statistical approaches to establishing bioequivalence guidance 2001

... popular tools for SNP discovery in NGS data that are easily incorporated into data-processing pipelines are SAMtools [13] and the Genome Analysis Toolkit UnifiedGenotyper [14,15] Other tools have ... model To further narrow the search, investigators have imposed a recessive model of disease when the pedigree suggests this mode of inheritance, requiring a putative causal In contrast to the autosomal ... frequencies (0.5 to 5%) too low to be detected by GWASs [45-47] These rare variants pose an analytical challenge, however, because they are present in so few individuals that there is low power to detect...

Ngày tải lên: 09/08/2014, 23:20

... the final step is to join them into the object WWTP With mathematic models brought into WWTP software, and software combined into the monitoring and control system, the monitoring and control ... still many things to to before it works in the real WWTP The mathematic models should be adjusted to real plant behavior, which means to adjust the parameters and calibrate the model to adapt the ... correspond to the sensors It also needs to some programme to achieve the data transfer from sensors or apparatus to the control system After the whole network is established, we still need to test...

Ngày tải lên: 05/09/2013, 09:08

... thi học sinh giỏi + Môn Hóa : đ/c Nguyễn Thị Liễu + Giải to n máy Casio : đ/c Phạm Đức Tuân + Môn Sinh : đ/c Nguyễn Thị Ngọc Lê + Giải to n máy Casio : đ/c Trịnh Văn Tuấn * Số lao động tuần Stt ... 9/ 2009 10/ 2009 11/2009 1/2010 2/ 2010 3/ 2010 Hình thức kiểm tra Chuyên đề Chuyên đề Chuyên đề To n diện Chuyên đề Chuyên đề Kết HỌC KÌ I HỌC KÌ II Ghi Môn Hóa 10 V HS2 HK Môn Hóa 11 V HS2 TG ... thi đua đầu năm * Chủ nhiệm - GVCN nhận lớp ,tổ chức lớp, tổ chức học sinh lao động - Giáo dục an to n giao thông cho học sinh - Hướng dẫn học sinh thực nội qui, rèn luyện nề nếp * Hoạt động khác...

Ngày tải lên: 20/09/2013, 03:10

... allow students to practice language skills (Lee, 1995)  Games encourage learners to interact and communicate with one another When taking part in the games learners have to talk to express or ... your classmates help you to learn vocabulary through games? a b c d Help you to guess unknown words Help you to recall the words you have learnt but forgotten Help you to remember words from the ... bringing fun to classes  Games can provide language practice  Games encourage learners to interact and communicate with one another  Games can motivate learners by bringing fun to classes Games...

Ngày tải lên: 29/01/2014, 14:36

... growth monitoring Multi-sectoral platform: Linking health efforts to those of other sectors in order to address determinants of ill health and sustain improvements in health The multi-sectoral platform ... women come together in a Care Group every two weeks to learn life-saving health messages from a health educator Each woman is then responsible to teach the health lessons they learn to 10–15 of ... Participatory research methods and community-based monitoring and evaluation efforts are important tools for communities to learn about and assume responsibility for these behaviors Ibid Community Approaches...

Ngày tải lên: 12/02/2014, 12:20

... flat rate If a town and county both impose a license tax, a company located in a town within such a county pays the tax only to the town unless the governing body of the town votes to permit the ... amended during the 2009 General Assembly session to allow manufacturing companies to elect to use a single factor apportionment based on sales to determine their Virginia taxable income This modification ... three-factor formula Under this formula, the sales factor is weighted 50 percent and the 2011-12 Virginia Guide to Establishing a Business State & Local Taxes payroll and property factors are...

Ngày tải lên: 18/02/2014, 00:20

... flat rate If a town and county both impose a license tax, a company located in a town within such a county pays the tax only to the town unless the governing body of the town votes to permit the ... amended during the 2009 General Assembly session to allow manufacturing companies to elect to use a single factor apportionment based on sales to determine their Virginia taxable income This modification ... three-factor formula Under this formula, the sales factor is weighted 50 percent and the 2011-12 Virginia Guide to Establishing a Business State & Local Taxes payroll and property factors are...

Ngày tải lên: 18/02/2014, 00:20

... common to organic synthesis but not yet amenable to protein modification As new methodologies emerge, the study of other PTMs and that of regulatory PTMs will hopefully provide a powerful tool for ... pastoris Nat Biotechnol 24, 210–215 Choi B-K, Bobrowicz P, Davidson RC, Hamilton SR, Kung DH, Li H, Miele RG, Nett JH, Wildt S & Gerngross TU (2003) Use of combinatorial genetic libraries to ... specific glycosylation of proteins Tetrahedron Lett 32, 6793–6796 38 Ito Y, Hagihara S, Matsuo I & Totani K (2005) Structural approaches to the study of oligosaccharides in glycoprotein quality control...

Ngày tải lên: 18/02/2014, 17:20

... required DBMS-X to be running in order to adjust them, it was unfortunately easy to lock ourselves out with no failsafe mode to restore to a previous state Vertica was relatively easy to install as ... required us to (1) write to a custom tuple object using Hadoop’s API, (2) modify our data loader program to transform records to compressed and serialized custom tuples, and (3) refactor each benchmark ... are two ways to load data into Hadoop’s distributed file system: (1) use Hadoop’s command-line file utility to upload files stored on the local filesystem into HDFS or (2) create a custom data loader...

Ngày tải lên: 19/02/2014, 12:20

... long day), we want to be able both to understand what makes proteins ÔtickÕ and to engineer proteins with native-like properties In this review we discuss combinatorial approaches toward understanding ... function can be tied to the survival of a cell or some easy -to- observe phenotypic property Ultimately, one would like to be able to study proteins whose There is no straightforward way to identify a ... sequence resemblance to each other or to proteins known in nature [69] However, these proteins were not sufficiently soluble to be examined in vitro except as fusions to maltose binding protein...

Ngày tải lên: 19/02/2014, 12:20

... subtype, thanks to the large amount of the receptor obtained from the electric organ of the Torpedo marmorata ray and availability of selective pharmacological tools like the snake a-neurotoxins The ... determinants have been mapped and a-conotoxins appear to bind mainly to loop C, but also clearly extend to microsites above this loop and on the b9b10 hairpin Indeed, a-conotoxins act at the competitive ... acetylcholine and nicotine BMC Struct Biol 2, 27 Dutton, J.L & Craik, D.J (2001) a-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads Curr Medical...

Ngày tải lên: 19/02/2014, 12:20

... territory Civil registration is an official record of a person’s existence, including the right to a name, the right to be registered at birth, the right to belong to a family, the right to nationality, ... Georgetown University, Washington DC Amy Liu, Deputy Director, Metropolitan Policy, Brookings, Asset-based Approaches to Katrina Disaster and Reconstruction 34 Lilianne Fan, Advocacy Coordinator, ... paper provides a brief introduction to asset-based approaches to poverty reduction in a globalized context The aim is to show the added value of asset-based approaches, in terms of both better...

Ngày tải lên: 21/02/2014, 00:21

... exclusively in rubber Exports from Laos to China are expected to increase mainly due to rubber, with both countries seeking to increase trade profits to at least $1 billion USD over the next ... area have to sell their yields to the Thien Loui Ye Company Ltd Therefore, the farmers are deprived of a significant alternative to contract farming Altogether, the instructions attached to the ... people thereby reducing their autonomy, whereas an actororiented approach places the social actors and their agency first (2001: 11) It attempts to analyze the social processes in which heterogeneity...

Ngày tải lên: 21/02/2014, 04:20

... monitoring of progress towards MDG target C: C: to halve, by 2015, results the global monitoring of progress towards MDG 7 target to halve, by 2015, results of the global monitoring of progress towards ... Ghana) or lack indicators to assess performance of the instruments (China) This lack of monitoring tools to assess the performance of indicators will continue to impact the ability to measure progress ... APPLICATION OF INTEGRATED APPROACHES TO WATER RESOURCES MANAGEMENT This chapter reports the extent to which countries have been able to apply tools and methods, often referred to as “management instruments”...

Ngày tải lên: 21/02/2014, 12:20

... transfer A Review of Approaches to Mobility Telemonitoring Telemonitoring data logging systems allow the person to be monitored regardless of their location and allow complex analysis to be performed ... have the capability to transfer their data, for long- term storage and analysis, to a remote monitoring center Data can be transmitted directly from the wearable to the monitoring center using ... required to remember to don the wearable unit for their mobility to be measured (Table 5) Though, it gives the possibility to the person to doff the wearable for a while and still be monitored by...

Ngày tải lên: 05/03/2014, 21:20

... RAND undertook a five-year progress assessment of the CERI effort that had three purposes: to provide feedback to sites to improve their efforts, to provide information to the foundation to inform ... and probes unique to that collaborative was appended to the common protocol to ensure that we covered site-specific issues In addition to the protocols, we had a list specific to each of the documents ... of these (Miami, Puerto Rico, and Santa Ana) were former UPP collaboratives that reorganized to apply for these funds The funds were to be used to develop collaboratives to unite the CBOs, schools,...

Ngày tải lên: 06/03/2014, 01:22

... curves to putative solutions of the equations Fn = y p and Ln = y p with even index n to Frey curves and apply level-lowering This, together with some elementary arguments, is used to reduce to the ... for variables, of solutions to exponential Diophantine equations (III) To show how local information obtained through the modular approach can be pieced together to provide a proof that there ... following: (I) To present theoretical improvements to various aspects of the classical approach (II) To show how local information obtained through the modular approach can be used to reduce the...

Ngày tải lên: 06/03/2014, 08:21

... “not for tomorrow – but for today” to promote and revive traditional roles, cultural values and to work with the Elders in rejuvenating the traditional approaches to healing, as well as to provide ... heidibartjohnston@gmail.com 10 SOCIAL DETERMINANTS APPROACHES TO PUBLIC HEALTH: from concept to practice Abstract Every year, globally, an estimated 66 500 women die attempting to terminate a pregnancy To ... doctors, FWVs and a few private doctors (Akhter, 1988) American medical consultants came to Bangladesh to train providers in the use of manual vacuum aspiration, and doctors were also sent to...

Ngày tải lên: 07/03/2014, 04:20

... Symptoms of local spread Into nasal cavity: Unilateral epistaxis Into orbit: Ocular dysfunction, proptosis, diplopia Into oral cavity: Pain/loosening of upper teeth; “dentures don’t fit” Into ... usually asymptomatic Most common in frontal and ethmoid Rare in maxilla! 2:1 male -to- female ratio Complications: Extension into nose: nasal obstruction/swelling Extension into orbit: proptosis External ... patient: Mr R Common signs/symptoms of sinus disease Radiological Menu of Tests Normal anatomy Differential diagnosis Radiological findings Companion cases Putting it all together: Mr R Nir Harish,...

Ngày tải lên: 07/03/2014, 13:20