... Small-Scale Structure of Space and Time. The union of the two most significant developments of 20th-century physics—general relativity and quan- tum theory—is one of the greatest challenges of contemporary ... properties of the geometry of space in the vicinity of black holes that are predicted by general relativity. • The measurement of the dragging of inertial frames due to the rotation of Earth at ... some of the important achievements of the past decade illustrates this point: • The confirmation of the existence of gravitational waves by the observed shortening of the orbital period of a...
Ngày tải lên: 12/02/2014, 16:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... conformation around the active site of ApeSOD is independent of the presence of a metal cofactor. Figure 3D shows the superimposition of the active site structures of apo, Mn-bound and Fe-bound Ape- SODs. ... (Fig. 3A). Three of the ligands, OD2 of Asp165, NE2 of His79 and NE2 of His169, formed an equatorial plane. The other protein ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, ... in the presence of either Fe or Mn. These types of SODs are referred as to cambialistic SODs. In addition to the tertiary structures of metal-specific SODs [4], crystal structures of several cambialistic...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Inequalities in Higher Education and the Structure of the Labour Market pdf
... proportion of whiteandAsiangraduateswithineachcategory of number of yearsworkedwasnotashigh asthat of otherracegroupsatthetime of thesurvey(Table8). Table8:Number of yearsworkedbythoseinmanagement,byrace Number of yearsworked Asian ... 7,5 Sector of employmentTherole of thepublicsectorasanemployeris of particular interest.Itisthefirstsector of employmentforalargeproportion of graduatesirrespective of field of study,raceandgender.ThisisespeciallytrueforAfricangraduateswhomake up ... whose labourmarketoutcomesarecomparativelypoor(thisisnotuniquetoSouthAfrica). Thelargemajority of thesegraduatesareAfrican.Hence,tosomeextent,itwouldbe expectedthattheseinstitutionswouldshowlowerlevels of successwithregardtothe employability of theirgraduates.However,thereareunexplaineddifferencesaswell. Irrespective of field of study,raceorgender,studentsfromHWUsseemtohavemore successinthelabourmarket.Apossibleexplanation of thesedifferencesmaylieinthe differingquality of educationintheseinstitutions,whetherperceivedorreal. Differences...
Ngày tải lên: 15/02/2014, 17:20
Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... Department of Biochemistry, University of Leicester, UK 2 CNAP, Department of Biology, University of York, UK Pentaerythritol tetranitrate (PETN) reductase was ori- ginally purified from a strain of Enterobacter ... analysis of the titration of H181A PETN reductase with progesterone. (C) Plot of absorbance change as a function of 2,4 dinitrophenol concentration for the data shown in (A). (D) Plot of absorbance ... formed directly by the binding of free steroid from solution. Discussion A number of crystal structures are now available for members of the Old Yellow Enzyme family [2,3,24,33– 35]. Each of these indicates...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC pdf
... 6BC, the chemical structures of which are already known [12,13]. The negative ion MALDI-TOF mass spectrum of the native LPS (Fig. 1) exhibited a complex pattern of several groups of ion peaks representing molecular ... of trachoma and there is an ongoing discussion on the putative role of Chl. pneumoniae in the development of atheroscler- osis which is also a chronic inflammation of the arterial walls. One of ... spectroscopy (Figs 5 and 6) and assignment of all signals (Table 2) revealed that the carbohydrate structure of the major component of C. tra- chomatis E LPS consisted of three Kdo- and two GlcpN- residues....
Ngày tải lên: 20/02/2014, 23:20
Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf
... AND DIALOGUE STRUCTURES 227 Gross and Sidner (1985) distinguishes three structures in a discourse structure: 1) the structure of the sequence of utterances, 2) the structure of the intentions ... about the nature of dialogue structures, about the validity and usefulness of the concept of a dialogue structure, about the role of the task structure in determining dialogue structure, and ... The goal of this paper is to find evidence for the validity of the notion of discourse structure derived from the task structure by: 1) describing a technique to derive the structure of dialogues...
Ngày tải lên: 21/02/2014, 20:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... atoms of liganded and unliganded structures of Bacillus glutaminase are superimposed. Displacement of 55 aa for Bacillus glutaminase (327 aa) is not shown because of the disordered regions in the structures. ... residues; F, major fragment of Mglu; G, presence of L-glutamate; Mglu, Micrococcus glutaminase; PDB, protein data bank; N, absence of additives; T, presence of Tris; TG, presence of Tris + L-glutamate. 738 ... mechanism of Bacillus glutaminase [5]. The structure of Bacillus glutaminase that cova- lently binds 5-oxo-l-norleucine (PDB 3brm) mimics that of the acyl-enzyme intermediate, while the Mglu TG structure...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity pdf
... purple. Fig. 4. Superimposition of preCbnB2 structures. (A) Superimposition of the backbone of the leader peptide a-helix for 20 structures. (B) Superimposition of the backbone of helix 2. Both helix ... help determine the structural basis of the inhibition of the antimicrobial activity of CbnB2 by the leader and to assist future analysis of the interaction of preCbnB2 with its ABC transporter ... preferred geometry of the precursor. We now report the chemical synthesis, bio- chemical production, and solution structure of preCbnB2, and compare it with the structure of the mature bacteriocin,...
Ngày tải lên: 07/03/2014, 15:20
Báo cáo khoa học: Covalent and three-dimensional structure of the cyclodextrinase from Flavobacterium sp. no. 92 pdf
... factor of 18.8% and an R free of 22.3% with over 90% of the residues in the most favored region of a Ramachandran plot (Table 2). The resulting model is depicted in Fig. 2. The Ca backbones of the ... group. As the polypeptide superposition of Fig. 8 places the three catalytic residues of CDase (Fig. 1) within less than 1A ˚ of the positions of those of TVA-II, and as the active centers closely ... domain of the other subunit, which restricts the size of the B domain (Fig. 7). Active center The active center of CDase is depicted in Fig. 8, which includes the superimposed structure of a TVA-II...
Ngày tải lên: 08/03/2014, 02:20
Báo cáo khoa học: "Understanding the thematic structure of the Qur’an: an exploratory multivariate approach" pdf
... following: “Figure 6. Plot of groups C and D” Results from figure 6 are also supportive of the thematic structure of each group. Suras of group C are more abundant in the use of narratives and addressing ... following plot of number of content words per sura, sorted in order of descending magnitude. “Figure 1. Plot of number of words per sura” Clearly, given a word with some probability of occurrence, ... thematic structure of the Qur’an based on a fundamental idea in data mining and related disciplines: that, with respect to some collection of texts, the lexical frequency profiles of the individual...
Ngày tải lên: 08/03/2014, 04:22
Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
... structure of hTRXL-N, 2–108), 2TRX (crystal structure of E. coli thioredoxin, 1–108), 1ERU and 1ERT (crystal structure of oxidized and reduced human thioredoxin, 1–105), 1DBY (NMR structure of ... little direct effect on the activity of the enzyme. The function of this unique C-terminal domain remains unknown. Overall structure Crystals of the catalytic domain of hTRXL (hTRXL-N) were obtained ... consisting of b sheets shows little difference with other TRX (Fig. 3B). Active site The location of the active site in all of the known thioredoxin structures is identical. It includes the end of b-2,...
Ngày tải lên: 08/03/2014, 22:20
Báo cáo khoa học: Structure of FocB – a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli pdf
... helices form Structure of FocB U. W. Hultdin et al. 3370 FEBS Journal 277 (2010) 3368–3381 ª 2010 The Authors Journal compilation ª 2010 FEBS Structure of FocB – a member of a family of transcription factors ... motif of the ParB homolog KorB. Nat Struct Mol Biol 11, 656–663. 57 Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL & Clardy J (1993) Atomic structures of the human Structure of FocB ... Leu13-Leu76 of the protein matched residues Ser27- Ala93 of FocB with a z-score of 5.1 (Table 2). The structures are shown in two orientations. The visual alignment is based on the position of the...
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase pdf
... helix 6 of E. coli DnaG-C observed in the crystal structure (Fig. 3D,E) raise questions about the flexibility of helix 6 of E. coli DnaG-C in solution. Structure verification of helix 6 of DnaG-C An ... more than half of them. The present structure of monomeric E. coli DnaG-C identifies the earlier crystal structure of the same pro- tein as a domain-swapped dimer, in which helix 5 of one monomer ... core of the structure. The solution structure of DnaG-C identifies the crystal Fig. 2. Sequence alignment of DnaG-C with homologs from different bacterial species. The sequence numbering of E....
Ngày tải lên: 16/03/2014, 12:20
Báo cáo khoa học: Crystal structure of human cystatin C stabilized against amyloid formation pdf
... of the L68Q mutation for the stability of monomeric HCC could only be inferred from the structures of 3D domain- swapped dimers of HCC. The present structure pro- vides the first possibility of ... domain-swapped dimer of HCC shows unaltered inhibition of legumain, whereas it is incapable of papain binding, because of the absence of the L1 ele- ment of the recognition site [4]. The backbones of mol- ecules ... lack of sequence conservation, i.e. the fact that the VPWQ motif of HCC is replaced by LPHE in stefin B. An additional factor may be the involvement of loop L2 of both molecules in the HCC-stab1 structure...
Ngày tải lên: 22/03/2014, 21:20
Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf
... 308–309 of the complete sequence in both molecules of the asymmetric unit. The structure is composed of two similar domains, each representing a b sheet sandwiched between two layers of a helices (Fig. ... helices of domains 1 and 2, respectively. The EF-hand-like calcium site of domain 2 was described earlier, and tight binding of the ion was shown to con- tribute to the integrity of the protein structure ... Least-squares superimposition of domain 1 of all of the GBP struc- tures is shown in Fig. 5B, illustrating the ‘fan’ of related conformations observed. The GGal complex is the most closed structure found to...
Ngày tải lên: 23/03/2014, 04:21
Báo cáo khoa học: The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) pdf
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima pdf
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf
Ngày tải lên: 23/03/2014, 10:21
Báo cáo khoa học: Solution structure of an M-1 conotoxin with a novel disulfide linkage pdf
Ngày tải lên: 30/03/2014, 09:20
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