step 3 in the pivottable wizard
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
Ngày tải lên :
06/03/2014, 09:22
... reflection index b 31 , 58, 59, 61, 67, 89 and 90 aa) The structurally homologous residues in Mglu (33 4, 33 6 -33 8, 34 4, 419, 420, 422 and 428 aa; nine aa in total) were located near the interface of the ... with the C-terminal domain residues (Asp345, Leu347, Thr352, Gly428 and Asp 435 ) in the physiological dimer in all the structures Therefore, the observed structural difference in the N-terminal ... differences in the interactions across the domain interface All the residues involved here seem to be unrelated to the Trisbinding site residues (including Arg2 23 and Ser227), either directly or indirectly...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
Ngày tải lên :
08/03/2014, 08:20
... activate p38 MAP kinase in a human intestinal epithelial cell line, HT-29, and promote the transcription of the interleukin-8 gene [42] In line with previous studies, Fig 7A shows that Li induced the ... SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation of Ó FEBS 20 03 GSK -3 and glucose metabolism (Eur J Biochem 270) 38 33 strongly that targeted inactivation of GSK3, using either Li or SB-415286, ... glycogen synthesis in L6 muscle cells during oxidative stress: Evidence for cross-talk between the insulin and SAPK2/p38 MAP kinase signalling pathways J Biol Chem 274, 36 2 93 36 299 Ó FEBS 20 03 32 Bradford,...
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Báo cáo khoa học: "Immunolocalization of anion exchanger 1 (Band 3) in the renal collecting duct of the common marmoset" pptx
Ngày tải lên :
07/08/2014, 20:23
... and in vesicles in the basolateral parts of the cytoplasm (A-C) The intensity of the band immunoreactivity of the basolateral plasma membrane in the CCD and OMCD cells is stronger than that in the ... immunolabeling of the basolateral plasma membrane was more intense in the CCD and OMCD, whereas immunolabeling of intracellular vesicles was more intense in the CNT In addition, we found that there ... immunolabeing in the mitochondria of type A interacted cells From these observations, we suggest that type A interacted cells of the CNT accumulate band protein in small transport vesicles in the inactivated...
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Báo cáo khoa học: " Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine" docx
Ngày tải lên :
07/08/2014, 23:22
... expressed in the intestinal epithelium The intense staining patterns of galectin -3 in the villous lamina propria (Fig 2D) largely overlapped with the acid-fast staining (Fig 2C) The rpoB DNA (36 8 bp) ... death In contrast to the increase of galectin -3 in macrophages during paratuberculosis, galectin -3 decreases in the intestinal epithelia of animals with intestinal bowel disease [19], suggesting ... granulation tissues in the intestines with a varying degree of inflammation The histological findings in three cases were similar Briefly, the lamina propria and submucosa of the small intestine was thickened...
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Báo cáo y học: "Hyaluronan modulates accumulation of hypoxiainducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model" potx
Ngày tải lên :
12/08/2014, 17:21
... much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and destruction of bone and cartilage in the synovial joint [ 23] The present ... joints and if appropriately applied to patients with acute arthritic pain [32 ] There was significantly less bradykinin found in the crystal-induced arthritic joint after injection of HA [33 ] ... accumulation of inflammation-induced HIF-1a, iNOS, and MMP3 expressions in the synovium may be involved in the therapeutic mechanism of HA intervention used in the treatment of RA Further molecular studies...
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Expression pattern and functions of dihydropyrimindase like 3 in the rodent microglia
Ngày tải lên :
12/09/2015, 11:24
... 21 1. 13 Expression of Dpysl3 in different cell types 21 vi 1. 13. 1 Dpysl3 in the developing nervous system 21 1. 13. 2 Dpysl3 in adult nervous system 22 1. 13. 3 Dpysl3 in the peripheral ... developing rat brain 62 3. 2 Expression of Dpysl3 is increased in activated microglia 62 3. 2.1 In LPS injected rat brains 62 3. 2 .3 Activated microglial cultures 63 3 .3 Distribution ... Dihydropyrimidinase like -3 (Dpysl3) or Collapsin response mediator protein-4 (CRMP4) - Gene Ontology predictions The molecular function of Dpysl3 includes SH3 binding domain, chondroitin sulfate binding...
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Report Development Tools Building Custom Reports in the R/3 System
Ngày tải lên :
27/10/2013, 07:15
... 3 36 Consider Background Processing 3 37 Copy Before You Create 3 37 Use Variation 3 37 Naming Conventions 3 37 Review 3 38 ... Saving a Local Copy of the Template 8–11 Step 3: Saving the Template to the InfoCatalog .8–12 Step 4: Inserting Queries into the Workbook 8–14 Step 5: Adding Visual Basic Functionality ... 3 9 Step 2: Find the Library 3 9 Step 3: Create Sets 3 9 Step 4: Create Variables 3 9 Step 5: Create Report 3 9 Define Rows ...
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Fill in the gaps 3
Ngày tải lên :
02/11/2013, 10:20
... could be used in place of the language shown in bold without changing the meaning of the sentence Remember that you may need to change the form or in some cases the grammatical class of the word: ... night to finish their work, but it is impossible to maintain this for very long and so it is not recommended _ One of the main causes of the increase in inner-city lawlessness is the number ... conform… The Pope in Rome is – according to the doctrine… Cars are not allowed to enter many civic… The police accompanied… The film was made on a very low budget, so all the minor… Mercury is the...
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Tài liệu Personal Web Usage in the Workplace: A Guide to Effective Human Resources Management Part 3 docx
Ngày tải lên :
24/12/2013, 18:15
... provided their employees Internet access in the workplace Forty-six of these companies were in the service sector, whereas the remaining were in the manufacturing sector These companies ranged in size ... work 831 151 -.04 1 43 814 111 137 04 784 122 229 130 778 164 206 1 13 692 130 09 194 034 808 036 195 099 792 171 092 157 759 147 010 027 749 0 43 325 105 08 781 2 53 140 03 767 118 133 126 636 252 ... 4 .30 1.74 1.86 4.14 1.82 3. 92 1.70 3. 89 3. 83 2.16 1.89 3. 70 1. 73 3.60 1.69 3. 55 1.65 3. 09 1.55 2.91 1.58 Copyright © 2004, Idea Group Inc Copying or distributing in print or electronic forms without...
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Tài liệu Color Atlas of Pharmacology (Part 3): Distribution in the Body docx
Ngày tải lên :
22/01/2014, 00:20
... conditions of license 30 Distribution in the Body Binding to Plasma Proteins Having entered the blood, drugs may bind to the protein molecules that are present in abundance, resulting in the formation ... drug-protein complexes Protein binding involves primarily albumin and, to a lesser extent, !-globulins and acidic glycoproteins Other plasma proteins (e.g., transcortin, transferrin, thyroxin-binding ... resupplied from binding sites on plasma proteins Binding to plasma protein is equivalent to a depot in prolonging the duration of the effect by retarding elimination, whereas the intensity of the effect...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... explaining the vast neuronal loss in the AD brain Further investigation of the increased neurotrophic activity of the AD brain revealed that it correlated with the loss of a specific neuroinhibitory ... investigated whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound ... might in uence the disease process in AD 2 936 Role of the neurite growth-inhibitory properties of GIF in AD There have been extensive studies examining the role of GIF in AD, linked to its initial...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
Ngày tải lên :
18/02/2014, 08:20
... 13 (green), the TF-interactive helix and the 170 loop (red), and the covalently attached inhibitor fFR-cmk (purple) The hydrogen bonds from Gly372(2 23) to Arg315(170C) and Ser -33 3(185) are indicated ... located in the vicinity of the active site and sensed by the peptidyl substrate are inuenced, in contrast to the remote exosites, e.g in the vicinity of the activation pocket, that affect FX binding, ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active...
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Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf
Ngày tải lên :
18/02/2014, 17:20
... of the rings face in the opposite direction in the membrane to the other two, forming the same pattern as in the AFM surface representation of Fig 2A By comparison with the 3D structure of the ... tartaricus c ring [24], the black rings represent the view from the cytoplasm (open rings in AFM) and the red ones the view from the extracellular side (smaller, closed rings in Fig 3) The inner and ... of the ion-binding site Therefore, the c ring of A woodii has only 10 membrane-buried negative charges that are essential for binding the ion and also for the rotational mechanism of the ring The...
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Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
Ngày tải lên :
19/02/2014, 16:20
... 24 .3% }, 73 {[Si(CH3 )3] +, 98.4%} 31 1 (M+, 30 .6%), 296 (M+-CH3, 100%), 266 (M+-CH3 · 3, 39 .3% ), 238 [M+-Si(CH3 )3, 11.7%], 222 [M+, Si(CH3 )3- O, 62.7%], 194 [M+-COOSi(CH3 )3, 39 .3% ], 147 {[(CH3)2¼O-OSi(CH3 )3} +, ... (M+-CH3, 100%), 436 (M+-CH3 · 2, 0. 53% ), 421 (M+-CH3 · 3, 0. 53% ), 37 7 [M+-OSi(CH3 )3, 0.64%], 36 3 [M+-Si(CH3 )3- CH3 · 2, 4.8%], 299 (M+-C6F5, 65.1%), 195 ([C6F5N2]+, 8.7%), 147 {[(CH3)2¼O-OSi(CH3 )3] +, ... reported the identification of the enzyme involved in the initial step of the metabolism of 4-amino -3- hydroxybenzoic acid in Bordetella sp 10d [10] This first step, catalyzed by 4-amino -3- hydroxybenzoate...
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Tài liệu Báo cáo khoa học: Involvement of two positively charged residues of Chlamydomonas reinhardtii glyceraldehyde-3-phosphate dehydrogenase in the assembly process of a bi-enzyme complex involved in CO2 assimilation doc
Ngày tải lên :
19/02/2014, 16:20
... Chlamydomonas reinhardtii phosphoribulokinase in the information transfer between glyceraldehyde -3- phosphate 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 dehydrogenase and phosphoribulokinase Eur ... for the binding of CP12 The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic changes observed for the binding of the substrate when the wild-type recombinant ... Lys involvement in GAPDHCP12PRK formation (Eur J Biochem 271) 4 739 Rossman fold (residues 1147 and 31 333 4 in spinach GAPDH (accession code in PDB:1JN0), the other being the catalytic domain (residues...
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Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx
Ngày tải lên :
20/02/2014, 01:20
... though it did contain one ADPbinding motif This suggests the ADP-binding motif in the a1 subunit mediates the observed ATP binding, and FMN is likely situated at the interface between the a1 and b1 ... suggests that the ADP-binding motif in the b1 subunit mediates FAD binding On the other hand, FMN was not detected bound to either subunit (Fig 5B,C) We also extracted the flavin compounds from the native ... two ADP-binding motifs [6] spanning residues 120–149 and 271 30 0 (Fig 3) [3] The a1 subunit of PDH1, by contrast, contained only one ADP binding motif spanning residues 108– 136 (Fig 3) , which...
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Tài liệu Báo cáo khoa học: A novel nuclear DNA helicase with high specific activity from Pisum sativum catalytically translocates in the 3¢fi5¢ direction docx
Ngày tải lên :
20/02/2014, 11:20
... the amount of enzyme that unwinds 30 % of the DNA helicase substrate at 37 °C in 30 (1% in one min) For examining the effect of DNA-interacting compounds on DNA unwinding activity of PDH120, the ... not inhibited by actinomycin C1 [22] Actinomycin C1, a polypeptide containing the properties of an antibiotic, intercalates into dsDNA and thereby inhibits nucleic acid synthesis [ 23] Nogalamycin ... in the unwinding reaction Under these conditions, there was no inhibition of the unwinding reaction (data not shown) This further confirmed that the inhibition was due to the formation of an inhibitor–...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
Ngày tải lên :
20/02/2014, 11:20
... to these interfaces is located in the PYR and middle domains The interface contains 10 hydrogen bonds in IPDC The dimer–dimer interface in IPDC is smaller than the corresponding interface in ... 20 03 3D structure of indolepyruvate decarboxylase (Eur J Biochem 270) 231 5 (http://prodes.toulouse.inra.fr/multalin) The analysis of protein interfaces was done using the Protein–Protein interaction ... domains with an open a/b class topology: the N-terminal PYR1 domain (residues 3 180), which binds the pyrimidine part of ThDP; the middle domain (residues 181 34 0); and the C-terminal PP domain...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
Ngày tải lên :
07/03/2014, 21:20
... in the biosynthesis of natural polyamines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, the ... precursor of spermidine and spermine To further analyze the regulation of the polyamine-synthetic pathway in virus infection, ODC expression in SeV-infected FEBS Journal 272 (2005) 31 20 31 31 ª 2005 FEBS ... ISG56 is involved in the inhibition of protein translation and cell proliferation [33 ,34 ], it may participate in IRF -3- mediated apoptosis Another potential mechanism involves spermine, which induced...
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