some of the many sources of human disease

... is obvious via the identification of disease causing mutations in the Omi/HtrA2 gene [6] The hypothesis of mitochondrial impairment was further emphasized by postmortem studies of PD brains [7] ... for sporadic PD[9,10] The question arises as to whether the PINK1 gene is also a candidate gene for lateonset forms of Parkinson's disease, similar to the suggested role of the Parkin gene 0.13 ... investigated whether sequence variations in the PINK1 gene play a role in the late-onset form of PD A recently described variation (Q115L) of the PINK1 gene [12] was identified in the German and the Norwegian...

Ngày tải lên: 11/08/2014, 08:20

... to study the etiology of CAD to facilitate the prediction and prevention of CAD 1.2 Overview of the epidemiology of coronary artery disease Cardiovascular disease is the leading cause of morbidity ... 1.1 Overview of coronary artery disease 1.2 Overview of the epidemiology of coronary artery disease 1.3 Overview of the etiology of coronary artery disease 1.4 Research ... and occlude the coronary arteries, causing death of heart muscles The main problem is that many people are unconscious of their disease status until they have angina or heart attack Therefore,...

Ngày tải lên: 09/09/2015, 08:17

... fo lµ gniniatnoc erutxim noitcaer a ni demrofrep saw RCP Co03− ta derots saw noitcudorp ANDc ehT nim rof Co59 ta tpek saw neht ,htab retaw a ni nim 06 rof Co24 ta detabucni saw erutxim noitcaer ... ,reffub lµ neht ,nim rof htab retaw-eci na ni yletaidemmi delooc neht dna htab retaw a ni nim 01 rof Co07 ot detaeh saw erutxim sihT )lµ/lomp 01( remirp 21nU lµ dna ANR lµ xim :swollof sa saw noitpircsnart ... noitanitulggameh yb noitceted suriv rof sdiulf ciotnalla eht detsevrah neht ,sgge detanoyrbme no snoitareneg rof sdiulf ciotnalla eht dessap yllaunitnoc eW ytivitca H rof detset erew sdiulf ciotnalla...

Ngày tải lên: 07/08/2014, 18:21

... in Germany The presence of high copy numbers of viral genomes in younger animals (≤ two years) points to an infection early in life The increase of the prevalence in older animals supports the ... far, no clear disease has been linked to the infection or persistence of these new parvoviruses The phylogenetic analysis showed a close relationship of the German PHoV sequences with the isolates ... analysis, interpretation of the data and manuscript draft HE: Critical interpretation of the data and manuscript draft GP: Study design, interpretation of the data and approval of the manuscript All...

Ngày tải lên: 12/08/2014, 04:20

... males of the chosen genotype would be obtained at the end of the experiment, and that many of them would not be sterile G males did not present the entire B2! genotype, but only half of it for the ... of course verified at the end of these experiments that no accidental fixation of the P allele had occurred in the Andasib6 strain while it was kept in the laboratory It is assumed that in other ... to the geographic origin The hypothesis of a multigenic determinism of the Andasib6 restriction of transmission might be favoured by the fact that no segregation was observed after yr in the...

Ngày tải lên: 14/08/2014, 20:20

... 3, 16, 17), the rate of MACE ranged from 3.1%,to 12.8%, at the end of the two-year period In our trial, however, the incidence of MACE in the ZES treated group was 10% at the end of the two year ... artery disease has been examined in the first four trials of the ongoing ENDEAVOR clinical trials program The results of these initial trials indicate that the ZES is safe and reduces the rates of ... showed a MACE rate of 17.8% at the end of the two-year follow-up, the MACE rates for the TAXUS trials ranged from 3% in TAXUS I trial (5) to 29% in the TAXUS III trial (7) The TAXUS IV trial...

Ngày tải lên: 25/10/2012, 11:18

... interest in the relation between kidney disease and the risk of CVD and is the focus of several recent studies These studies have shown that the association of CKD to CVD is independent of any traditional ... prediction of CVD In addition, many of our patients were on medications that have protective effects on cardiovascular disease Another important limitation is the lack of consistent measurements of other ... presence of DM were the independent predictors of CVD in the earlier stages of CKD (Table 4) Table 1: Characteristics of patients with CKD stage II to IV excluding patient with history of renal...

Ngày tải lên: 03/11/2012, 11:52

... Based on the Cdc and Prevention in Atlanta, U s States, the amount of obese children in the united states has greater than bending, from percent in 1980 to 18 percent this year The amount of obese ... create their lunches until senior high school, in which the greatest putting on weight is viewed The speed of weight problems in women residing in urban centers held steady from 1976 to 2000 In the ... routine, its likely to safeguard their heart, renal system, eyes and braches in the damage frequently triggered by diabetes, and eliminate most of the complications they might be beginning to see...

Ngày tải lên: 16/01/2014, 14:27

... 47/78 (60%) of the children had a history of anemia The anti-tTG assays were positive in 3.8% of cases (3/78) These patients had AEA assayed as well, and one of them resulted positive The patient ... body mass index (BMI) and age, i.e., they were below the 5th percentile of the reference standard With relation to complaints, 58/78 (74%) of the mothers said their children had difficulty gaining ... mechanisms The causes of short stature are described as primary when there is an abnormality in the potential for bone growth, as in bone diseases(2) In the presence of secondary causes, the potential...

Ngày tải lên: 12/02/2014, 19:20

... of motion The immune system is profoundly altered by the direct consequences of alloreactivity and indirect effects of immu­ nosuppressive therapy for treatment of chronic GVHD Infection is the ... 2004) Further research is needed to examine the incidence of chronic GVHD in children after HSCT Considerations specific to the incidence include sources of transplantation and the time point of assessment ... GVHD by using the NIH criteria The incidence of chronic GVHD by using the time point may be underestimated NIH standardizes the criteria for diagnosis of chronic GVHD (Table 1) The criteria require...

Ngày tải lên: 12/02/2014, 19:20

... group The aim of this paper is to describe the clinical and diagnostic features and the results of therapeutic conduct in a group of pediatric patients with these diseases sections of the Department ... is small due to the structure of the Pediatric Department and the rarity of the disease We assessed our patients and compared them with some published series.15,19,20 The use of a routine approach ... in most of the cases The same nence within the group of chronic pulmonary diseases was true of exertional dyspnea, so parents should be asked Table - Signs and symptoms of presentation of 25 patients...

Ngày tải lên: 12/02/2014, 19:20

... to the objectives of the study, given assurance of confidentiality of information offered and assurance of feedback at the end of the study, all these assurances made the participants give their ... knowledge about the cause(s) of sickle cell disease of the participants and their attitude towards their children with sickle cell disease Knowledge of the impact of sickle cell disease will not ... and the attitude of parents towards their children with sickle cell disease Hypothesis 4: Knowledge of the impact of sickle cell disease will not make significant difference in the attitude of...

Ngày tải lên: 12/02/2014, 19:20

... while  in  others,  appropriate  medical  treatment  and  interventions  may  retard the progression of the disease [2]. In the absence of a national registry, there is paucity  of information  ... information  regarding  the etiology  of CKD  in  children  from  Iran[4].  An  understanding  of the causes of CKD is important as it may guide  the distribution  of limited  resources  towards  ... cause  of morbidity  and  mortality in children worldwide [2,3].       The causes  of CKD  vary  from  one  geographic area to another due to genetic and  environmental  factors.  Some of these ...

Ngày tải lên: 12/02/2014, 19:20

... Characteristics of study participants The characteristics of the study cohort are presented in Table The majority of the study participants lived in cities of the Ruhr area The mean age of these women at the ... used the five year mean of the year of the baseline examination (within 1985 to 1994) and the preceding four years and, for exposure at follow-up, the means of the years 2002 to 2006 Due to the ... majority of the participants did not change Conclusion Parallel to the decline of ambient air pollution over the last 20 years in the Ruhr area a reduction of the prevalence of chronic respiratory diseases...

Ngày tải lên: 17/02/2014, 22:20

... composed of two each of the a and b subunits Analysis of the N-terminal transit peptide of CLGAT Analysis of the CLGAT cDNA predicted a chloroplast transit peptide upstream from the N-terminus of CLGAT ... [22,23]); In fact, the N-terminal residue of the b peptide from purified CLGAT matched the second residue of this conserved motif These results strongly suggest that the precursor peptide of CLGAT in ... watermelon leaves (Table 1) The purification procedure was developed by taking advantage of the thermal stability of the GAT activity in crude extracts After centrifugation of the total leaf extract...

Ngày tải lên: 20/02/2014, 03:20

... chronic disease can no longer be considered just a problem of the elderly (Suhrcke et al 2006; Mathers et al 2003) The burden of chronic disease risk factors The shape of the future burden of chronic ... to patients with this disease Chronic disease is responsible for most of the disease and deaths in Europe One measure of the overall burden of disease, developed by WHO, is the disability-adjusted ... About the authors Reinhard Busse is Professor and Director of the Department of Health Care Management at the Berlin University of Technology, Germany, and Associate Head for Research Policy of the...

Ngày tải lên: 05/03/2014, 10:20

... the knee flexed to 90 and the ankle supported in a neutral position The axis of the foot is then compared with the long axis of the thigh Alternatively, the degree of tibial torsion can be measured ... defined as the angle formed between the articular axes of the knee and ankle joint Tibial torsion is often measured using an assessment of the thigh–foot angle The child is placed prone with the knee ... attempt to keep the hips in an abducted position The amount of time the specific device is used depends on the severity of the hip migration, type of device used, and child’s tolerance Some systems...

Ngày tải lên: 05/03/2014, 10:20

... research described in this thesis was intended to include the patient’s perspective in the assessment of the consequences of the disease The aims were to map out the health status of patients with non-classic ... information on the progression of the disease by presenting the results of the first two years of followup Chapters 7-9 focus on the results of specific assessment scales: health-related quality of life, ... life, fatigue, and the impact of Pompe disease on the daily life of the patients Chapter 10 provides a general discussion of the findings described in this thesis, the pros and cons of our approach,...

Ngày tải lên: 05/03/2014, 10:20

... in the relatives of diabetics was close to that of the control group and healthy Turkish children In children with T1DM, increased prevalence of CD is well documented (2) The association of CD ... investigated the prevalence of CD in non-diabetic relatives, and there is no recommendation for routine screening of these subjects The first study conducted by Hummel et al (6) showed the frequent ... IgA level was normal in all of them (Table 1) The prevalence of seropositivity for CD was higher in patients with T1DM than their relatives (siblings and parents of diabetic children) and healthy...

Ngày tải lên: 05/03/2014, 12:20