statistical issues in gene association studies

... used as genetic markers in gene association studies Haplotype tag SNPs are an important tool in mapping genetic determinants of disease and, therefore, there is much interest in developing a haplotype ... subsequent complications Finally, gene- environment interactions are also important to consider in gene association studies Many interventions in the intensive care unit alter the cytokine cascade, such ... techniques Since differences in expression of proteins involved in the cytokine cascade are hypothesized as candidate genes, interactions between cytokine gene polymorphisms and these interventions...

Ngày tải lên: 13/08/2014, 02:24

... same statistical issues apply to public health data however published, but interactive web-based systems make certain issues more acute In addition, identifying and addressing these issues for interactive ... in maintaining the willingness of the public and health care providers to participate in data-gathering activities that are in the public interest Although confidentiality concerns are like Statistical ... protection in public health data systems tend to be ad hoc and generally not based in any kind of theory Although web dissemination systems are intrinsically less Statistical Issues in Web-Based...

Ngày tải lên: 18/02/2014, 21:20

... for Hemoglobin F levels to very low for autism Since finding variants that explain the remaining phenotype variability will improve our understanding of the role of genetic factors in complex ... methodology of collapsing within a region by introducing Combined Multivariate and Collapsing (CMC) method In the CMC approach rare variants are collapsed within groups defined, for example, by ... reconstruction in sequencing studies 18 The proposed rare haplotype tests include the weighted haplotype method74, generalized haplotype liner model75 and haplotype kernel association test76 In general,...

Ngày tải lên: 09/09/2015, 11:12

... Statistics in Population Genetics CHAPTER 1.1.0 INTRODUCTION The present thesis is an attempt to address several issues of interest, from a statistical point of view, in the discipline of population genetics ... Population Genetics protein-coding genes, the effects of certain variants are nevertheless well-documented In diploids, depending on whether a particular allele of a gene is present in one or two ... framework, instead of the commonly used analysis of molecular variance (AMOVA), is the appropriate one for analysing genetic structure in a collection of populations where interest in intrinsically...

Ngày tải lên: 14/09/2015, 08:26

... certain medications, in particular antihistamines, inhibit SPT responses by interfering with mast cell and histamine responses 20 2.11 Reason and aims of doing this study Owing to preceding studies ... background staining, the agarose gel is de-stained by soaking in de-ionized water for 10 minutes 3.7 Sequencing for polymorphisms Chain termination sequencing was employed This method involves the ... disease in children There is increasing evidence suggesting the pivotal role of interactions between the environment and genes in the pathogenesis of these multi-factorial diseases Prior linkage studies...

Ngày tải lên: 30/09/2015, 14:23

... research citing confounding in observational studies, the limited ability of observational studies to assess Discussion on Statistical Issues in the Women’s Health Initiative 905 Table Clinical outcomes ... occurring within years of treatment initiation, in triggering the trial stopping rules Notwithstanding this paper, and the companion paper in the American Journal of Epidemiology, the headlines generated ... terminated early due to a convincing adverse risk of clotting problems as evidenced by increases in stroke, pulmonary embolism, and deep vein thrombosis In addition, there was an increase in breast...

Ngày tải lên: 28/03/2014, 12:20

... would support a presumption in favor of continuing the development of germline genetic engineering That is, we have argued that germline genetic engineering is not intrinsically morally objectionable ... distinctions in mind we can raise some additional ethics issues regarding gene therapy from a social point of view Is there anything intrinsically morally objectionable about gene therapy in any ... engaged in germline genetic engineering Failing that, however, we would still have the alternative of creating multiple eight-cell embryos in vitro, genetically analyzing them, then implanting only...

Ngày tải lên: 10/04/2014, 22:10

... constructed of a number of interacting proteins making an individual contribution to disease susceptibility Page of (page number not for citation purposes) Competing interests The author declares ... stratification in genome-wide association studies Nat Genet 2006, 38: 904-909 10 Li M, Li C, Guan W: Evaluation of coverage variation of SNP chips for genome-wide association studies Eur J Hum Genet 2008, ... number of genes with a smaller effect size (odds ratio 1.1 to 1.2), so that we will need an increased number of samples in the study cohort to gain sufficient power to find a significant association...

Ngày tải lên: 09/08/2014, 14:22

... used in a simulation study In summary, our results provide investigators planning exploratory biomarker studies with data on biases due to changes in marker levels that may aid in interpreting findings ... Journal of Clinical Bioinformatics 2011, 1:9 http://www.jclinbioinformatics.com/content/1/1/9 Page of could lead to missed associations, i.e increased numbers of false negative findings, as effects ... corresponding values for the same samples measured in September 2009 Methods The key parameter of interest is the log-odds ratio b that measures the increase in risk for a unit increase in marker...

Ngày tải lên: 10/08/2014, 09:22

... search querying for the disease name in the HuGeNet Navigator [50] gave completely overlapping results, showing studies for additional genes, albeit reporting negative findings Most studies (72.3%) ... angiotensin-converting enzyme; CXCL2, chemokine CXC motif ligand 2; F5, coagulation factor V; IL-6, interleukin-6; IL-10, interleukin-10; MBL2, mannose-binding lectin-2; MIF, macrophage migration inhibitory ... ofassessment of genetic association studies supporting for the quality assessment of genetic association studies supporting susceptibility and/or outcome in acute lung injury LD, linkage disequilibrium;...

Ngày tải lên: 13/08/2014, 11:23

... multifactorial involvement in the pathogenesis of sepsis and multiple organ dysfunction after trauma [39] In fact, there is increasing evidence indicating that genetic polymorphisms of other genes are ... carcinomain Chinese Han ethnic population Hepatobiliary Pancreat Dis Int 2005, 5:60-64 19 Zhang K, Hei P, Deng L, Lin J: Interleukin-10 gene promoter polymorphisms and their protein production in ... would be important in influencing severity to the development of sepsis and MODS in trauma patients by changing the balance of pro-inflammatory and anti-inflammatory cytokines There were no significant...

Ngày tải lên: 13/08/2014, 20:21

... Proteins, Ensembl Fgenesh FGENESH00000037205 FGENESH 00000037219 ab initio Proteins, Softberry Fgenesh S.C_Group11.13000016A ab initio Proteins, Softberry Fgenesh++ S.C_Group11.13000019B ab initio ... using an OmniGrid 300 spotting robot (GeneMachines, San Carlos, CA, USA) Spot and printing quality were assessed visually under a dissecting microscope after printing While a few slides had minor ... contaminations acquired during sample collection Finally, 17 assembled sequences appeared to be derived from viruses, including the recently identified S invicta SINV-1 and SINV1A viruses [28,29] Interestingly,...

Ngày tải lên: 14/08/2014, 17:22

... multiple genetic variants associated with CAD Most of the associations have been replicated in independent studies, indicating that the findings are genuine novel 23 associations The main GWAS findings ... significant gene- gene interactions influencing HDL-C iii) Validate the interactions in additional cohorts We believe investigations of CAD in Asians would provide insights into Asian genetics, ... Singapore Coronary Artery Genetics Study xv SCES: Singapore Chinese Eye Study SCES: Singapore Chinese Eye Study SCHS: Singapore Chinese Health Study SiMES: Singapore Malay Eye Study SINDI: Singapore...

Ngày tải lên: 09/09/2015, 08:17

... applied in many areas Thus, it is important to investigate high dimensional feature selection in generalized linear models In addition, it is common that interaction effects are prominent in explaining ... to generalized linear models with main effects and interactions by deducing different penalties on the number of main effects and the number of interactions In the third part, we introduce the generalized ... the Generalized Tournament Approach in Genomewide Association Studies 72 5.1 Introduction to the multiple testing for genome-wide association studies 73 5.2 The generalized tournament screening...

Ngày tải lên: 11/09/2015, 16:05

... mainly in correc12 Previously, in the morning the court would give a judgment ordering the opening of proceedings and then, in the evening, bring the observation period to an end and order winding-up ... significant changes in the general scheme of the proceedings The aims of the Act were set out in article 1: ț to protect the business; ț to allow the business to continue operating and maintain jobs; ț ... the prosecuting authorities21 in two matters: the appointment of the bodies constituted in the proceedings and remedies against decisions made during the proceedings Insolvency proceedings sometimes...

Ngày tải lên: 13/10/2016, 11:12

... in the context of ethical issues in withdrawing life-sustaining treatment He writes, ‘Life-sustaining treatment implies that treatment is being given in order to maintain or create the best possible ... results in the infant becoming involved in a growing number and variety of social relationships In summary, none of the views discussed above provides an adequate account of moral standing In looking ... donor insemination are outlined Elina Hemminki (Chapter 12), a Finnish epidemiologist and health technology assessment expert, approaches antenatal screening from an evidencebased medicine viewpoint...

Ngày tải lên: 21/09/2012, 10:54

... encrypted messages being exchanged Such information could be useful to the attacker as it can reveal useful information in guessing the nature of the information being exchanged [2,3] In general, passive ... inserting a record in a file Interception This is an attack on the confidentiality of the network such as wiretapping or eavesdropping to capture data in a network Eavesdropping is easy in a wireless ... eavesdropped from outside the building where the network is operating In most wireless networks, there is a kind of link level ciphering done by the MAC entities Jamming Interruption of service attacks...

Ngày tải lên: 29/09/2013, 21:20

... interventions and cloning trates on practical issues, within the context of licensing clinics for testing speciWc inherited conditions and restricting access through guidelines that limit which ... pertinent Indeed if dignity has to be deWned in any essential manner, as it must be if enshrined in international declarations, it is the unique quality of all human beings, also recognized in ... strangeness, in other words, the stranger within ourselves (Kristeva, 1991) The implication for cloning is that the parent(s) seeking reproductive cloning cannot accept that strangeness carried in...

Ngày tải lên: 01/11/2013, 08:20

... certainty Before the issue of withholding or withdrawing life-sustaining treatment can be considered, the present condition of the infant must be assessed in the Ethical issues in withdrawing ... be severe gastrointestinal abnormalities and renal agenesis making death inevitable from renal failure within a very few days Consideration of withholding or withdrawing life-saving medical treatment ... termination is often now a logical and legitimate choice for the parents ∑ The third area in which these issues arise are the term babies who are Ethical issues in withdrawing life-sustaining...

Ngày tải lên: 01/11/2013, 08:20

... Opinion in Infectious Diseases 12: 21–6 UK Intercollegiate Working Party for Enhancing Voluntary ConWdential HIV Testing in Pregnancy (1998) Reducing Mother to Child Transmission of HIV Infection in ... disappointing that at the time of writing, President Mbeki of South Africa appears to be reversing this positive trend Rather than endorsing a programme of national funding for perinatal zidovudine ... least in resource-rich countries) since 1994, anonymous antenatal testing inexorably continues in the UK and in several other developed countries (Nicoll et al., 1998) This may be justiWed in countries...

Ngày tải lên: 01/11/2013, 08:20