solidstate nmr spectroscopy of pharmaceutical materials
Tài liệu Báo cáo khóa học: Determination by electrospray mass spectrometry and 1H-NMR spectroscopy of primary structures of variously fucosylated neutral oligosaccharides based on the iso-lacto-N-octaose core doc
... and NMR has proved a powerful strategy forcomplete assignment of the branched structures. NMR Fig. 7. 1D and 2D1H-NMRspectra(600MHz)ofTFiLNOat27°C. Upper trace, the 5.5–0.5 p.p.m. region of ... this report, we demonstrateour strategy of the combined use of ES-MS and NMR foranalysis of the core-branching pattern and full sequenceassignment of four oligosaccharides isolated from humanmilk. ... different techniques, of which MS and NMR are two of the most powerful.Previously, we demonstrated the distinction of chain typeand blood-group type (such as Lea/xand Leb/y) of underi-vatized...
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Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx
... the spectroscopic analysis of themyristate-dependent conformational changes of the Nand B states of Mn(III)heme–HSA, by optical absorb-ance spectroscopy and NMR spectroscopy, that showallosteric ... the affinity of Mn(III)heme for HSA andthe spectroscopic properties of the Mn(III)heme–HSAadduct in the presence of myristate are similar to those of the B conformational state of HSA, suggesting ... presence of 4.5 · 10)5M (dotted line) and 1.0 · 10)4M myristate (dashed line).Fig. 5. Change of the relaxivity measured at 10 MHz of a1.0 · 10)3M solution of Mn(III)heme–HSA as a function of...
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Chemistry of nanostructured materials
... mesoporous materials [11-13]. A number of reviews dealing with different types of periodic mesoporous materials such as aluminophosphates [14], non-silica materials [15-17], inclusion materials ... Robson R., Design and Construction of a New Class of Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D-Linked Molecular Rods. A Reappraisal of the Zn(CN)2 and Cd(CN)2 ... use of germanium has also led to the synthesis of the pure polymorph C of zeolite beta (BEC) even in the absence of the fluoride medium that is generally believed to assist in the formation of...
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The chemistry of nanostructured materials
... frequently used term in the field of microporous materials is “molecular sieves” [5] that refers to a class of porous materials that can distinguish molecules on the basis of size and shape. This chapter ... Robson R., Design and Construction of a New Class of Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D-Linked Molecular Rods. A Reappraisal of the Zn(CN)2 and Cd(CN)2 ... MOF-5 [97,98,109]. A key structural feature of Cu-BTC is the dimeric Cu-Cu (2.628Å) unit. A detailed investigation of sorption properties showed that Cu-BTC may be useable for separation of...
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Machining of Hard Materials
... possible to obtain a surface finish of Ra about 0.3 àm. Typical applications of HB include finishing of a variety of internal profiles such as prismatic internal profiles, internal gear flanks, ... Hastelloy, Stellite and other exotic materials are clas-sified as hard-turned materials. Machining of Hard Materials 117 In the contact zone, the austenite temperature of the workpiece material is ... speeds of up to 42,000 rpm and finishing laser machining can be very profitable for hard part machining. The elimination of EDM operations and the use of laser shaping result in shortening of the...
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Static properties of granular materials Philippe Claudin
... probably one of the issues that has been at the origin of the interest of many physicists for granular materials [359]. The last point of this subsectionwill be dedicated to the study of the stress ... horizontal position of the apex of thepile – also, changing the sign of x changes that of the shear σxz. More generally,the stress state of the jammed grain packing is assumed to be of the formxx= ... properties of granular materials Fig. 14.6 Polar representation of the contact orientation distribution obtained ina numerical simulation of a granular layer prepared by a uniform ‘rain’ of grains[455]....
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The thermodynamics of granular materials Sir Sam Edwards and Raphael Blumenfeld
... thermodynamics of granular materials Fig. 13.2 An example of two states of a granular system that differ only by thepositions of three particles confined to within a region, .The first rigorous theory of ... heap of hotsand will have many of the characteristics of a heap of cold sand) and we can writeS = Sth+ Sconf. (13.19)It is interesting to note that confirmation of this ‘thermodynamics’ of ... sketch of the density of granular matter in a vessel after being shakenat amplitude A. Adapted from [172, 173, 356].Detailed studies of the density of shaken granular systems as a function of thenumber...
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Tài liệu Mechanical Properties of Engineered Materials P2 pptx
... ặ1ẳ1=5boundaryisoneinwhich1in5ofthegrainboundaryatomsmatch,asshowninFig.2.8(c).Twinboundariesmayformwithincrystals.Suchboundarieslieacrossdeformationtwinplanes,asshowninFig.2.8(d).Notethattheatomsoneithersideofthetwinplanesaremirrorimages.Stackingfaultsmayalsobeformedwhentheperfectstackinginthecrystallinestackingsequenceisdisturbed,Figs2.8(e)and2.8(f).Thesemaybethoughtofastheabsenceofaplaneofatoms(intrinsicstackingfaults)ortheinsertionofrowsofatomsthatdisturbthearrangementofatoms(extrinsicstackingfaults).IntrinsicandextrinsicstackingfaultsareillustratedschematicallyinFigs2.8(e)and2.8(f),respectively.NotehowtheperfectABCABCstackingofatomsisdisturbedbytheinsertionorabsenceofrowsofatoms.2.3.4VolumeDefectsVolumedefectsareimperfectionssuchasvoids,bubble/gasentrapments,porosity,inclusions,precipitates,andcracks.Theymaybeintroducedintoasolidduringprocessingorfabricationprocesses.AnexampleofvolumedefectsispresentedinFig.2.9.ThisshowsMnSinclusionsinanA707steel.AnotherexampleofavolumedefectispresentedinFig.1.16(d).This ... approximately 0.3–0.5 of the melting temperature in degrees Kelvin.Since the evolution of microstructure is often controlled by diffusionprocesses, a brief introduction to elementary aspects of diffusion ... picture of nucleation and growth presented above is gen-erally observed in most crystalline metallic materials. However, the rate of nucleation is generally enhanced by the presence of pre-existing...
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Tài liệu Mechanical Properties of Engineered Materials P1 pptx
... macroscopic level of understanding of structure [Figs 16(a)–(d)]. They are often unaware of the atomic and micro-structural constituents that can affect the mechanical behavior of materials and of the ... types/classes of materials. Following a brief introduction to materials science andbasic strength of materials, the fundamentals of elasticity and plasticity arepresented, prior to a discussion of strengthening ... treatment of the fundamen-tals of the mechanical behavior of materials. The text provides a rigorousreview of the fundamental mechanics aspects of the mechanical behavior of materials. Shackleford,...
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Tài liệu Supply and stock of raw materials pptx
... stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 4/5 Check of delivery documentsThe delivery note transferred by the driver is compared with the specification of ... Supply and stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 1/5 Process owner: Hr. Bauer Process purpose and target: Transfer and storage of conformal material ... false storage Environment: Disposal quantity because of false storage PB-Nr: S05 Supply and stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 2/5 flow/process...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... gradient probe. All NMR spectra were acquired at 303 K. NMR data were processedusing nmrpipe ⁄ nmrdraw [53], and assigned using ansig[54,55]. NMR titration studiesThe stock solutions of substrates ... upon addition of ATP inthe absence of pantoate. An important feature of the NMR study is the fact that a single set of resonanceswere observed for nPS in the absence or presence of substrates. ... effects of one of the substrates, i.e. pantoate [8,9]. One of theinteresting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9].This sequence of amino...
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Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc
... resonance assignments of the 18.5 kDaisoform of murine myelin basic protein (MBP). J Biomol NMR 29, 545–546.31 Nygaard E, Mendz GL, Moore WJ & Martenson RE(1984) NMR of a peptic peptide ... Thus, comparison of the tertiary structures of this epitope under variousconditions is of interest to understand its pharmaco-kinetics.We have initiated solution NMR studies of 18.5 kDa rmMBP ... [7].There had been several previous, contradictory predic-tions of the kind of secondary structure of this segment of MBP, due to the plethora of experimental conditions,and the SDSL ⁄ EPR experiments...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII.Fig. 6. Structure of a representative folded conformer of AII showing the van der ... discussionHigh-resolution NMR structure of AIIin aqueous solutionHigh-field NMR spectroscopy. The NMR experimentswere performed at low temperature (277 K) to limit theconformational ensemble of the hormone ... 2003 Comparison of the free and bound structure of angiotensin II (Eur. J. Biochem. 270) 851 On the molecular basis of the recognition of angiotensin II (AII) NMR structure of AII in solution...
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