structures domains and functions in cell death dd ded card pyd
Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
Ngày tải lên :
23/03/2014, 11:20
... TIMP2 and b-catenin can in uence cell adhesion and apoptosis [23,28] DDR1 is an integrin-independent cell adhesion molecule DPIV reduces cell adhesion by dephosphorylating p38 MAP kinase and b1-integrin ... iodide-stained (red) dead ⁄ apoptotic cells cell- surface expression of DPIV and FAP probably has additional effects on cell behavior via fibronectin and integrin binding [10,18,29] The increased STS-induced ... b1-integrin [29], so the effects of DP8 and DP9 on p38, b1-integrin and DDR1 phosphorylation require examination Changes in TIMP2 and b-catenin expression may be secondary to effects on integrins and...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
Ngày tải lên :
18/06/2014, 19:20
... assessing the sub-G1 population (Figure 4B) In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342 Annexin V/PI staining ... decreased in VX-680 treated NB4-R2 cells In addition, we also found that Akt signaling inhibitor API-2 could inhibit Akt-1 phosphorylation and induced apoptosis (data not show), indicating NB4-R2 cell ... VX-680 treated cells VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 cells Next, we studied if VX-680 could suppress proliferation in NB4-R2 cells in vitro NB4-R2 cells were treated...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... matrix shown in C is indicated in D Similar analysis as in A and B was used, but included only MPTP-treated values and assigned value of for no treatment and 10, 30 and 50 for increasing dosage ... of oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% of the remaining of the initial death) combined with the initial loss ... to dopaminergic neuronal death by oxidizing dopamine to a reactive dopamine quinone [51], by increasing DNA oxidation [7], or through increased microglial activation leading to chronic inflammation...
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báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
Ngày tải lên :
20/06/2014, 03:20
... assessing the sub-G1 population (Figure 4B) In addition, apoptotic cells were also detected by both Annexin V/PI staining and immunofluorescent staining with Hoechst 33342 Annexin V/PI staining ... decreased in VX-680 treated NB4-R2 cells In addition, we also found that Akt signaling inhibitor API-2 could inhibit Akt-1 phosphorylation and induced apoptosis (data not show), indicating NB4-R2 cell ... VX-680 treated cells VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 cells Next, we studied if VX-680 could suppress proliferation in NB4-R2 cells in vitro NB4-R2 cells were treated...
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Báo cáo y học: "Analysis of host- and strain-dependent cell death responses during infectious salmon anemia virus infection in vitro" doc
Ngày tải lên :
12/08/2014, 04:21
... and separated into four populations; viable cells, Annexin V positive cells, AV and PI positive cells and PI positive cells A representative scatter of mock and ISAV infected cells is shown in ... Figure staining of ISAV infected cells TUNEL TUNEL staining of ISAV infected cells TUNEL staining of ASK cells; positive control, negative control, staurosporine treated (1 μM SS 24 h), ISAV infected ... biotin-dUTP nick end labeling) staining was performed in ASK cells using the In Situ Cell Death Detection Kit, Fluorescein (Roche Diagnostics GmbH, Mannheim, Germany) 1.5 × 105 cells were seeded...
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The role of caspase 1 in a murine model of influenza pneumonitis, and studies on cell death inhibitors in vitro
Ngày tải lên :
13/10/2015, 16:41
... embryonic stem cells FBS foetal bovine serum g gram h hours xv H&E haematoxylin and eosin stain HRP horseradish peroxidase ICE interleukin-1β-converting enzyme IFN interferon IL interleukin INF infected ... anchored in the envelope, functions as an ion channel between the interior of virus and its environment and maintains a low pH during virion uncoating during initial stages of infection (Pinto, Holsinger ... speck-like protein containing a caspase recruitment domain (ASC) is recruited to NLRs through homophilic pyrin domain (PYD) -PYD interactions and via its CARD domain ASC, in turn, interacts with...
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Tài liệu Use Variables and Functions in T-SQL pptx
Ngày tải lên :
14/12/2013, 20:16
... Initialing Local Variables in T-SQL To initialize the variables, you will use the SET command, shown in these two lines of code: SET @Cust_Id = 'ANTON' SET @Order_Date = '11/27/1996' By setting ... the initial values, you are then ready to use the variables within the rest of your procedure, any way that you need them, again, by using the @varname syntax Utilizing Built -In Functions Within ... a Windows Form Then place the controls listed in Table 6.2 and seen in Figure 6.3 with the following properties set Table 6.2 Control Property Settings for This How-To Object Property Setting...
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Báo cáo khoa học: Typical 2-Cys peroxiredoxins – structures, mechanisms and functions ppt
Ngày tải lên :
07/03/2014, 01:20
... C-terminal helix hinders this required local unfolding In robust Prxs, the C-terminal helix containing the YF motif is absent, allowing for more facile unfolding (see fig in Wood et al [27]) In the ... by hydrogen peroxide correlated with two amino-acid sequence motifs – a GGLG-containing motif in the middle of the protein, and a YF-containing C-terminal extension (Fig 2A); second, that the ... YF-containing C-terminal helix packs above the active site region like a cork in a bottle, limiting the active site dynamics and hindering it from unfolding; because of this, the local unfolding...
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CURRENT FRONTIERS AND PERSPECTIVES IN CELL BIOLOGY doc
Ngày tải lên :
28/03/2014, 10:20
... claudins and the TAMP proteins Integral proteins establish cell- cell contact in the intercellular space The peripheral proteins, act as a bridge between the integral proteins and the actin cytoskeleton ... junction proteins with PDZ domains Proteins that belong to the MAGUK protein family contain SH3 and GK domains in addition to PDZ modules ZO proteins have PDZ domains whereas Pals1 has a single one ... paracingulin JACOP and paracingulin are the same protein JACOP/paracingulin is a 160 kDa protein with a domain organization similar to cingulin and 40% sequence identity JACOP/paracingulin besides...
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Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx
Ngày tải lên :
30/03/2014, 20:20
... matrix and was instrumental in gaining new insight into mitochondrial Ca2+ handling, i.e the topic of this review [13] In the chimeric cDNA, an aequorin moiety including an HA1 tag was fused in frame ... mechanoenzyme involved in membrane constriction and fission), OPA1 (a dynamin related GTPase, involved in fusion and mostly located in the inner mitochondrial membrane) and mitofusins (also involved in fusion ... demonstrated, both in cell lines and in intact tissues, the occurrence of rapid [Ca2+]m transients in cells as diverse as HeLa, hepatocytes, cardiac and skeletal muscle and neurons [27] A striking example...
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báo cáo khoa học: " Rice Hypersensitive Induced Reaction Protein 1 (OsHIR1) associates with plasma membrane and triggers hypersensitive cell death" potx
Ngày tải lên :
11/08/2014, 11:21
... member of the Band 7-domain-containing proteins (Figure 1) Many of these proteins are lipid raft-associated and may cluster to form membrane micro -domains, and in turn recruit multi-protein complexes ... embedded within a Band 7-domain, which covers most of the OsHIR1 protein (Figure 1b) In an unrooted phylogenetic tree (Figure 1c), HIR proteins can be further divided into two branches: dicots and ... and Death) superfamily, whose members function in cell proliferation, ion channel regulation and cell death [15] HIR protein expression in maize and barley is associated with localized host cell...
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Báo cáo y học: "Hypercapnia and hypokalemia in near-death experiences" ppt
Ngày tải lên :
13/08/2014, 20:22
... qualitative and quantitative study of the incidence, features and aetiology of near death experiences in cardiac arrest survivors Resuscitation 2001, 48:149-156 Gliksman MD, Kellehear A: Near -death ... ventricular tachycardia cardiac arrest in the prehospital setting Crit Care 2003, 7:R139-R144 doi:10.1186/cc9016 Cite this article as: Greyson B: Hypercapnia and hypokalemia in near -death experiences ... Britton WB, Bootzin RR: Near -death experiences and the temporal lobe Psychol Sci 2004, 15:254-258 Grmec S, Lah K, Tusek-Bunc K: Difference in end-tidal CO2 between asphyxia cardiac arrest and ventricular...
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Establishment of cell polarity in zebrafish role of staufen and GRB2 in cell migration
Ngày tải lên :
12/09/2015, 08:18
... that are transacting along with the translocation machinery The transacting proteins are RNA binding proteins, Poly-A-binding proteins, other mRNA binding factors that aid in conferring specificity, ... vegetal cortex in Xenopus oocytes, Vg1 RNA binding protein (RBP) (indigo) with Staufen (yellow) is loaded into microtubules (red) using adaptor proteins and motor proteins Kinesin I and II Vg1 mRNA ... understanding of cell polarity in a global perspective This thesis addresses the function of two proteins namely Staufen and Grb2, in controlling the migration of cells 1.2 Cell polarity in unicellular...
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Dual functions of AP 1 in neuronal cell death and differentiation
Ngày tải lên :
16/09/2015, 15:54
... entry and the induction of cyclin D1 expression JunB inhibits G1 to S phase progression by inducing p16 and repressing cyclin D1 JunD inhibits S phase entry and increases the numbers of resting cells ... subfamilies (Karin et al., 1997) These protein families contain three important domains: a transactivation domain (TAD), a DNA binding domain (DBD) and a leucine zipper region The Jun proteins are most ... I) and autophagic cell death (type II) Morphologically, cells undergoing apoptosis exhibit membrane blebbing, cytoplasmic shrinkage and chromatin condensation Apoptotic cells are degraded into...
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Muscle Functions in Polymyalgia Rheumatica and Giant-Cell Arteritis docx
Ngày tải lên :
14/03/2014, 20:20
... reactants, including interleukin (IL-6) In GCA, an immune response in the vascular wall initiates a reaction in the artery that leads to structural changes, intimal hyperplasia and luminal occlusion.3 ... bone and muscle tissues.6 There is some evidence that mitochondrial functions may be deteriorated in muscle cells, leading to diminished production of energy-rich compounds in muscle cells and increased ... function and is a target for prevention in older patients suffering from PMR Acknowledgements This study was funded in co-operation by the Finnish Funding Agency for Technology and Innovation and...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
Ngày tải lên :
16/03/2014, 00:20
... required, at least in part, for imatinib-induced apoptosis in BCR–ABL-transformed murine progenitor cells [64] and in BCR–ABL+ K562 CML cells in response to both imatinib and nilotinib [65] INNO-406, ... imatinib therapy have point mutations in the BCR–ABL kinase domain, including the T315I gatekeeper mutation that impairs imatinib binding [58,59] Accordingly, new therapies are being tested and ... in repressing BIM and in promoting aberrant cell survival in tumours that harbour mutations in oncogenes which control these pathways and (b) the role of BIM in tumour cell death arising from...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
Ngày tải lên :
23/03/2014, 17:20
... which in turn recruits the adaptor molecule Fas-associated death domain (FADD) via interaction between their death domains (DD) FADD also contains a death effector domain (DED) , which aggregates and ... HERs are commonly activated upon binding of a ligand in their extracellular domain, resulting in dimerization of HERs and triggering the intrinsic tyrosine kinase activity of the receptors responsible ... translocation domain originating from a protein toxin, Pseudomonas Exotoxin A (PEA), was embedded in the fusion protein to mediate a translocation of the apoptotic proteins from an intracellular vesicle...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
Ngày tải lên :
29/03/2014, 08:20
... differentiation and cell survival Thus, the decision by sustained ERK1 ⁄ to induce cell death or survival possibly depends on additional factors NGF, in addition to inducing sustained ERK1 ⁄ 2, ... hand, in non-neuronal cells, cytoplasmic retention of ERK1 ⁄ is required for death- associated protein kinase-mediated cell death [35] Thus, ERK1 ⁄ might promote cell death depending upon the cell ... observed in CGN [25] In addition, a recent study suggested that sustained 24 Fig Model of ERK1 ⁄ in life and death Both survival and death signals can activate ERK1 ⁄ The mechanisms involved in such...
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