standards for clinical trials in dupuytren s surgical outcome
Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx
Ngày tải lên :
12/08/2014, 15:22
... cells and T cells is an essential step in T-cell-dependent immune responses, including autoimmune responses Salivary gland epithelial cells in pSS have been shown to express HLA class II and co-stimulatory ... antibodies in pSS Surprisingly, instead of targeting this proinflammatory cytokine, IFNα itself has been used as a therapeutic agent in pSS Shiozawa and colleagues found an increase in saliva production ... trials in systemic lupus erythematosus and dermatomyositis/polymyositis are underway There are strong arguments, as discussed above, to design clinical trials with these monoclonal antibodies...
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Establishment of Effluent Standards for Industrial Wastewaters in Korea: Current Issues and Suggestions for Future Plan
Ngày tải lên :
05/09/2013, 10:15
... possible In this study, the approach in setting the effluent standards with a limited data set obtained so far according to the kind of pollutants and industries was investigated This paper focused ... toxic pollutants to be controlled Because new pollutants in Korea are assessed and selectively included into e ffluent standards by framework for classifying toxic substances in water environment ... current state of effluent standards in Korea and the considerations to be used in revising effluent standards and the framework referring to the cases of developed countries The purpose of this study...
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Tài liệu Clinical trials in gynecological cancer ppt
Ngày tải lên :
13/02/2014, 07:20
... results of clinical trials but does not publish explicit guidelines Outcomes from clinical trials are routinely used in the development of gynecological cancer guidelines, such as those issued ... process The recent EU directive on clinical trials requires that all clinical trials have a legal sponsor This has created particular problems in running international trials, as academic sponsors ... possible benefits for relapsed disease, these trials could provide valuable information for first-line therapy Infrastructure for clinical trials In the remainder of the article, we have set forward our...
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Tài liệu STANDARDS FOR HEALTH PROMOTION IN HOSPITALS doc
Ngày tải lên :
14/02/2014, 13:20
... of standards The standards presented in this document are the result of series of workshops and consultations They have been piloted in 36 hospitals in nine European countries and were assessed ... assessment of health promotion in hospitals measurable elements and indicators are being defined and a tool for selfassessment is being developed It is not the aim of WHO to externally assess ... hospital This is kept under review and adjusted as necessary according to changes in the patient 's clinical condition or on request 2.4 The patients' needs assessment ensures awareness of and sensitivity...
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Access to unapproved therapeutic goods Clinical trials in Australia pdf
Ngày tải lên :
07/03/2014, 08:20
... person s use of devices of those kinds for these purposes; (c) the monitoring of another person s use, and the results of that use, of devices of those kinds for those purposes; (d) the circumstances ... Reporting of adverse reactions during a clinical trial of medicines 69 Definitions Reporting of adverse reactions occurring in clinical trials Clinical trial event reporting algorithm for sponsors ... trials in Australia October 2004 Page 10 of 104 Therapeutic Goods Administration Classification of Clinical Trials Clinical Trials of Medicines Clinical trials of medicines are generally classified...
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Báo cáo "Sensory Properties and Consumer''''s Preference for Fondue Cheeses in Hanoi''''s Market " pdf
Ngày tải lên :
20/03/2014, 19:20
... intensity), Taste (sweetness, sourness, bitterness, saltiness), Mouth-feel (Firmness, solubility, fineness, stickiness, elastic, variety of aroma, fatness), Aftertaste (sweet, sour, bitter, salty) ... Butter odor Stickiness President Bo deo no Lactic odor Fineness Overall odor intensity Solubility Elastic Sweetness Firmness Sourness Saltiness Bitterness Figure Conventional Profile scores of fondue ... served for each assessor for tasting at x x cm sized in covered glass containers at 20°C Methods Descriptive analysis This test aimed at pointing out the essential vocabulary needed for cheese...
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WHO Regional Office for Europe and BZgA Standards for Sexuality Education in Europe pot
Ngày tải lên :
28/03/2014, 20:20
... responsible, safe and satisfactory ways, instead of focussing primarily on individual issues or threats This holistic view, in which “sexuality” is defined in much broader terms, not necessarily focussing ... starts at birth Babies focus entirely on their senses: touching, listening, looking, tasting and smelling Through their senses, babies can experience a cosy, safe feeling Cuddling and caressing ... useful starting points for discussing sexuality education Thus in this document the term “sexual health” is used, but this includes the meaning and notion of ”sexual well-being” Sexual health is not...
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Báo cáo y học: "Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports" ppt
Ngày tải lên :
09/08/2014, 10:23
... are trials lasting to 12 weeks; red symbols are trials of longer duration GI, gastrointestinal; NSAID, nonsteroidal anti-inflammatory drug analyses of trials lasting to 12 weeks Gastrointestinal ... [16] in arthritis, for efficacy outcomes in acute pain [31,32] and for adverse events for contraceptives [33] In this case it was possible to examine discontinuation rates and causes in some ... being a useful measure, perhaps as much or more so in clinical practice as in clinical trials, although discontinuations have been mentioned previously in clinical trials in rheumatology, as with...
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Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''s Disease" doc
Ngày tải lên :
11/08/2014, 08:20
... Clin 1999, 15(1):87-96, vii Gudmundsson KG, Arngrimsson R, Sigfusson N, Bjornsson A, Jonsson T: Epidemiology of Dupuytren' s disease: clinical, serological, and social assessment The Reykjavik Study ... as APC may be altering the sensitivity of DD cells to Wnt signalling We are presently assessing the activity of GSK-3β in DD to determine if upstream signalling molecules are regulating kinase ... finding being down-regulated Wnt 11 mRNA expression in disease tissue As Wnt11 signalling is independent of β-catenin and no other Wnt family members display consistent alteration in expression,...
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Báo cáo khoa học: "Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials" pot
Ngày tải lên :
12/08/2014, 20:20
... when evaluating the performance of scoring systems [14] Discrimination measures the predictive performance of scoring systems, and when the outcome is dichotomous it is usually described by a ... Hosmer-Lemeshow goodness of fit test values: hours Score Mortality probability classes (%) Expected deaths Observed deaths Observed survivors Expected survivors χ2 goodnessof-fit test values PIM hours ... systems are used to compare or control for severity of illness in clinical trials and have been integrated into guidelines [6] The question is, what kind of scoring system we need if we are to include...
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Báo cáo khoa học: " Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature" pptx
Ngày tải lên :
13/08/2014, 03:21
... pressure (MAP) goals in sepsis trials (b) Central venous pressure (CVP) goals in sepsis trials trials (c) Pulmonary artery occlusion pressure (PAOP) goals in sepsis trials (d) Cardiac index in sepsis ... pressure goal in the majority of studies suggests heterogeneity in thought as regards filling pressure targets in patients with sepsis Similar heterogeneity is seen in the cardiac index goals in ... narrowed cardiac index range (data not shown) Discussion The present systematic review of hemodynamic goals in sepsis clinical trials has two major findings First, of the 126 clinical studies that were...
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Báo cáo y học: "Protein C as a surrogate end-point for clinical trials of sepsis" docx
Ngày tải lên :
13/08/2014, 10:20
... possible to tailor the infusion to normalize protein C levels by 96 hours Indeed, the RESPOND (Research Evaluating Serial PC Levels in Severe Sepsis Patients on DrotAA) study [8] is examining ... Freedman LS, Graubard BI, Schatzkin A: Statistical validation of intermediate endpoints for chronic diseases Stat Med 1992, 11:167-178 Vasan RS: Biomarkers of cardiovascular disease: molecular basis ... and analysis presented in the report by Shorr and colleagues [1], what is the potential value of protein C as a surrogate end-point for treatment trials using DrotAA? The authors propose several...
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Another epistemic culture reconstructing knowledge diffusion for rural development in vietnam’s mekong delta
Ngày tải lên :
19/11/2015, 13:59
... learning for social systems themselves as well as inter-learning among social systems with their differences I am indeed arguing for societies where knowledge processes are institutionalised for ... preliminary findings have suggested that four main systems should be included in our knowledge diffusion analysis: the agricultural extension system, the research system, the agribusiness system, ... interactionism A systems thinking approach allows for the scrutiny of actors within their social structures, which are amalgamated to shape this research s system of system analysis Previous research...
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báo cáo hóa học: " Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorder" doc
Ngày tải lên :
18/06/2014, 19:20
... expensive test-administration kits and at least 30 minutes for administration In contrast, the Mini-Mental State Examination (MMSE) [13], a staple in the assessment of cognitive deficits associated ... episodes, Feasibility The relatively brief training session for the SCIP administration resulted in a mean kappa index of agreement in The SPSS version 12.0 statistical software was used with significance ... Supplemental tests will be required in situations where these skills are a priority However, we are also investigating supplemental scoring strategies, including errors of intrusion and perseverations on...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
Ngày tải lên :
18/06/2014, 22:20
... objectives: 1) assessment of the responsiveness to treatment of selected RDQ scales; 2) assessment of the concordance between RDQand physician-generated ratings of disease severity; and 3) assessment ... RDQ is amenable to translation into Norwegian and Swedish, and that it represents a viable instrument for assessing symptom severity and response to treatment in clinical trials of patients with ... the results of the current investigation provide strong evidence that the RDQ represents a viable instrument for assessing symptom severity, subject selection and response to treatment in clinical...
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The use of hypothesis-testing statistics in clinical trials
Ngày tải lên :
01/11/2013, 11:20
... methods instead in looking at clinical subgroups in RCTs Power analysis Most authors focus on the false positive risks of subgroup analyses But important false negative risks also exist This brings ... perhaps most directly, statisticians and clinicians have opposite goals A statistician wants to get results that are as valid as possible and as far removed from chance as possible This requires isolating ... kinds of errors, the clinical trial needs to establish a single, primary outcome By essentially putting all its eggs in one basket, the trial is stating that the p-value for that single analysis...
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Tài liệu A Women’s Health Intervention for Gynecological Problems in the Deployed Environment ppt
Ngày tải lên :
13/02/2014, 07:20
... urination) Vaginal symptoms: Itching, burning, pain, & discharge Menstrual complaints: Pain, heavy bleeding, missed or irregular periods, PMS Women in Bureau of Medicine Operational Obstetrics ... measures to avoid vaginal infections, urinary tract i f i infections, (UTIs) and menstrual symptoms are not (UTI ) d l routinely taught to women as part of the Soldier Readiness Process Process Women ... to avoid vaginitis, UTIs, and menstrual symptoms during deployment This study has potential of significantly contributing to improving female Soldiers’ readiness and filling a gap in military...
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Tài liệu A junk-free childhood 2012 - The 2012 report of the StanMark project on standards for marketing food and beverages to children in Europe pptx
Ngày tải lên :
18/02/2014, 21:20
... Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes37 Yes Yes Yes Yes Yes Yes Yes Yes No Yes No No No No Yes No Yes Yes43 No No Yes No Yes No No No No Yes No Yes No No No Yes No Yes Yes No Yes No Yes ... Danone ESA36 Ferrero General Mills Kellogg s Kraft Foods Mars McDonald s Nestlé PepsiCo Pepsi beverages Unilever Yes Yes Yes Yes Yes37 Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes37 Yes Yes ... accountable For sponsorship media this includes sports event hosts For promotional techniques embodied in a food product this includes importers, retailers and caterers Cross-border marketing standards...
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SURVEY OF CURRENT GUIDANCE FOR CHILD HEALTH CLINICAL TRIALS pot
Ngày tải lên :
05/03/2014, 10:20
... children, some addressed general aspects of clinical trials in children and the others described various issues in specific domains of the design or conduct of pediatric clinical trials, such as study ... the informed consent procedure of pediatric clinical trials complicated The informed consent procedure was addressed in 16 guidelines Informed consent for the inclusion in clinical trials must be ... benefit/risk balance The interest of the study subject should prevail over those of science and society Risk assessment A careful risk assessment is required, taking into account aspects such as the...
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