studies on oral cancer

... tissues, and oral cancer cell lines and primary oral cancer tissues (A) Expression of survivin mRNA in oral cancer cell lines and primary oral cancer tissues from two patients G3PDH expression was ... study, we focused on the survivin expression in oral cancer cell lines In concurrence with previous reports [5], survivin was highly expressed in oral cancer tissues as well as oral cancer cell lines ... Survivin-2B80-88 peptide vaccination in patients with http://www.translational-medicine.com/content/7/1/1 advanced colorectal cancer, breast cancer, lung cancer, bladder cancer, and oral cancer [24-26] Though...

Ngày tải lên: 18/06/2014, 15:20

... p53/p21-expression Effects of the combination of irradiation and hormone incubation In combination with irradiation both tested hormones exhibited similar effects on clonogenic survival dependent on the ... incubation with low concentration of genistein or estradiol (0.01 μM) (figure 6) In contrast, incubation with high hormone concentrations (10 μM) abolished the increase in p21 expression Irradiation ... proliferation studies where cells were incubated up to days with concentrations between 0.0001 – 10 μM [36,37] In these studies even high estra- diol concentrations induced cell proliferation In contrast...

Ngày tải lên: 09/08/2014, 09:22

... Undersulphation also disturbed cell cycle progression in breast cancer cells Reduction in heparan sulphation in breast cancer cells was shown to increase cancer cell adhesion and ix Summary formation of ... species on migration of breast cancer cell 116 3.9 Undersulphation of GAGs inhibited invasion of breast cancer cell in vitro 120 Discussion 123 HSPG and breast cancer ... inhibition of heparan sulphation as well as the presence of HS-BK, both led to a significant reduction in cell migration In contrast, HS-PM was able to block inhibitory effect on migration Reduction...

Ngày tải lên: 12/09/2015, 08:18

... Transformations of Gene Expression Information 25 iv 2.3.2 Targeted Analysis of Regions Exhibiting Coordinated Gene Expression Suggests a Correlation with DNA Amplifications and Deletions ... other cancers as well viii Publications based on present work: Research Articles: Amit Aggarwal, Siew Hong Leong, Cheryl Lee, Oi Lian Kon, Patrick Tan Wavelet Transformations of Tumor Expression ... Amplification and expression of the c-myc oncogene in human lung cancer cell lines, Nature 1983;306:194-196 Slamon DJ, et al Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer...

Ngày tải lên: 15/09/2015, 17:09

... COX-2 expression in HCA7 xenografts 159 5.3.6 Effects of parthenolide feeding on PGE2 level in vivo 5.4 147 163 152 163 Discussion CHAPTER GENERAL DISCUSSION AND CONCLUSION Anti -cancer potential ... sensitized various cancer cells in response to TNFα-mediated apoptosis The inhibition of NF-κB activation and induction of a sustained JNK activation were proved to be the major mechanisms contributing ... Activators of Transcription (STAT) pathway and cytokine signaling 1.1.3.5 Effects on cell proliferation and induction of apoptosis 13 1.1.3.6 Effects on cell cycle regulation 15 14 1.1.4 in vivo...

Ngày tải lên: 16/09/2015, 17:14

... activation of NK-κB, one of regulators of iNOS gene expression (Wong and Menendez, 1999) Similar effect of parthenolide on iNOS 10 promoter activity was observed in human monocyte cells in conditions ... predominantly on the mitochondrial membrane On the contrary, other pro-apoptotic Bcl-2 proteins (Bax, Bak, Bid, Bim, Bad) appear to be cytosolic under normal conditions Upon apoptotic stimulation, these ... conditions Various death stimulations, especially the truncated form of Bid (tBid), can trigger an N-terminal conformational change of Bax and cause a consequent Bax translocation to mitochondrial...

Ngày tải lên: 16/09/2015, 17:14

... Definition 2: An object query is defined by a conjunction of n attribute constraint Q = (c1 ^ c2 ^ … ^ cn) Some constraints would be constant when the user does not care about the attributes Each constraint ... regular expression, the features “where such regular expression existed” should be used - Constraint satisfaction features (CSF) Since the object queries contain constraints on each attribute ... Information Extraction Systems and Text Information Retrieval Systems Each solution based on its approach with different advantages, however, they also have some shortcomings Information Extraction...

Ngày tải lên: 23/11/2012, 15:04

... 1.4 Oral Presentations 10 1.4.1 Definition and Characteristics 10 1.4.2 The Importance of Oral Presentations 11 1.4.3 Oral presentation Composition ... For the Institution: Conducting oral presentation-oriented testing 49 Part 3: Conclusion and recommendations 51 References Appendices Appendix 1: The questionnaire for the students Appendix ... 1.4.4 Types of Oral Presentations 13 1.4.5 Teaching Oral Presentation Skills 15 v Chapter II: The study 18 2.1 An Overview of the Current Situation of Teaching...

Ngày tải lên: 07/09/2013, 13:02

... preparation 9 1.4 Oral Presentations 1.4.1 Definition and Characteristics Ohio Wesleyan University, in their Guidelines for Oral Presentations define oral presentations as brief discussions of ... communicate, exchange information with their peers and thereby develop personal confidence 1.4.3 Oral Presentation Composition According to the literature on oral presentations (see Comfort: 1995; Dwyer: ... 2004, Paulson: 2000; etc.) an oral presentation consists of three main parts: the introduction, body and conclusion The introduction aims to state the topic and get the audiences attention It gives...

Ngày tải lên: 29/01/2014, 10:43

... conduit 7.2.4 Continent cutaneous urinary diversion 7.2.5 Ureterocolonic diversion 7.2.6 Orthotopic neobladder 7.3 Morbidity and mortality 7.4 Survival 7.5 Conclusions on urinary diversion ... surgery (7) 10.1.1 Conclusion and recommendation for TURB Conclusion and recommendation LE GR Transurethral resection of bladder tumour (TURB) alone is not a curative treatment option in most patients ... sign The authors concluded that EBRT monotherapy was an option only in highly selected patients 10.2.1 Conclusions and recommendation for external beam radiotherapy Conclusions LE External beam...

Ngày tải lên: 14/02/2014, 21:20

... electronic environment The nature and type of amino acids and their side-chain orientations around iron– sulfur cluster coordination sites are the likely cause of minor variations in the electronic ... solvent-induced conformational change, which is possibly because of changes in the chemical environment around the iron–sulfur cluster, the partial destruction of the cluster or its conversion to other ... order to acquire firm evidence for this observation, the total iron content of proteins purified under different conditions was measured The total iron content of the native and in-column refolded...

Ngày tải lên: 18/02/2014, 12:20

... scavenging and remobilization when the cells are under stress and consequently mononucleotide phosphate concentrations are high 5862 Materials and methods Cloning and purification of St SurE The SurE ... R192 Stability of St SurE Urea denaturation studies were carried out by incubating the protein at a concentration of 0.5 mgÆmol)1 with varying concentrations of urea (0–7 m) for h after which CD ... melting studies were conducted using circular diachronic monitoring at both 209 and 222 nm The protein lost its secondary structure at a temperature of around 45 °C (Fig 4B) This was also confirmed...

Ngày tải lên: 18/02/2014, 14:20

... conformations in E53QbsSHMT-Gly In one conformation, the carboxylate group forms hydrogen bonds with R357, as in bsSHMT-Gly [12] In the second conformation, the carboxylate forms hydrogen bonds ... present close to the position corresponding to the second conformation of the carboxylate group (Fig 2A,B) The hydrogen bonding between Q53 and the second conformation of carboxylate of Gly found ... illustrating electron density (omit map) corresponding to PLP and Gly in E53QbsSHMT-Gly The two conformations of Gly are shown A water molecule is present close to the second conformation of Gly with...

Ngày tải lên: 18/02/2014, 16:20

... troponin-tropomyosin regulation of skeletal muscle contraction Annu Rev Biophys Biophys Chem 16, 535–559 Farah CS & Reinach FC (1995) The troponin complex and regulation of muscle contraction ... site to the inhibitory region) participates in the Ca2+-dependent activation In addition, at 15°C, similar activation is observed for the troponin containing the corresponding vertebrate TnI-fragment, ... molluskan muscles, the C-terminal region does not function and troponin regulates contraction only through the activation exerted by the N-terminal region of TnI Experimental procedures Muscle proteins...

Ngày tải lên: 20/02/2014, 01:20

... containing mM dithioerythritol The column was developed with the same buffer Fractions were combined and concentrated using a Centriprep-10 concentrator (Amicon) The final protein concentration ... nonmevalonate pathway Tetrahedron Lett 41, 703 –706 Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T & Seto, H (2000) Studies on the nonmevalonate pathway: conversion of 4-(cytidine 50 -diphospho)-2-C-methyl-D ... by reversed phase ion pair HPLC monitored by scintillation counting HPLC analysis of phosphorylated metabolites Isolation of chromoplasts from N pseudonarcissus The isolation followed a procedure...

Ngày tải lên: 22/02/2014, 07:20

... Perception Questionnaire (B-IPQ) [26] The scale has items, measuring (a) cognitive representations (consequences, timeline, personal control, treatment control, identity); (b) emotional representations ... National Coalition for Cancer Survivorship; OOG-CCCS: Organization Oncologic Gynecology of the Comprehensive Cancer Center South; RCT: Randomized Controlled Trial; ROGY: Registrationsystem Oncological ... information The questionnaire contains the following scales: (a) Information about the disease; (b) Information about medical tests; (c) Information about treatment; (d) Information on other...

Ngày tải lên: 05/03/2014, 15:20

... 12.3.4 Conclusions 12.4 LHRH agonists 12.4.1 Achievement of castration levels 12.4.2 Flare-up phenomenon 12.5 LHRH antagonists 12.5.1 Abarelix 12.5.2 Degarelix 12.5.3 Conclusions 12.6 Anti-androgens ... recommendation Grade Nature of recommendations A B  ased on clinical studies of good quality and consistency addressing the specific recommendations and including at least one randomised trial B Based on ... positive surgical margins A  dditional information may be provided on multifocality, diameter of the dominant tumour and the zonal location (transition zone, peripheral zone, anterior horn) of the dominant...

Ngày tải lên: 06/03/2014, 00:22

...  non-seminoma NSGCT CS1 (31) Non-seminoma CS I Low risk no vascular invasion Standard option Option if conditions against surveillance High risk Vascular invasion present Option if conditions ... recommendations A Based on clinical studies of good quality and consistency addressing the specific recommendations and including at least one randomised trial B Based on well-conducted clinical studies, but ... non-seminoma Procedure Year 3-5 6-10 Physical examination times times Once/year Once/year Tumour markers times times Once/year Once/year Chest X-ray Twice Twice Abdominopelvic CT scan Once Once...

Ngày tải lên: 06/03/2014, 00:22

... decision analyses examined the cost-effectiveness of breast cancer gene expression assays, and overall were inconclusive Conclusions: Oncotype DX is furthest along the validation pathway, with strong ... addition to the conclusions above, a series of other observations were made on the basis of what was learned in this investigation Assay Validation In general, it is clear that validation studies ... of evidence on economic outcomes was inconclusive Limitations of the Report The report included only English publications and was restricted to three gene expression tests Limitations of the Literature...

Ngày tải lên: 06/03/2014, 01:20

... Second Opinion 26 Nutrition 28 Reconstruction 29 Rehabilitation 30 Follow-up Care 31 Sources of Support 31 Taking Part in Cancer Research 33 Dictionary 35 National Cancer Institute Publications ... questions, or just listen For the latest information about oral cancer, please visit the NCI Web site at http://www .cancer. gov/ cancertopics/types /oral Or, call the NCI Cancer Information Service ... to the lungs, the cancer cells in the lungs are actually oral cancer cells The disease is called metastatic oral cancer, not lung cancer It’s treated as oral cancer, not lung cancer Doctors sometimes...

Ngày tải lên: 06/03/2014, 01:20