stress glucocorticoids and the metabolic syndrome

... with the metabolic syndrome, these studies cast important light on some of the pathways involved in the pathophysiology of the metabolic syndrome 8    LIST OF TABLES  Table Definitions of the metabolic ... increase in the risk of CVD in the Singapore population Over half of the CVD events occurring in our population are attributable to the metabolic syndrome We further show that the metabolic syndrome ... in Asian 68 populations on the association between the metabolic syndrome and ischemic heart disease 4.2 The role of central obesity in the definition the metabolic syndrome 74 4.3 Study 4: Disordered...

Ngày tải lên: 12/09/2015, 10:42

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...

Ngày tải lên: 09/08/2014, 01:22

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...

Ngày tải lên: 09/08/2014, 13:22

... drinking on the same day In the laboratory, a nurse recorded how these instructions had been followed and then took the blood samples The samples were centrifuged at the examination site and placed ... abuse and dependence, and other substance dependence and abuse As part of the assessment, the participants filled in the items of lifetime seasonal variations in mood and behavior taken and adapted ... contributions AE drafted the manuscript LK carried out the genotyping and helped to draft the manuscript AE, LK, JH and TP participated in the design of the study and performed the statistical analysis...

Ngày tải lên: 10/08/2014, 09:20

... psychosocial stress was calculated by adding the points for each item The higher the score values were, the more perceived demands are experienced as stressful The observed range of psychosocial stress ... "Disagree, and I am not at all distressed" to = "Agree, and I am very distressed" The scale was tested in a pretest The items gave a Cronbach's α = 0.86, indicating that they are reliable The score ... determined with a self-developed score There are valid and reliable models and instruments for the evaluation of psychosocial stress in the literature, e.g the job demand – control Model [15] or Siegrist's...

Ngày tải lên: 20/06/2014, 00:20

... andand the presence ofmetabolic syndrome according to the definition used used * P < 0.05 EGIR The relationship between methotrexate use the presence of the the metabolic syndrome according to the ... patients The prevalence of the MetS increased with age up until the seventh decade and fell off thereafter, and was similar in males and females (P = 0.429; Table 3) Associations of the metabolic syndrome ... drafted the manuscript KMD acquired the data GDK made substantial contributions to the conception and design of the study and revised the draft manuscript All authors read and approved the final...

Ngày tải lên: 09/08/2014, 14:22

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...

Ngày tải lên: 11/08/2014, 03:20

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...

Ngày tải lên: 11/08/2014, 06:22

... discuss the evidence on the relationships between TB and DM, and the possible mechanisms through which this link may be caused, we then discuss the link between antiretroviral therapy (ART), metabolic ... and precursor to DM), increased levels of cholesterol and triglycerides, lipodystrophy, and the onset or complication of diabetes[18,60] HIV, Metabolic Syndrome, and Heart Disease Metabolic Syndrome ... recent years there was a lack of good evidence on the strength and nature of the association between TB and DM At present recognition of the association between diabetes and TB is low The link goes...

Ngày tải lên: 11/08/2014, 14:21

... resources and needs as a component of the syndrome The arrival of the MET brings a critical care environment to the bedside In a sense, when an MET syndrome develops, it could be argued that both the ... power due to the large variance in outcome incidence and wide standard deviation and the lower-than-expected incidence of the outcome measures under investigation Given the incidence and variance ... of control and the fact that nurses can activate the MET without requiring permission from them Ignoring these problems and not seeking to reassure medical staff is likely to increase the chance...

Ngày tải lên: 25/10/2012, 10:35

... through the lung capillary beds and into the systemic circulation An obvious mechanism is movement of the material through the lungs in the same way they enter into and move through the intestine ... due to the ease of observing events occurring in the eye and the highly significant consequences of eye damage compared with limited local damage in other areas of the body and the possible therapeutic ... intestine They can penetrate anywhere, including into the brain through the foramen magnum Once lodged, these structures migrate, and the rate of migration depends only on the rate of movement of the...

Ngày tải lên: 13/02/2014, 15:20

... ‘below’ the Q119 guanidiniums of the four domains, holding the domains together and blocking the channel Adding charges (one proton per domain) breaks the plug, the side chains separate, and the ... was higher in the N–C+ group than in the N+C– group, and the frequency of metastasis and number of cases with stage D were lower in the N+ group than in the N- group Furthermore, the number of ... of the aromatic ring of the position and amino acid residues seem to be critical for the stimulation of the [35S] GTPcS binding and the activation of the downstream effector systems PP-76 The...

Ngày tải lên: 19/02/2014, 07:20

... involvement for the enzymatic reaction of Lad1 and could also be due to an indirect effect of lad1 knockout on the regulation of other genes On the other hand, the lack of growth of the wildtype ... pentitols and hexitols, most of the substrate-product pairs of Lad1 and SDH are the same, i.e they use the same catalytic mechanism A major difference in the substrate specificity between the two, ... all the amino acids which are involved in polyol binding in the SDH [25] are also absolutely conserved in Lad1, and thus cannot determine the binding efficacy of hexitols and pentitols On the other...

Ngày tải lên: 07/03/2014, 15:20

... the web, the resulting vibrations are transmitted and amplified throughout the web These vibrations alert the spider, which moves in for the kill 33 34 the inflammation syndrome The cells of the ... for the first time in their lives, they’ve been able to “connect the dots” in their inflammatory disorders and then take small and big steps toward regaining their health You can, too! PART I The ... understanding of the science behind the health benefits of nutrition and supplements In many ways, The Inflammation Syndrome expands on the concepts described in my previous book Syndrome X: The Complete...

Ngày tải lên: 15/03/2014, 04:20

... localizes to the nucleus and cytoplasm and, upon environmental stress, concentrates in stress granules The novel ROQ domain mediates localization to stress granules and induces spontaneous stress granule ... above the relevant lanes, and the absence of any added protein is indicated by ()) The position of the free RNA and of the loading slots is indicated to the right of each gel A B abolished by the ... localizes to stress granules and binds RNA in the ability to induce stress granules and importantly was not recruited to TIA-positive stress granules even in stressed cells (Figs and S3D) By contrast,...

Ngày tải lên: 15/03/2014, 11:20

... structure [5] These findings raise the interesting question of whether the balance between acharan sulfate and this other GAG species remains unchanged from birth to the adult life of the snail The presence ... from the nacreous layer of the shell from the pearl oyster, Pinctada maxima Although these and other reports suggest the presence of GAGs or proteoglycans in the mollusk shell organic matrix, the ... mucus and the organic shell matrix Fractionated GAGs from both mucus and the whole snail body (see above for methodology) were applied to a mm The GAG component of the soft body, mucus and the...

Ngày tải lên: 16/03/2014, 16:20

... anterograde and retrograde tracers have shown that the NI, together with the median raphe and interpeduncular nuclei, may form a midline behavior control network, and many targets of the NI, such as the ... expressed in the PVN and SON [12,17,21] The structure and function of the relaxin family peptide receptors, including RXFP3 and RXFP4, were recently reviewed by Kong et al [22] Cont Stress B Stress ... sion and leads to an increase in relaxin-3 mRNA levels in the NI [12] On the other hand, relaxin-3-positive neurons project fibers to the hypothalamus, and RXFP3 is intensely expressed in the PVN...

Ngày tải lên: 29/03/2014, 21:20

... participating in these programs participate in regular classes during part of the day, and then leave for their jobs at offices, banks, and other places of business for the rest of the day These jobs ... carrying the extra cash around at the expense of your education If your job is getting in the way of your academics there are many things you can do: • Evaluate the pros and cons of keeping the job ... maintaining a look that they consider to be most desirable These unhealthy habits deprive the body of the nutrients necessary to grow, heal, and yes, think These years are also the prime years for...

Ngày tải lên: 18/06/2014, 17:20

... between the two heads of the pronator teres muscle, just distal to the origins of the motor branches to the superficial forearm flexor muscles and then runs with the IA on the anterior surface of the ... bifurcation of the AIN We were not able to visualize the path of the glass fragment because of the hematoma and the time lapse between the accident and the exploration Retrospectively, the partial ... Once the circulation had been restored (pneumatic tourniquet off) and the hematoma removed, the aneurysm had the possibility to re-expand This explains why the lesion became clinically and radiologically...

Ngày tải lên: 20/06/2014, 04:20

... adiponectin The link between LKB1 and PJS, and the identification of LKB1 as a tumor suppressor and now as the long-sought AMPKK, provide a molecular basis for the interaction between metabolism and ... types other than HeLa or MEFs, the paucity of LKB-like kinases in the human genome argues against this idea This difference between yeast and mammalian cells may reflect the more extreme metabolic ... which AICAR and phenformin readily activate AMPK, the AMPK in lkb1-/- MEFs is not activated by either treatment [16] Thus, LKB1 is both necessary and sufficient for activation of AMPK These mammalian...

Ngày tải lên: 06/08/2014, 18:20