study a course management system

... depletion interaction can be described by Asakura–Oosawa (AO) model (Asakura and 20    Chapter Literature Review Oosawa, 1958) The AO model assumes the colloidal particles as hard spheres, and the polymer ... Publications Jianguo Li, Raj Rajagopalan, and Jianwen Jiang Molecular Modeling and Simulation for Phase Behavior of Protein Solutions A chapter in the book: 'Thermodynamics of Amino Acid and Protein ... protein concentration), and a “fluid-solid” phase separation (crystallization) Protein phase separations have a wide range of applications in chemical and biological processes, such as protein threedimensional...

Ngày tải lên: 14/09/2015, 14:06

... concentration of data points that have positive z-scores, whereas the data reported by Gavin and coworkers [10] and Krogan and colleagues [11] have maximal density for negative z Systematic artifacts ... research The following additional data are available with the online version of this paper Additional data file demonstrates a full end-to-end analysis of the protein interaction datasets Additional ... reciprocated FN observations is PFN n Software implementation and availability The R/Bioconductor packages used in the statistical analysis in this report are all available as freely distributed and...

Ngày tải lên: 14/08/2014, 08:20

... maintained on 2% isoflurane and 0.8 L/minute oxygen The surgical area was shaved and a three-part preparation was applied containing hibitane soap (Ayerst, Montreal, Quebec, Canada), isopropyl alcohol ... degeneration in cartilage explants, and this has been associated with increased activity of various aggrecanases Knockout animals of the gene encoding the aggrecanase ADAMTS5 are protected to a great ... alcohol and betadine solution (Purdue Pharma, Pickering, Ontario, Canada) During surgery, the body temperature of the animals was maintained by placing them on a warm circulating water pad Standard...

Ngày tải lên: 09/08/2014, 01:22

... histological evaluation Hargreaves' plantar test Thermal hyper/hypoalgesia was assessed by Hargreaves' plantar apparatus (Plantar test, Ugo Basile, Italy) [19] The test was performed at 1, 3, and 24 ... platform and a removable infrared generator (radiant heat 137 mW/cm2/s) was placed underneath the animal's hind paw The apparatus automatically detected the withdrawal of the paw Latency of each ... Hargreaves apparatus, to evaluate respectively tactile allodynia and thermal hyperalgesia at 1, 3, and 24 hours after carrageenan/saline injection, followed by paw thickness measurement, using a...

Ngày tải lên: 11/08/2014, 03:20

... Kasinska and Sussan Kianpour, the secretarial assistance of Marie Colbert, and Gordon Gaschler for discussion and preparation of the manuscript Additional technical assistance was provided by Jagbir ... Churg A, Wang RD, Tai H, Wang X, Xie C, Dai J, Shapiro SD, Wright JL: Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release Am J ... induction was unaltered and yet eosinophilic inflammation was markedly attenuated These results are at variance with previous work that implicated BRP-39 as a crucial inflammatory component in similar...

Ngày tải lên: 12/08/2014, 13:22

... relationship was obtained by plotting log k vs l/T and an activation energy of 1.3 Kcal was calculated A higher activation energy (3.6 Kcal) was calculated from drainage constants of foams prepared ... clear liquid/foam boundary, hence the volume of buffer added was approximated From the data obtained in this initial study the foaming apparatus can be used to evaluate the important foaming characteristics ... foaming apparatuswas a calibrated water-jacketedglasscondenser(85 cm long; 1.10 cm i.d.) with a 24/40 joint at one end (Fig and 2) A Forma Constant TemperatureCirculator (cat no 2095) maintained...

Ngày tải lên: 16/12/2012, 15:10

... pro-choice advocates to meet pro-life advocates on the same footing, by arguing that pro-choice women are dedicated to being good mothers, and that obtaining an abortion is a necessary means a woman ... the woman for its survival, the types of demands 225 226 E McDonagh it makes upon a woman exceed what any moral person need make Thus, a pregnant woman is justiWed in being a bad Samaritan by ... child, planning to have a total of six children, who had assumed the economic support of a husband The initial situation is one of traditional, harmonious, family life More broadly, we can characterize...

Ngày tải lên: 01/11/2013, 08:20

... Contact Ratio brain Ab ⁄ CSF Ab CSF Ab Ratio brain Ab ⁄ plasma Ab Plasma Ab Brain Ab (pmolÆg)1) Age-of -onset (months) humans (Table 1) It has been proposed that Ab exists in a state of dynamic equilibrium ... Dodart JC, Paul SM & Holtzman DM (2001) Peripheral anti -A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease Proc Natl ... amyloid angiopathy Am J Pathol 158, 1065–1071 Maeda A, Yamada M, Itoh Y, Otomo E, Hayakawa M & Miyatake T (1993) Computer-assisted threedimensional image analysis of cerebral amyloid angiopathy Stroke...

Ngày tải lên: 16/02/2014, 09:20

... A. -R Karala and L W Ruddock bacitracin contains at least nine different peptides, of which bacitracin A is the most abundant, and it is mainly used as an antibiotic against infections caused ... thiol–disulfide exchange enzymes, Escherichia coli DsbA and DsbC, as well as the isolated catalytic a domain of PDI Both the PDI a domain and DsbA have a catalytic site, with an associated substrate-binding ... precipitation that can be followed as an absorbance increase at 540 nm (A) Representative changes in absorbance as a function of time From left to right, the traces are: PDI, PDI + bacitracin, noncatalyzed...

Ngày tải lên: 16/02/2014, 14:20

... minus a short rate), and curvature (e.g., a mid-maturity rate minus a short and long rate average) Another approach, which is popular among market and central bank practitioners, is a fitted Nelson-Siegel ... of various maturities all trade simultaneously in active markets at prices that appear to preclude opportunities for financial arbitrage Accordingly, the assumption that market bond prices allow ... in Charles Nelson and Andrew Siegel, 1987) which can be extended as a dynamic factor model (Diebold and Li, 2006) A third approach uses the a ne arbitrage-free canonical finance latent factor...

Ngày tải lên: 17/02/2014, 03:20

... Omura T (2006) Mitochondrial P450s Chem Biol Interact 163, 86–93 Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (1999) Dual targeting property of the N-terminal ... of Pennsylvania Journal compilation ª 2007 FEBS N B V Sepuri et al Boopathi E, Anandatheerthavarada HK, Bhagwat SV, Biswas G, Fang JK & Avadhani NG (2000) Accumulation of mitochondrial P450MT2, ... conserved among mammals and yeast [24,25] As protein trafficking has been very well characterized in budding yeast and is thought to involve a similar translocation mechanism as that in mammalian cells,...

Ngày tải lên: 18/02/2014, 16:20

... fragment ions, and then reacting them with a second anion that functions as a base rather than an electron donor The carboxylate anion of benzoic acid satisfies this requirement and deprotonates ... radical anion abstracts a proton and generates a radical site that triggers dissociation to produce a complementary pair of fragment ions of type c¢ and z¢Æ Subtraction of the m ⁄ z values for ... resolving highly charged fragment ions and measuring their masses accurately to three or four decimal places Preliminary data from several different approaches to this problem have already been reported...

Ngày tải lên: 18/02/2014, 16:20

... [55,56] Alternatively, the lectins’ glycan bias was exploited in a serial lectin approach separating N-glycosylated (concanavalin A) from O-glycosylated peptides (Jacalin) [57] Chemical trapping and ... equipped with an autosampler, and can be purchased from a variety of companies; and, at least in our hands, HPLC solvent gradients and flow rates can nowadays be controlled such that the overall reproducibility ... the characterization of the actual protein cleavage site has typically remained elusive Nonetheless, the latter information is highly valuable, as it can lead to more rational design of protease...

Ngày tải lên: 18/02/2014, 16:20

... cleavage of the 116 kDa caspase substrate poly(ADP-ribose) polymerase (PARP) to produce its characteristic 89-kDa cleavage product The results in Fig show that TRAIL alone induced partial cleavage ... other systems, increased apoptosis seen in response to IFNa plus TRAIL is characterized by elevated caspase-8 and caspase-9 activity, with enhanced degradation of BID and translocation of Bax to ... 277–292 Nanbo A, Inoue K, Adachi-Takasawa K & Takada K (2002) Epstein–Barr virus RNA confers resistance to interferon -a- induced apoptosis in Burkitt’s lymphoma EMBO J 21, 954–965 Chawla-Sarkar M,...

Ngày tải lên: 19/02/2014, 06:20

... generated at its maximal projection, whereas head words are generated at the leaf nodes Since lexical categories are generated at the maximal projection, our model has the same structural probabilities ... 37th Annual Meeting of the ACL Michael Collins 1999 Head-Driven Statistical Models for Natural Language Parsing Ph.D thesis, University of Pennsylvania Julia Hockenmaier and Mark Steedman 200 2a Acquiring ... Compact Lexicalized Grammars from a Cleaner Treebank In Proceedings of the Third LREC, pages 1974–1981, Las Palmas, May Julia Hockenmaier and Mark Steedman 2002b Generative Models for Statistical...

Ngày tải lên: 20/02/2014, 16:20

... belangrijkst? Ranking Score (max 100) Nog te verdelen: Randen massa 100 Vorm massa Grootte van massa Vascularizatie Zuurstofsaturatie Locatie massa Stijfheid en dichtheid van massa Per karakteristiek ... limited amount of information and data available Therefore, in the analysis and interpretation of the results, much attention was paid to assess the validity and accuracy of the data Especially ... score van 0-100 punten toekennen MRI PAM Randen massa Vorm massa Grootte van massa Vascularizatie Zuurstofsaturatie Locatie massa Stijfheid en dichtheid van massa | Master Thesis: Expert Elicitation...

Ngày tải lên: 20/02/2014, 16:20

... bar graph indicates that 86% of the proteins of the set is predicted to have a contact surface with an accuracy higher than random Noticeably, 66% of the proteins are predicted to have a contact ... C was also partially supported by a grant for a target project in Biotechnology of the Italian Centro Nazionale delle Ricerche (CNR) We thank the Italian ` Ministero della Universita e della Ricerca ... accuracy ‡ 80% The results shown in Fig indicate that also the P(c) values are increasing at increasing reliability index (R) The rate of false positives can be evaluated as [1-P(c,R)] and is...

Ngày tải lên: 21/02/2014, 15:20

... (only trace amounts of UCP2 mRNA can be found) and display well coupled mitochondrial respiration (see below) These characteristics make L6 myoblasts particularly suited for studies aimed at analysing ... promoter, a 198-bp fragment containing the adenovirus serotype 5-tripartite leader sequence, the hUCP3 cDNA, and an SV40 early polyadenylation signal Construction and in vitro characterization of ... inclusion bodies was  80% (as estimated by Coomassie Brilliant Blue staining), and the crude mitochondrial preparation used in the analysis was still contaminated by other membrane fractions, the...

Ngày tải lên: 21/02/2014, 15:20

... particular, the parameters for VIHN complexes not deviate systematically from those of DAHam and DAHKam This means that the side chain carboxylate of Asp1 does not have a direct effect on metal ... (log a values) of Cu(II)-VIHN, Cu-DAHKam and Ni-DAHKam systems The parameters of CD and EPR spectra of all major complexes present at pH 7.4 are provided in Table UVVis spectroscopy Table Protonation ... the range of 300900 nm before and after reaction In a separate experiment, a titration of DAHK-am with Ni(II) was performed, also monitored at 420 nm All other experimental details were analogous...

Ngày tải lên: 22/02/2014, 04:20

... Hagiwara, Y., Hagiwara, H., Ueyama, H & Goldstein, A. L (1994) Isolation of a vitamin E analog from a green barley leaf extract that stimulates release of prolactin and growth hormone from rat anterior ... antibody or rabbit anti-PKC polyclonal antibody at : 1000 dilution and anti-(rabbit IgG) Ig horseradish peroxidase conjugated antibody at : 5000 dilution as a primary antibody and a secondary antibody, ... the antioxidants BHA and AsA These results suggested that active oxygens and free radicals did not participate in the TS effect, and that the inhibitory effect of a- T was mediated by a nonantioxidative...

Ngày tải lên: 22/02/2014, 04:20