studies of transgenic mice and of human genetic matrix diseases

... into proficient formidable hunters and then agriculturalists, the balance of power between humans and other animals gradually shifted in favour of humans The balance of power between humans and ... relationship between humans and other animals, but also precipitated profound Animals, disease and human society changes in the structure of human society and the nature of social relations Domesticated ... the object of the exercise My intention is to give the reader an impression and understanding of changing human relations and the long-term and far-reaching consequences thereof for human society...

Ngày tải lên: 06/03/2014, 16:20

... is Professor of Bioethics and Philosophy of Law, University of Manchester MATTI ¨ HAYRY is Lecturer, University of Iceland, in Privacy Law at the Faculty of Law, and in Computer Security and Cryptography ... protection of personal genetic and medical information; (ii) consent – a conceptual analysis of consent and an ethical analysis of issues of consent of participants in population-based human genetic ... and (iii) genetic discrimination – an ethical and conceptual analysis of the issue of possible genetic discrimination in the context of population-based human genetic databases In the minds of...

Ngày tải lên: 05/08/2014, 13:20

... human dignity is genetic, and it can be found in UNESCO’s Universal Declaration on the Human Genome and Human Rights.31 This document states that human dignity is based on the human genome, and ... Genetic Links, Family Ties and Social Bonds: Rights and Responsibilities in the Face of Genetic Knowledge’, Journal of Medicine and Philosophy 23 (1998), pp 10–30 Cf., however, Tuija Takala and ... these cases On the significance of these, see, e.g., Onora O’Neill, ‘Informed Consent and Genetic Information’, Studies in History and Philosophy of Biological and Biomedical Sciences 32 (2001),...

Ngày tải lên: 05/08/2014, 13:20

... in Iceland that aims at discovering more about Icelanders’ perceptions of privacy of personal information in general and privacy of medical and genetic data in particular, and their trust of private ... random sample of 1,000 Swedes between eighteen and seventy-five years of age The questions were aimed at mapping attitudes and opinions and did not measure actual knowledge of the field of genetics ... in the Use of Personal Genetic Data (May 2002) UK Human Genetics Commission, Public Attitudes to Human Genetic Information Cragg Ross Dawson, Public Perceptions of the Collection of Human Biological...

Ngày tải lên: 05/08/2014, 13:20

... Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine, Oviedo, April 1997, ETS 164 Consent and ... local history and the nationalistic discourse of Icelanders, emphasizing the uniqueness of the Icelandic biological and cultural heritage.17 Weighing risks and benefits In the context of public acceptance ... the University of Tartu, also one of the main founders of the genome project and a board member of the EGP As such, Metspalu appeared as one of the main spokespersons and promoters of the EGP since...

Ngày tải lên: 05/08/2014, 13:20

... denied Human Genetics Commission’s survey of public attitudes: Human Genetics Commission, Public Attitudes to Human Genetic Information – People’s Panel Quantitative Study Conducted for the Human Genetics ... on Human Rights and Biomedicine, unclassified CM (96) 175 final (Strasbourg: Council of Europe, Committee of Ministers, 1997) Convention on the Protection of Human Rights and Dignity of the Human ... Conference of UNESCO at its 29th Session on 11 November 1997, art 4, and in the Convention on the Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and...

Ngày tải lên: 05/08/2014, 13:20

... reasons, such as different cultural understandings of disease and genetics, of identity, and different perceptions of the benefits of genetic technologies Benefits and costs: alternative interpretations ... on the Human Genome and Human Rights has recognized the fundamental unity of humankind manifested in our sharing of the genome and suggested the linkage of this unity to the concept of human dignity ... reconsideration of the definition of an orphan medicine, with particular reference to the implications of genetic stratification of both patients and diseases .21 Here the relevance of the normative and...

Ngày tải lên: 05/08/2014, 13:20

... prohibited’, Convention on the Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine, Oviedo, April ... disclose results from genetic tests There is backing in the Council of Europe’s Convention on Human Rights and Biomedicine1 and the Universal Declaration on the Human Genome and Human Rights.2 The ... best use of money), governance of the project, aims of the project, scientific value of the project (reliability of the data) and the perception of the public Trust 195 In order to create and maintain...

Ngày tải lên: 05/08/2014, 13:20

... Blood and Data: Ethical, Legal and Social Aspects of Human Genetic Databases (Reykjavık: University of Iceland Press and Centre for Ethics, 2004), pp 111–119 ´ 199 200 ´ Sigurdur Kristinsson and ... Beauchamp and Childress, Principles, p 83 Informed consent and human genetic database research 205 background knowledge can limit understanding of the conceptual and causal implications of propositions ... ‘Breaking the Stalemate’; Caulfield, Upshur and Daar, ‘DNA Databanks ´ and Consent’; and Arnason, ‘Coding and Consent’ Informed consent and human genetic database research 215 asking for consent...

Ngày tải lên: 05/08/2014, 13:20

... team of scientists have completed their celebrated survey of the human genetic code and entered a brave new world of discovery’ (Andrew Cohen, ‘Scientific Team Crosses Genetic Frontier’, Globe and ... Levitt and Sue Weldon, Genetic Databases and Public Trust’, in Gardar ´ ´ Arnason, Salvor Nordal and Vilhjalmur Arnason (eds.), Blood and Data: Ethical, Legal ¨ ´ and Social Aspects of Human Genetic ... 818 Convention on the Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine, Oviedo, April...

Ngày tải lên: 05/08/2014, 13:20

... Council of Europe Explanatory Report to the Convention for the Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and Medicine: Convention on Human ... June 2000, D6 Anderson, A., ‘In Search of the Holy Grail: Media Discourse and the New Human Genetics’, New Genetics and Society 21 (2002), 327–337 Andrews, L B., ‘Contacting Relatives and Recontacting ... Arendt, H., The Human Condition, Chicago: University of Chicago Press, 1958 ´ ´ Arnason, G., S Nordal and V Arnason (eds.), Blood and Data: Ethical, Legal and Social Aspects of Human Genetic Databases,...

Ngày tải lên: 05/08/2014, 13:20

... changes of C393 to G and C1629 to T that not lead to amino acid changes, nucleotide changes of A378 to T and G481 to A lead to amino acid substitutions of R126S and G161R, respectively Two human ... identity of the resultant plasmids pBAD/Thio-huTDP, pBAD/Thio-huTDPND39, and pBAD/Thio-huTDPND174 Production and refolding of recombinant human TDP from E coli Wild-type and mutant human TDP ... huTDPND39 variant, and (B) huTDPND174 variant with lane and 2: uninduced (–) and induced (+) culture, lane and 4: soluble (S) and insoluble (I) fraction of the crude lysate, lane 5, 6, 7, and 8: load,...

Ngày tải lên: 31/03/2014, 21:21

... development of WikiProfessional BM, JW and GM conceived of the original idea of coupling the relational Wikidata software to the Knowlet space, which later developed into the full design of WikiProfessional ... rate of growth of high throughput data and published information in the life sciences renders comprehensive and timely annotation of the literature for actual facts by any central team of experts ... Figure Screenshot of the broad concept space of the concept 'antimalarials' and 46 actual antimalarial drugs Screenshot of the broad concept space of the concept 'antimalarials' and 46 actual antimalarial...

Ngày tải lên: 14/08/2014, 08:21

... members of clade IV) on the one hand, and of WH7803 and WH7805 on the other hand, appears to be much more recent Although Figure 4a represents well the evolutionary history of the majority of the ... concept, through study of the relationships between ribotype and genome diversity, we significantly advance our understanding of the phylogeny and evolution of this major group of marine photosynthetic ... accessory genomes of marine picocyanobacteria The core and accessory genomes of marine picocyanobacteria (a) Number of genes distributed between the core and accessory components of each of the 11 Synechococcus...

Ngày tải lên: 14/08/2014, 08:21

... include lack of accurate pain assessment and lack of understanding on gender differences in pain perception This thesis is concerned with exploring objective measures of human pain perception and investigating ... across-subject grand averages of HEP in the Cold Pain 1, no-pain control and no-task control conditions 97 5.3 Scalp power maps of the across-subject grand averages of HEP 98 ... activity (beta2 and beta3) reflects alertness, agitation and general activation of mind NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE 2.1 EEG 11 and body functions, as compared to a state of being alert...

Ngày tải lên: 30/09/2015, 06:37

... characterization of numerous complexes of the human HPRT and several bacterial and protozoan HPRTs have been undertaken [13–17] The structure of human HPRT can be divided into two domains: a core domain and ... FEBS 4927 Studies of the human PRTFDC1 M Welin et al 300 mm NaCl, and mm MgCl2 Following initial screening, a subset consisting of IMP, GMP, XMP, AMP, CMP and PRPP were screened at 500 lm and 10 ... kinetics, ligand binding, and crystallography Biochemistry 45, 6615–6627 24 Raman J, Sumathy K, Anand RP & Balaram H (2004) A non-active site mutation in human hypoxanthine Studies of the human PRTFDC1...

Ngày tải lên: 15/02/2014, 01:20

... study, the interaction of human arginase II with substrate and metal ions was examined by sitedirected mutagenesis and kinetic studies Selection of target residues (Asp149, His120 and His145) was based ... the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II Values, ... properties of the wild-type, His120Asn, His145Asn and Asn149Asp variants of arginase II Purified wild-type, His120Asn and His145Asn variants of arginase II were active even in the absence of added...

Ngày tải lên: 20/02/2014, 02:21

... possible dimeric structures of LPL, the head-tohead and the head-to-tail models, the studies of the chimeric proteins of hepatic lipase and LPL and the tandem repeat approach of LPL [21,34] support ... of hydrogen, modification of bonds, potentials of forcefield, and fixation of heavy atom, backbone, and Ca, were performed for molecular mechanics calculations and then the energy minimization of ... temperature of 298.0 K for 5000 steps of 1.0 fs time-step RESULTS Model structure of human LPL All model structures of dimeric human LPL were constructed using the INSIGHT II program and were based...

Ngày tải lên: 21/02/2014, 15:20

... the content of the sentence compared to a human gold-standard Yet, the assessments of the two aspects were often the same—readability/fluency of the sentence is important for understanding the ... lowest fluency scores among machine translations and 300 randomly chosen human translations We then tried the classification task of distinguishing human and machine translations with different fluency ... overall text quality (Pitler and Nenkova, 2008) The articles were chosen at random and comprised a total of 290 sentences One human assessor was asked to read each sentence and mark the ones that seemed...

Ngày tải lên: 22/02/2014, 02:20

... NMR studies [16,19,20,23] The energy of folding these various forms and the energetic cost of converting one form to another is of fundamental importance for understanding telomere biology and ... practical details of UV melting studies of G-quadruplexes, with an thorough discussion of common problems and pitfalls [32] The use of fluorescence to monitor the thermal denaturation of quadruplex-forming ... signal for the determination of the fraction of folded or unfolded DNA strand, allowing for the calculation of the equilibrium distribution of conformational forms Standard methods using UV absorbance...

Ngày tải lên: 06/03/2014, 09:22