structural form and the reduced form models
Báo cáo khoa học: Purification and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf
Ngày tải lên :
07/03/2014, 15:20
... structures; the bands at 1683, 1669 and 1663 cm)1 are possibly assigned to turns or bends; and the band at 1647 cm)1 is likely to be the random coil structure As occurred in FTIR, the Raman amide III¢ and ... protein and one might expect the above solution structure to be reflected in Fig The 1652 and 1270 cm)1 bands can be assigned to a-helix in the human PKIb; the 1666 and 1247 cm)1 bands are the characteristic ... According to the activity assay, the activity was retained above 95% (data not shown) and the recovery is 24% during the heat-treatment It implied that PKIb was a thermostable protein and part of the...
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Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot
Ngày tải lên :
07/03/2014, 21:20
... by and °C, respectively, than the corresponding values of proCPY and Dgly proCPY (Fig 2B), indicating that the precursor form was less thermally stable than the mature form, regardless of the ... that the cleft of the active site will be located in the interface between the two structural domains of CPY and would be filled by the propeptide, thus uniting the two domains in a body, as if the ... enzyme, and the in vivo structure is either the native or denatured form (without the presence of intermediate structures) because only the native form leads to an active enzyme, while others are...
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A Study on the Effects of Argentine Tango as a Form of Partnered Dance for those with Parkinson Disease and the Healthy Elderly pptx
Ngày tải lên :
28/03/2014, 20:20
... get together with others like them because of the supportive and therapeutic aspects They requested that they have lunch together at the end of the sessions During the dance classes, they were ... new people and having the regular opportunity to socialize and ‘work together’ were appreciated They felt the exercises were not boring, and neither did they ‘feel’ like exercise The afternoon ... ongoing basis The touch of others, the rhythm of the music, and the novelty of the experience all contributed to the beneficial effects The sense of community spirit was evident when the tango group...
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Báo cáo y học: "HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form" pdf
Ngày tải lên :
13/08/2014, 01:20
... analysis, therefore the high frequency of CRF49_cpx isolates observed in the Gambia may not extend to neighboring Senegal The geographical and subtype information in the LAHDB are gathered from ... env and gag sequencing, participated in the sequence and phylogenetic analysis and participated in writing the manuscript, RT was responsible for amplifying and sequencing most of the envs and ... analysis, organized the patient data and participated in writing the manuscript, CO participated in designing the sequencing strategy and methods and assisted in the initial analysis of the sequences,...
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REPRESENTATIVE FORM AND THE VISUAL IDEOGRAPH: THE OBAMA “HOPE” POSTER
Ngày tải lên :
24/08/2014, 11:55
... political, pop culture, and social action messages employing the representative form As Edwards and Winkler did in their study, I will first discuss the creation of the images and then their dissemination ... this limits the analysis and excludes the possibility of understanding the fragmented nature of contemporary audiences and their receptions of the manifest ideology Swenson argues “a poststructuralist ... analyzes, critiques, and expands his original theory and methods This section further illuminates McGee’s theories of the ideograph as well as the methods for analyzing them Next, a selection...
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A study on the teachers' application of task-based method and the 10th form students' use of learning strategies in their listening lessons at Tran Phu High Sch
Ngày tải lên :
28/03/2015, 08:50
... the students report back to the class orally or read the written report The teacher decides when they present their reports and may give them some quick feedback on the content and their performance ... pre-listening stage is that the students read out to get information from the tasks The better they this activity, 39 the more information about the tasks they get Then, they will predict more accurately ... language and of discourse This type of competence reveals an understanding of the social context in which language is used, of the roles of the participant, of the information they share and of the...
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Data Models, Datasets, and the ADO.NET Interface
Ngày tải lên :
05/10/2013, 08:48
... provider In the case of SQL Server, we need SqlCommand, and for Microsoft Access, we need OledbCommand Among other tasks, the main jobs of Command are to take the SQL query from the client and pass ... SQL query The second line specifies the connection to the command, and the third line is the actual SQL query statement instructing the database to send all columns and all rows from the table ... button, and use the following steps to attach the database; the instructions are the same for both the full and express releases of SQL Server 2005: From the Connect to Server dialog box, select the...
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Tài liệu Macro-Finance Models of Interest Rates and the Economy pdf
Ngày tải lên :
17/02/2014, 03:20
... orthodoxy Therefore, it also seems likely that the recent financial and economic crisis the Great Panic and Recession of 2008 and 2009—will both rearrange the economic landscape and affect the focus ... solved and responses given Quarters of the term premium and the other variables of the model to economic shocks can be computed Figures and show the impulse response functions of the term premium and ... premium is the difference between these two lines The model does not match the data perfectly, so the model’s residuals the difference between the model predictions taking into account risk and the data—are...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
Ngày tải lên :
18/02/2014, 16:20
... investigation of the catalytic mechanism and substrate specificity and to understand the differences therein for this class of enzymes In order to identify the subsites of the ervatamins and to understand ... this class of enzymes On the other hand, the Ser32Oc of ervata428 min-C pointing away from the helix forms a hydrogen bond with Arg172Ne from the other domain, and helps to form an intricate interdomain ... facilitates the transfer of the proton from the catalytic Cys present at the N-terminus of the helix to the His of the dyad [19,50,51] The first stage of catalysis is mediated by the highly active...
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Tài liệu Báo cáo khoa học: The nuclear lamina Both a structural framework and a platform for genome organization pdf
Ngày tải lên :
19/02/2014, 02:20
... determining and supporting the position of the nucleus in the cell [62,63] Now, the recent identification of an interaction between the outer nuclear membrane protein nesprin and the intermediate ... [37,38], with the most gene-poor chromosomes found at the nuclear periphery abutting the nuclear lamina (Fig 2) It is as yet unclear whether the nonrandom spatial positioning of the genome within ... sequence data for the IF multigene family, they were grouped into the so-called sequence homology class V, thereby distinguishing them from the cytoplasmic class I acidic keratins, the class II basic...
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Tài liệu Báo cáo khoa học: Influence of modulated structural dynamics on the kinetics of a-chymotrypsin catalysis Insights through chemical glycosylation, molecular dynamics and domain motion analysis pptx
Ngày tải lên :
19/02/2014, 05:20
... (Tables and 5) for the glycoconjugates to determine the dependence of the individual rate constants on the changes in the enzymes structural dynamics The parameters for both the lactose and dextran ... k2) and (B) deacylation steps (DG k3) for the Lac-a-CT (s) and Dex-a-CT (n) conjugates were independent of the size of the glycan (Tables and 5, [36]) The analysis revealed that the changes in these ... protein structural dynamics were performed to explain the observed kinetic catalytic behavior Thus, the question of whether the kinetics of a-CT catalysis are inuenced by the enzymes intrinsic structural...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
Ngày tải lên :
20/02/2014, 02:21
... that the reactive bond was optimally aligned with the flavin N5 atom in the catalytically relevant 2-electron reduced form of the enzyme-steroid complex We conjectured that the reduced form of the ... substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation Rescue of the unreactive ... and are bound between the progesterone and the protein (Fig 7A) In comparison to the oxidized structures, the FMN isoalloxazine ring is less planar, with both the N5 atom and the C8-C7 methyl groups...
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Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
Ngày tải lên :
20/02/2014, 11:20
... position at the top of the hF/ s3A-loop right above the inserted s4A while in the stressed conformation of PAI-1stab and a1PI, they stack against the aromatic moiety of the s3A residues Y172 and F189, ... 5), and the salt-bridge between E132 and R135 [18] contribute to the thermodynamic stability of the stressed conformation and/ or are important for the positioning of hF in a way delaying the ... assume that the aliphatic moiety of the introduced K in PAI-1(M149K) allows the side chain to adapt the same orientation as the original M and therefore the stabilizing effect of the M149K substitution...
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