statistical considerations in analysis and interpretation of biomarker studies

... taking a history, performing a physical examination, ordering laboratory examinations, giving guidance and advice, delivering medication and therapy, specifying follow-up [17] Reports combining ... measures, and allowed for clustering of consultations within clinicians Results Fifteen reports of eleven studies met the inclusion criteria [8-22]; three of these studies were reported in more ... similar validity: some of the heterogeneity in findings may be due to inappropriate statistical methods The planning of future studies would benefit from an evaluation of the range of approaches used...

Ngày tải lên: 11/08/2014, 05:21

... arrays, starting from the initial stages of whole experiment summarization and filtering, through to fine-grained transcriptomic analyses of exon expression and of splicing at the level of individual ... (1-3) are similar to standard microarray analysis Step is specific for exonmap, and is a combination of filtering and mapping between genes, transcripts, exon and probesets using genomic annotations ... of individual genes to be plotted, and colored according to probeset intensities or fold changes Figures and show example genes selected according to their inter-exon CV Identifying regions of...

Ngày tải lên: 14/08/2014, 07:21

... objectives of the current research work It involves developing a frame work for modeling and analyzing microbial and mammalian systems using a combined statistical and in silico approach to gain insights ... preprocessing and statistical analysis of experimental data (fermentation data from cell cultures) followed by in silico modeling and analysis of intracellular metabolic fluxes to gain insights into ... consider, analyze, and ultimately understand the living world, whereas physics and chemistry come handy in probing the behavior of molecules and their activity inside living cells Engineering applications...

Ngày tải lên: 11/09/2015, 21:27

... sites is defined as inter-cell interference The ratio of the intra-site interference to inter-site interference is defined as R= Iintra Iinter (14) From the simulation results illustrated in Figure ... number of paths of which the jn = θ, and the Pn, θ is the power of the corresponding path 4.2 Data analysis and angular offset modeling Figure depicts a spatial sample of the SAGE results The points ... colors stand for distinct paths extracted in one cycle in polar coordinate system, with total of 50 paths The angles of those points are the jn from SAGE results Besides, the radius of each point...

Ngày tải lên: 20/06/2014, 21:20

... Academy of Finland (under Project no 116423, “Understanding and Mitigation of Analog RF Impairments in Multiantenna Transmission Systems”), Tampere Graduate School in Information Science and Engineering ... alone This is indeed due to the interaction of the individual radio impairments and the space-time coding principle in the considered multiantenna scenario, and it is nicely incorporated in the system-level ... distribution of the overall interference, and thus it is important when carrying out the statistical interference analysis in the continuation Another difference lies in the structure of the coefficients...

Ngày tải lên: 22/06/2014, 19:20

... clot and centrifuged for 10 minutes at 800 g to obtain serum The organs were fixed in 4% formalin before embedding in paraffin, sectioning, and staining with haematoxylin and eosin Sections obtained ... analytes in serum and 75 proteins in saliva Thirty and 62 of these molecules have not yet been investigated in SS patients and SS-like disease in NOD mice, respectively Thirty-six and 54 of the biomarkers ... intramuscular injection of ketamine and medetomidine Salivary secretion was induced by intraperitoneal injection of 0.5 μg pilocarpine/g body weight (#P6503; Sigma, St Louis, MO, USA) and collected during...

Ngày tải lên: 09/08/2014, 10:23

... theory in more of the studies, but not reported it in the main study publications due to space constraints or lack of recognition of importance of explicitly outlining the rationale for interventions ... Davies et al.: A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations Implementation ... theories and constructs were used was not apparent in the majority of studies Discussion This study examined the use of theories within a large sample of rigorous evaluations of guideline dissemination...

Ngày tải lên: 11/08/2014, 05:21

... theory in more of the studies, but not reported it in the main study publications due to space constraints or lack of recognition of importance of explicitly outlining the rationale for interventions ... Davies et al.: A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations Implementation ... theories and constructs were used was not apparent in the majority of studies Discussion This study examined the use of theories within a large sample of rigorous evaluations of guideline dissemination...

Ngày tải lên: 11/08/2014, 16:20

... in the protein profiles of both organs In order to obtain further information, in this work we investigated protein accumulation changes induced by nitrate in both roots and leaves of Zea mays ... sugars and sucrose in roots (A, C, E and G) and leaves (B, D, F, and H) and chlorophyll content in leaves (I) of Zea mays plants, previously grown in the absence of nitrogen for 17 days (T0) and incubated ... material and growth conditions Maize (Zea mays L.) seeds of T250 inbred line, kindly provided by Prof Zeno Varanini of Udine University – Italy, were germinated in the dark at 26°C on blotting paper...

Ngày tải lên: 12/08/2014, 03:21

... subunits: troponin T, which binds to tropomyosin and facilitates contraction; troponin I, which binds to actin and inhibits actin-myosin interactions; and troponin C, which binds to calcium ions ... exposure of myofibrillar proteins to active caspase results in α-actin, α-actinin and troponin T and myosin light chain cleavage [14] In experimental sepsis, our studies suggest that activation of ... disarray and are involved in the cleavage of α-actin, α-actinin and troponin T [14] Alternatively, TNF-α may have an important role in cardiac injury through a variety of mechanisms, including second...

Ngày tải lên: 13/08/2014, 01:20

... assessing the efficiency of resources used in a situation of dwindling health care funds and steeply increasing demand The main objective of this paper is therefore to provide input into an analysis ... Central Statistical Office: Census 1992 Provincial profile, Midlands Harare: Government of Zimbabwe; 1994 Central Statistical Office: Census 1992 Provincial profile, Manicaland Harare: Government of ... number of individuals cured through treatment j by excluding ineffective services from the total number of individuals seeking treatment and translating the resulting health benefits into DALYs...

Ngày tải lên: 13/08/2014, 11:22

... thereby minimizing the risk of overtraining and irreproducibly optimistic performance evaluations that is inherent in the use of machine learning methods [39] Due to the complex structure of mammalian ... restarting the machine learning analysis with custom settings and selecting all available machine learning algorithms for inclusion (Figure 3c) EpiGRAPH's cross-validation results indicate that linear ... range of calculations and filtering methods that facilitate the selection of biologically interesting regions for further analysis Finally, it is often desirable to perform statistical analysis and...

Ngày tải lên: 14/08/2014, 21:20

... Discrimination in Roots and Shoots of Major Weed Species of Southern U.S Rice Fields and Its Potential Use for Analysis of Rice–Weed Root Interactions David R Gealy and Glenn S Gealy* Assessing ... from inputs including the total mass, carbon mass, carbon fraction, and d13C levels of roots and soil increased greatly the accuracy of root mass estimates and increased slightly the accuracy of ... 0.9%) in samples containing soil Similar corrective equations were derived for mixtures of rice and C4 weed roots and soil, and are proposed as a labor-saving option in 13C discrimination root studies...

Ngày tải lên: 04/09/2015, 07:24

... the help of tensor analysis we generalize ray tracing machinery in a coordinate-free style and we show in detail how ray tracing in anisotropic media in arbitrary coordinate systems and curved ... concept of space-folding and its role in the perfect imaging and superscattering Interested readers are first referred to [21] in which the theory of space-folding and transformation media is explained ... Summary In this thesis we study different features of Graded-Index Media from the Geometrical Optics point of view and we explore effective techniques of analysis and design of interesting optical...

Ngày tải lên: 09/09/2015, 11:11

... for handling uncertainties In the framework of fuzzy logic, the concept of fuzzy set was introduced by allowing the membership grade to be any value within the interval [0, 1], instead of the ... boundary (red line) that divides the input space into the two operating mode in 3.8 Ujmin 56 Partition of the input space by Rule (green line), Rule (blue line) and the boundary ... uncertainties In order to improve the ability of fuzzy logic in handling complex uncertainties, type-2 fuzzy logic was introduced While the concept of type-2 fuzzy set was introduced by Zadeh in...

Ngày tải lên: 09/09/2015, 18:49

... containing Zr, Hf, Ti and Y Indeed, in each of the Al-rich Al-Ni-Zr, Al-Ni-Hf and Al-Ni-Y alloys system, two optimal glass formers were located in a single eutectic Kinetic considerations pointed ... Melt Spinning 20 47 Al-Gd – 12 at% Melt Spinning 20 47 Al-Tb – 14 at% Melt Spinning 20 48 Al-Dy – 12 at% Melt Spinning 20 48 Al-Ho – 12 at% Melt Spinning 20 48 Al-Er – 12 at% Melt Spinning 20 ... at the Atomic Level of Amorphous Alloys While the problem of determining the structure of crystalline materials involved only of identifying the coordinates of all the atoms in a unit cell, albeit...

Ngày tải lên: 11/09/2015, 09:04

... down, lying to sitting, level walking, ascending stairs and descending stairs However, in sitting, standing, and lying down detection, instead of detecting static postures, we detect stand-sit/sit-stand, ... thigh in detecting sitting, standing, and lying static activities The dc response of the radial sternum accelerometer was used to distinguish sitting/standing posture from lying posture and that of ... consisting of seven types of activities, sitting, standing, lying supine, level walking, ascending stairs, descending stairs, and cycling The recorded acceleration signals were manually separated in...

Ngày tải lên: 14/09/2015, 18:27

... AEROBIOLOGY, IMAGE ANALYSIS AND ALLERGENICITY OF POLLEN AND SPORES IN SINGAPORE ONG TAN CHING 2004 AEROBIOLOGY, IMAGE ANALYSIS AND ALLERGENICITY OF POLLEN AND SPORES IN SINGAPORE ONG TAN CHING B Sc (Honours), ... (light weight and rich in proteins and enzymes) that have resulted in the deposition of pollen onto the mucosal surfaces of human, and animals, subsequently resulting in allergies (Ciprandi et al., ... 2) improvement of diagnostic techniques (Ng et al., 2001), 3) changes in lifestyles resulting in decreasing birth rates as a result of the increase in mean age of marriage, increasing exposure...

Ngày tải lên: 15/09/2015, 21:49

... Connections of phase windings 101 Figure 4.20 Comparison of armature reaction field of the winding on a single tooth 102 Figure 4.21 Comparison of armature reaction field of the winding on ... Structure and winding layout of 8-pole 9-slot PM motors 147 Figure 5.34 Structure and winding layout of 8-pole 12-slot PM motors 148 Figure 5.35 Current flowing in the phase windings ... express my most sincere and heartfelt gratitude to Dr Z J Liu with Data Storage Institute, Singapore and Prof M A Jabbar with Electrical and Computer Engineering, National University of Singapore, for...

Ngày tải lên: 15/09/2015, 22:03