stressors affect endocrines and the immune system in humans
scientific american - 1993 09 - special issue - life, death, and the immune system
Ngày tải lên :
12/05/2014, 14:50
... insulin-producing cells in the pancreas, and in multiple sclerosis, they direct their fury against the insulation surrounding nerve Þbers in the brain and spinal cord Treating autoimmune diseases necessitates ... marrow and lymph nodes into a strain of mice that had no immune system of their own They succeeded in establishing a functioning human blood-forming and T cellÐdeveloping system Since doing this ... attack the invader (bottom ); T cells generate lymphokines, chemicals that boost the activity of other cells in the immune system the junctions between the V and D or D and J segments when they interlink,...
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Báo cáo y học: "A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis" pps
Ngày tải lên :
12/08/2014, 12:20
... centrifuged for minutes at 1,000 g Murine IL-1β, IL-6, and TNFα levels were determined using the Luminex multianalyte technology and the BioPlex system in combination with BioPlex Mouse Cytokine Assays ... remain to be elucidated In this study, we investigated the effects of TNFR1mediated signaling in synovial lining cells (SLCs) and the reticuloendothelial system (RES) during experimental arthritis ... protection against cartilage destruction and a significant reduction in the amount of synovial inflammatory cell infiltrate and joint space inflammatory cell exudate (Figure 4c) TNFR1 silencing in the...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
Ngày tải lên :
10/09/2015, 15:50
... making the microenvironment unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the ... selected for and remain in equilibrium with the immune system in a state of dormancy When these dormant tumor cells have gained sufficient mutations to circumvent the immune system, they emerge ... II and IL-12 expression and show increased expression of the anti-inflammatory cytokine IL-10, scavenger receptor A, and arginase (Arg) These macrophages are mainly involved in wound healing...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
Ngày tải lên :
10/09/2015, 15:50
... expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating cells in the lungs ... is the fraction of proliferating cells in the tumor of control mice and k d is the fraction of proliferating cells in the tumor of PMN-MDSC-depleted mice For tumors with ellipsoid shape, the ... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... HindIII, Bgl II and Nco I The amplified fragment was cloned into pd19 by digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the ... underlined, the transmembrane domain is in bold and amino acids in the ITIM motifs in the cytoplasmic domain are boxed The intron/exon boundaries as determined from accession no AC008750 are indicated ... was missing from the Y667F mutant indicating this to be the preferred tyrosine for interaction with SHP-1 SHP-2 binding, however, was only diminished by < 50% in the Y667F mutant, indicating that...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the periphery The possibility ... transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells remains unknown The balancing act required by the immune ... tissues, including the liver, the lung, and the intestine, and they appear to function via IL10 secretion [32,38–40] Wakkach and colleagues [41] recently identified a subset of dendritic cells in the...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin ... switching Cell-fate determination in the immune system A few talks focused on the role of asymmetric division in cell-fate determination, and provided compelling evidence suggesting that the cell ... at H3K4 and symmetrically dimethylated at H3 arginine 2, in both mouse and human systems While dispensable for in vitro VDJ recombination, the PHD finger was essential in vivo for recruiting Rag2...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
Ngày tải lên :
22/02/2014, 07:20
... against a sequence between the N-terminal and the first transmembrane domain of the protein of the human and rat CB2 receptor The specificity of the CB1 and CB2 antibodies was described in McIntosh ... cells, are the most potent antigen-presenting cells of the immune system They play a central role in the initiation of primary immune response and in the enhancement of secondary immune response ... nonspecific interactions is supported by the observation that preabsorbing of the CB1 antibody with its corresponding blocking peptide eliminated almost all of the staining of these bands (Fig 3A) The...
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Báo cáo khoa học: A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin pptx
Ngày tải lên :
23/03/2014, 13:20
... 8.1 and 15.6 The first peak had m/z, retention time and UV spectra (inset in D) corresponding to the 7-DHP standard (inset in D and inset in C) The product was at the limits of detectability in the ... that the genes and proteins required for the P450scc system are expressed concomitantly in the skin and skin cells Moreover, using an array of methods including chemical synthesis with TLC and ... produced in the skin The level of 7-DHP production and its hypothetical conversion into other metabolites (including 17-, 20-, 21- and 11-hydroxy-7DHP) are the subject of investigations in our...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
Ngày tải lên :
06/08/2014, 19:20
... pathogens demanding conflicting response patterns, the fine-tuning effect of multiple allelic variants allows the immune system to be variably calibrated across the population In the absence of infection, ... showing greatest variability included some encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in ... exceptionally susceptible to either infection or pathology, and a deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
Ngày tải lên :
06/08/2014, 19:21
... role in promoting (though not in initiating) the differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the ... functional subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets ... IL-22 is now defined in mice as well as humans, this is just the beginning We still know little about the physiological impact of AhR expression on other cells of the immune system and the consequences...
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Báo cáo khoa học: " Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet" potx
Ngày tải lên :
07/08/2014, 18:20
... factor to maintain fertilization Genistein inhibits the induction of acrosomal exocytosis and binding of spermatozoa to the zona pellucida (ZP) [34] ZP-induced acrosomal exocytosis in domestic ... Research Inc., Waltham, MA, USA) Total RNA (1.0 mg) was synthesized by using the 1st strand cDNA synthesis kit (Boehringer Mannheim, Germany) following the manufacturer’s instruction The PCR mixture ... Gaithersburg, MD, USA), according to the manufacturer’s instruction [22] The RNA pellet obtained in the final step was dissolved in 50 ml of sterile diethylpyrocarbonate (DEPC)-treated water and...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
Ngày tải lên :
12/08/2014, 18:20
... biology and prospects for future intervention Clin Exp Allergy 1993, 23:237–246 15 Platts-Mills TAE: Changes in the 20th century environment: they explain the increase in asthma? In Proceedings of the ... inconsistencies impinging on the hygiene hypothesis? Clin Exp Allergy 2000, 30:1506–1510 23 Wold AE: The hygiene hypothesis revised: is the rising frequency of allergy due to changes in the intestinal ... virus) induce asthma in predisposed individuals [13], whereas others (eg rhinoviruses) exacerbate pre-existing atopic bronchial inflammation [14] The rising trend in severe asthma cases in poor, and...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
Ngày tải lên :
13/08/2014, 16:20
... thermodynamic noise in the course of protein binding to the proteasome, in protein translocation and binding to the cleavage terminal Could this noise counter-intuitively play a constructive role and not ... rigid rules and protocols, and processed into basic modular building blocks In the core, critical decisions about the sorting and the fate of the system outputs are taken Finally, again through ... fulfilling the basic requirement of minimizing the cost of immune- neuroendocrine responses [76] On the other hand, emerging evidence about genetic networks links up wiring patterns of interactions...
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Báo cáo y học: " Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection" docx
Ngày tải lên :
13/08/2014, 20:22
... [7] The aim of the study was to identify if the early statuses of the innate and adaptive immune systems of septic patients differ in relation to the underlying type of infection stimulating the ... Germany) and subsequently incubated for 15 minutes in the dark with the monoclonal antibodies anti-CD3, anti-CD14 and anti-CD19, and the protein ANNEXIN-V at the fluorochrome fluorescein isothiocyanate ... Vianex SA, Athens, Greece; and Wyeth Hellas SA The funding bodies did not have any role in study design, in collection, analysis, and interpretation of data, in writing the manuscript, or in the decision...
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Báo cáo y học: "Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b" ppt
Ngày tải lên :
13/08/2014, 23:20
... sterol terminus of the VDR binding pocket Olmesartan bound into the sterol terminus of the VDR binding pocket Note: This is the 12 nanomolar conformation of Olmesartan in the binding pocket The core ... Atoms involved in hydrophobic contact His 53 Figure 11 Candesartan docked into the VDR ligand binding pocket Candesartan docked into the VDR ligand binding pocket Note: The core structure of the ... into the PPARgamma ligand in hydrogenpocket, showing the primary residues involved binding Farglitazar Farglitazar docked into the PPARgamma ligand binding pocket, showing the primary residues involved...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
Ngày tải lên :
14/08/2014, 14:21
... If elimination is unsuccessful, the immune system and the cancer can reach an equilibrium in which immune cells keep the cancer in check but cannot remove it completely During the elimination ... treatment and will also increase our understanding of how the underlying biology correlates with survival, thereby suggesting potential new avenues for intervention In the study of Dave and colleagues ... this reinvigorated approach These studies highlight the importance of studying the genetics and phenotypes not only of cancer cells but also of the surrounding microenvironment The immune system...
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Basic immunology functions and disorders of the immune system
Ngày tải lên :
04/08/2016, 15:18
... Concurrently, TNF and IL-1 act on the endothelium to stimulate expression of ligands for integrins The firm binding of integrins to their ligands arrests the rolling leukocytes on the endothelium The cytoskeleton ... concentration to the leukocytes that are rolling on the endothelium These chemokines stimulate a rapid increase in the affinity of the leukocyte integrins for their ligands on the endothelium Concurrently, ... Functions and Disorders of the Immune System collagen and contain a carbohydrate-binding (lectin) domain Surfactant proteins in the lung also belong to the collectin family and protect the airways...
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