strain epsilon at the pipe soil interface in in

... towards the interface Despite the differences of turbulence generation, the interaction between the interface and the turbulence has similar characteristics as that occurring at the water surface in ... elucidate the abrupt concentration changes (∂C/∂z) in the region approximately mm below the water surface using the data obtained by the LIF measurements, • to determine the contribution of the ... and their breakdown into ejections and bursts In line with Rashidi et al (1991), they suggested that at low interfacial shear rates, the mass transfer is dominated by the ejection generated at the...

Ngày tải lên: 29/03/2014, 18:20

... some of the specific features naturally occurring in the language used during the Task Cycle Learners examine the language forms in the text and look in detail at the use and the meaning of lexical ... educators in the world as the purpose of learning a second language is to communicate with each other in society This is a reason why the Ministry of Education and Training needs to innovate the ... comprehending, manipulating, producing or interacting in the target language while their attention is principally focused on meaning rather than form" (p.10) He suggests that in all definitions of tasks,...

Ngày tải lên: 07/09/2013, 13:02

... the consecutive string of the 11 winning years ending in a five? And how about that eight year in the pattern—would it also produce gains similar to those as it had in the past? Years ending in ... at a road map that pointed to some type of buying point coming in the mid to latter part of 2002 as well as in late 2003 In lectures across the United States I told investors what I saw as a rare ... making it the strongest year in the 10-year pattern Years ending in eight showed winners in out of 10 occurrences The poorer-performing years were those ending in seven and those years ending in...

Ngày tải lên: 10/12/2013, 10:15

... the consecutive string of the 11 winning years ending in a five? And how about that eight year in the pattern—would it also produce gains similar to those as it had in the past? Years ending in ... at a road map that pointed to some type of buying point coming in the mid to latter part of 2002 as well as in late 2003 In lectures across the United States I told investors what I saw as a rare ... making it the strongest year in the 10-year pattern Years ending in eight showed winners in out of 10 occurrences The poorer-performing years were those ending in seven and those years ending in...

Ngày tải lên: 21/12/2013, 02:15

... planning groups & Pre-planning groups)  Records: All the group discussions and the individual presentations from No planning group & Pre-planning group Group Data Analysis Language Related Episodes ... Suggestions  Group planning prior to individual presentations is really useful  Group planning should be applied and encouraged in the classroom  Further study: - Investigate in three areas: fluency, ... group work - Relationship between group work and individual presentation Objectives of the study  contribute more theory to the understandings of group discussion  find out the essentials of...

Ngày tải lên: 29/01/2014, 10:33

... of the form 145 2.3 Step 3: connect the Uterals The final step in assembling the proof net is to connect together the literal nodes at the top of the graph It is at this stage that unification ... unification is applied to the variables in order to assign them the values they will assume in the final meaning Each different way of connecting the literals and instantiating their variables corresponds ... of Cs to the relevant items within the lexicon The licensing takes place precisely at the syntax-semantics interface, since it is implemented entirely in the interface glue language Finally, we...

Ngày tải lên: 22/02/2014, 03:20

... schools The intervention also helped in improving confidence After participating in the initiative, students reported feeling more confident in protesting and registering complaints against unwanted ... as keypoints to cutting the cycle of violence and achieving SRHR They have to be meaningfully involved in policy making, programme planning, implementation, monitoring and evaluating at all levels ... leaving more women and girls in crisis vulnerable to preventable death and disability The SPRINT Initiative, led by the International Planned Parenthood Federation (IPPF) in collaboration with the...

Ngày tải lên: 05/03/2014, 17:20

... sever the neck of the forming invagination, thereby securing the inclusion of cargo proteins within ILVs [60] The main link between PI3K-III and the ESCRT pathway is the fact that Vps27 ⁄ HRS, ... and PtdIns3P binding proteins in cytokinesis A surprising finding when using a green fluorescent protein-tagged version of the 2xFYVE probe was that PtdIns3P accumulates in the bridge separating two ... functions of PtdIns3P [29] Additional PtdIns3P-binding proteins that not contain FYVE or PX domains include the Proppin ⁄ WIPI proteins, which bind PtdIns3P [and to some extent the related PtdIns(3,5)P2]...

Ngày tải lên: 06/03/2014, 01:23

... but they support the idea of administrating of low doses of ASA along with ACE-I (Fig 3) • • Statins In our in vivo model statins (e.g atorvastatin and simvastatin) produce endothelium-mediated, ... statins, i.e atorvastatin, simvastatin and lovastatin (but not a hydrophilic pravastatin) at a concentration of 30 lm mobilize free cytoplasmic calcium [Ca2+]i to 30–50% of that induced by Bk at ... Long-term treatment with antioxidant vitamins does not in uence the course of the disease or correct endothelial dysfunction in patients with atherosclerosis [8] The great expectations for the therapeutic...

Ngày tải lên: 07/03/2014, 21:20

... mammalian DG contain several well-conserved domains: (a) the N-terminal domain, the mucin-like region and the C-terminal region of a-DG, the latter containing the b-DG binding epitope (amino acids 550–565); ... specifically bind WGL, which indicates that they are at least partially glycosylated (Fig 5B); furthermore, laminin pull-down experiments show that mutated DG precursors harbour some laminin binding epitopes ... address these points At the present stage, our identification of multiple point mutations that inhibit or affect the DG maturation pathway may provide a useful tool to investigate and shed light on the...

Ngày tải lên: 16/03/2014, 02:20

... contact, strain, or compactness (or some combination thereof) of the O2-bound space may have contributed to the increase in the rates of auto-oxidation for the L99F and L115F mutants O2 binding kinetics ... that these structural changes in the heme-bound PAS domain are related to intramolecular signal transduction to the catalytic domain Interestingly, CO and NO bind to the Fe(II) heme complex, inactivating ... myoglobin and hemoglobin Examination of the effects of these hydrophobic amino acids on the kinetics of O2 and CO binding to the Ec DosH heme is important because both diatomic molecules act as inhibitors...

Ngày tải lên: 16/03/2014, 13:20

... also in the endothelial cells of patients suffering Fig Schematic representation of hematopoietic development in the embryo The surface markers proving hematopoietic commitment at each stage of the ... and demonstrate the importance of selecting the appropriate mouse strain when designing experimental work For instance, truncation of IL2 receptor gamma chain (IL2rc as in NSG mice) in the genetic ... showed that the p53 pathway acts not only as a tumor suppressor, but also suppresses iPSC generation as determined using small interfering RNA and p53 mutation [89] These findings indicate the need...

Ngày tải lên: 22/03/2014, 17:20

... particular, I was interested in determining the role of CDKs in the regulation of mitotic Clb cyclin degradation, by examining the consequences of CDK inactivation on mitotic Clb cyclin degradation I arrested ... predicted that the phosphatase ought to become active during anaphase to bring about mitotic CDK inactivation The observation that the phosphatase changed its localization during the stage of the cell ... components that function at the top of the pathway are located? She found that Tem1 (and we now know all other MEN components) localized to the SPB that migrates into the bud during anaphase The MEN...

Ngày tải lên: 23/03/2014, 06:20

... present in many other splicing proteins [18] The UHM in U2AF65 recognizes splicing factor (SF1), and this cooperative protein–protein interaction strengthens the binding to the Py-tract (Fig 1) The ... by determining their tissue expression patterns, elucidating their RNA-bind4814 ing specificities, and identifying the genes that they control Ultimately, understanding the function of the diverse ... Solid lines represent presence of the indicated protein in all species that diverged from humans within the corresponding period of time Dashed lines represent loss of the indicated proteins in all...

Ngày tải lên: 23/03/2014, 10:20

... repressive chromatin domain that is less accessible to the cellular recombination machinery NoRC – a chromatin remodeling complex that mediates transcriptional silencing Switching between the active ... reduced in differentiated cells, indicating that UBF levels regulate rDNA transcription during growth and differentiation [9] UBF acts synergistically with SL1, a complex containing the TATA-binding ... transcription regulation Cells regulate rRNA synthesis by modulating the rate of transcription initiation, thereby controlling the number of nascent pre-rRNA molecules (green lines) that are generated from...

Ngày tải lên: 29/03/2014, 21:20

... a-lactalbumin (MAL), which indicates that the solid–liquid interfaces of the chromatography column may mimic in vivo conditions Protein oligomerization induced by oleic acid Equine lysozyme within the ... of coincubation At 59 min, the cell wall was ruptured, allowing ELOA to stream in and fill the cell interior (60 min) and oleic acid used were equivalent to their content in the ELOA complex The ... Schematic representation of the ELOA formation at the solid–liquid interface within column chromatography (A) The Sepharose matrix is positively charged under our experimental conditions (B) Binding...

Ngày tải lên: 30/03/2014, 01:20

... regulated through subcellular localization Indeed, Kuge et al [14] demonstrated that Yap1 nuclear retention is mediated by the cysteine-rich domain (CRD) located at the C-terminus of the protein ... cerulenin and 1,10-phenanthroline among others, suggesting a role in the response to drug stress Indeed, several target genes encoding a set of proteins involved in the stabilization and folding ... Yap2 and Yap1 in the C-terminal CRD (residues 570–650 in Yap1 and 330–409 in Yap2) was used to further provide an insight into the function Yap2 Domain swapping of the Yap1 c-CRD by that of Yap2...

Ngày tải lên: 30/03/2014, 16:20

... counteracts the efficacy of death pathways acting through the mitochondrial checkpoint Interestingly, the link between Ca2+ signalling and cell death has been reinforced by the study of an unrelated ... mitochondrial Ca2+ handling, i.e the topic of this review [13] In the chimeric cDNA, an aequorin moiety including an HA1 tag was fused in frame with the N-terminal portion (including the 25 amino acids cleavable ... effect that was not observed with truncated mutants lacking the Ca2+-binding domain [33] Substantial evidence has built up in recent years indicating that metabolic regulation is only one of the roles...

Ngày tải lên: 30/03/2014, 20:20

... the serine/threonine kinase, C-TAK1 that phosphorylates KSR1 at a site that confers 14-3-3 binding, thus sequestering the KSR1 complex in the cytoplasm in the absence of stimulation [22] In response ... a major role in the inactivation of the first peak of ERK activation The delayed phase of ERK inactivation is dependent on protein synthesis, indicating that neosynthesized phosphatases are required ... activator, MEK, is reduced upon activation of the signalling cascade [33] Interestingly, crosstalk with other signalling pathways can be mediated by regulating docking interactions On the matter...

Ngày tải lên: 31/03/2014, 07:20

... concentration in the subphase shifted the isotherms to larger molecular areas, suggesting that the molecular packing of was disturbed by interaction between the nucleotides and at the air-water interface ... pressure The calculated values are summarized in Figure In all the cases, assumption of an equimolecular binding gave the best fitting of the binding curves As shown in Figure 4A, the binding constants ... and KA evaluate molecular recognition at the air-water interface All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests...

Ngày tải lên: 21/06/2014, 04:20