structure metabolism and tissue roles of chondroitin sulfate proteoglycans

... LANGUAGE PROFICIENCY • German: mother language • English: written and spoken COMPUTER PROFICIENCY... PROFICIENCY • Windows including Office 2007 • ChemDraw 12.0, SciFinder, Beilstein, EndNote X4, ... Date of birth: 8 July 1975 • Place of birth: Bernkastel-Kues, Germany • Marital status: Single • Nationality: German th rd Singapore, 03 May 2011 ... treatment and prevention of cancer ... Clair J J Discovery of Laetiporina A as a Selective Mitotic Blocker (poster presentation) PROFESSIONAL POSITIONS Member American Chemical Society 2009 - present LANGUAGE PROFICIENCY • German:

Ngày tải lên: 10/09/2015, 15:50

... Bohari Mohd. Yamin5 and? ?Kim Wei Chan6 Abstract  Background:  Although the development of antibiotic and antioxidant manufacturing, the problem of bacterial resistance and food and/ or cosmetics oxidation ... study of OCT revealed that it produces blue light when expose to UV-light and its’ quantum yield equal to 26% Antioxidant activity, which included ­DPPH· and ­ABTS·+ assays was also performed and ... ARTICLE Chemistry Central Journal Open Access Microwave synthesis, crystal structure, antioxidant, and? ?antimicrobial study of? ?new 6‑heptyl‑5,6‑dihydrobenzo[4,5]imidazo[1,2‑c] quinazoline compound

Ngày tải lên: 29/05/2020, 13:30

... abundance of 30 UTR isoforms of heparanase in healthy tissues and non-metastatic and metastatic IDCs plotted on a linear scale HS fine structure depends on the expression and action of multiple ... sulfation of the amino group which is catalyzed by four different isoforms of N-deacetylase/N-sulfotransferases, NDST1, NDST2, NDST3 and NDST4 [4,16] Transcripts of only two of these isoforms, NDST1 and ... healthy tissues, while NDST3 and were undetectable in most patients (Figure 3A and 3B) When the analysis was conducted in tumor tissues, no significant differences of transcript levels of isoforms and

Ngày tải lên: 05/11/2020, 06:58

... RNAseq analysis of xylose-inhibited cultures revealed several up-regulated genes potentially involved in pentose transport and metabolism, which were targeted for disruption Deletion of the ATP-dependent ... decreased total xylitol production and yield by 41% and 46%, respectively Finally, xylose-induced inhibition corresponds with the up-regulation and biogenesis of a cyclical AgrD-type, pentapeptide ... utilizing strains of C thermocellum and reveal the first functional Agrtype cyclic peptide to be produced by a thermophilic member of the Firmicutes The cellulolytic capabilities of the thermophilic

Ngày tải lên: 04/12/2022, 15:48

... proximate estimation of the size and structure molecular conformation of the polymer chains in a given solvent The Huggins and Kraemer constants kH and kK for alfalfa gum were 0.85 and 0.02, respectively, ... techno-functionality and bioactivity of the hemi­ cellulosic and pectic polysaccharide fractions isolated from hot alkali extracts of alfalfa stems Despite the differences in their structure conformational profile, ... steady, dynamic and thermo-rheological properties of galactomannan from the endosperm of alfalfa seeds 2.2 Extraction and isolation of the alfalfa gum A schematic representation of the method used

Ngày tải lên: 01/01/2023, 12:02

... communication and transmission of chemical signals The patterns of cell development and morphogenesis for the production of biological structures and tissues are closely linked to the polysaccharides of ... control and spread of spores and in the production of pigments Mushrooms like Boletus have the top of the pileus quite slimy and moist Polysaccharides excreted out of the pileus control the amount of ... the roles of polysaccharides in the biology of fungi and their relationship in the development of new technologies The comparative approach between the evolution of fungi and the chemistry of

Ngày tải lên: 01/01/2023, 12:44

... [glyceraldehyde-3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP)] Because of the small amount of posterior tissue of the HD animals (used also for the immunohistochemistry and for the optimization of the assay ... values of all glycolytic enzymes, or of only HK, did not result in good fits for lactate and pyruvate An increase of the Vmax of GAPDH to that of the control sample without, or with, an increase of ... all metabolite levels related to GAPDH and aldolase and (b) the absence of the reduction of Km of GAP for GAPDH and aldolase should cause an elevation of all metabolite levels related to these

Ngày tải lên: 23/03/2014, 10:20

... comparison of Kd values for enzyme -sulfate complexes of wild-type and the two Arg fi Ala mutants reveals that a direct participation of the side chains of Arg234 or Arg242 in binding of sulfate is ... Mucha2 and Bernd Nidetzky1,3 Institute of Food Technology and 2Centre of Applied Genetics, University of Agricultural Sciences, Vienna, Austria; Institute of Biotechnology, Graz University of Technology, ... helix of StP Because arginine are common components of interfaces of oligomeric proteins and frequently show interaction with oxyanion ligands such as phosphate or sulfate, the ÔTOWER argininesÕ of

Ngày tải lên: 31/03/2014, 01:20

... contrasting roles of PPARδ and PPARg in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue Lee D Roberts1,2, Andrew J Murray3, David Menassa3, Tom Ashmore1, Andrew ... staining of neutral lipids (Figure 4c) The combination of steady state metabolomic changes in adipose tissue and adipocytes and isotope labeling studies indicated a profound upregulation of glucose and ... influence of PPAR activation on adipose tissue metabolism in a model of insulin resistance and obesity The ob/ob mouse model is robust, well characterized and used extensively to study T2DM and its

Ngày tải lên: 09/08/2014, 23:20

... and the pyruvate kinase isozymes M1/M2 (KPYM). Other pharmacologi- cal effects of GS involve the modulation of cellular orga- nization processes (increase of gelsolin and decrease of actin) and ... verification studies of some of these changes (which would allow both the inclusion of more samples to be analyzed and the performance of time-course or dose- response experiments). As a proof of the act, ... (Figure 2), and two other metabolism- related proteins (AK1C2 and UGDH), points also to a reduction of cellular metabolism. GANAB is an ER-enzyme that has profound effects on the early events of glycoprotein

Ngày tải lên: 12/08/2014, 14:22

... chondroitinase-ABC, sodium chlorate, β-D-xyloside and differentially sulfated chondroitin sulfate glycosaminoglycans (CSGAGs), I dissected the structure of CSPG and attribute the regulation of ... Embryo-derived stem cells: of mice and men Annu Rev Cell Dev Biol 17, 435-462 Smith, G., and Strunz, C (2005) Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes ... inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration Nat Neurosci 7, 261-268 Skandalis, S.S., Kletsas, D., Kyriakopoulou, D., Stavropoulos, M., and Theocharis,

Ngày tải lên: 12/09/2015, 21:26

... pool of proteoglycans; 2) a reduced level of their sulfation; 3) a reduction in the amount of chondroitin sulfate coinciding with raising the amount of keratan sulfate; and 4) reduced levels of ... Decreases in the share of PG1 in the total pool of PG and in the level of sulfation, which reduces the amount of chondroitin sulfate (CS) and raises the amount of keratan sulfate (KS), were detected ... was performed using the package Microsoft Office Excel 2007 and the standard software package STATISTICA 6,0 The arithmetic mean value (M) and standard error of the mean value (m) were determined

Ngày tải lên: 15/01/2020, 05:18

... concentrations of TCDD 0, 10, 50 and 100 ng L−1 In each treatment, shoots and roots of plant were taken and subjected separately to the extraction and analysis of TCDD Concentration of TCDD in plant tissues ... factor (TEF) of 1.0, is the most toxic congener of dioxins Consequently, TCDD was used as a good candidate for investigations of the physiological and toxicological effects of this class of chemicals ... accumulation of dioxins in vegetative tissues and in seeds may reflect their biological fate in plants and suggest a possible tissue- specific mechanism for accumulation and subsequent detoxification of

Ngày tải lên: 26/05/2020, 21:54

... novel sentences and structures Nonetheless, the model shares a number of limitations with that of McClelland and Kawamoto, including the use of a small number of fixed semantic roles Despite the ... models of semantic role assignment, verb-argument structure construction learning, and models that learn about semantic roles and argument structure in the service of simulating comprehension and ... a greater number of verbs and constructions LEARNING ARGUMENT STRUCTURE THROUGH COMPREHENSION AND PRODUCTION A number of models have successfully captured aspects of argument structure by learning

Ngày tải lên: 12/10/2022, 20:46

... energy of 30 eV and 15 eV for analysis of the regions and of 285 eV for calibration of the binding energies of the peak C 1s The atomic percentage of the elements present on the surface of the ... CHI/CS/Lecithin NPs were obtained with the addition of 5.0 mL of 3.5% (w/v) of lecithin ethanol solution to 100 mL of CHI solution, and then 150 mL of the chondroitin sulfate solution was added slowly The ... release of curcumin, simulating physiological pH At pH 7.4, the −NH2 groups of chitosan (pKa = 6.3) are not ionized, while the −COOH and −SO3H groups of the chondroitin sulfate (pKa = 2.6 and 4.5) and

Ngày tải lên: 07/01/2023, 21:27

... side is shown the position of the 225 and 92 kDa forms of proMMP-9 in serum-free culture medium of THP-1 cells and the 72 kDa form of proMMP-2 in serum-free culture medium of human skin fibroblasts ... addition of 10 mM EDTA to the reaction mixture At the right is shown the position of the 225 and 92 kDa forms of proMMP-9 in serum-free culture medium of THP-1 cells and the 72 kDa form of proMMP-2 ... the stacking and the separating gel At the left side is shown the position of the 225 and 92 kDa forms of proMMP-9 in serum-free culture medium of THP-1 cells and the 72 kDa form of proMMP-2 in...

Ngày tải lên: 17/03/2014, 10:20

... cancer cell lines and prostate tissues Page | xvi     List of figures   LIST OF FIGURES Chapter Figure 1.1 Structure of proteoglycans and glycosaminoglycans 17 Figure 1.2 Structure of glycosaminoglycans ... remodelling of chondroitin/ dermatan sulphate 25 and heparan sulphate chains Page | iv     Table of contents    1.2.4 Functions of chondroitin/ dermatan sulphate and heparan 26 sulphate and/ or proteoglycans ... addition of GlcA and GlcNAc N-deacetylation and N-sulphation of GlcNAc units N-deacetylation and N-sulphation of GlcNAc units N-deacetylation and N-sulphation of GlcNAc units N-deacetylation and N-sulphation...

Ngày tải lên: 12/09/2015, 11:08

... architecture of OYE1 and PETN reductase, and (ii) geometry for the binding of steroid compounds and 2-cyclohexen-1-one [2,19] The structure of the Y186F enzyme is essentially identical to that of wild-type ... Properties of the H181A and H184A enzymes The structure of PETN reductase solved in complex with prednisone, progesterone, 1,4-androstadiene (Fig 1A) and 2-cyclohexen-1-one indicate that these ligands ... s, and indicate re-oxidation of the flavin and the formation of the hydride-Meisenheimer complex of TNT (C) As for panel B except the spectral changes are recorded over an extended time period and...

Ngày tải lên: 20/02/2014, 02:21

... influence of of cooling rate on the structure and resulting mechanical performance is explored for a set of isotactic polypropylenes with varying molecular weight, insertion of co-units and addition of ... Schrauwen Deformation and Failure of Semicrystalline Polymer Systems: Influence of Micro and Molecular Structure Ph.D thesis, Eindhoven University of Technology, 2003 Quantification of Non-Isothermal, ... properties of the product A method is presented to quantify the effect of thermal and pressure history on the isotropic and quiescent crystallization kinetics of four important structures of polypropylene,...

Ngày tải lên: 22/02/2014, 09:20

... expressed and purified from Escherichia coli When ferrochelatase was phosphorylated in E coli, (Fig 4F, lower), the intensity of phosphoferrochelatase of S130A and S303A was decreased, and the band ... were separated into inner and outer membranes and immunoblotting was performed (D) Densitometric quantitation of ferrochelatase, COX IV, ABCB7 and b5-reductase of the inner and outer membranes (E) ... expression of ferrochelatase, which plays a role in the iron-removal reaction of exogenous heme and the change in position of the heme-moiety of hemoproteins The protoporphyrin ring of the heme-moiety...

Ngày tải lên: 16/03/2014, 00:20