structural chemistry of chalcones
báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx
Ngày tải lên :
10/08/2014, 22:20
... Chemical structure of ABT-263 Chemical structure of ABT-263 Figure Chemical structure of HA 14-1 Chemical structure of HA 14-1 Page of 14 (page number not for citation purposes) Journal of Hematology ... interact with the hydrophobic cleft of MDM2, thus mimicking the binding of the helical portion of p53 However, one of the enantiomers of this racemic mixture of compounds was found to possess higher ... understanding of the biological factors underlying the development of FL The identification of new targets and development of novel targeted therapies is imperative to exploit the biological indolence of...
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Success as a real estate agent for DUMmIES
Ngày tải lên :
27/03/2014, 01:27
... others like them have changed the lives of hundreds of thousands of real estate agents worldwide Dirk is one of the most published authors in the areas of success, life balance, sales training, ... Advancing or Accepting an Offer .251 Presenting a buyer’s low offer 252 Receiving a buyer’s low offer 253 Taking the insult out of an insulting offer .254 Getting beyond ... perfection personally and with thousands of coaching clients and hundreds of thousands of training program participants This book is not a book of theory but of “real stuff” that works and is laid...
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Báo cáo hóa học: " Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro" pdf
Ngày tải lên :
21/06/2014, 08:20
... Preparation of Poly(lactic acid) Nanofibers Poly(lactic acid) nanofibers were fabricated by electrospinning First, the poly(lactic acid) (Mn = 340,000) was dissolved in the solvent of chloroform (10%, ... of a Au nanoparticles, and b PLA nanofiber Li et al Nanoscale Res Lett 2011, 6:29 http://www.nanoscalereslett.com/content/6/1/29 Page of Figure Typical AFM images of nano PLA/Au polymer nanofibers ... temperature with a gap between the substrate electrode and the tip of the capillary of 10 cm at driving voltages of 10 kV The PLA nanofibers were characterized by scanning electron microscopy (Magnification:...
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Báo cáo hóa học: "Error Sign Feedback as an Alternative to Pilots for the Tracking of FEXT Transfer Functions in Downstream VDSL" pptx
Ngày tải lên :
22/06/2014, 23:20
... considered For the computation of the constellation sizes, a target error probability of 10−7 is considered with a coding gain of dB and a noise margin of dB The first set of simulations aims at comparing ... one, a set of 1000 simulations is run Each simulation uses a block of K = 60 000 symbols The output of the algorithm is taken at the end of the K blocks and the performance (in terms of the estimation ... constellation size of the symbols they replace, and thus on the SNR of the corresponding tone for the different users If we denote by bi the number of bits that could be transmitted on the tone of interest...
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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx
Ngày tải lên :
09/08/2014, 09:20
... Figure Boxplot depicting changes of mean ADC of nontreated and treated tumors at early and follow-up MRI compared to baseline MRI Boxplot illustrates changes of mean ADC of non-treated and treated ... cytochemical determination of cell death by apoptosis Histochem Cell Biol 2008, 129:33-43 Gromoll C, Karg A: Determination of the dose characteristics in the near area of a new type of 192Ir-HDR afterloading ... D, Krishna MC, Waldmann TA, Mitchell JB, et al: Application of a Page of macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation Clin Cancer...
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DHA modified tat peptide as an effective antimicrobial agent
Ngày tải lên :
04/10/2015, 15:58
... Briefly, 6.46 mg of NHS was weighed and was dissolved in ml of DMF by vortex This was followed by addition of 19.4 µl of DHA (Molar ratio of DHA: NHS: DCC = 1:1:1) To this, 56.2 µl of DCC in M DCM ... arranged in the form of a barrel inside the lipid bilayer The hydrophobic region of the peptide is aligned with that of the lipids of the bilayer, while the hydrophilic residues of the peptide are ... used in cases of infection by H.influenza With the rise of drug resistant strains, the treatment of pneumonia is becoming much more difficult Having reviewed the current state of some of the major...
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The phenomenon of evaporative cooling from a humid surface as an alternative method for air-conditioning
Ngày tải lên :
05/09/2013, 16:10
... the University of Valladolid History of evaporative cooling Many examples of the application of the phenomenon of evaporative cooling can be found, such as the metabolic regulation of the human ... Life Cycle Assessment Prof Rey was member of the Eurotherm Committee, and currently is member of ATECYR and is the head of Thermal Engineering Research Group of University of Valladolid E-mail address: ... systems and evaporative coolers Prof Velasco is member of the Thermal Engineering Research Group of University of Valladolid, ATECYR (Spanish Technical Association of HVAC systems) E-mail address:...
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Báo cáo khoa học: Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers Implications for the epilepsy seen in the dementia FENIB ppt
Ngày tải lên :
07/03/2014, 16:20
... rate of °CÆmin)1 at a concentration of 0.7 mgÆmL)1 The second derivative of the resulting data was used to calculate the inflection point of the transition and hence the Tm [14] Assessment of the ... incubation of h at a Ser52Arg neuroserpin to tPA ratio of 1, and 10; lanes 12–13 correspond to an incubation of h at a Ser52Arg neuroserpin to tPA ratio of and 10 (B) SDS/PAGE (10% gel) of wild-type ... inhibitor of tPA Wild-type neuroserpin forms complexes with tPA with a stoichiometry of inhibition of and an association rate constant (kass) of 1.2 · 104 M)1Æs)1 [6] At higher ratios of enzyme...
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Báo cáo khoa học: Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation pptx
Ngày tải lên :
16/03/2014, 10:20
... bottleneck in structural and functional characterization of GPCRs is the production of sufficient amounts of protein sample Although considerable improvements have been made, the overproduction of GPCRs ... presence of Brij58 Lane 3: supernatant of ETBcHx expression in the presence of Brij78 Lane 4: ETBcHx after Ni–chelate acid chromatography Lane 5: supernatant of ETBStrep expression in the presence of ... cHx cHx A B Fig PAGE analysis of CF-expressed ETB fragments on SDS gels (A) CF expression of ETB fragments in the presence of Brij78; 0.7 lL of supernatant (S) and lL of eluate (E) after Ni–chelate...
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Báo cáo khoa học: Identification of sodium salicylate as an hsp inducer using a simple screening system for stress response modulators in mammalian cells pptx
Ngày tải lên :
17/03/2014, 10:20
... that the increase of Luc activity by SA reflect the levels of transcription and translation of Hsp105, not due to an indirect effect of SA on the basal activity of Luc Enhancement of Luc activity ... only activation of HSF but also accumulation of Hsp70 in mouse cells [19] Here we showed that relatively high doses of SA (45–60 mM) induced the activation of promoter activities of Hsp105 and ... transcription of hsp genes Hsps are suggested to play important roles in the acquisition of resistance of cells against various forms of stress [1] Here we showed that SA induced the activation of HSF,...
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Competitiveness as an Engine for Economic Growth: Implications for Saudi Arabia doc
Ngày tải lên :
23/03/2014, 19:20
... professional management Degree of customer orientation Extent of marketing Prevalence of foreign technology licensing Extent of regional sales Extent of incentive compensation Breadth of international markets ... sophistication 81 Reliability of police services 45 Quality of management schools 73 Quality of private property rights 72 Absence of trade barriers 69 Decentralization of economic policymaking 69 ... Sophistication of local customers and needs – Strict quality, safety, and environmental standards Availability of suppliers and supporting industries Presence of clusters instead of isolated firms...
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Báo cáo khoa học: Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagicEscherichia coli: a case for EspB as an intrinsically less-ordered effector pptx
Ngày tải lên :
29/03/2014, 09:20
... However, because of the tendency of this protein to assume a less-ordered conformation, the structural properties of EspB are currently unknown EspB consists of a substantial amount of a-helical ... pedestal formation Bundling of actin filaments EspB -catenin Adherence junction -catenin Actin filaments Dissociation of -catenin Fig Schematic representation of roles of EspB EspB secreted into ... prevent both the initiation of phagocytosis and the production of microvillus effacing [12] It has been reported that deletion of the central domain (amino acids 159–218) of EspB creates a mutant...
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nanocarriers as an emerging platform for cancer therapy
Ngày tải lên :
28/05/2014, 15:07
... density of receptors should be in the range of 104–105 copies per cell Those with lower density are less effectively targeted14 In a breast cancer model, a receptor density of 105 copies of ErbB2 ... in various stages of pre-clinical and clinical development4,56,68,69 Concerns arising from the use of polymerbased nanocarriers include the inherent structural heterogeneity of polymers, reflected, ... reaction seen with high doses of many types of chemotherapy — can be addressed by changing the dosing and scheduling of the treatment83 Other challenges facing the use of liposomes in the clinic...
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báo cáo hóa học:" Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer" pdf
Ngày tải lên :
18/06/2014, 15:20
... http://www.translational-medicine.com/content/7/1/49 Figure Confirmation of activity of the murine anti-CD52 immunotoxin Confirmation of activity of the murine anti-CD52 immunotoxin A (1) FACS analysis of CD14+ and CD3+ cells in peripheral ... or absence of complement; (1) In the presence of Alemtuzumab and heat inactivated sera, the majority of VLC are viable Annexin V (-) and PI (-) cells In contrast, in the presence of Alemtuzumab ... Alemtuzumab a population of CD45+/VE-Cadherin+ cells was clearly detectable (box) In contrast in the presence of active Alemtuzumab there is as significant reduction of VLC (2) Loss of CD45+/VE-Cadherin+...
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báo cáo hóa học: "Infrared thermography as an access pathway for individuals with severe motor impairments" docx
Ngày tải lên :
19/06/2014, 08:20
... ending of each mouth opening, the end points of the line maximally spanning the width of the mouth at the onset of opening and the end points of the line maximally spanning the height of the ... Biomedical applications of thermal imaging Infrared thermography refers to the measurement of the radiation emitted by the surface of an object in the infrared range of the electromagnetic spectrum, ... http://www.jneuroengrehab.com/content/6/1/11 Figure The action of the different modules of the mouth opening detection algorithm The action of the different modules of the mouth opening detection algorithm (a)...
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báo cáo hóa học: " Methyl salicylate 2-O-b-D-lactoside, a novel salicylic acid analogue, acts as an antiinflammatory agent on microglia and astrocytes" docx
Ngày tải lên :
19/06/2014, 22:20
... have shown various degrees (risk reductions of up to 50%) of benefit from the use of NSAIDs on onset of disease and on dementia, with increased duration of NSAIDs use having increased protective ... the expression of inflammation-related proteins (iNOS, COX-1, and COX-2) in LPS-activated microglia and astrocytes, and we explored the association of these effects with activation of the NF-B ... expression of iNOS, COX-1, COX-2, and NF-B pathwayrelevant proteins such as IB-a, total/phosphorylated IKK Figure Chemical structure of compound DL0309 (methyl salicylate 2-O-b-D-lactoside) Page of...
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báo cáo hóa học: " Intention as an indicator for subjective need: A new pathway in need assessment" doc
Ngày tải lên :
20/06/2014, 00:20
... course of disease or disability status is not central to this kind of prognostic research We are mainly concerned with the value of intention as a predictor of enrolment in and attendance of preventive ... The responses to these different modes of questioning are indicators of an ambiguous concept [15] of perceived need Furthermore, the theoretical integration of this concept into psychological theories ... domain of prevention are a weaker predictor than intention and that, on top of this, intention mediates the effect of health conditions on behaviour Methods Design This study is part of a larger...
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báo cáo hóa học:" Interleukin-6 as an early marker for fat embolism" docx
Ngày tải lên :
20/06/2014, 01:20
... due to the toxic effects of the free fatty acids released from the breakdown of fat Histology of the lungs in this study confirmed the presence of inflammation at the time of death (Figure 3) One ... the rise of IL-6 In an attempt to remove this influence, we subtracted the IL-6 levels measured in the control Figure Presence of fat (stained black) in the lungs of the rat Presence of fat (stained ... hours and 24 hours) with the amount of fat embolism seen Correlation of the number of fat emboli and IL-6 levels at hours, 12 hours and 24 hours irrespective of the three groups was carried out...
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