studies in mouse models and implications for human disease
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... model systems, including lower eukaryotes and invertebrates, in order to obtain clues for building important hypotheses The rapidity and efficiency of in vivo studies in many nonmammal models have ... expressed in areas affected by Parkinson’s disease in the adult mouse brain Eur J Neurosci 23, 659–666 40 Taymans JM, Van den Haute C & Baekelandt V (2006) Distribution of PINK1 and LRRK2 in rat and mouse ... the studies of mutant phenotypes for the two ROCO proteins in D discoideum indicate their roles in regulating cytoskeleton structures Interestingly, it was previously noted that human LRRK2 binds...
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studies in surface science and catalysisAAAA4cMETHODS FOR MONITORING AND DIAGNOSING THE potx
... applicant and the date of publication are indicated for each document cited in the book A patent number index, an inventors index, a company index and a viii Methods for Monitoring and Diagnosing the ... USA in the 1980s In 1997, a second stage of European legislation was introduced for all new cars, covering both petrol and diesel engines These standards brought EU rules into line with US standards ... effectiveness and to production in the meantime It must be borne in mind that the driving cycles of EC2005 and ULEV involved differ significantly (see [6] and [ ] For the 7) TLEV, LEV and ULEV standards...
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báo cáo hóa học:" Gender and sexuality: emerging perspectives from the heterosexual epidemic in South Africa and implications for HIV risk and prevention" pdf
... the persistence of gender violence remains a worrying continuity that shapes and binds forms of femininity and masculinity Jewkes and Morrell Journal of the International AIDS Society 2010, 13:6 ... hegemonic masculinity involve sexual and other forms of risk taking These include driving cars fast and dangerously, and heavy alcohol consumption; indeed, social norms around alcohol drinking are such ... individual behaviours In real terms, this means focusing attention on building more gender-equitable and caring masculinities, and less acquiescent femininities In so doing, interventions are needed...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... follow in humans because not all autoantigen-specific T cells seem to be effective in treating an ongoing autoimmune disease as described in the T1D model [22] Therefore in humans such a prescreening ... generated and expanded in vitro, might tip the balance and allow a true curative action in animal models of T1D [12], and much work is now directed to this area [20] Two recent studies in T1D and experimental ... whether harnessing CD4+CD25+ Treg will represent a viable therapy for RA and other autoimmune diseases in the future Competing interests The author(s) declare that they have no competing interests...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... diseases including T1D [6] T1 D is a chronic autoimmune disease that results in the destruction of the insulin-producing beta (b) cells of pancreatic islets of Langerhans, resulting in insulin ... be examined Page of 12 In humans, exposing CD4+ T cells to both IL-2 and rapamycin in vitro leads to an increase in the cellular frequency of FOXP3+ T cells, originating from nTreg cells and de ... targets the cytosolic protein FK-binding protein 12 (FKBP12) and downstream mTOR pathway, and in turn inhibits IL-2 responsiveness in activated T cells [86] Investigations into its mechanism of action...
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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx
... of inflammation in neurodegenerative disease Numerous studies have shown that the immune cells in the vicinity of amyloid deposits in AD express mRNA and proteins for pro-inflammatory cytokines, ... related chitinase genes, namely CHI3L1 and CHI3L2 are overexpressed in AD brain Both forms of chitinase 3-like proteins not have enzymatic chitinase activity and instead, inhibit IL-1 and TNFα-mediated ... ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury Neurobiol Aging 2002, 23:31-39 Townsend K, Town T, Mori M, Lue L, Shytle D, Sanberg P, Morgan D, Fernandez...
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Báo cáo y học: "Recent key advances in human immunodeficiency virus medicine and implications for Chin" potx
... tolerance by expanding methadone maintenance treatment (MMT) and needle and syringe programs (NSPs), removing the requirement for viral hepatitis testing before school and job entry, and lifting the ... such as vaccine and microbicide development, expanding HIV testing and treatment, discovering and developing new ARV drugs, optimizing the ART delivery system, and improving therapy for non-AIDS ... combating fear, stigma, and discrimination against people living with HIV and AIDS As a result, the XIX International AIDS conference will be held in Washington, DC in July 2012 Implications for...
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Báo cáo y học: " Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation" ppsx
... porcine endogenous retrovirus in transmitting miniature swine Virol J 2006, 3:91 Suling K, Quinn G, Wood J, Patience C: Packaging of human endogenous retrovirus sequences is undetectable in porcine ... most porcine pathogens; however, porcine endogenous retroviruses (PERVs) are integrated in the pig genome and can be released from normal pigs and infect human cells in vitro [16,17] In the past, ... detection of minimal traces of retroviruses but also detect sample contamination Indeed, contaminating retroviruses, mainly gammaretroviruses, have been found in numerous human cell lines (for literature...
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Tài liệu SEXUALITY EDUCATION IN SCHOOLS: THE INTERNATIONAL EXPERIENCE AND IMPLICATIONS FOR NIGERIA pdf
... contraception and HIV/STI prevention; inadequate teaching materials and training; a scattershot approach to providing specific information that undermines comprehensive student understanding; and a tendency ... education? Inform the debate Accurate and understandable information can defuse conflict and mobilize support for programs by demonstrating the magnitude of adolescent health problems Such information ... “examinable” and others not test students on their achievements in learning the subject matter (Senderowitz, 2000) Training teachers Teacher training is a challenge everywhere, including in developed...
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ROUTLEDGE STUDIES IN SCIENCE, TECHNOLOGY AND SOCIETY: Human-animal relations and the rise of veterinary medicine pot
... ANIMALS, DISEASE AND HUMAN SOCIETY Human- animal relations and the rise of veterinary medicine Joanna Swabe ANIMALS, DISEASE AND HUMAN SOCIETY Human- animal relations and the rise of veterinary medicine ... contends, inescapably went hand in hand with the advance of disease While humankind flourished and multiplied so did disease- causing organisms In short, epidemic infectious disease can only exist in ... including links between human and animal disease; • the rise of a veterinary regime, designed to protect humans and animals alike; • the implications of intensive farming practices, pet-keeping...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... biochemical studies including investigations in human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative ... corresponding rat tissues show expression only in duodenum, colon and rectum In both mouse and rat, Adh4 is found in the epithelial lining of upper GI tract including the tongue, esophagus and stomach, ... the villi and in the intestinal glands, while submucosal glands were empty In jejunum and ileum, Adh1 1214 mRNA showed a similar expression pattern as described for duodenum In colon and rectum,...
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Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot
... dephosphorylation Elegant work in cell models provided an intriguing two-way mode of action in which a ‘substrate-binding’ PTP combines phosphorylationdependent and -independent protein interactions to regulate ... into the nucleus and enhances secretory granule gene expression by binding and protecting STAT5 phosphotyrosines For the R4 (RPTPa and RPTPe) and R5 (RPTPc and RPTPf) receptor-type PTPs the individual ... cadherinlike; CRB, cellular retinaldehyde-binding protein-like; D1 and D2, membrane-proximal and membrane distal PTP domains, respectively (enzymatically active domains are in green, PTP domains...
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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
... and swing are indicated for the right hind limb Duration of braking and propulsion are indicated for the left fore limb Results Gait in saline-treated mice The ventral view of a C57BL/6J mouse ... gait cycle timing in Parkinson's disease and Huntington's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability ... duration, and stance duration Step-to-step gait variability in humans has also provided important information about possible mechanisms involved in neurodegenerative diseases, including PD and HD...
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báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care" docx
... The Infectious Diseases Institute (IDI) in Kampala, Uganda, is a centre of excellence for HIV clinical care in the country, and maintains a large observational clinic database and a nested research ... (age and CD4+ cell count) Table Number and incidence rates of opportunistic infections in the initial 24 months after ART initiation, and percent underreporting of OI events in routine clinic ... discontinuation and modification This gives a total error rate (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART discontinuation...
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Báo cáo khoa học: "Human vascular adhesion proteın-1 (VAP-1): Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease" pdf
... added into the wells, and the plates were allowed to incubate at room temperature again for h Finally, plates were washed six times with Tween/PBS and generated after combining with chemiluminescence ... preceding hepatocellular cancer We suggest that the increased levels of sVAP-1 may be a clinically useful marker in liver diseases Materials and methods History and clinical properties were interrogated ... Kurkijärvi R, Adams DH, Leino R, Möttönen T, Jalkanen S, Salmi M: Circulating form of human vascular adhesion protein-1:Increased serum levels in inflammatory liver diseases The J Immunol 1998,...
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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps
... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... goal of evaluating and optimizing therapeutic intervention within the contexts of these models [11] In this report we describe a kinetic model of tumor transport in the craniospinal axis (subarachnoid ... γf and γt, as described above The value for Qf, the volumetric flow rate and the spine and brain CSF volumes are taken from Bergsneider [12] The values used for the volumes of the brain and spine...
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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot
... identified citrulline-modifications in multiple proteins in inflamed CIA joint and EAE brain tissue Our results suggest that citrullination of synovial proteins in CIA and brain proteins in EAE generate ... in RA or MS, and their potential role in human disease is unclear The synovial and myelin microarrays contained predominantly mouse and/ or human versions of the proteins and peptides, depending ... citrullinated proteins were structural proteins and included fibrinogen, vimentin, keratin, filaggrin and MBP Citrullination is known to alter the structural properties of keratin and MBP, and thus...
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báo cáo khoa học: "Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease" potx
... be essential for understanding noncoding variation in human disease Cell-type-specific regulatomes as a tool for understanding the role of non-coding mutations in human disease During the past ... non-coding component in human phenotypic variation and disease Indeed, several studies document a critical role for genetic aberrations occurring within individual distal enhancer elements in human ... using in vitro and in vivo models, of which iPSC-based disease in a dish’ models appear particularly promising [123] For example, disease- relevant cell types obtained from patient-derived and...
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Báo cáo y học: " Reduced peak oxygen uptake and implications for cardiovascular health and quality of life in patients with schizophrenia" ppsx
... factors for CVD and evaluation of VO2peak should be incorporated in clinical practice Finally, these finding represent an urging need for developing effective physical training interventions for ... artery disease, known chronic obstructive pulmonary disease, and not being able to perform physical treadmill testing and exercise Patients were examined by a physician at inclusion to the study and ... monitoring and management guidelines for second-generation antipsychotics J Clin Psychiatry 2007, 68:14-18 20 21 Ware JE, Kosinski M, Gandek B: SF-36 health survey: manual & interpretation guide Lincoln,...
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