stress testing the chemistry of drug degradation
THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
... substances in the aqueous cavity and hydrophobic drugs in the membrane Avoid the hydrolytic degradation of drugs in water Reduce the RES uptake due to the rapid clearance of drugs from bloodstream ... Frequencies of dosing A1, A2, A3, A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of ... tissues Carrier: binding other components and altering the physicochemical properties (ex solubility) of prodrug ADVANTAGES OF PRODRUG OF TYPE (c) The conditions of drug release can be precisely...
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The chemistry of nanostructured materials
... the synthesis of the pure polymorph C of zeolite beta (BEC) even in the absence of the fluoride medium that is generally believed to assist in the formation of D4R units [42] Both ITQ-7 and the ... ITQ-7 and the polymorph C of zeolite beta contain D4R units and their syntheses were strongly affected by the presence of germanium The effect of germanium in the synthesis of D4R-containing high ... show the importance of controlling the synthesis conditions including the selection of solvent This is somewhat similar to the synthesis in zeolites where the primary building units are the same...
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FACING THE REALITY OF DRUG-RESISTANT TUBERCULOSIS: CHALLENGES AND POTENTIAL SOLUTIONS IN INDIA pot
... Predictors of success in the treatment of MDR TB are the use of pyrazinamide and ethambutol if the strain of TB is susceptible to these drugs, the use of a fluoroquinolone, the use of more than five drugs, ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... forecasting One of the most urgent needs is to obtain accurate data on the existence of totally drugresistant (TDR) TB, said Cassell, because only then will the rest of the world take notice of the problem...
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THE CHEMISTRY OF MILK pptx
... to the dominating localisation of κ-casein to the surface of the micelles, the solubility of calcium κ-caseinate prevails over the insolubility of the other two caseins in the micelles, and the ... content and thereby of the softness of the fat The iodine value of butterfat normally varies between 24 and 46 The variations are determined by what the cows eat Green pasture in the summer promotes ... times of the year The iodine value is a direct measure of the oleic acid content of the fat Nuclear Magnetic Resonance (NMR) Instead of analysing the iodine value or refractive index, the ratio of...
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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
... whether or not to include an indication in their drug summaries Compendia face the objective task of evaluating the evidence for the novel use of a drug or device, amid the competing pressures of: ... allowing for the introduction of competing interests Factors that affect the usability of an abstract include issues such as the extent of the analysis, the degree of completeness of the study (clinical ... measure of the effect of conflict of interest on the final product (the actual compendia), an assessment could be made of the number of approved drugs and the quality of the evidence accepted...
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Addressing the Threat of Drug-Resistant Tuberculosis potx
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... ineffective because of the development of resistance Thus a minimum of three to four new drugs are needed immediately to avert the escalation of drug- resistant TB The delivery of drugs to the populations ... of This Report, 18 THE GLOBAL SPREAD OF MULTIDRUG-RESISTANT AND EXTENSIVELY DRUG- RESISTANT TUBERCULOSIS Scope of the Problem, 19 Underreporting of MDR TB in Africa, 25 The Threat of Totally Drug- Resistant...
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new developments in the chemistry of war gasses 1950
... the preparation of these compounds led to the discovery of many interesting substances and to the development of several new methods of synthesis In addition, the results of the toxicological ... effects of these amines are a consequence of their ability to form aziridinium ions, which react very rapidly with the functional groups of a number of substances essential to the economy of the ... period of time deposit a fluffy mass of small crystals, the rate of formation of which increases with an increase in temperature Changes in the length of the alkyl chain R and the presence of solvents...
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the chemistry of nanomaterials, 2004, p.761
... The distribution of particle sizes The nature of the core The nature of the shell The nature of the final coat The above describe the physical composition of the particle; other properties may ... ligand, which binds to the surface of the nanoparticle, the growth of particles is further inhibited by e.g limiting the supply of the constituents forming the material, either by working at high ... Synthesis of Nanomaterials 155 Microwave Synthesis of Nanometallic Particles 155 The Synthesis of Nanoparticles of Metal Oxides by MWH 157 Acknowledgements 163 References 164 Solvothermal Synthesis...
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the chemistry of nanomaterials. synthesis, properties and applications, 2004, p.761
... The distribution of particle sizes The nature of the core The nature of the shell The nature of the final coat The above describe the physical composition of the particle; other properties may ... ligand, which binds to the surface of the nanoparticle, the growth of particles is further inhibited by e.g limiting the supply of the constituents forming the material, either by working at high ... Synthesis of Nanomaterials 155 Microwave Synthesis of Nanometallic Particles 155 The Synthesis of Nanoparticles of Metal Oxides by MWH 157 Acknowledgements 163 References 164 Solvothermal Synthesis...
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The chemistry of heterocycles (second edition)
... imagine that the bonding MO of the C-O bonds are formed by interaction of the HOMO of an ethene molecule with an unoccupied AO of an O-atom, and also through interaction of the LUMO of the ethene molecule ... kJ mol"1), the activation enthalpy of the pyramidal inversion of the N-atom is so high that the configuration of the N-atom is fixed at room temperature Thus, the configuration of the starting ... Heterocycles Summary of the general chemistry of three-membered heterocycles • The reactivity of the compounds is determined mainly by the ring strain, but also by the nature of the heteroatom or...
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vol 2 the chemistry of wine, stabilization and treatments
... Handbook of Enology: The Chemistry of Wine Table 1.14 Demonstrating the limitations of the reliability of the mini-contact test in assessing the stability of a wine by adding increasing quantities of ... that of the model dilute alcohol solution Therefore, the difference between the results for this sample and the higher values of the supersaturation fields of ‘fined’ samples define the effect of the ... in the buffer capacity of an aqueous solution of malic acid (40 mM in the presence of several amino acids (Dartiguenave et al., 2000)) 18 Handbook of Enology: The Chemistry of Wine The impact of...
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Báo cáo hóa học: " Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies" pptx
... designing the study and the writing of the manuscript DFS participated in designing the study, coordinating the study and the writing of the manuscript All authors have read and approved the final ... expression were determined by the relative quantification method; the Ct values of the test genes were normalized to the Ct values of endogenous control GAPDH The fold change or the relative quantity ... hours of maturation (up-regulated 18-fold) Moreover, the expression of Oncostatin M (OSM), which enhances the expression of the CCR7 ligand CCL21 by microvascular endothelial cells and increases the...
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Báo cáo hóa học: " Testing the potential of a virtual reality neurorehabilitation system during performance of observation, imagery and imitation of motor actions recorded by wireless functional nearinfrared spectroscopy (fNIRS)" potx
... display the VR environment [9] The subjects were asked to place their hands on the table with the palms facing downwards, and faced the monitor at a distance of approximately 70 cm The image on the ... movements to interact with the VR environment By adjustably mapping the movements of both the paretic and healthy limb onto the virtual limbs, the system offers individual training of upper limb motor ... of combined VR NIRS applications Taken together the findings of the uni- and bilateral groups, the results show that our VR system can activate the action-observation system as described by the...
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Báo cáo hóa học: " Modeling the effects of drug resistant influenza virus in a pandemic" doc
... page) the drug sensitive virus (solid lines in black), the drug resistant one (dashed lines) and the sum of Prevalence of infection with the drug sensitive virus (solid lines in black), the drug resistant ... analysis on the influence of social distancing measures in the comparison of reintroduction of drug sensitive and drug resistant infection The data provided represent the sensitivity analysis on the ... for the importation of the resistant strain is shifted towards the initial phase of the epidemic, the resistant strain increasingly replaces the sensitive strain (Figure 1c) Early importation of...
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báo cáo hóa học:" Quality of life and the impact of drug toxicities in a South African community-based antiretroviral programme" docx
... describes the types of drug toxicities that occurred during the first year of HAART Efavirenz hypersensitivity reactions were the cause of drug toxicities within the first 16 weeks of HAART Between ... shown to be the reason for up to 75% of drug switches for toxicity within the first three years of first-line HAART [21] In South Africa, there is an ongoing debate about whether or not the side-effect ... numbers of HIV-positive individuals being enrolled onto HAART and increasing survival among these patients, there is a growing need to understand the impact of HAART use on the quality of lives of...
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The Chemistry of Food and Nutrition, by A. W. Duncan pdf
... depends upon the details of the method of analysis In the analyses other than U, the cellulose is excluded in calculating the calories Nutrient ratio is the proportion of the sum of the carbo-hydrate ... unassimilated in the body This is for the reason of the intestinal refuse consisting not only of undigested food, but also of residues of the digestive juices, mucus and epithelial debris These latter ... potash (K2O) The quantity of water which could be poured off was with the German lentils, half as much more than the original weight of the pulse; not quite as much could be poured off the others G...
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Project Gutenberg''''s The Chemistry of Hat Manufacturing, by Watson Smith pptx
... under the microscope, and now we see the reason of the saw-like edge in the longitudinal section, for just as the tiles lie on the roof of a house, or the scales on the back of a fish, so the whole ... depends the distinction of the value of many classes of wool and fur These scales vary both as to nature and arrangement in the case of the hairs of different animals, so that by the aid of the microscope ... finger and thumb together, it will then invariably move in the direction of the root, quite independently of the will of the person performing the test A glance at the form of the typical wool fibres...
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The Chemistry of Workbook pptx
... Dossey, MD, author of The Power of Premonitions and Reinventing Medicine L The Chemistry of Joy Workbook gently, lovingly, and assuredly offers us the tools to reach the oasis of serenity we all ... executive director of the Mindsight Institute and clinical professor D at the University of California, Los Angeles School of Medicine “As I read through The Chemistry of Joy Workbook, the word heuristic ... in the mind The mind has a strong influence, of course But there are many other factors at work in creating inner emotional states, whether The Chemistry of Joy Workbook those are states of well-...
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Báo cáo y học: "Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices" pptx
... toxicogenomics with the goal of reducing adverse drug reactions After describing the power of the technique in general terms, he presented an informative case study on determining the toxicity of potential ... to the chemokine receptor CCR5, a receptor used by the human immunodeficiency virus (HIV) to enter cells Making the right clinical decisions There remains the challenge of matching the “right drug ... computational approaches to the prediction of drug- induced toxicity Kyle Kolaja (Iconix Pharmaceuticals, Mountain View, USA) explained the potential of the company’s DrugMatrix, a proprietary chemogenomics...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25