structural elements of the nervous system
Tài liệu Báo cáo khoa học: Mutational analysis of plasminogen activator inhibitor-1 Interactions of a-helix F and its neighbouring structural elements regulates the activity and the rate of latency transition pdf
Ngày tải lên :
20/02/2014, 11:20
... of PAI-1 at the various timepoints, i.e the fraction of the total amount of PAI-1 forming a stable complex with uPA, was calculated from the amount of PAI-1 required to inhibit half the uPA The ... close to the point of initial insertion of the RCL [36] represents an obstacle for the local structural rearrangements required for the movements of the RCL during latency transition N152 is often ... mimicking the effect of the K325A substitution (Fig 5) Of note is that the side chain of E285 forms a hydrogen bond to the backbone of the hF/s3A-loop in PAI-1stab [18] (Fig 5) and in contrast with the...
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THE structure of the multiprogramming system
Ngày tải lên :
12/09/2012, 15:05
... proved the eon'eetness of the system with a rigor and explicitness that is unusual for the great majority of mathematical proofs A Survey of the System gtructure Storage Allocation In the classical ... in their homing position Each process blocked in the course of task execution relies on the other processes for removal of the barrier Essentially, the proof in question is a demonstration of the ... the value of the semaphore called "sem" by If the resulting value of the semaphore concerned is positive, the V-operation in question has no further effect; if, however, the resulting value of...
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Development of the Microfinance system in Russia
Ngày tải lên :
24/10/2013, 03:15
... 4.5 millions of individual entrepreneurs); 90 % of the total number of establishments; 44 % of GDP; 45 % of employment Sources of financing Business partners, relatives or other people ... stimulation of goods and services production and distribution, and also for a mutuality of start-up enterprises in the acquisition of getting profits and a capital accumulation experience Main tasks of ... of Microfinance to stimulate efficiency access to the financial resources; to create work places; to grow of tax proceeds; to create a credit history for the further development of SMEs...
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The Critique of the Morality System
Ngày tải lên :
01/11/2013, 07:20
... with the historical facets of his position, some with the philosophical, and some with both.4 What are the defining features of the morality system? At the end of Chapter 10 of Ethics and the Limits ... Kant, some of the most fundamental moral obligations concern the promotion of general ideals or ends such as our own perfection and the happiness of others The obligations of the morality system ... 66216 The Critique of the Morality System July 11, 2007 113 KANT AND THE MORALITY SYSTEM Now that we have a better idea of what Williams means by the morality system, ” what are we to make of his...
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an overview of the financial system
Ngày tải lên :
05/01/2014, 16:55
... An Overview of the Financial System • Primary function of the Financial System is financial Intermediation • The channeling of funds from households, firms and governments ... shortage of funds (borrowers) • Direct finance vs Indirect finance 2-2 An Overview of the Financial System II 2-3 Structure of Financial Markets I Debt Markets • Short-term (maturity < year) – the ... expertise and taking advantage of economies of scale 2- Function of Financial Intermediaries III Risk Sharing • Create and sell assets with low risk characteristics and then use the funds to buy assets...
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Tài liệu Color Atlas of Pharmacology (Part 12): Inhibitors of the RAA System ppt
Ngày tải lên :
26/01/2014, 19:20
... impair the pumping action of the heart, or when there is a threat of other complications The choice of drug is empirical If the desired effect is not achieved, another drug is tried Combinations of ... membranous sacs of the sarcoplasmic reticulum (SR); c) Ca2+ bound to the inside of the plasmalemma The plasmalemma of cardiomyocytes extends into the cell interior in the form of tubular invaginations ... Overview of Modes of Action (A) The pumping capacity of the heart is regulated by sympathetic and parasympathetic nerves (pp 84, 105) Drugs capable of interfering with autonomic nervous function therefore...
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Tài liệu Báo cáo khoa học: Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans pptx
Ngày tải lên :
20/02/2014, 02:21
... the RCL of the serpin inserts into the major A b-sheet causing the protease to be rapidly translocated from the top to the bottom of the inhibitor [6] In the process, the structure of the protease ... polymers of serpins, where the insertion of another molecule’s RCL takes place [8] Both of these result in the irreversible inactivation (generally) of the serpins, and, in the case of the anticoagulant ... ‘crushed’ against the bottom of the inhibitor [7] In particular, this deformation of the protease affects the geometry of the catalytic triad, preventing the completion of catalysis beyond the acyl intermediate...
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Tài liệu Báo cáo khoa học: "The Second Release of the RASP System" pdf
Ngày tải lên :
20/02/2014, 12:20
... account both of the probability of derivations yielding a specific relation and of the proportion of such derivations in the forest produced by the parser A weighted set of GRs from the parse forest ... general) level in the hierarchy The micro-averaged precision, recall and F1 score are calculated from the counts for all relations in the hierarchy The macroaveraged scores are the mean of the individual ... to some extent tune the parser to different genres without the need for retraining The current version of the grammar finds at least one parse rooted in S for about 85% of the Susanne corpus (used...
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Tài liệu Báo cáo Y học: Proteolysis of bovine b-lactoglobulin during thermal treatment in subdenaturing conditions highlights some structural features of the temperature-modified protein and yields fragments with low immunoreactivity pptx
Ngày tải lên :
21/02/2014, 15:20
... amount of time At the end of the heat treatment the mixtures were placed in an ice/water bath, and the enzymatic activity was stopped by lowering the pH of the reaction mixture to by addition of ... during the thermal treatment, hydrolysis of BLG was extensive, in spite of significant inactivation of the enzymes This indicates that the transient conformers originating in the course of thermal ... in these preparations could stem from the inability of the hydrolytic reaction to address all the sequential epitopes even in the denatured protein In fact, despite the apparent simplicity of the...
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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
Ngày tải lên :
22/02/2014, 07:20
... 2001 cleavages of the sites were in the order: Tyr146/Asn147 ! Phe114 ! other sites The weakness of bands of fragments I and IV and the appearance of fragment II in the degradation of the Tyr146 ... in the rate of cleavage of the autolysis loop At the same time the amount of fragment III was similar to that observed in the degradation of D-chymotrypsinogen (panel a) showing that the rate of ... cleavage was the same as seen from their inactivation rates in the presence of equimolar amounts of trypsin (Table 2) The cleavage of the interdomain and autolysis loops To follow the autolysis of D-chymotrypsin...
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Tài liệu Báo cáo Y học: Purification, characterization, immunolocalization and structural analysis of the abundant cytoplasmic b-amylase from Calystegia sepium (hedge bindweed) rhizomes ppt
Ngày tải lên :
22/02/2014, 07:20
... activity of the enzyme was determined using the Betamyl b-amylase test reagent (Megazyme, Wicklow, Ireland) To determine the pH stability of the b-amylase, aliquots of a solution of the purified ... for h at 25 8C Then 0.1 vol of a solution of 0.5 M sodium acetate (pH 5.0) was added and the activity of the enzyme was measured by the dinitrosalicylic acid method Inhibition of the enzyme activity ... at their 50 and 30 boundaries, respectively, and were inserted between the third letter of one codon and the first letter of the following codon Molecular modeling of the C sepium b-amylase The...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
Ngày tải lên :
22/02/2014, 07:20
... marrow stem cells, are the most potent antigen-presenting cells of the immune system They play a central role in the initiation of primary immune response and in the enhancement of secondary immune ... the RNA content and cDNA synthesis in the different preparations Furthermore, the PCR primers for glyceraldehyde3-phosphate dehydrogenase and FAAH were selected on the basis of the sequence of ... one of the enzymes mostly involved in endocannabinoid inactivation The heterogeneous distribution of CB2 receptors among cells of the immune system suggests that these receptors might exert their...
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Aging of the Respiratory System: Impact on Pulmonary Function Tests and Adaptation to Exertion pdf
Ngày tải lên :
05/03/2014, 21:20
... recoil of the lung (Fig 2) [9] The kyphotic curvature of the spine and the anteroposterior diameter of the chest increase with aging, thereby decreasing the curvature of the diaphragm and thus its ... Conversely, there is a progressive decrease in vital capacity to approximately 75% of best values Because of the increased stiffness of the chest wall, the age-related diminished elastic recoil of the ... intercept) and a decrease in the surface area of airspace wall per unit of lung volume beginning in the third decade of life The decrease in surface area of airspace wall per unit of lung volume approximately...
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PROTOCOL ON THE STATUTE OF THE EUROPEAN SYSTEM OF CENTRAL BANKS AND OF THE EUROPEAN CENTRAL BANK pdf
Ngày tải lên :
06/03/2014, 10:20
... months of the publication of the decision or of its notification to the plaintiff or, in the absence thereof, of the day on which it came to the knowledge of the latter, as the case may be 14.3 The ... 17 of the Act concerning the conditions of Accession of the Czech Republic, the Republic of Estonia, the Republic of Cyprus, the Republic of Latvia, the Republic of Lithuania, the Republic of ... equal to the sum of: — 50% of the share of its respective Member State in the population of the Community in the penultimate year preceding the establishment of the ESCB; — 50% of the share of its...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
Ngày tải lên :
07/03/2014, 05:20
... value of the mutant TNSALP was less than one-tenth of the Kcat ⁄ Km value of the soluble form of the wild-type enzyme, indicating that the replacement of valine with alanine at position 406 in the ... expression system, even the wild-type enzyme formed a disulfide-bonded aggregate, probably as a result of the synthesis of an excess amount of TNSALP (Fig 1C, lanes 4–6, see the top of gel) In the present ... of TNSALP In support of our hypothesis, the cysteine residue at position 433 in one subunit of TNSALP (R433C) becomes crosslinked to the counterpart of the other subunit [29], implying that the...
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Báo cáo khoa học: Structural mobility of the monomeric C-terminal domain of the HIV-1 capsid protein pptx
Ngày tải lên :
07/03/2014, 06:20
... parameters, there is no relationship between S2 and the location of structural elements (Fig 4) Furthermore, the Rex terms are distributed throughout the 3D structure of the protein, and most of them ... Furthermore, the internal motions of each bond vector are independent of each other, but the rotational diffusion of the molecule affects each of those bond vectors identically [42,43] On the other ... responsible, from a thermodynamic point of view, for the binding of the monomeric species of CAC? We have previously discussed the variation in the free energy of binding as a function of the changes...
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Báo cáo khoa học: Purification and structural analysis of the novel glycoprotein allergen Cyn d 24, a pathogenesis-related protein PR-1, from Bermuda grass pollen pot
Ngày tải lên :
07/03/2014, 12:20
... alignment of Cyn d 24 (A) Nucleotide and deduced amino acid sequences of Cyn d 24 The numbers on the right of the figure indicate the positions of the nucleotide sequence The numbers on the left of the ... Formation of this type of oligosaccharide in BG60 has been suggested to be the result of degradative reactions, rather than imperfect biosynthesis [13] Of the plant allergens listed in the of cial ... to 230 proteins and about 65 of these are IgE binding proteins [20]; however, some of these are known to be either isoforms or the degraded products of allergens Furthermore, allergic patients...
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Báo cáo khóa học: Structural properties of the protein SV-IV potx
Ngày tải lên :
07/03/2014, 14:20
... the total number of charges measured by electrospray MS Theoretical mass is the mass calculated on the basis of the protein amino-acid sequence The relative abundance refers to the ratio of the ... acetylation at one of the three residues, because the signal of the triacetylated species was less intense than that of the diacetylated species The MS/MS Ó FEBS 2003 Structural properties of SV-IV (Eur ... the mass increase of 42 mass units The relative level of acetylation of a peptide was estimated on the basis of the intensity ratio of the native and acetylated species From the data summarized...
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Báo cáo khoa học: Purification and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf
Ngày tải lên :
07/03/2014, 15:20
... for further study The concentration of the proteins was determined by the method of Lowry et al [14] and the purity was examined by SDS/PAGE [15] Assay of human PKIb activity The activity of purified ... regulation of the PKI and PKI isoforms of the inhibitor protein of the cAMP-dependent protein kinase J Biol Chem 272, 20011–20020 Byler, D.M & Susi, H (1986) Examination of the secondary structure of ... 2) The assay of its activity demonstrated that the purified PKIb inhibited the catalytic subunit of cAPK with the specific activity of 6.0 · 104 unitÆmg)1 (Fig 3A) .The Ki value determined from the...
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Báo cáo khoa học: Unique features of the hemoglobin system of the Antarctic notothenioid fish Gobionotothen gibberifrons ppt
Ngày tải lên :
08/03/2014, 08:20
... and C mawsoni) However, the lack of a clear relationship with the Hb sequences of other nototheniid species suggests that in this case the evolution of the oxygen-transport system has occurred in ... species of the family Nototheniidae have one major and one minor Hb (Hb and Hb 2, 95% and 5% of the total, respectively) [2, 4,14] The two Hbs have the b-chain in common, with the exception of those ... cancels the contribution of the N-terminus to the Bohr effect These substitutions are also found in the two Hbs of G gibberifrons, characterized by the Bohr and Root effects However, these Hbs...
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