... is obvious via the identification ofdisease causing mutations in the Omi/HtrA2 gene [6] The hypothesis of mitochondrial impairment was further emphasized by postmortem studies of PD brains [7] ... for sporadic PD[9,10] The question arises as to whether the PINK1 gene is also a candidate gene for lateonset forms of Parkinson's disease, similar to the suggested role ofthe Parkin gene 0.13 ... investigated whether sequence variations in the PINK1 gene play a role in the late-onset form of PD A recently described variation (Q115L) ofthe PINK1 gene [12] was identified in the German and the Norwegian...
... to study the etiology of CAD to facilitate the prediction and prevention of CAD 1.2 Overview ofthe epidemiology of coronary artery disease Cardiovascular disease is the leading cause of morbidity ... 1.1 Overview of coronary artery disease 1.2 Overview ofthe epidemiology of coronary artery disease 1.3 Overview ofthe etiology of coronary artery disease 1.4 Research ... and occlude the coronary arteries, causing death of heart muscles The main problem is that many people are unconscious of their disease status until they have angina or heart attack Therefore,...
... in Germany The presence of high copy numbers of viral genomes in younger animals (≤ two years) points to an infection early in life The increase ofthe prevalence in older animals supports the ... far, no clear disease has been linked to the infection or persistence of these new parvoviruses The phylogenetic analysis showed a close relationship ofthe German PHoV sequences with the isolates ... analysis, interpretation ofthe data and manuscript draft HE: Critical interpretation ofthe data and manuscript draft GP: Study design, interpretation ofthe data and approval ofthe manuscript All...
... males ofthe chosen genotype would be obtained at the end ofthe experiment, and that manyof them would not be sterile G males did not present the entire B2! genotype, but only half of it for the ... of course verified at the end of these experiments that no accidental fixation ofthe P allele had occurred in the Andasib6 strain while it was kept in the laboratory It is assumed that in other ... to the geographic origin The hypothesis of a multigenic determinism ofthe Andasib6 restriction of transmission might be favoured by the fact that no segregation was observed after yr in the...
... 3, 16, 17), the rate of MACE ranged from 3.1%,to 12.8%, at the end ofthe two-year period In our trial, however, the incidence of MACE in the ZES treated group was 10% at the end ofthe two year ... artery disease has been examined in the first four trials ofthe ongoing ENDEAVOR clinical trials program The results of these initial trials indicate that the ZES is safe and reduces the rates of ... showed a MACE rate of 17.8% at the end ofthe two-year follow-up, the MACE rates for the TAXUS trials ranged from 3% in TAXUS I trial (5) to 29% in the TAXUS III trial (7) The TAXUS IV trial...
... interest in the relation between kidney disease and the risk of CVD and is the focus of several recent studies These studies have shown that the association of CKD to CVD is independent of any traditional ... prediction of CVD In addition, manyof our patients were on medications that have protective effects on cardiovascular disease Another important limitation is the lack of consistent measurements of other ... presence of DM were the independent predictors of CVD in the earlier stages of CKD (Table 4) Table 1: Characteristics of patients with CKD stage II to IV excluding patient with history of renal...
... Based on the Cdc and Prevention in Atlanta, U s States, the amount of obese children in the united states has greater than bending, from percent in 1980 to 18 percent this year The amount of obese ... create their lunches until senior high school, in which the greatest putting on weight is viewed The speed of weight problems in women residing in urban centers held steady from 1976 to 2000 In the ... routine, its likely to safeguard their heart, renal system, eyes and braches in the damage frequently triggered by diabetes, and eliminate most ofthe complications they might be beginning to see...
... 47/78 (60%) ofthe children had a history of anemia The anti-tTG assays were positive in 3.8% of cases (3/78) These patients had AEA assayed as well, and one of them resulted positive The patient ... body mass index (BMI) and age, i.e., they were below the 5th percentile ofthe reference standard With relation to complaints, 58/78 (74%) ofthe mothers said their children had difficulty gaining ... mechanisms The causes of short stature are described as primary when there is an abnormality in the potential for bone growth, as in bone diseases(2) In the presence of secondary causes, the potential...
... of motion The immune system is profoundly altered by the direct consequences of alloreactivity and indirect effects of immu nosuppressive therapy for treatment of chronic GVHD Infection is the ... 2004) Further research is needed to examine the incidence of chronic GVHD in children after HSCT Considerations specific to the incidence include sourcesof transplantation and the time point of assessment ... GVHD by using the NIH criteria The incidence of chronic GVHD by using the time point may be underestimated NIH standardizes the criteria for diagnosis of chronic GVHD (Table 1) The criteria require...
... group The aim of this paper is to describe the clinical and diagnostic features and the results of therapeutic conduct in a group of pediatric patients with these diseases sections ofthe Department ... is small due to the structure ofthe Pediatric Department and the rarity ofthedisease We assessed our patients and compared them with some published series.15,19,20 The use of a routine approach ... in most ofthe cases The same nence within the group of chronic pulmonary diseases was true of exertional dyspnea, so parents should be asked Table - Signs and symptoms of presentation of 25 patients...
... to the objectives ofthe study, given assurance of confidentiality of information offered and assurance of feedback at the end ofthe study, all these assurances made the participants give their ... knowledge about the cause(s) of sickle cell diseaseofthe participants and their attitude towards their children with sickle cell disease Knowledge ofthe impact of sickle cell disease will not ... and the attitude of parents towards their children with sickle cell disease Hypothesis 4: Knowledge ofthe impact of sickle cell disease will not make significant difference in the attitude of...
... while in others, appropriate medical treatment and interventions may retard the progression ofthedisease [2]. In the absence of a national registry, there is paucity of information ... information regarding the etiology of CKD in children from Iran[4]. An understanding ofthe causes of CKD is important as it may guide the distribution of limited resources towards ... cause of morbidity and mortality in children worldwide [2,3]. The causes of CKD vary from one geographic area to another due to genetic and environmental factors. Someof these ...
... Characteristics of study participants The characteristics ofthe study cohort are presented in Table The majority ofthe study participants lived in cities ofthe Ruhr area The mean age of these women at the ... used the five year mean ofthe year ofthe baseline examination (within 1985 to 1994) and the preceding four years and, for exposure at follow-up, the means ofthe years 2002 to 2006 Due to the ... majority ofthe participants did not change Conclusion Parallel to the decline of ambient air pollution over the last 20 years in the Ruhr area a reduction ofthe prevalence of chronic respiratory diseases...
... composed of two each ofthe a and b subunits Analysis ofthe N-terminal transit peptide of CLGAT Analysis ofthe CLGAT cDNA predicted a chloroplast transit peptide upstream from the N-terminus of CLGAT ... [22,23]); In fact, the N-terminal residue ofthe b peptide from purified CLGAT matched the second residue of this conserved motif These results strongly suggest that the precursor peptide of CLGAT in ... watermelon leaves (Table 1) The purification procedure was developed by taking advantage ofthe thermal stability ofthe GAT activity in crude extracts After centrifugation ofthe total leaf extract...
... chronic disease can no longer be considered just a problem ofthe elderly (Suhrcke et al 2006; Mathers et al 2003) The burden of chronic disease risk factors The shape ofthe future burden of chronic ... to patients with this disease Chronic disease is responsible for most ofthedisease and deaths in Europe One measure ofthe overall burden of disease, developed by WHO, is the disability-adjusted ... About the authors Reinhard Busse is Professor and Director ofthe Department of Health Care Management at the Berlin University of Technology, Germany, and Associate Head for Research Policy of the...
... the knee flexed to 90 and the ankle supported in a neutral position The axis ofthe foot is then compared with the long axis ofthe thigh Alternatively, the degree of tibial torsion can be measured ... defined as the angle formed between the articular axes ofthe knee and ankle joint Tibial torsion is often measured using an assessment ofthe thigh–foot angle The child is placed prone with the knee ... attempt to keep the hips in an abducted position The amount of time the specific device is used depends on the severity ofthe hip migration, type of device used, and child’s tolerance Some systems...
... research described in this thesis was intended to include the patient’s perspective in the assessment ofthe consequences ofthediseaseThe aims were to map out the health status of patients with non-classic ... information on the progression ofthedisease by presenting the results ofthe first two years of followup Chapters 7-9 focus on the results of specific assessment scales: health-related quality of life, ... life, fatigue, and the impact of Pompe disease on the daily life ofthe patients Chapter 10 provides a general discussion ofthe findings described in this thesis, the pros and cons of our approach,...
... in the relatives of diabetics was close to that ofthe control group and healthy Turkish children In children with T1DM, increased prevalence of CD is well documented (2) The association of CD ... investigated the prevalence of CD in non-diabetic relatives, and there is no recommendation for routine screening of these subjects The first study conducted by Hummel et al (6) showed the frequent ... IgA level was normal in all of them (Table 1) The prevalence of seropositivity for CD was higher in patients with T1DM than their relatives (siblings and parents of diabetic children) and healthy...
... impairment of splenic function In others, although the Hb F may remain above 50% these children are still at risk of splenic hypofunction Even though the spleen may be enlarged during the first years of ... 21-1 Management of Sickle Cell Disease in Children Page of 15 Inclusion Criteria: • Sickle cell patients presenting with signs of VOC • Presenting sign relative to the site ofthe VOC and conditions ... taken, 15-20% of infants and young children with sickle cell anemia die before the age of 5, usually of septicemia or meningitis In children under years of age with sickle cell disease, the predominant...