spla 2 degradation of drug delivery liposomes a new drug delivery principle

... Laboratory, Sandia National Laboratories, Los Alamos National Laboratory, National Renewable Energy Laboratory, Argonne National Laboratory, Oak Ridge National Laboratory, and the Department of ... Project Assistant ANA-MARIA IGNAT, Project Assistant SHANNA LIBERMAN, Project Assistant NAE = National Academy of Engineering viii Acknowledgments The committee wishes to thank all of the members of ... Princeton, New Jersey Staff JAMES ZUCCHETTO, Director RICHARD CAMPBELL, Program Officer ALAN CRANE, Program Officer MARTIN OFFUTT, Program Officer SUSANNA CLARENDON, Financial Associate PANOLA GOLSON,...

Ngày tải lên: 06/03/2014, 15:20

... and a semantic role of a head word All definition sentences in RSK were analyzed by JUMAN, a Japanese morphological analyzer, and KNP, a Japanese syntactic and case analyzer (Kurohashi and Nagao, ... the case analysis 4 .2 Algorithm Given an input phrase N1 no N2, b o t h D B A and SBA are applied to the input, and then the two analyses are integrated 4 .2. 1 Dictionary-based Analysis Dictionary ... the parsing system In Proceedings of the First International Conference on Language Resources ~ Evaluation, pages 719 724 Sadao Kurohashi, Masaki Murata, Yasunori Yata, Mitsunobu Shimada, and Makoto...

Ngày tải lên: 08/03/2014, 06:20

... b-amyrin synthase [6], was prepared by PCR using GgbAS1 as a template, Taq DNA polymerase (Takara Shuzo, Kyoto, Japan), the primers 50 -GAAGCATA TCCACTATGAAGATGA-30 and 50 -TGAATACTCCCGTG ATTTCCTGTTG-30 ... PSX), AB 025 344 (Olea OEX), AB009 029 (Panax PNX), U 025 55 (Arabidopsis CAS1), AB033334 (Luffa LcCAS1) and AB 025 353 (Allium AMX) bAS, b-amyrin synthase; CAS, cycloartenol synthase; LUS, lupeol synthase; ... at 72 8C) with Pfu DNA polymerase (Stratagene) used as the DNA polymerase Two primers of 50 -CTGGTACCGATTGAGTTGAGGTG ATTG-30 (Kpn I site underlined) and 50 -CCTCTAGAGTA AAAGTCTCCAATC-30 (Xba I...

Ngày tải lên: 08/03/2014, 23:20

... C-PAM + AKD after machine screen 40sec Drainage 60sec Agitator setting High shear Medium shear Low shear A- PAM after machine screen (*) Tested at Mütec DFS retention analyzer Result of laboratory ... (C-PAM +A- PAM) 0.030 35 30 25 20 15 10 0.000 Simulation of new chemical mixing points Simulation of conventional chemical mixing points 0.010 0. 020 Dosing rate of retention aids [%] (C-PAM +A- PAM) ... Chord for CPAM and AKD Ü Installation in October, 20 08 Conclusion of installation in PM7 for CPAM & AKD ÜResults: PM7, additive savings after flash injection installed also for CPAM and AKD Filler...

Ngày tải lên: 24/03/2014, 05:20

... 4.1 Calibration We calibrate the system of steady-state equations to match key features of annual euro area data, taking, in particular, recent demographic observations until 20 08 as a benchmark, ... lack of scal consolidation Scenario VI relaxes the assumption that the steady-state debt ratio can be stabilized at the benchmark value of Instead we assume a higher value of = The additional ... Working age(15-64) population growth rate (Euro Area), percent UN European Commission -1 1990 20 00 20 10 20 20 20 30 20 40 20 50 Life Expectancy (Euro Area), years 85 80 75 70 20 00 20 10 20 20 20 30 20 40 20 50...

Ngày tải lên: 29/03/2014, 13:20

... Clinton; Newt Gingrich, the new House Speaker; and Bob Dole, the new Senate majority leader, jointly put forward a $40 billion package of loan guarantees for congressional approval As dramatic as that ... of financial crises that began with the collapse of the Thai baht and Malaysian ringgit in the summer of 1997 and grew into a threat to the world economy Almost immediately, Thailand and Malaysia ... was born What set it off was the initial public offering of Netscape, a tiny two-year-old software maker in Silicon Valley that had al- most no revenues and not a penny of profits Netscape was...

Ngày tải lên: 09/08/2014, 19:22

... effect of Fabian socialism that many argued would make market economies politically palatable and keep communism from spreading Fabians took part in founding Britain's Labour Party They also had a ... wealth and lack of stress, appears to rest on its history and the culture it has spawned By culture, I mean the shared values of members of a society that are inculcated at an early age and that ... Japanese banks became heavily invested in loans backed by real estate as collateral, as real estate prices soared When the turn came and prices cascaded downward, the collateral became inadequate But...

Ngày tải lên: 09/08/2014, 19:22

... virtues of markets a decade earlier, accelerated its march toward free-market capitalism without, of course, ever acknowledging that that was what it was doing India began to awaken from the bureaucratic ... equal to global savings—the net means of financing these investments Every asset must have an owner The market value of "paper" claims against newly created capital assets must equal the market ... earliest statistical analyses for t h e National Industrial Conference Board, m o r e than a half century ago, showed that American farmers, despite lower average incomes, saved a larger share of their...

Ngày tải lên: 09/08/2014, 19:22

... travel, 6, 7, 23 4, 421 deregulation of, 71- 72, 81- 82 airplanes, 42, 56, 397 Alaska, 4 52, 456, 457 Alcoa, 45, 49, 50, 77, 20 9, 428 , 493-94 Alfonsin, Raul, 3 42 Alibris, 25 7 al Qaeda, 22 6, 22 7 Altman, ... exuberance speech of, 176-77, 20 1 -2 as libertarian Republican, 20 8, 23 8, 496 math skills of, , , 28 - 32 media coverage of, 9, 115-16, 177, 180, 1 92, 197-98, 20 1, 20 7-8, 22 0 -22 , 24 0 as musician, 23 -28 , ... Qwest, 20 0 radio, 22 , 24 , 25 railroads, 71, 72, 139, 1 62, 196, 20 0, 355n, 444n timetables of, 22 -23 transcontinental, 27 5 Rand, Ayn, - , - , 97, 138, 26 5, 323 "random walk," 466 Rao, P V Narasimha,...

Ngày tải lên: 09/08/2014, 19:22

... e.b In ADC-7, BAB has some positional decanalization, and ABB is clearly positionally and numerically decanalized These observations are statistically proved by positional standard test a posteriori ... generation 44, because there are fewer individuals from class ; there is a slight increase of classes smaller than 2, and also of the classes higher than These modifications may perhaps be attributed ... selection was made for 44 generations in four isofemale lines originating in a natural population caught in Asturias (North of Spain) In each generation, the phenotypes of 60 males and 60 females were...

Ngày tải lên: 09/08/2014, 22:22

... Sonography and MR imaging of posterior tibial tendinopathy AJR Am J Roentgenol 20 02, 178 :22 3 -23 2 64 d'Agostino MA, Ayral X, Baron G, Ravaud P, Breban M, Dougados M: Impact of ultrasound imaging ... Musculoskeletal Alliance: Standards of Care for People with Inflammatory Arthritis London Arthritis and Musculoskeletal Alliance; 20 04 75 Podiatry Rheumatic Care Association: Standards of Care for ... metatarsophalangeal joints in rheumatoid arthritis: comparison with magnetic resonance imaging, conventional radiography, and clinical examination Arthritis Rheum 20 04, 50 :21 03 -21 12 Page 10 of 10 61 Grassi...

Ngày tải lên: 10/08/2014, 21:24

... (page number not for citation purposes) Journal of Inflammation 20 09, 6 :20 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane ... Shaffer A, Talley JJ, Masferrer JL, Seibert K, Isakson PC: Pharmacological analysis of cyclooxygenase-1 in inflammation Proc Natl Acad Sci USA 1998, 95:13313-13318 Futaki N, Takahashi S, Yokoyama ... isomerase that contains an amino-terminal domain, the tryptophan-tryptophan (WW) domain, which is characterized by two tryptophan residues separated by 22 amino acids that can bind to phosphorylated...

Ngày tải lên: 11/08/2014, 08:22

... with a UV detector at 23 2 nm The main pharmacokinetic parameters were calculated by DAS 1.0 (Anhui, China) program Bioavailability (BA) is a measurement of the rate and extent of a therapeutically ... 20 09): ((AUC ) × Dose ) × 100% ((AUC ) × Dose ) A BA R = B B A where AUC is the area under the curve Statistical analysis All data are presented as a mean value with its standard deviation indicated ... consists of intravenously administered drug, this is known as relative bioavailability (BAR) The BAR of PA/EPI after administration was calculated using the following formula (Sonaje et al., 20 09):...

Ngày tải lên: 23/04/2013, 21:38

... AATCACCA-3Â; reverse primer, 5Â-AGAGGAGAGTTAG AGCCTTACAAGAAGGGTCCAAAGA-3Â) The PCR product was puried, treated with T4 exonuclease to create vector-compatible overhangs and annealed to a prepared ... al Degradation of a- and b-chitin The degradation rates of a- and b-chitin were assayed with LlChi1 8A in the presence or absence of LlCBP3 3A As both chitin variants, and especially a- chitin, are ... Vaaje-Kolstad et al containing 100 lm of (GlcNAc)14 was analysed at the start, in the middle and at the end of each series of samples The resulting average values of the standards (displaying standard...

Ngày tải lên: 18/02/2014, 08:20

... (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL Nucleic Acids Res 26 , 3 62 367 47 Takahashi S, Takahashi Y, Ito K, Nagano T, Shibahara S & Miura T (1999) Positive and negative ... expression of heme oxygenase -2 20 21 22 23 24 25 26 27 28 29 30 31 Y Zhang et al explants and immortalized trophoblast cells Am J Physiol Heart Circ Physiol 28 4, H853–H858 Poss KD, Thomas MJ, Ebralidze ... 11 62 1168 Nakayama M, Takahashi K, Kitamuro T, Yasumoto K, Katayose D, Shirato K, Fujii-Kuriyama Y & Shibahara S (20 00) Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells Biochem...

Ngày tải lên: 19/02/2014, 06:20

... whether a small amount of a- L-1,3-arabinofuranosidase was responsible for the disappearance of Fig HPAEC analysis of the hydrolysis of arabinogalactans by GALA Three different arabinogalactans were ... in Materials and methods Purification and characterization of GALA Hydrolysis of arabinogalactans To obtain an A niger transformant that produces increased levels of b-1,4-endogalactanase, a construct ... D-galactose and D-galacto-oligosaccharides The calculated areas for D-galactose and D-galacto-oligosaccharides were expressed as percentages of the area of mM D-galactose A niger b-1,4-endogalactanase...

Ngày tải lên: 21/02/2014, 01:21

... 1 42, 122 3– 123 3 1187 Arylsulfatase A degradation 21 Molinari M, Galli C, Piccaluga V, Pieren M & Paganetti P (20 02) Sequential assistance of molecular chaperones and transient formation of covalent ... by a further maturation of epitopes A2 and A5 After 25 of chase, precipitation with mAbs A2 and A5 is almost as efficient as with mAb B1 The location of epitopes suggests that folding of ASA starts ... experiments are unrelated to ASA and A5 , and amino acid residues 20 2 20 6 by mAb C, respectively For this reason the reduced reactivity of mAbs A2 and A5 with Gly86Asp and Arg84Gln substituted ASA and mAb...

Ngày tải lên: 07/03/2014, 17:20

... (pink arrow), Y241-D2 42 (red arrow), and M2 62- A2 63 (blue arrow) From the amino-acid sequence analysis, the cleavage at E 124 -G 125 was the most prominent Therefore, it appeared that HpU-9-L can access ... monomer In contrast, the intensity of the band (1) ( 52. 2 kDa) became stronger and two new bands (2; 39 .2 kDa) and (3; 38.3 kDa) appeared Bands and became darker, whereas the band of the a- subunit showed ... little change At h of incubation (lane 3), the band of the b-subunit became very faint Some new bands between bands and became clearer and several bands around bands and also became darker The band...

Ngày tải lên: 07/03/2014, 21:20

... of ASA heteromers A nine amino acid HA tag was added to the C-terminus of wtASA (wtASA-HA) or ASAs carrying various amino acid substitutions (D335V-ASA-HA, T274M-ASAHA, P136L-ASA-HA, G86D-ASA-HA ... 4 .2 ng of plasmid expressing wtASA was cotransfected with 4 .2 ng of plasmids expressing various inactive, misfolded ASAs (P377L-pdASA, D335V-ASA, T275M-ASA, P136LASA, G86D-ASA, T201C-ASA and D255H-ASA) ... vector that contains the hASA cDNA [26 ,27 ] using the primers: forward: 5¢-dAAAGAATTCAAGCGTAATCTGGAACA TCGTATGGGTAGGCATGGGGATCTGGGCAATG-3¢, reverse: 5¢-dTTTGAATTCCATGTCCATGGGGGCACC GCGGTC-3¢ The...

Ngày tải lên: 15/03/2014, 23:20

... mutagenesis: ELM13M14 (5¢-AAGTCCCAAAATATTATGGA TATGATGGCTCGATTTCTCGAG-3¢); ELE28 (5¢-ATG AAAGTTCAAGAGAAGATCAATCTC-3¢); ELM99 (5¢ATGAGGGGTGCTATGAAGATCAAGG-3¢); ATL100 (5¢-ATTAGGGGTGCGCTGAAGATCAAGG-3¢); ... polar residue His18 in A thaliana SCP -2 is replaced by Phe17 in E lagascae SCP -2, and the polar residue Glu 22 in E lagascae SCP -2 is replaced by Ala23 in A thaliana SCP -2 E lagascae SCP -2 also ... for E lagascae SCP -2 (SCPElNE, 5¢-ACTGGAA TTCAACTCAAGTCCCAAAATATTTTGGAT-3¢; SCPElCN, 5¢-TCATGGCGGCCGCTCACAGCTTCGACGGCTTGG GGAA-3¢) and E lagascae EF1 -a (ELEFF, 5¢-TATGGT GGTTGAGACTTTTGCAG-3¢;...

Ngày tải lên: 16/03/2014, 12:20