... human and rat CB1 receptor The CB2 antibody was raised against a sequence between the N-terminal andthe first transmembrane domain ofthe protein ofthe human and rat CB2 receptor The specificity of ... marrow stem cells, are the most potent antigen-presenting cells ofthe immune system They play a central role in the initiation of primary immune response and in the enhancement of secondary immune ... for AEA, PalEtn and 2AG, respectively Analysis of cannabinoid receptors and fatty acid amide hydrolase To determine the presence ofthe cannabinoid receptors (CB1 and CB2) andofthe fatty acid...
... The spin axes ofthe Sun andthe planets 7.4.1 Spin axes andthe Solar Nebula Theory 7.4.2 Spin axes andthe Modern Laplacian Theory 7.4.3 Spin axes andthe Accretion Theory 7.4.4 Spin axes and ... Newton the basic structure ofthe solar systemandthe laws that govern the motions ofthe bodies within it have been well understood One central body, the Sun, containing most ofthe mass ofthesystem ... picture ofthe origin and evolution ofthe solar system is the Capture Theory developed by the author and colleagues since the early 1960s This explains the basic structure ofthe solar system...
... 90–15) and 255 (M+ – 131) The loss of mass 131 results from the scission ofthe C1–C2 and C4–C5 bonds Figure 4C illustrates mass spectra of isolated 7-DHP-MO-TMS, andthe synthesized standard The ... (Invitrogen), andthe isolation of RNA followed the manufacture’s protocol The synthesis of first-strand cDNA was performed using the Superscript preamplification system (Invitrogen) Either lg of total ... investigation on the cutaneous expression of each ofthe components ofthe P450scc enzymatic system In addition, we tested reconstituted and mitochondrial P450scc systems for their ability to...
... The spin axes ofthe Sun andthe planets 7.4.1 Spin axes andthe Solar Nebula Theory 7.4.2 Spin axes andthe Modern Laplacian Theory 7.4.3 Spin axes andthe Accretion Theory 7.4.4 Spin axes and ... Newton the basic structure ofthe solar systemandthe laws that govern the motions ofthe bodies within it have been well understood One central body, the Sun, containing most ofthe mass ofthesystem ... picture ofthe origin and evolution ofthe solar system is the Capture Theory developed by the author and colleagues since the early 1960s This explains the basic structure ofthe solar system...
... deeper understanding ofthe intimate co-evolution of pathogens andthe immune system 10 11 12 13 14 Acknowledgements The author’s research is supported by grants from the Wellcome Trust, the Medical ... pathogens demanding conflicting response patterns, the fine-tuning effect of multiple allelic variants allows the immune system to be variably calibrated across the population In the absence of infection, ... to the development of damaging immune reactions in autoimmunity and allergy The identification of precise genetic variants controlling both parasite susceptibility and immunopathology offers the...
... understanding ofthe anatomy and function ofthe ear andthe auditory nervous system, and it discusses the cause and treatment of hearing disorders Most books on hearing focus either on the anatomy ... comprehensive coverage of disorders ofthe auditory system emphasizing the interaction between pathologies ofthe middle ear andthe cochlea andthe function ofthe nervous systemand vice versa Hyperactive ... function ofthe cochlea than of any other sensory organ C H A P T E R Anatomy ofthe Ear ABSTRACT 10 The ear consists ofthe outer ear, the middle ear andthe inner ear The outer ear consists of the...
... at the entrance ofthe ear canal compared with the sound pressure that is measured in the place ofthe head The effect ofthe head on the sound at the entrance ofthe ear canal is related to the ... ratio between the effective area ofthe tympanic membrane andthe area ofthe stapes footplate, but the lever ratio ofthe middle ear bones also contributes The ratio of areas ofthe BOX 2.2 SOUND ... remarkable in the light ofthe FIGURE 2.12 (A) Average displacements ofthe umbo, the head ofthe stapes andthe lenticular process ofthe incus (B) The lever ratio at 124 dB SPL at the tympanic...
... between the classical andthe non-classical auditory pathways While the ICC is a part ofthe classical ascending auditory systemthe ICX andthe DC are parts ofthe non-classical auditory systemThe ... in the ventral parts ofthe MGB ofthe thalamus, the nonclassical sensory pathways use the dorsal and medial division ofthe MGB as relay (Fig 5.10) [122] These divisions ofthe MGB receive their ... ofthe fourth ventricle (Fig 5.15B) [72] The other part ofthe olivocochlear system projects mainly to the contralateral cochlea andthe fibers of that system travel deeper in the brainstem The...
... The caudal portion ofthe floor ofthe lateral recess is the (dorsal) surface ofthe dorsal cochlear nucleus andthe rostral portion ofthe floor ofthe lateral recess is the dorsal surface of ... difference between the latency ofthe N1 ofthe AP and that ofthe response from the intracranial portion ofthe auditory nerve is the travel time in the auditory nerve from the ear to the recording ... the latency ofthe first peak in the dipole andthe length is the relative strength ofthe dipoles Note the short distance between the two first dipoles (peak I and II ofthe ABR) andthe third...
... and standard error ofthe mean are shown as a function ofthe intensity ofthe noise The TTS was measured 20 s after the end ofthe exposure In this study the noise exposure consisted of a band ... basis ofthe elevation ofthe hearing threshold in disorders ofthe middle ear andthe cochlea but the effect on the function ofthe nervous system may affect speech discrimination Impairment of speech ... decreases the input to the cochlea and thereby decreases the contraction ofthe stapedius muscle, and that in turn causes the input to the cochlea to again increase, and that increases the contraction...
... increase the sensitivity and frequency selectivity ofthe ear (cf Chapter 3) The widening ofthe tuning ofthe basilar membrane broadens the “slices” ofthe spectrum of broad band sounds from which the ... this view of flexibility ofthe function ofthe auditory system That injury and loss of cochlear hair cells can cause profound changes in the structure and function ofthe central auditory system ... perpendicular to the surface ofthe flat portion ofthe incudo-stapedial joint and that does not cause any movement ofthe incus and thus no displacement ofthe tympanic membrane If the pressure in the perilymphatic...
... have 3The limbic system is a complex systemof nuclei and connections consisting ofstructures such as the hippocampus, amygdala, and parts ofthe cingulate gyrus These structures connect to other ... tinnitus and abnormal perception of sounds such as hyperacusis and phonophobia) are some ofthe most diverse and complex disorders ofthe auditory systemand their causes are often obscure Often ... corresponding to the F1 frequency andthe other corresponding to the frequency of F2 The rate ofthe impulses is that of F0 for voiced sounds, and a quasi-random rate (average of 100 pps) for...
... Commission, UK Financial Services Authority, and, in the United States, the Office ofthe Comptroller ofthe Currency, the Securities and Exchange Commission, andthe Federal Reserve. For their joint review, see SSG 2008. ... of life), the Act mandates the formulation of so‐called “living wills” in the form ofthe preparation of resolution plans and credit exposure reports. The Act calls upon the Board of Governors ofthe Fed to require nonbank financial companies and bank ... its assets, all institutions ultimately rely on the banking system for support in the case of a shortfall of cash inflows andthe need to refinance their liabilities. Andthe banking system relies on the Fed. Thus, limiting discount lending to the banks means allowing a liquidity crisis to morph into an insolvency crisis ...
... Near the end ofthe compression stroke, the spark ignites the compressed air-fuel mixture, raising the temperature ofthe gases in the cylinder to the range of few thousands of degrees, and increasing ... supplied to the engine, otherwise known as the “charge” ofthe engine In the scenario where the only method of charging the engine is by the vacuum pressure created by the expanding ofthe combustion ... intake system, to reduce the impact ofthe air restrictor on the entire engine system Location of Engine The dominant design ofthe Formula SAE race car has the engine located in the rear of the...
... Pro154, Ile156 and Pro161 ofthe other monomer Similarly, Gly175Ala181 forms an anti-parallel intermolecular b sheet with the b12 ofthe other monomer, and towards the C-terminus, the subsequent ... in the binding ofthe phosphate group(s) of FMN or FAD Lys92 forms a salt bridge with the O3P of FMN A salt bridge that involves avin species has not been reported in thestructuresofthe other ... Resolution ofthe structure of NADP+-bound FeR revealed that the nicotinamide moiety of NADP+ faces the re-side ofthe isoalloxazine ring, and that the 2Â-P-AMP moiety is held in the groove between the...
... However, the contextual effects that determine the relevance ofthe different functionsof customer reference marketing are beyond the scope of this study Theoretical implications The results ofthe ... Frow P (2008) “Managing the co-creation of value”, Journal ofthe Academy of Marketing Science, Vol 36 No 1, pp, 83-96 Penrose, E T (1959) The Theory ofthe Growth ofthe Firm, New York: John ... related to other intangible assets in that they help in building the industrial brand (Blombäck and Axelsson, 2007) andthe firm's reputation and credibility (Salminen and Möller, 2006) The existing...
... molecules [7–9] Thefunctionsof DP8 and DP9 are unknown The known characteristics of DPIV and FAP may provide hypotheses concerning DP8 and DP9 function DPIV is predominantly expressed on epithelial ... Despite their close sequence relatedness, DP8 and DP9 exert these differences in their cellular effects Therefore, these two proteins are likely to have different functionsand ligands These data ... and dipeptidyl peptidase (DP9)–GFP reduced in vitro wound healing Ratios ofthe percentage of fluorescent cells in the wound area to the percentage of fluorescent cells in nonwound regions of the...
... The Advancement of Animal Welfare The Promotion ofthe Efficiency ofthe Armed Forces ofthe Crown, or ofthe Efficiency ofthe Police, Fire and Rescue Services ... the profiling offunctionsand policy in respect of Australia and New Zealand, the United States, Singapore and Canada Part IV, the final section, reflects on the findings of Part III and considers ... to furthering the public benefit ofthe disadvantaged and in the eyes of society confers upon them a stamp of virtue Free from the exigencies of government, and to some extent also from the competitive...
... the thrust to the foot ofthe cantilever tower, andthe two sides ofthe towers balance each other The downward forces from the towers sit directly on and compress the foundations This idea of ... According to the latest theory the ‘critical number’ of people above which these wobbles will occur depends on the weight ofthe bridge, its natural frequency, andthe amount of damping (i.e the degree ... lengths of rope and pieces of steel or other materials used in a real bridge to find out how strong they are The internal force is acting all along the length ofthe rope from one ofthe teams to the...
... matn-1 To further test this hypothesis, we determined whether the presence ofthe inhibitors of matrix proteases affected the proteolytic processing of matn-1 The presence of mM EDTA in the medium ... I192N, T120M, and E134K [13] Interestingly, all of these MED-causing mutations are located in the β strands in the center ofthe vWF A domain, which are important for the folding ofthe protein ... shown that the number ofthe EGF repeats does not affect the assembly of matrilins [4] In this study, we investigate whether the presence or absence ofthe vWF A domain adjacent to the coiled-coil...