... association of MMPs and TIMPs and the possible therapeutic aspects of these proteinases in potentially malignant and malignant head and neck lesions. So far, no promising drug target therapy has ... the head and neck is a multi-step process. Head and neck malignancies consist of a heterogeneous group of neoplasia. They constitute the sixth most common malignancy, and more than 90% of these ... to review the role, polymorphic association, gene expression of ECM and pos- sible therapeutic aspects of MMPs and TIMPs in potentially malignant and malignant lesions of the head and neck. Classification
Ngày tải lên: 10/08/2014, 05:21
... Volu m e Surgical Pathology of the Head and Neck Third Edition EDITED BY LEON BAR NES Surgical Pathology of the Head and Neck Volu m e Surgical Pathology of the Head and Neck Third Edition EDITED ... retention of the normal architectural and cytological pattern of the squamous epithelium The epithelium is thickened as a result of an increased prickle cell layer The cells of the basal and parabasal ... 25 Infectious Diseases of the Head and Neck 1609 Panna Mahadevia and Margaret Brandwein-Gensler 26 Miscellaneous Disorders of the Head and Neck
Ngày tải lên: 20/01/2020, 13:56
Ebook Surgical pathology of the head and neck (Vol 3 - 3/E): Part 2
... of head and neck lesions about the editor LEON BARNES is Professor of Pathology and Otolaryngology, Chief of the Division of Head and Neck? ?? Endocrine Pathology and Director of the Head and Neck? ??Endocrine ... infiltrating, epithelium Chapter 23: Pathology of Selected Skin Lesions of the Head and Neck 1479 and history of recent growth as clinical features of malignancy (12) Consistent among these reports of metastasizing ... Zygomycetes, 1638 Pathology about the book… Surgical Pathology of the Head and Neck, Third Edition is a complete stand-alone reference covering all aspects of head and neck pathology Providing an interdisciplinary
Ngày tải lên: 21/01/2020, 13:07
Ebook Surgical pathology of the head and neck (Vol 3 - 3/E): Part 1
... Volu m e Surgical Pathology of the Head and Neck Third Edition EDITED BY LEON BAR NES Surgical Pathology of the Head and Neck Volu m e Surgical Pathology of the Head and Neck Third Edition EDITED ... Neck 997 Alexander C L Chan and John K C Chan 16 Pathology of Neck Dissections Mario A Luna 1135 17 The Occult Primary and Metastases to and from the Head and Neck ... 25 Infectious Diseases of the Head and Neck 1609 Panna Mahadevia and Margaret Brandwein-Gensler 26 Miscellaneous Disorders of the Head and Neck
Ngày tải lên: 22/01/2020, 10:24
Ebook Surgical pathology of the head and neck (Vol 2 - 2/E): Part 1
... Pathology of the Head and Neck Surgical Pathology of the Head and Neck Second Edition, Revised and Expanded (in three volumes) Volume edited by Leon Barnes University of Pittsburgh School of Medicine ... Contents of Volume 1 Uses, Abuses, and Pitfalls of Frozen-Section Diagnoses of Diseases of the Head and Neck Mario A Luncr Fine-Needle Aspiration of the Head and Neck 15 David Dusenbery Electron ... Surgical Pathology of the Head and Neck Jerome B Rrxy Molecular Pathology of Head and Neck Cancer 87 113 Regina Candour-Edwards rrnd Pcul H Gumerlock Diseases of the Larynx, Hypopharynx, and Esophagus
Ngày tải lên: 22/01/2020, 21:30
Cytopathology of the head and neck
... aspiration cytology of the head and neck, 1.3 Ultrasound guided FNAC, 1.1 Introduction The Head and Neck (HN) area is one of the most complex regions of the body because of its anatomical and functional ... malignant lymph nodes, in assessing the patency of normal vessels, and in the investigation of vascular and lymphatic malformations Cytopathology of the Head and Neck: Ultrasound Guided FNAC, Second ... Cytopathology of? ?the? ?Head and? ?Neck Ultrasound Guided FNAC Cytopathology of the Head and Neck Ultrasound Guided FNAC Second Edition Author: Gabrijela
Ngày tải lên: 08/09/2020, 14:36
Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and nonoropharyngeal patients
... the bone marrow and spleen and increased recruitment of leucocytes to the tumour [28] Thus, the p16 status of a patient may also alter the inflammatory response and contribute both directly and ... 2002) stage and treatment plan Additionally, radiotherapy dose, number of fractions and the start and end date of radiotherapy were recorded for each patient The pre-treatment neutrophil and lymphocyte ... determined from the start of radiotherapy until the date of the event or death from any cause (date of death obtained from hospital records) The exploratory variables analysed in univariate and multivariable
Ngày tải lên: 21/09/2020, 11:23
Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
... RNA and cDNA synthesis The mean of triplicates of the WT1 gene copy numbers was divided by the mean of duplicates of copy numbers of the β-actin Primers and probes for the WT1 and βactin gene and ... cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer and also the most common tumor type in the head and neck region The 5-year survival is approximately 50% and has increased ... suppressor or activator of tumourigenesis in different types of human malignancies The role of WT1 in squamous cell carcinoma of the head and neck (SCCHN) is not clear Overexpression of WT1 has been
Ngày tải lên: 29/09/2020, 16:23
Hypoxia, blood flow and metabolism in squamouscell carcinoma of the head and neck: Correlations between multiple immunohistochemical parameters and PET
... [18F]FDG SUV and p53 expression (p =0.029) using median SUV as the cut-off There was a significant association between tumor volume and the amount of apoptotic cells (p =0.029) The intensity of VEGF ... Conclusions: A high uptake of [18F]FDG expressed as SUV is linked to an aggressive HNSCC phenotype: the rate of apoptosis is low and the expressions of p53 and VEGF are high None of the studied biomarkers ... previously described the pharmacokinetic properties of [18F]FETNIM as a hypoxia tracer in experimental tumors [13,14] and in patients with squamous-cell carcinoma of the head and neck (HNSCC) [12,15,16]
Ngày tải lên: 14/10/2020, 13:08
Phase II Trial of Post-operative Concurrent Radiation and Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
... complete head and neck and cutaneous exam and review of systems focusing on head and neck, cutaneous and pulmonary complaints QOL and functional assessments (the Functional Assessment of Cancer Therapy -Head ... malignancies of the head and neck, with suboptimal outcome The goal of this trial is prospectively study the addition of concurrent cetuximab to radiotherapy for locally advanced CSCCHN in the post-operative ... between 20 and 50 Gy Out -of- Field Local-Regional Relapse- Review of the imaging of the local-regional relapse and the patient’s previous RT treatment data reveals that the “epicenter” of the localregional
Ngày tải lên: 18/10/2022, 13:06
A Multicenter Study of Carbon-Ion Radiotherapy for Mucosal Melanoma of the Head and Neck: Sub-analysis of the Japan Carbon-Ion Radiotherapy Study Group (J-CROS) Study (1402 HN)
... Kamada T, and the Japan Carbon Ion Radiotherapy Study Group, A Multicenter Study of Carbon-Ion Radiotherapy for Mucosal Melanoma of the Head and Neck: Sub-analysis of the Japan Carbon-Ion Radiotherapy ... MANUSCRIPT Introduction Mucosal melanoma of the head and neck (MMHN) is an infrequent RI PT tumor comprising ~10% of melanomas arising in the head and neck and ~1% of all malignant melanomas (1-3) MMHN ... affect the content, and all legal disclaimers that apply to the journal pertain ACCEPTED MANUSCRIPT A Multicenter Study of Carbon-Ion Radiotherapy for Mucosal Melanoma of the Head and Neck: Sub-analysis
Ngày tải lên: 19/11/2022, 11:40
mucosal melanoma of the head and neck a population based study from slovenia 1985 2013
... (26) In the 29-year period from 1985 to 2013, MMHN represented 0.5 % of all head and neck malignancies, 0.8 % of all melanomas, 4.4 % of all melanomas in the head and neck region and 42 % of all ... resection of the primary tumor offers the best chance of local control and cure, whereas the role of © 2016 The Author(s) Open Access This article is distributed under the terms of the Creative ... assess the incidence and to review experience with the treatment of mucosal melanoma of the head and neck (MMHN) in Slovenia between 1985 and 2013 Methods: The National Cancer Registry database and
Ngày tải lên: 04/12/2022, 15:42
Báo cáo khoa học: "Parotid gland-recovery after radiotherapy in the head and neck region: 36 months follow-up of a prospective clinical study" pdf
... in terms of parotid gland sparing The IMRT technique should therefore represent the standard of care for the treatment of head and neck tumors Parotid-gland-sparing up to mean doses of 26 Gy ... mention the expected anatomical changes of the parotid glands during the head and neck irradiation [29] This is known from studies in centers with the use of helical tomotherapy Due to weight loss and ... quarter of IMRT and only one third of 3D-CRT patient’s benefit from salivary gland sparing by an increasing of the salivary flow rates to 12 and 24 months after radiation However, the aim of the
Ngày tải lên: 09/08/2014, 09:21
Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma
... perineural invasion, and muscular invasion The depth of invasion was measured from the surface of the normal mucosa to the deepest border or edge of the tumor The mode of invasion at the tumor-host ... conceived of and designed the study, performed the data analysis, and drafted and finalized the manuscript KS provided support for the experiments and performed the data analysis KK and MS provided and ... showed the highest specificity of 94.6 % and the highest PPV of 71.4 % Oct3/4 and Nanog had the equal accuracy of 82.0 % Discussion The clinical role of CSC-specific molecular markers is not only the
Ngày tải lên: 22/09/2020, 23:50
Multimodal optical spectroscopy and imaging for improving cancer detection in the head and neck at endoscopy
... IN THE HEAD AND NECK AT ENDOSCOPY LIN KAN 2012 MULTIMODAL OPTICAL SPECTROSCOPY AND IMAGING FOR IMPROVING CANCER DETECTION IN THE HEAD AND NECK AT ENDOSCOPY LIN KAN A THESIS SUBMITTED FOR THE ... diagnosis and 24 detection in the head and neck 25 Therefore, the primary aims of this work are to develop multimodal optical 16 1 point-wise spectroscopy (AF/DR/Raman) and ... 10% [27] What is more, the long 22 processing time of biopsy and the interpretation of the results may leads to diagnostic 23 delay and the added possibility of taking an unrepresentative
Ngày tải lên: 09/09/2015, 10:09
Comparative effectiveness trial of transoral head and neck surgery followed by adjuvant radio(chemo)therapy versus primary radiochemotherapy for oropharyngeal cancer (TopROC)
... guidelines, these modalities may be combined in a multimodality concept for the treatment of loco-regionally advanced head and neck tumors in the first place For these diseases, the standard of care ... performed with the patient, surgeon and radiotherapist together to improve the inclusion of patients Recently, results of a study randomizing between surgery and radiotherapy were presented to the community ... therapy has established itself as a Page 11 of 13 standard therapy The key question is therefore whether one of these therapeutic approaches is more effective in clinical routine, i.e under the
Ngày tải lên: 06/08/2020, 05:33
Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis
... S The prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer: a systematic review and meta-analysis of trends by time and region Head Neck 2013;35:747–55 ... between the presence of HPV16 L1 DNA and E6/E7 transcript detection (p = 1) or the presence of HPV16 E6/E7 DNA and E6/E7 transcript detection (p = 1) Of the samples expressing HPV 16 E6/E7, the primary ... peter.goon@nhs.net Department of Pathology, University of Cambridge, Cambridge, UK Full list of author information is available at the end of the article the development of HNSCCs include tobacco and alcohol use
Ngày tải lên: 21/09/2020, 01:35
The High-Resolution Structures of the Neutral and the Low pH Crys
... and the nitrogen of histidine ligands, since their side chains are within the first and second coordination spheres of the two metal ions and the pH is above the individual pK as for the liganded ... without the presence of hydrogen atoms with that of the calculated hydrogen position and by measuring the distance between the center of the peak and the associated protein atom The final R factor of ... Movement of metal ions during catalysis During the course of the enzymatic reaction, the distances of the metal ions to their ligands may change in accordance with the chemical state of the substrate/intermediate
Ngày tải lên: 22/10/2022, 21:37
Tài liệu Infectious Diseases of the Head and Neck pptx
... a nodular mass at the angle of the jaw The masses gradually increase in size and number and form sinuses that open onto the face and neck Although infection is often seen in the jaw area, Actinomyces ... several ways in the head and neck area Many of these lesions have been (or will be) discussed separately Almost 70% of HIV-infected patients will have lesions involving the head and neck. 130-136 ... EBV, and human herpesvirus (HHV)-6, HHV-7, and HHV-8 can have manifestations in the head and neck HSV-1 and HSV-2 Infection with HSVs may result in significant head and neck manifestations The...
Ngày tải lên: 19/02/2014, 08:20
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