stimulation of the deep brain for the treatment of chronic pain

... with chronic intractable benign pain of the neck and/or back Pain 1989, 37:279-287 Bronfort G, Bouter LM: Responsivness of general health status in chronic low back pain: a comparison of the COOP ... IOPP Comparison of pre/post pain intervention The patients presented with marked deficiencies in the eight categories of the SF-36 before, as well as after completion of the IOPP They were particularly ... through IOPP from the beginning of 1999 until mid 2000 (Table 2) They suffered from chronic non-malignant pain and had multiple failed therapies in their history Occurrence of pain for a duration...

Ngày tải lên: 11/08/2014, 08:20

... catheter to administer a continuous infusion of anesthetic in the early postoperative period does not appear to decrease donor site pain and may increase the risk of wound infection at the catheter ... [20,21] Complete avoidance of autologous bone graft harvest is the only way to eliminate the significant risk of chronic donor site pain Unfortunately, the high cost of effective alternatives ... setting of anterior cervical fusion surgery, pain associated with autograft harvest often overshadows pain from the primary surgical site [11] A perceived high rate of donor site pain has been one of...

Ngày tải lên: 18/06/2014, 18:20

... for the Study of Pain defines chronic pain as pain that persists for at least months and also includes more than 200 clinical syndromes in the classification of chronic pain (Merskey, 1986) Chronic ... together with the AMPA and the most popular NMDA receptors (Table 1.2) can be used as targets for pharmacological intervention for the treatment of pain The major limitation for the use of clinically ... activation of nociceptive transducers in skin or other tissues of the body in the absence of tissue damage The function of such pain to the individual is related to its speed of onset after stimulation...

Ngày tải lên: 12/09/2015, 09:55

... serves as the director of the Beer Ya’akov Mental Health Center ZA works at the Department of Neurobiology of the Weizmann Institute of Science and also serves as a research consultant for Brainsway ... negative effects of rTMS on cognition [4] The H1 coil, used for deep TMS, has been shown to be effective in the treatment of major depression [12-14] Deep TMS coils are designed to maximize the electrical ... charge on the surface of the brain, which can give rise to an electrostatic field that might reduce the magnitude of the induced electric field both at the surface and inside, and reduce the depth...

Ngày tải lên: 09/08/2014, 01:21

... between endothelial cells of the BBTB to enhance the permeation of drugs across the BBTB[34,47,48] The overall ineffectiveness of these approaches can be attributed to the fact that there is only ... strategy to improve the effectiveness of systemic chemotherapy The novel strategy that I propose here to improve the effectiveness of systemic chemotherapy in the treatment of malignant brain tumors ... Significance of the luminal glycocalyx layer of the BBTB of malignant brain tumor microvasculature The well-defined physiologic upper limit of pore size in the BBTB of 12 nm would be attributable to the...

Ngày tải lên: 18/06/2014, 15:20

... studies of patients with TRD, there have been no studies of the use of VNS therapy among pregnant patients A report of eight pregnancies in patients receiving VNS therapy for pharmacoresistent epilepsy ... mild programmed pulses through an implanted lead to the left vagus nerve in the neck Approved for the treatment of epilepsy since 1997, VNS therapy has been administered to more than 32,000 patients ... pregnancy or the neonate Case presentation The study from which this case report was derived was conducted in accordance with the ethical principles defined in the Declaration of Helsinki of the World...

Ngày tải lên: 08/08/2014, 21:20

... after TBI, or that one drug is better than the other, the future for barbiturates still looks bright Early combination therapy of barbiturates with hypothermia or progesterone, in concert with ... anesthetized to EBS [5] Barbiturates lessen the release of S-100B, excitatory neurotoxins, and amino acid markers of energy failure, but it has not been proven that EBS is a requirement for these ... drug therapy and mild hypothermia Stroke 2003, 34:1526-1532 Majewska MD, Schwartz RD: Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobuyric acid receptor complex in brain? Brain...

Ngày tải lên: 13/08/2014, 11:22

... as they pass the edge of the dural window (the pillars were made of hemostastic sponge wrapped by absorbable thread), and then the superficial vessels supporting the portion of brain run in the ... methods of decompressive craniectomy in the treatment of TBI Different methods of decompressive craniectomy have been developed for, or applied to, decompression of the brain at risk for the sequelae ... similar to circular decompression, the area of the skull removed is small and the room that it can provide for the expansion of the brain is restricted; furthermore, this procedure may lead to...

Ngày tải lên: 25/10/2012, 11:40

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... should be incapable of re-innervating the joint In this study we investigate the long-term efficacy of facet debridement for the treatment of chronic back pain originating in the facet joint MATERIALS...

Ngày tải lên: 26/10/2012, 09:32

... device, the RAGodoy® apparatus 4-7 was developed for the treatment of the lower extremities by producing dorsoflexion of the foot and allows treatment sessions of hours or more daily with losses of ... and supervision when performing these activities are necessary for this form of treatment until the patients are aware of the precautions they need to take Another line of research is related ... types of movement The same activity can increase or decrease the volume of the limb depending on several factors such as, for example, the weight and the fitness of the patient and the duration of...

Ngày tải lên: 26/10/2012, 09:39

... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... (VAS) pain scores Scores were assessed at baseline and again at follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results of the study...

Ngày tải lên: 26/10/2012, 09:57

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...

Ngày tải lên: 05/09/2013, 09:38

... with the increased HRT of the adsorption tank From an engineering application point of view, the appropriate operational parameters of the recycle ratio, HRT of the regeneration tank, HRT of the ... in the PO43 P removal These results revealed that the selection of the operational parameters of the CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT of the regeneration tank, HRT of the adsorption tank and SRT of the system were evaluated The removal efficiency...

Ngày tải lên: 05/09/2013, 09:38

... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect of the drug It also ... from the perspective of the NHS Unlike the manufacturer’s models the outcome data were based on published overall survival curves from the two studies The utility value for pre-progression was the...

Ngày tải lên: 14/02/2014, 22:20

... reported on the efficacy and/or effectiveness of hydroxyurea treatment of hematologic diseases, the toxicity of hydroxyurea in the treatment of any disease, and the barriers to the treatment of sickle ... reviewer reconciled the results of the first two reviewers in the case of the randomized trials 29 For the other study designs, the results of the two reviewers were averaged The quality assessment ... reliability of the instruments used A pair of reviewers each performed the quality assessment independently In the case of the RCTs, a third reviewer reconciled the results of the first two reviewers; for...

Ngày tải lên: 05/03/2014, 10:20

... the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the AD brain ... plaque-free) neuropil of the AD brain are approximately 400% higher than in the neuropil of the healthy brain, and that within the AD brain itself Cu levels are approximately 30% higher within the amyloid ... responsible for the deficit in energy metabolism characteristic of AD brain [21] There are conflicting reports in the literature about levels of the cuproprotein ceruloplasmin (Cp) in AD brain [22,23],...

Ngày tải lên: 07/03/2014, 10:20

... information) The Work Group, with the assistance of the ERT, made the final decision for the inclusion or exclusion of all articles These articles were either reviewed in a narrative form by the ... information for descriptive purposes The minimum mean duration of follow-up of months was chosen on the basis of clinical reasoning, accounting for S14 the hypothetical mechanisms of action For ... review in 2008 before publication The KDIGO Co-Chairs appointed the Co-Chairs of the Work Group, who then assembled the Work Group to be responsible for the development of the guideline The Work Group...

Ngày tải lên: 22/03/2014, 09:20

... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization of the receptor or influencing the intracellular trafficking The proteome of the target cell also influences the pathway We have observed large differences in the ... 14) of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of...

Ngày tải lên: 22/03/2014, 15:21

... evidence for the optimal period of treatment and number of treatments? We found evidence for the efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis of the ... exercise dosage is the critical factor is unclear The optimal length of treatment and the number of treatment episodes could be useful information for the marketing of physical therapy for SUI Some ... effective for the treatment of SUI The other studies in the review were considered for the generalisability of their findings to clinical practice by identifying the patient populations from which the...

Ngày tải lên: 28/03/2014, 14:20

... upon the peer review comments, the best practice statement was submitted to and approved by the PGC and the Board of Directors of the AUA Funding of the Panel and of the PGC was provided by the ... addressed Placement of a thermosensor to monitor the temperature of the external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal ... Cryosurgery for the Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized...

Ngày tải lên: 28/03/2014, 23:20