... metal–thiolate clusters; protein structure; zincCorrespondenceP. Faller, CNRS, LCC 205, route deNarbonne, 31 077 Toulouse, FranceFax: +33 5 61 55 30 03 Tel: +33 5 61 33 31 62E-mail: peter.faller@lcc-toulouse.fr*This ... Zn4cluster of Cu4Zn4MT -3 [32 ] formation of Cu4Zn 3 MT -3 with disulfideNot studiedKd of Cu(I) Kdestimated to be 1 · 10)19M Stronger Cu(I) affinity? [35 ] Weaker Cu(I) affinity? [35 ]Cu(II) ... with human apo-T3 and its separatedomains reproduced closely the features of the isolatednative MT3 forms (bovine, equine) [32 ,33 ]. Moreover,titration experiments of Cu(I) to apo-T3 (or to apo-a-...
... at a resolution of 2.0 A˚. The monomerpresent in the asymmetric unit contains 33 2 residuesout of 33 6, one zinc ion, one DHAP molecule, one glyc-erol molecule and a total of 216 solvent molecules. ... significant depletion of theNAD+ level [31 ,33 ]. We propose that hACMSD inhi-bition could result in alleviation of cerebral malariasymptoms by controlling both PA and NAD levels[7 ,34 36 ].Recently, ... 2.0Observations 63 794Unique reflections 24 525Rmerge 0.124Multiplicity 2.6Completeness (%) 94Number of protein atoms 2 635 Number of solvent molecules 216Number of DHAP ⁄ Zn atoms 10 ⁄ 1Number of glycerol...
... COMTE.PAGEIntroduction 33 7Influence of Saint Simon 34 0Marriage 34 3Serious illness 34 5Official work 34 7Completion of Positive Philosophy 34 9J. S. Mill 35 0Question of Subsidy 35 2Money 35 3Literary method 35 4Hygiène ... 35 4Hygiène cérébrale 35 6Madame de Vaux 35 6Positive Polity 35 8Death 35 9Comte's philosophic consistency 36 0Early writings 36 1Law of the Three States 36 3Classification of sciences 36 6Miscellanies ... MISCELLANIES (3 OF 3) ******** This file should be named 29 033 -8.txt or 29 033 -8.zip ***** This and all associated files of variousformats will be found in: http://www.gutenberg.org/2/9/0 /3/ 29 033 /Produced...
... methodsSources of substrates, cofactors and inhibitorsThe synthesis of 1 ,3- BPGA analogues used in this studyhas been described elsewhere [30 32 ]. NADH, NAD+, 3- phosphoglycerate (3- PGA), ATP, ... Biochemistry 34 , 14975–14986. 23. Due´e, E., Olivier-Deyris, L., Fanchon, E., Corbier, C., Branlant,G. & Dideberg, O. (1996) Comparison of the structures of wild-type and a N313T mutant of Escherichia ... endowment of unique kinetic andCorrespondence to S. Ladame, University Chemical Laboratory,Cambridge University, Lensfield Road, Cambridge CB2 1EW, UK.Fax: + 44 12 23 336 9 13, Tel.: + 44 12 23 762 933 ,E-mail:...
... 20 03, revised 28 March 20 03, accepted 2 April 20 03) Eur. J. Biochem. 270, 231 2– 232 1 (20 03) Ó FEBS 20 03 doi:10.1046/j.1 432 -1 033 .20 03. 036 01.xThis study reports the three-dimensional structure of IPDC ... (19 93) A thiamin diphosphate binding fold revealedby comparision of the crystal structures of transketolase, pyruvateoxidase and pyruvate decarboxylase. Structure 1, 95–1 03. Ó FEBS 20 03 3D structure ... consistent with a role of this helix inclosure of the active site [36 ].A model of the a-carbanion/enamine intermediate of thesubstrate indole -3- pyruvate with ThDP in the active site of IPDC was built...
... determined part of the C-termi-nal domain in the T and TG structures suggests a revised F structure (PDB 3if5). There are disordered regions in the F (35 4-4 03 and 449-456 aa), N (35 4 -37 6, 39 5-401 and ... residuesTyr27c1. 43 Tyr37 -dTyr191 0.16 Tyr201 0.20Tyr2 43 0 .33 Tyr2 53 1.16Average ± SD 0.25 ± 0.12 0.68 ± 0.68aBackbone atoms of the N-terminal domains (1 -30 5 aa) in the Tand TG structures are ... (98.6)Rmerge(%)a,bOverall 11.1 12.4 11.9 13. 1Highest-resolution shell 54.6 49.2 35 .6 41.2Lowest-resolution shell 6.1 8.2 8.7 5.7Multiplicitya 3. 6 (3. 6) 3. 7 (3. 7) 3. 5 (3. 5) 3. 1 (2.8)Unit-cell constantsa(A˚)...
... effective five paragraphessay places the thesis, or argument, at the beginning of the essay so the writer can offer support for the argument in subsequent paragraphs. The essay also has ... five paragraphessay shows not only a writer’s ability to make an argument but organizational skills as well. A well-structured essay should draw the reader in, reveal a strong argument, offer ... serve as a map for the rest of the essay. It must be narrowly focused and able to be supported with evidence in subsequent paragraphs.A good thesis statement offers reasons , or “because...
... the extraction of cellulose.2.1.2β-(1 3) -GlucansThere are a number of structural variations within the class of polysaccharidesclassified asβ-(1 3) -glucans. The group of β-(1 3, 1→6) linked ... Chemical structureof alginate2.1 Structural Features 9Fig. 2.4. Structureof pullulanThe polysaccharide possesses hydroxyl groups at position 2, 3 and 4 of differentreactivity (Fig. 2.4). The structure ... solution of acetic acid. Chitin containing about 40% of GlcNAc moieties is insoluble while thesoluble polysaccharide is named chitosan [38 ].Fig. 2.10. Structureof chitin consisting of N-acetylglucosamin...
... Figs. 3. 13a 3. 13b, clusters of approximately 30 0 spheres which represent the corresponding structures are shown. It is evidentthat the two structures are fundamentally different, with the structure ... correctly, care must be 3. 2 The structureof shaken sand – some simulation results 39 00.050.10.150.20 0.1 0.2 0 .3 0.4rP(r)Fig. 3. 9 Distribution functions F(r) for the radii r of the overlapping ... forma-tion of cooperative structures such as bridges [33 ], or indeed the very existence [21] of an angle of repose [ 23] ; neither would be possible in the presence of Brownianmotion. In this...