubor, local pain, and itching were observed in all patients at the injection sites (grade I toxicity) P2 (Fig.1A) and P3 (Fig.1B) developed vitiligo during...

Ngày tải lên: 18/06/2014, 16:20

... clinical efficacy Therefore, it will be desirable to examine the clinical efficacy of rh-HGF in additional clinical trials involving patients with less severe conditions Systemic administration ... extremely serious condition This life-threatening condition was influenced by the degree of impaired hepatic reserve and varying complications Indeed, in this trial, all eligible patients with FH or ... Registration of Pharmaceuticals for Human Use (ICH)-Good Clinical Practice (GCP)-registered phase I/ II clinical trial of rh-HGF As this application is the first clinical trial to administer rh-HGF to humans,...

Ngày tải lên: 18/06/2014, 19:20

... is still associated with a significant intrinsic risk Side effects include opportunistic (mainly biliary) infections in the short-term and drug-specific side effects or malignancies in the intermediate ... ejection fraction ≤50% HIV seropositive, HTLV seropositive, varicella virus active infection, or syphilis active infection History of any malignancy (including lymphoproliferative disease and hepatocellular ... events anticipated to be specific for stem cell-based therapy in liver transplantation This dose-limiting toxicity (DLT), which covers specific events that model significant toxicity likely caused...

Ngày tải lên: 18/06/2014, 22:20

... is still associated with a significant intrinsic risk Side effects include opportunistic (mainly biliary) infections in the short-term and drug-specific side effects or malignancies in the intermediate ... ejection fraction ≤50% HIV seropositive, HTLV seropositive, varicella virus active infection, or syphilis active infection History of any malignancy (including lymphoproliferative disease and hepatocellular ... events anticipated to be specific for stem cell-based therapy in liver transplantation This dose-limiting toxicity (DLT), which covers specific events that model significant toxicity likely caused...

Ngày tải lên: 20/06/2014, 04:20

... pharmacokinetics: Implications for oral and intravenous use Ann Int Med 2004; 140: 533 D’Amico AV and Hanks GE Linear regressive analysis using prostate-specific antigen doubling time for predicting ... given every to hours in this study During the 12 week course of the study, PSADT was the primary endpoint Using this criterion, thirteen of 17 patients had significant increases in PSA doubling ... before definitive therapy For example, PSADT significantly correlated with biochemical recurrence16, linearly correlated with the interval to clinical relapse after PSA failure following radiation...

Ngày tải lên: 08/08/2014, 17:20

... competition experiment shown in Figure 6a, preincubating antibody-positive day 14 plasma from subject 013 with up to 200 µg/ml unnmodified recombinant uricase did not inhibit the ELISA, indicating ... preliminary experiments, specific signals could be obtained with NPC-activated mPEG and mPEG-glycine, but not with mPEG itself Because mPEGs, when in solution, did inhibit in competition experiments ... treatment with PEG-uricase Lack of inhibition of uricase activity by antibody against PEG-uricase Aliquots of plasma from a subject in the 'long-circulating' group, in which there was uricase activity...

Ngày tải lên: 09/08/2014, 07:20

... glandular tissue, suggesting the need for pre- and post-therapy biopsies of minor salivary glands Additional findings in terms of statistically significant improvement from baseline in fatigue, and in ... derived from an eight-point standard curve with varying dilutions of anti-idiotype antibody in bovine serum albumin Patient serum samples are diluted 1:2 with bovine serum albumin and assayed in ... in individual efficacy parameters, B- and T-cell counts, Igs, duration of infusion times, and other continuous numerical variables were summarised using descriptive statistics The Wilcoxon signed...

Ngày tải lên: 09/08/2014, 08:22

... outside of the radiotherapy fields With improving local control, the ability to control micrometastatic disease has increasing importance in improving overall survival It is possible that higher ... stage IIIA; stage IIIB) and patients had oligometastatic (3 brain, bone) stage IV disease Histology was squamous in patients, adenocarcinoma in patients, and nototherwise-specified (NOS) in patients ... Safety Monitoring Board in addition to the investigators Patients/Eligibility This study was available to patients with locally advanced NSCLC who required definitive full dose radiotherapy as...

Ngày tải lên: 09/08/2014, 09:20

... Arcangeli G, Saracino B, Gomellini S, et al: A Prospective Phase III Randomized Trial of Hypofractionation Versus Conventional Fractionation in Patients With High-Risk Prostate Cancer International ... and urinary toxicity, late urinary toxicity, biochemical disease free-survival (bDFS), DFS and overall survival (OS) Biochemical failure was defined as per the Phoenix criteria as the postradiotherapy ... by the radiation oncologist The protocol was approved by the clinical research and ethical committees of participating institutions Written informed consent was obtained from all patients before...

Ngày tải lên: 09/08/2014, 09:21

... late toxicity As in our study, the acute toxicity consisted of dose-limiting GI toxicity Application of the linear quadratic model indicates that 42 Gy in 2.8 Gy-fractions is biologically equivalent ... nelfinavir [24] or erlotinib, gefitinib and bevacizumab [25-27] with a CRT regimen, although further confirmation of initial positive results in phase I studies is warranted by randomised trials ... NE participated in the patient evaluation DB participated in the patient evaluation DVB participated in the patient evaluation LG participated in the study design and patient follow up during RT...

Ngày tải lên: 09/08/2014, 09:22

... cancer is not increased Further phase II and III testing is required for efficacy testing IGF-R Insulin-like growth factor receptor mg Milligram MRI Magnetic resonance imaging Abbreviations AP ... encouraging preliminary outcome results An additional phase I/ II trial concerning 27 patients with brain metastases treated with radiation and celecoxib [77] confirmed the feasibility and safety Govindan ... more importantly, when additional cytotoxic drugs are applied A different picture emerges from some other phase I/ II trials showing that celecoxib combined with radiation or chemoradiation is safe...

Ngày tải lên: 09/08/2014, 10:20

... belimumab was biologically active in vivo and was safely administered to patients with SLE These findings supported the initiation of phase II studies investigating the safety and clinical activity ... or two doses of belimumab compared with placebo This is consistent with the ability of belimumab to inhibit BLyS biologic activity Significant reductions in anti-dsDNA antibody were observed ... binds to soluble BLyS with high affinity The antibody exerts its biologic activity by preventing the binding of BLyS to its receptors [19] Belimumab potently inhibits BLyS-induced proliferation...

Ngày tải lên: 09/08/2014, 13:21