study in patients with disabling intermittent claudication

... observed in clinical nonresponders to infliximab is in accordance with the findings of a recent study [8] that demonstrated protective effects on joint destruction in the absence of clinical response ... changes in BMD values Discussion To our knowledge, this appears to be the first study to examine the effect of infliximab on BMD in RA patients and to compare the findings with those in a control ... The major finding of our study is that bone loss was prevented in RA patients treated with infliximab This protective effect was also observed in patients who did not exhibit a clinical response...

Ngày tải lên: 09/08/2014, 10:20

... degradation were inhibited by blocking IL-1β but not IL-1α In RA patients, IL-1β is overexpressed in inflamed synovial tissue, in particular in the lining layer and in sublining cells [9], and ... Scoring was performed on decoded slides by two separate observers, using the following parameters In the haematoxylin/eosin stained slides the amount of cells infiltrating the synovial lining ... 24% With 20 patients receiving the highest ACZ885 dose (six patients in the last escalation step plus 14 patients in the expansion phase) and 15 patients receiving placebo (two patients in each...

Ngày tải lên: 09/08/2014, 10:23

... respectively, in five patients with cardiogenic shock (cardiac index 1.7 l/min per m2) Pulmonary arterial SO2 was nearly equal to the computed mean SO2, indicating a predominant role for IVC SO2 in the ... reported in published studies measuring SO2 in the central veins, the right heart, and pulmonary artery in humans [27-31] With the exception of a subset of eight patients who were 'not in shock', ... Written informed consent was obtained from each patient Nine individuals who were older than 18 years, of either sex, were enrolled sequentially in the study All patients were ambulatory Patients...

Ngày tải lên: 13/08/2014, 03:20

... further study Other approaches for introducing IL2 into the tumor environment include injection of the cytokine intratumorally [17] and administering intratumoral injections of adenovirus encoding ... examined (Table 4) The IHC images from case 4104 are depicted in Figure 2D as a representative example of the post-dosing decrease in GD2 staining, and increase in S100 staining intensity and in ... associated with immunologic effects as reflected by an increase in immune-related cytokines in serum and intratumoral changes in some patients consistent with increased intratumoral infiltration...

Ngày tải lên: 18/06/2014, 15:20

... transferred to the clinical site with continuous temperature monitoring The vaccine was administered within one hour of thawing and reconstituting in mL of sterile saline Patients were scheduled to receive ... initial clinical trial with IDD-3 [3], restricting inclusion to patients with limited metastatic disease allows a more adequate patient selection for the testing of this therapeutic vaccine In ... immunological activity was determined by determining the proportion of patients showing an induction or increase in immune response to melanoma lysates or TAAs following treatment Patients evaluable for...

Ngày tải lên: 18/06/2014, 16:20

... study was conducted in accordance with the principles of the Declaration of Helsinki, and all study sites received approval from independent ethics committees All patients provided written, informed ... Other Week Dosing in Moderate to Severe Psoriasis TriAL (REVEAL) study, a 52-week, Phase III clinical trial in adult patients with moderate to severe chronic plaque psoriasis [23] Patients were ... symptomatology, including pain and itching, combined with concerns about the appearance of one's skin can substantially affect a patient's psychological well-being and can result in emotional distress,...

Ngày tải lên: 18/06/2014, 19:20

... present study examines perceptions of sleep in an international clinical trial aimed at evaluating the efficacy and safety of the pregabalin, a treatment for pain relief in patients with painful ... their sleep It consists of a single-item with an 11-point numerical rating scale, ranging from (pain does not interfere with sleep) to 10 (pain completely interferes with sleep) that allows the ... weekly mean sleep interference score and the weekly mean pain score at baseline were used to define groups of patients differing in severity Since patients had to have pain at baseline to qualify...

Ngày tải lên: 18/06/2014, 19:20

... conditions including FM [14] A recent study in patients with FM suggests sleep disturbance may be predictive of pain [15] Not surprisingly, both pain and sleep are considered core domains essential ... the study investigators Individuals were required to have a current pain rating of > on an 11-point numerical rating scale (NRS) to enable enrollment of individuals with a broad range of pain ... alteration in patients with fibromyalgia? J Rheumatol 2004, 31(6):1193-1199 McKracken LM, Iverson GL: Disrupted sleep patterns and daily functioning in patients with chronic pain Pain Res Manag...

Ngày tải lên: 18/06/2014, 19:20

... mortality in healthy adults [10,28,29], in individuals with CVD [30] in individuals with risk factors for CVD [31,32] and in men with diabetes [33] HRR is positively associated with insulin sensitivity ... data [46-48], in fact, confirmed that exercise training is effective in reducing BMI and improving insulin sensitivity markers in PCOS women, even thought no significant changes in sex hormones ... reduction in BMI, and to the powerful anti-inflammatory effect of training [46,47] However, exercise training should be continued regularly in order to maintain the described beneficial effects [48]...

Ngày tải lên: 20/06/2014, 07:20

... chose the male patient to be included in the final sample by random drawing from a list while being blinded to the rest of the parameters included in this study The matching process was done prospectively ... differences in any domain for Stage III and IV patients This is an interesting finding considering that female with FEV1%

Ngày tải lên: 20/06/2014, 16:20

... threshold, to promote and maintain rolling interactions [28] In our study, expression of L-selectin was depressed in the HT group This finding is consistent with previous findings and suggests that ... cytokine interleukin-6 (IL-6), anti-inflammatory cytokine interleukin-10 (IL-10), chemokine interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractive protein-1 ... adult patients with septic shock were screened for inclusion in the study Septic shock was defined according to standardized criteria [12] Patients were randomized to receive intravenous administration...

Ngày tải lên: 20/06/2014, 23:20

... shift, causing decreased LV compliance and mild increase in LV filling pressures Therefore, we hypothesized that BNP in mechanically ventilated patients with ALI would be higher in patients with RV ... change significantly [11,41] In summary, in patients with acute lung injury the plasma levels of BNP are increased, yet the reasons for this increase remain unclear In this study, BNP levels were elevated ... different findings may be explained by the timing of measurements obtained Pulmonary hypertension with subsequent RV dilatation and dysfunction in mechanically ventilated patients with ALI is...

Ngày tải lên: 21/06/2014, 03:20

... for in- hospital mortality rates between the two groups Subjects with AKI had a baseline serum creatinine of 67 ± 15 μmol/L with a peak inpatient serum creatinine of 217 ± 86 μmol/L compared with ... control subjects, baseline creatinine were the lowest creatinine from the 365 days before admission until hospital admission Potential subjects with a baseline creatinine of greater than 1.1 ... baseline serum creatinine of 69 ± 20 μmol/L and a peak serum creatinine of 81 ± 17 in non-AKI subjects (p < 0.001 for peak levels) As noted earlier, we excluded potential study subjects with...

Ngày tải lên: 21/06/2014, 03:20

... dysfunction Our study replicates the findings of numerous studies that demonstrated the presence of neurocognitive deficits in patients with schizophrenia on most domains tested, including attention, ... time [6] In patients with schizophrenia, delusions and hallucinations could arise as a result of deficits in cognitive functions involving perceptual and attributional biases [7,8] People with schizophrenia ... sample that remained employed in spite of the significant cognitive deficits Similar employment rates have been shown in previous studies from India [14] The findings in the present study emphasize...

Ngày tải lên: 08/08/2014, 23:20

... verified by studies performed with patients with respiratory failure, with depression being observed in 30% of patients with moderate failure and in 50% in patients with severe obstructive pulmonary ... clinical experience accepts high comorbidity in pulmonary patients, studies assessing and comparing anxiety and depression levels among patients with different pulmonary diseases are lacking in ... p > 0.05) Patients with COPD had the higher depression scores, followed by patients with BA, whereas patients with TB had the lowest depression scores Anxiety was higher in patients with COPD...

Ngày tải lên: 08/08/2014, 23:20

... aripiprazole comparator Olanzapine week study, patients with schizophrenia and acute exacerbation, paliperidone ER comparator Quetiapine week study, inpatients with chronic or subchronic schizophrenia ... 30% decrease in PANSS from baseline to study endpoint or CGI-I ≤ 23.3 40.0 [35] 10 ≥ 30% decrease in PANSS from baseline to study endpoint 27.4 50.1 [21] [22] [23] 750 ≥ 30% decrease in BPRS at ... any time during treatment 35.0 49.0 [41] 80 and 160 ≥ 30% decrease in PANSS from baseline to study endpoint 17.6 29.9 [44] 20 and 30 ≥ 30% decrease in PANSS from baseline to study endpoint or CGI-I...

Ngày tải lên: 08/08/2014, 23:21

... release compared with alternative oral antipsychotic agents in patients with schizophrenia in Greece: a cost effectiveness study Annals of General Psychiatry 2008, 7:16 Publish with Bio Med Central ... effectiveness compared with paliperidone ER: Cost (€) 52 Effectiveness -0.3 -7.0 Correction Following the publication of our article [1], it has come to our attention that there was an error with the values ... Effectiveness Olanzapine Risperidone Quetiapine Ziprasidone Aripiprazole 7.030 272.5 7.034 272.2 7.082 265.5 8.321 260.7 7.807 258.6 7.713 260.5 1.291 -11.8 777 -13.9 683 -12.0 Incremental cost and...

Ngày tải lên: 08/08/2014, 23:21

... in our study, in which an increase in HDL levels was seen in patients receiving longterm GCs (P = 0.011) The observed rise in HDL levels may also be explained by the indirect effects of GCs Patients ... improves glucocorticoid induced insulin-like growth factor 1(IGF1) resistence without influencing myoglobin and IGF1 binding proteins and Ann Rhuem Dis 2006, 65:301-305 Fraser R, Ingram MC, Anderson ... there is smaller bank of conflicting data demonstrating that GC use in RA paradoxically restores glucose handling to normal whilst also inducing hyperinsulinism [68] In the present RA population,...

Ngày tải lên: 09/08/2014, 01:22

... drug arms of a trial of interferon-β-1a in patients with rheumatoid arthritisa Response, according to ACR criteria, of subjects in a trial of β interferon-β-1a in patients with rheumatoid arthritis ... is induced by activated T lymphocytes Involvement of VLA-4 and inhibition by interferonbeta-1b J Clin Invest 1997, 100:604-612 Coclet-Ninin J, Dayer JM, Burger D: Interferon-beta not only inhibits ... those patients terminating the study before week 24, only two in the IFN-β-1a arm and one in the placebo arm left the study secondary to adverse events The majority of patients Available online...

Ngày tải lên: 09/08/2014, 01:23

... occurred after infusion This will most likely not reflect the true ratio between acute and delayed reactions involving the skin, since acute reactions with skin involvement occur in 4% of the infusions ... patient-year) TNF-α-blocking therapy was permanently withdrawn because of dermatological events 21 times in 19 patients Infections Thirty-three infections were recorded in 27 patients, consisting of 20 fungal, ... infliximab without recurrence of his skin problems TNF-α-blocking therapy was continued in the other eight patients, and in four of these the ulcers recovered; follow-up was missing in the other...

Ngày tải lên: 09/08/2014, 06:22