specific risk factors for alzheimer s disease

... and a specificity of 87% in a large MCI study population [15] Statistics Statistical analysis was performed using the PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., ... community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale (ADAS-cog 85 points), clock test, cube copying test and A Quick Test of ... laboratory assistant Marit Emilsson for assistance in the TIMP-1 analysis This study was supported by unconditional grants by the Swedish Research Council; Stiftelsen för Gamla Tjänarinnor; Skåne county...

Ngày tải lên: 22/03/2014, 14:20

... Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially in Alzheimer s disease patient s brain [47] ... Mesulam MM (1993) Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima ... Butyrylcholinesterase shares many structural and physicochemical properties with acetylcholinesterase [49] Therefore, butyrylcholinesterase was evaluated as a possible molecular chaperone for amyloid formation...

Ngày tải lên: 23/03/2014, 07:20

... University Scale for Psychopathology in Alzheimer s Disease, is brief and effective in assessing psychotic symptoms, but is not appropriate for assessing changes in severity of symptoms (Devanand, ... Americans now have Alzheimer s Disease (Alzheimer s Association, 2008), an increase of 25% since the previous version of this Guideline was published Alzheimer s Disease destroys brain cells, causing ... presentation or history of depression is atypical or complex (Lyketsos & Lee) Since administering assessment tests for depression to Alzheimer s Disease patients is often challenging (Warshaw,...

Ngày tải lên: 23/03/2014, 23:21

... expression of neurotrophic factors under many of the same conditions in which they show inflammationrelated responses such as phagocytosis, retraction of processes, release of excitotoxins, and ... by Aβ was at least partially responsible for AD-associated degeneration, others had pointed to microglial phagocytosis as a desirable consequence of activation For the purposes of discussion, the ... of progression – by nonsteroidal antiinflammatory drugs (NSAIDs); such correlations have now been born out in a prospective study [6] Perhaps most compelling, polymorphisms in the genes for proinflammatory...

Ngày tải lên: 19/06/2014, 22:20

... postmortem interval (hours) for AD cases was 2.59 ± 0.45 and for ND cases was 2.63 ± 0.62 (mean ± SD) Stimulation of sPLA2-IIA mRNA expression in astrocytes from human post-mortem brains Astrocytes ... was used for determination of levels of sPLA2-IIA mRNA in brain tissues Taqman primers and probes specific for human sPLA2-IIA and ribosomal 1 8S RNA were obtained from Applied Biosystems (Foster ... Tukey posthoc multiple comparison test was used to analyze data using the GraphPad Prism software Significant differences between groups were assumed for P values < 0.05 Results Expression of sPLA2-IIA...

Ngày tải lên: 19/06/2014, 22:20

... Alzheimer s disease: the challenge of the second century Sci Transl Med 2011, 3:77sr1 De Strooper B: Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process Physiol ... from each sample was used for first-strand cDNA synthesis using the Invitrogen SuperScript III reverse transcription system cDNA was amplified using quantitative real-time PCR with Assays-onDemand ... Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer s disease Brain Res 2001,...

Ngày tải lên: 19/06/2014, 22:20

... Haines JA: Genetic susceptibility to Alzheimer disease Trends Genet 1995, 11:504-508 23 Sisodia SS: Series Introduction: Alzheimer s disease: perspectives for the new millennium J Clin Invest 1999, ... polymorphisms; SPR: Surface plasmon resonance Authors Contributions JPD performed the FISH- based detection for chromosomal abnormalities and microfluidic chip- based detection for Alzheimer s Disease ... lysis and 2) DNA, RNA extraction, as shown in Figure Cell lysis is classified into four major types: 1) mechanical lysis 2) thermal lysis 3) chemical lysis, and 4) electrical lysis [112] Lysis...

Ngày tải lên: 10/08/2014, 05:21

... and loss of neurons (Fig 7C), with a similar loss evident for all peptides Discussion Because extensive evidence supports a crucial role for Ab in Alzheimer s disease pathogenesis, there is huge ... urea Mass spectrometry, amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using ... V All reagents were supplied by Electron Microscopy Sciences (Hatfield, PA, USA) Assessement of SEC-isolated peptides by HPLC and SDS-PAGE Samples (100 lL) of peptides isolated by SEC were injected...

Ngày tải lên: 18/02/2014, 13:20

... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... a risk factor for Alzheimer s disease? J Alzheimers Dis 3, 471–477 17 Lovell MA, Robertson JD, Teesdale WJ, Campbell JL & Markesbery WR (1998) Copper, iron and zinc in Alzheimer s disease senile ... availability for treating AD P J Crouch et al established, but the role for metal dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial...

Ngày tải lên: 07/03/2014, 10:20

... are capable of forming amyloid deposits The presence of amyloid deposits is necessary for making the diagnosis CONFORMATIONAL DISORDERS Alzheimer s Disease Mainly Random Coil Monomers Non-Toxic ... is called ‘the species barrier’ Therefore, scrapie (a prionosis affecting sheep) is not transmissible to humans The species barrier does not provide absolute protection; therefore, transmission ... fibrillizes and deposits as plaques within the brain This process is facilitated by various pathological chaperones as well as several metals The aim of most therapeutic interventions for these conformational...

Ngày tải lên: 07/03/2014, 10:20

... Tambalis KD, Panagiotakos DB, Psarra G, Sidossis LS Inverse but independent trends in obesity and fitness levels among Greek children: a time-series analysis from 1997 to 2007 Obes Facts 2011;4(2):165-74 ... Diagnosis of Pediatric NAFLD 4.1 Biochemical Tests Liver biopsy is the gold standard for diagnosis, but giv- en that it is not feasible in large epidemiological studies, surrogate markers such as serum ... USA 130 children with biopsy-proven NAFLD To assess clinical and laboratory predictors of NAFLD severity Fibrosis was present in 87% of patients; of these, stage (bridging fibrosis) was present...

Ngày tải lên: 29/03/2014, 18:20

... 0.36) Similar patterns were seen both in controls and in cases Possible associations of AD with HLA-B & C alleles Tables and show the overall results for the 26 studied alleles Apart from the associations ... blind to diagnosis Unadjusted p values were by Fisher 's exact test; odds ratios were also adjusted for age, gender and APOE4 status by logistic regression analysis Potential interactions were examined ... Long-term use of non-steroidal anti-inflammatory drugs is associated with reduced risk of AD [4-6] The region has proved a challenge for the study of disease associations, because it is highly...

Ngày tải lên: 19/06/2014, 22:20

... statistically significant All p-values were two-tailed Statistical analyses were performed using The SAS System for Windows version 9.2 Power and sample size analyses All calculations were based on a significance ... differences with this approach Methods Serum samples Serum samples were obtained from the Rush Alzheimer s Disease Center (Chicago, IL) from individuals whose diagnosis on the basis of post-mortem clinical ... = Alzheimer s disease; NCI = aged noncognitively impaired; MCI = mild cognitive impairment; Undissoc = undissociated; Dissoc = dissociated) undissociated sera, 13% increase in dissociated sera),...

Ngày tải lên: 19/06/2014, 22:20

... factors (STEPS) STEPS involves three primary “steps”: 1) the use of a structured questionnaire to assess study subjects’ self-reported behavioral and lifestyle risk factors for chronic diseases, 2) ... disease and its risk factors in Bavi Social patterning of risk factors for chronic diseases Of particular interest are the associations we found between risk factors (hypertension, smoking, overweight, ... chronic diseases is to reduce the prevalence of their risk factors (4,8,10,11) Because people who have major risk factors for chronic diseases are at greatly increased risk of developing chronic diseases...

Ngày tải lên: 26/07/2014, 06:20

... a case control study Can Vet J 1979, 20, 131-135 55 SAS SAS System, Release 8.1, SAS Inst Inc, Cary, 1999 56 Schindler H, Eger S, Davidson M, Ochowski D, Schermerhorn EC, Foote RH Factors affecting ... dairy cows J Dairy Sci 1985, 68, 1793-1803 Correa MT, Curtis CR, Erb HN, Scarlett JM, Smith RD An ecological analysis of risk factors for postpartum disorders of Holstein-Friesian cows from thirty-two ... Chung, Department of Statistics, Chungbuk National University, Korea for statistical analysis of data References Bendixen PH, Vilson B, Ekesbo I Disease frequencies in dairy cows in Sweden II Retained...

Ngày tải lên: 07/08/2014, 18:21

... measures The standard psychometric tool used to assess cognition in the majority of these studies is the Alzheimer' s Disease Assessment Scale (ADAS) [15] The section of the scale from which scores ... needs of the caregiver, who may be especially burdened by disease progression The disease process AD progresses through several clinical stages (Figure 1) Loss of recent memory, or forgetfulness, ... Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M and Ferris S An inventory to assess activities of daily living for clinical trials in Alzheimer' s disease The Alzheimer' s Disease...

Ngày tải lên: 08/08/2014, 20:23

... mechanisms of different effects of these SSRIs [4-6] although a further detailed study is necessary Delirium is regarded as syndrome that consists of several domains of symptoms, such as disturbance ... patients with Alzheimer s disease because of the risk of extrapyramidal side effects by antipsychotic drugs More detailed double-blind studies should be performed to clarify the role of sigma-1 ... is currently stable Discussion To our knowledge, this is the first report demonstrating that fluvoxamine monotherapy is effective for treating the delirium of patients with Alzheimer s disease...

Ngày tải lên: 08/08/2014, 23:21

... Lovestone S: Alzheimer s disease- do tauists and baptists finally shake hands? Trends Neurosci 2002, 25:22-26 14 Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, ... combinations for allowing objective and efficient diagnostics in AD HS is a Professor of neurology Her main research field is Alzheimer s disease, specifically genetic and life style risk factors, biomarkers ... for this disease A similar strategy could also be useful in the studies involving transgenic mouse models of AD [56] Conclusions The pathogenesis of AD is complex and there is a strong case for...

Ngày tải lên: 11/08/2014, 12:21

... cardiovascular diseases (CVD) Besides information about these risk factors, the study contains information about genetic data of about 50,000 single nucleotide polymorphisms (SNPs) Risk factors were measured ... cardiovascular diseases Here for, the data was divided based upon subjects into two sets; one test set containing 546 subjects and an estimation set of 2,000 subjects to estimate the weights in ... to associate a large set of gene expression variables with a large set of SNP variables The set of SNP variables was transformed using optimal scaling [14,15]; each SNP variable was transformed...

Ngày tải lên: 12/08/2014, 17:20

... A This study may open a new avenue for structure-based drug design for Alzheimer' s disease by considering the 3D-pharmacophoric features of the complex responsible for discriminating these two ... access position [48] For cleft-spanning ligands such as DECA, Phe330 assumes an open access position in which the side chain is shifted 3.5 Å towards the exterior and parallel to the DECA, resulting ... may also be taken into consideration for selecting pose as the best model for further study A comparison of the pose energies of conformations 1, and provides a sound justification for selecting...

Ngày tải lên: 13/08/2014, 16:20