structure activity relationships of steroidal glycosides against hl 60 cells

... drugs should have moderate lytic activity as drugs with mild activity cannot lyse the phlegm and those with strong activity will lyse the soft parts of the phlegm and make the remaining parts ... School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Department of Dental Prosthesis, School of Dentistry, Mashhad, University of Medical Sciences, Mashhad, Iran Department of ... phlegms Therefore, thick phlegms would remain, become hard, and form a stone that could not be lysed In case of tumor injury, application of the following balm is suggested: equal portions of...

Ngày tải lên: 05/03/2014, 21:21

... the use of as much as g/day of OFAs in the general population Methodologically rigorous studies of OFAs in pediatric BPD are needed to determine what role OFAs might have in the treatment of young ... For example, children with ADHD are frequently full of energy and activity For this symptom to count toward a diagnosis of mania, the level of activity or agitation has to be more than is typically ... side effects of each agent Attention-Deficit/Hyperactivity Disorder ADHD is one of the most common comorbid conditions, occurring in 70% to 90% of prepubertal children and 30% to 40% of adolescents...

Ngày tải lên: 12/02/2014, 19:20

... aspartate mutants of SPP/SPPLs phenocopy a morpholino-mediated, knockdown phenotype of the respective SPP/SPPL family member (Krawitz et al 2005) The formal proof of the requirement of the aspartate ... the intramembrane proteolysis of βAPP contributes to the production of Aβ (Fig 4) and therefore to the pathogenesis of AD, the intramembrane proteolysis of Notch is of much greater physiological ... al 2007; Weihofen et al 2003) and are likely to also block the members of the SPPL family, since the active site of the GxGD proteases is highly conserved Therefore, the development of selective...

Ngày tải lên: 14/02/2014, 17:20

... gases have a pH of 7.40 to 7.45, and a PCO2 of 28 to 32 mm Hg There is a mild increase in PO2 of 106 of 110 mm Hg Increased pH is compensated for by increased renal excretion of bicarbonate (which ... exacerbation rate of 51.9% and a hospitalization rate of 26.9%.9 Thus, knowing the classification of a patient’s asthma is important in assessing her risk of exacerbation Initial investigations of asthma ... fetus.15 Despite the lack of precise knowledge of the pathophysiologic interactions of asthma with the fetus, it is clear that with worsening severity of asthma comes the risk of increasingly negative...

Ngày tải lên: 06/03/2014, 12:20

... modification of proteins has occurred in the target cells of this disorder A relatively selective inhibitor of the neuronal isoform of nitric oxide synthase, 7-nitroindazole, protects against MPTP-induced ... mutations not decrease antioxidant activity of the enzyme, but result in gain of an adverse pro-apoptotic activity, which may involve increased peroxidase activity Mutant Cu/Zn-SOD causes increased ... increase soluble APP production High levels of Fe inhibit the maturation of APP production of downstream catabolites Iron modulation of APP may be at the level of -secretase cleavage Fe and lipid 26...

Ngày tải lên: 11/04/2014, 10:00

... of both the individual experience of mental disorder and the effect of it on the embedding of the individual within both social relationships and cultural or environmental milieu Distortion of ... proportion of triads in a network out of the total number of potential triads, i.e C= 3N∆ , N3 ( 5) where N∆ is the number of triads in the network and N3 is the number of connected triples of nodes, ... the researcher seriously confronts the world of meaning and experience of members of non-Western societies, many of our assumptions about the nature of emotions and illness are cast in sharp relief...

Ngày tải lên: 13/08/2014, 23:20

... value of the local field h i thus have a low probability of flipping into the direction against the field; such spins may be thought of as being highly constrained by their neighbours The dynamics of ... distribution of local connectivities is Poissonian with mean and variance c The resulting structure is locally tree-like but has loops of length of order ln(N ) Although there is no geometric concept of ... the process of compaction in granular media thus also consists of a competition between the compaction of local clusters and the minimisation of voids globally, and that this feature of Eq 6.1...

Ngày tải lên: 01/11/2013, 08:20

... continued attitude of colonialism by Western countries toward African independence in disallowing the use of DDT in the fight against malaria is causing the unnecessary deaths of millions of Africans ... written evidence of only one cat drop According to the April/June 2005 issue of the Quarterly News of the Association of Former WHO Staff, the flight manifest from a March 1 960 delivery mission ... more than 160 species of the Plasmodium parasite, four of which infect humans, including the deadly Plasmodium falciparum that accounts for 80 percent of all malaria cases and 90 percent of deaths...

Ngày tải lên: 14/02/2014, 17:20

... virus destroys immune cells, leaving those infected vulnerable to a whole host of opportunistic infections Eventually, one of them causes death Thanks largely to the discovery of a “three-drug cocktail,” ... damage is one of the leading causes of death for people infected with HIV The protease inhibitors and other components of the three-drug cocktail, which is now referred to as “highly active antiretroviral ... understanding of the importance of the liver and no frame of reference to know how a liver disease could affect the bones in his body Researchers still not understand the cause of this childhood...

Ngày tải lên: 05/03/2014, 23:20

... risk of oversimplification, I suggest that medicalization three factors underlie most of those analyses First, there was the power and authority of the medical profession, whether in terms of professional ... affect the degree of medicalization Much of what is called self-care involves the use of medical approaches by lay people in the absence of professional medical treatment Most analysts of medicalization ... problems, usually in terms of illness and disorders Some analysts have suggested that the growth of medical jurisdiction is “one of the most potent transformations of the last half of the twentieth century...

Ngày tải lên: 11/06/2014, 12:48

... unknown origin [4] Of note, those subjects with a gait disorder of unknown origin had a higher risk of mortality during a five year follow up period, compared to the group of age-matched subjects ... widening of the base of support [7] Previous studies have shown that older adults with a cautious gait and HLGD also walk with increased stride variability and unsteadiness, have an excessive fear of ... Variability of foot placement, at least during gait termination, may also be increased when lighting is not adequate [12] These changes are reminiscent of the walking pattern of older adults with a HLGD...

Ngày tải lên: 19/06/2014, 10:20

... association of two types of variables of the same corpus These results reinforce the use of samples of spontaneous communication as a useful alternative to the assessment of children of the autism ... analysis of the occupation of communicative space and of the number of communicative acts produced per minute by the subjects of this research shows variations in both aspects The occupation of the ... advantage The analysis of MLU-w (mean length of utterance in words) identifies the medium number of words per utterance on a sample of 100 utterances The analysis of MLU-m (mean length of utterance in...

Ngày tải lên: 28/06/2014, 05:20

... medication of parents of children with psychiatric disorders who are users of a child psychiatry service Methods Materials Study subjects were 134 out of 140 (90.3%) parents of an equal number of children ... and adolescents under 18 years of age All were residents of the Byron-Kesariani area of the city of Athens, Greece Methodology The Service for the Mental Health of Children and Adolescents is ... Annals of General Psychiatry 2007, 6:32 first contact of the parents with the child psychiatry service of the Center The questionnaire comprised of questions regarding the attitudes and beliefs of...

Ngày tải lên: 08/08/2014, 23:20

... years of age Age group 5: 31-35 years of age Age group 9: 51-55 years of age Age group 13: 71-75 years of age Age group 2: 16-20 years of age Age group 6: 36-40 years of age Age group 10: 56 -60 ... age range of 60 to 93 years compared to the participants below 60 years of age Thus, the results showed a linear increase in the prevalence of PTSD However, the increase in prevalence of PTSD among ... 10: 56 -60 years of age Age group 14: 76-80 years of age Age group 3: 21-25 years of age Age group 7: 41-45 years of age Age group 11: 61-65 years of age Age group 4: 26-30 years of age Age group...

Ngày tải lên: 09/08/2014, 01:21

... patients were indicative of isolated damage of the peroneal nerve None of the patients had abnormalities in the distribution of other peripheral nerve of the limb, indication of lumbosacral radiculopathy, ... amount of axonal damage In case 9, with a seven year history of peroneal nerve palsy, the findings were indicative of residual axonal damage The involvement of a considerable proportion of axons ... in the Declaration of Helsinki Initially, the following clinical data were acquired: symptoms and duration, type of onset, psychiatric history, duration of illness, number of previous hospitalizations,...

Ngày tải lên: 10/08/2014, 10:20

... description of the offences committed The offences were classified into violent offences (all offences involving interpersonal aggression and threats, robbery, arson), sexual offences (offences against ... None of the offenders was sentenced to mandatory care Crime rates Of the total sample of 541 persons, 131 (24%) were found in the crime registry at follow-up (Table 2) Of these, 114 (31%) of the ... overlap of the various crimes committed in the convicted group, n = 131 ª : sexual offences, of these sexual offences only ( )* = in combination with “other crimes” (Ex: 10 (2)*= of ten offences...

Ngày tải lên: 11/08/2014, 15:22

... peer-related activity between subtypes have also been reported [15] The effects of methylphenidate on the neuropsychological profiles of subtypes of ADHD patients are still controversial [16,17] Of the ... aggression scale of the CBCL, with a cutoff point of 60 Chisquare was used to compare the rate of lost to followup between subtypes The Student’s t-test or One-way analysis of variance (ANOVA) ... mean age of 7.84 ± 1.64 years Fifteen of them were inattentive type, 11 were hyperactive-impulsive type, and 24 were combined type Using a cutoff point of 60 on the aggression scale of the CBCL,...

Ngày tải lên: 11/08/2014, 15:22

... south-western section of Montreal, Canada This area has a population of 258,000 and encompasses a broad range of social structures, socio-economic status, education, availability of health-care services, ... characteristics and patterns of service use, however, is essential to the efficacious planning of mental health-care delivery [38] In an effort to enhance knowledge of service needs profiling, this Canadian ... services they used, type and frequency of utilisation, and degree of appropriateness of the service they used Services covered by this questionnaire were those offered in hospitals (including hospitalisation),...

Ngày tải lên: 11/08/2014, 15:22

... submission of the final version of the manuscript Declaration of competing interests Drs Szegedi, Zhao, Nations, and Mackle are full-time employees of Merck Dr Panagides was an employee of Schering-Plough ... oversight of the trials, the analysis and interpretation of these post hoc analyses, and in the preparation and finalization of the manuscript JP was involved in the design and oversight of the ... range of values reported in a meta-analysis of controlled bipolar depression trials of quetiapine, olanzapine, and aripiprazole, which reported overall mean MADRS total score reductions of 3.91...

Ngày tải lên: 11/08/2014, 15:22

... and the preferences of the patient Although CCP offers a goaloriented structure, it comes to the professionalism of the nurses to adjust this structure to the preferences of the patient, the ... indicators Quality of life The Manchester Short Appraisal (MANSA) is a self-report scale, which measures quality of life It is a short version (16 items) of the Lancashire Quality of Life Profile (LQoLP) ... decisions, expertise and availability of professionals, and outcomes of treatment Quality of the therapeutic relationship The Scale to Asses Therapeutic Relationships in Community Mental Health...

Ngày tải lên: 11/08/2014, 15:22