states oxidative stress and cellular damage
Tài liệu Báo cáo khoa học: Intralysosomal iron chelation protects against oxidative stress-induced cellular damage doc
Ngày tải lên :
19/02/2014, 06:20
... against oxidative stress- induced mitochondrial and cellular damage when present in low concentrations during the oxidative stress period [15,33] sih was rst synthesized in 1953 [34] and its iron ... following oxidative stress Cells were seeded (500 000 well) and 24 h later exposed to oxidative stress, with or without sih-protection as described before Directly after end of the oxidative stress ... further 15 before being exposed to oxidative stress After the oxidative stress period cells were returned to standard culture conditions for 15 and then scraped and assayed by ow cytouorometry The...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
Ngày tải lên :
12/02/2014, 16:20
... Relationship Between Thyroid States, Oxidative Stress and Cellular Damage 413 Cano-Europa, Blas-Valdivia Vanessa, Franco-Colin Margarita and Ortiz-Butron Rocio Chapter 19 Oxidative Stress in Human Autoimmune ... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition metals, some herbicides and...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
Ngày tải lên :
06/03/2014, 19:20
... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis ... insights into the roles and mechanisms of PM2.5-associated physiology and pathology In summary, our data demonstrate the important effects of PM2.5 exposure on oxidative stress and mitochondrial alterations...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
Ngày tải lên :
22/03/2014, 16:20
... overexpression of CYP2E1 both in vivo and in vitro is associated with several cellular markers of oxidative stress, including products of lipid peroxidation (e.g 4-hydroxynonenal and malondialdehyde), as ... dilation and contractile dysfunction, as well as myocyte disarray, interstitial fibrosis, ultrastructural degeneration with myofibrillar disorganization and mitochondria damage) (Figs and and Table ... cardiac oxidative stress, myocyte apoptosis and the DCM phenotype Materials and methods * Animals WT CYP2E1 cTnTR141W Fig Determination of the levels of cytochrome c release, cleaved caspases and...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
Ngày tải lên :
23/03/2014, 07:20
... exposed to oxidative stress (2.5 mm and mm HA) with PARP inhibition and allowed to develop, the spores showed faster germination (32 h and 60 h) as compared to cells exposed to oxidative stress alone ... 20 Oxidative stress induces PARP activation PARP activity in D discoideum was assayed at various time points (5, 10, 20 and 60 and h) after HA stress PARP activity was increased initially, and ... oxidative stress (Fig 4A,B) Under oxidative stress, partial inhibition of PARP activity led to altered growth, suggesting that oxidative stress could be leading to cell cycle arrest [22] and that...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
Ngày tải lên :
29/03/2014, 09:20
... protein in Scrambleand ANT1 and ANT2 siRNA-transfected cells; the 33 kDa band corresponds to ANT proteins, the 43 kDa band corresponds to actin (E) Western blot analysis of FLAGANT1 and FLAG-ANT2 ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... survival, thus indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
Ngày tải lên :
30/03/2014, 10:20
... hyperthermal stress on antioxidant induction and on apoptotic markers (caspase-like activation and ⁄ or DNA degradation) in order to demonstrate the concomitant involvement of oxidative stress and apoptosis ... 6B) Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A viridis The occurrence of oxidative stress in the animal tissue (ectoderm and gastroderm) and freshly isolated ... of oxidative FEBS Journal 273 (2006) 4186–4198 ª 2006 The Authors Journal compilation ª 2006 FEBS 4193 Apoptosis and oxidative stress in bleaching S Richier et al stress in the animal host and...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
Ngày tải lên :
18/06/2014, 19:20
... ADMSC Transplantation Attenuates Inflammatory Response, Suppresses Oxidative Stress, and Limits Cellular Apoptosis and Architectural Damage in Kidney Following Acute IR Injury–Impact of Immune Modulation ... and oxidative markers in kidney after ischemia-reperfusion (IR) A) Remarkably higher expression of intercellular adhesion molecule (ICAM)-1 in IR group than in control and IR + ADMSC group, and ... another anti -oxidative biomarker, was remarkably lower in group than in groups and 3, and significantly lower in group than in group at 24 h and 72 h after IR injury On the other hand, this protein...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
Ngày tải lên :
20/06/2014, 00:20
... variation in oxidative stress markers in healthy and type II diabetic men Chronobiol Int 2002, 19:423-439 68 Hardeland R, Coto-Montes A, Poeggeler B: Circadian rhythms, oxidative stress and antioxidative ... against oxidative stress [7] was verified by testing the correlation between levels of 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a defense against oxidative stress) ... 121:2331-2378 Halliwell B, Gutteridge JMC: Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death In Free Radicals in Biology and Medicine edition Edited by: Halliwell...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
Ngày tải lên :
07/08/2014, 23:22
... of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water [11,29] GSH-Pxs catalyze the peroxides and reduce the glutathione to form oxidized glutathione and water [30] A significant ... GST catalyzes the conjugation of the reduced glutathione to electrophiles and protects cellular components from oxidative damage [16] Increased activity of GST was reported in Drosophila melanogaster ... Press, New York, 1983 Andreyev AY, Kushnareva YE, Starkov AA Mitochondrial metabolism of reactive oxygen species Biochemistry (Mosc) 2005, 70, 200-214 Athar M Oxidative stress and experimental carcinogenesis...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" potx
Ngày tải lên :
12/08/2014, 15:21
... 0.01, and §p < 0.001 compared with control group L = Live; A = Apoptosis; N = Necrosis References Kode A, Yang SR, Rahman I: Differential effects of cigarette smoke on oxidative stress and proinflammatory ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results ... cells underwent morphological changes in response to CSE and lost their characteristic spindle-shaped morphology as is evident from figs c and d SAEC were shown to be more sensitive to CSE compared...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" pps
Ngày tải lên :
12/08/2014, 16:20
... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... of free iron These agents induce an oxidative burden by disturbing the oxidant:antioxidant balance and could lead to cellular damage in the lungs Oxidative stress caused by cigarette smoking can ... in airways and alveolar epithelium of smokers and COPD subjects [38] Glutathione (GSH) is a major intra- and extracellular antioxidant in the lung We studied the effect of CSE on intracellular...
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Báo cáo y học: "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis" pot
Ngày tải lên :
12/08/2014, 17:22
... reduction in oxidative stress is affected Previous studies have demonstrated positive effects of anti-TNF-a treatment on oxidative damage in RA, where urinary levels of oxidative DNA damage and lipid ... between oxidative stress, inflammation and angiogenesis, where increase in tpO2 and reduce oxidative stress observed in responders is associated with lower microscopic scores of T-cells (CD4 and ... treatment and we found significant positive association between synovial 4-HNE expression and clinical measures of arthritis Several cellular and environmental sources of synovial oxidative stress...
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Hypersensitivity to cell death under glucose starvation involves oxidative stress and AMPK instability
Ngày tải lên :
22/10/2015, 21:19
... two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, ... intracellular stress conditions, such as oxidative stress, DNA damage, excessive cytosolic Ca2+, endoplasmic reticulum (ER) stress, growth factor starvation, etc (Galluzzi et al., 2012; Long and...
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Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt
Ngày tải lên :
23/03/2014, 15:21
... the oxidative modifications within the tubulin molecule, and to elucidate the role of these modifications in the functional damage to tubulin Interestingly, for the two modes of oxidative stress ... the intracellular proteins on oxidative stress induced by PDT of the cells A tyrosine analogue, tyramine, coupled covalently to fluorescein (Tyr-Fluo), was used as a probe to label the cellular ... Labeling of cytoskeletal proteins (a-tubulin and b-tubulin, and slight labeling of actin) suggests that the cytoplasmic compartment is exposed to the oxidative stress generated by PDT with Hypocrellin...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... excitotoxicity leading to neuronal damage in anoxia The increased concentration of TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible ... conditions and were given normal diet for days and decapitated and the different brain regions (CC, CB and BS) were used for study It was reported by Ananth et al (23) that days showed most severe damage ... direct and secondary excitotoxic neuronal injuries in vivo Excitotoxicity, oxidative stress and apoptosis comprise major routs of hypoxic-ischemic neuronal death Each route is likely activated and...
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Tài liệu OXIDATIVE STRESS – MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS doc
Ngày tải lên :
12/02/2014, 16:20
... and Volodymyr I Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and Oxidative ... glycoxidation and carbonyl /oxidative stress 30 Oxidative Stress Molecular Mechanisms and Biological Effects The existence of a strong relation between carbonyl and oxidative stresses can be ... oxidative stress, it can be proposed that carbonyl stress is an acute or chronic increase in steady-state level of RCS, ALEs and AGEs disturbing cellular metabolism and leading to damage of cellular...
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Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
Ngày tải lên :
19/02/2014, 06:20
... the other hand, nutritional or conditional zinc deficiency will increase cellular damage by aldehydes Zinc deficiency elicits oxidative stress [55], thus increasing lipid peroxidation and aldehyde ... toxicologic and pathobiochemical mechanisms Acrolein Concentrations of cellular aldehydes increase during environmental and nutritional exposures, as well as in various diseases with oxidative stress ... Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells Free Radic Biol Med 28, 1091–1099 Vasak M (1991) Metal removal and substitution in vertebrate and invertebrate metallothioneins...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
Ngày tải lên :
06/03/2014, 00:21
... upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress ... lM) or vitamin C (1 mM), and then incubated for h in the presence or absence of ATZ (20 mM) and mercaptosuccinic acid (7 mM) Cell were collected and lysed, and both firefly and Renilla luciferase ... showing that transient oxidative stress for or h did not induce apoptosis [38] In conclusion, ERK activation resulting from sustained oxidative stress increased the amounts of total and phosphorylated...
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