solidstate nmr spectroscopy of pharmaceutical materials

... and NMR has proved a powerful strategy for complete assignment of the branched structures. NMR Fig. 7. 1D and 2D 1 H-NMRspectra(600MHz)ofTFiLNOat27°C. Upper trace, the 5.5–0.5 p.p.m. region of ... this report, we demonstrate our strategy of the combined use of ES-MS and NMR for analysis of the core-branching pattern and full sequence assignment of four oligosaccharides isolated from human milk. ... different techniques, of which MS and NMR are two of the most powerful. Previously, we demonstrated the distinction of chain type and blood-group type (such as Le a/x and Le b/y ) of underi- vatized...

Ngày tải lên: 19/02/2014, 12:20

Ngày tải lên: 31/03/2014, 21:21

... the spectroscopic analysis of the myristate-dependent conformational changes of the N and B states of Mn(III)heme–HSA, by optical absorb- ance spectroscopy and NMR spectroscopy, that show allosteric ... the affinity of Mn(III)heme for HSA and the spectroscopic properties of the Mn(III)heme–HSA adduct in the presence of myristate are similar to those of the B conformational state of HSA, suggesting ... presence of 4.5 · 10 )5 M (dotted line) and 1.0 · 10 )4 M myristate (dashed line). Fig. 5. Change of the relaxivity measured at 10 MHz of a 1.0 · 10 )3 M solution of Mn(III)heme–HSA as a function of...

Ngày tải lên: 20/02/2014, 02:22

Ngày tải lên: 08/03/2014, 10:20

Ngày tải lên: 16/03/2014, 18:20

Ngày tải lên: 17/03/2014, 10:20

Ngày tải lên: 23/03/2014, 13:20

Ngày tải lên: 30/03/2014, 20:20

... mesoporous materials [11-13]. A number of reviews dealing with different types of periodic mesoporous materials such as aluminophosphates [14], non-silica materials [15-17], inclusion materials ... Robson R., Design and Construction of a New Class of Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D- Linked Molecular Rods. A Reappraisal of the Zn(CN) 2 and Cd(CN) 2 ... use of germanium has also led to the synthesis of the pure polymorph C of zeolite beta (BEC) even in the absence of the fluoride medium that is generally believed to assist in the formation of...

Ngày tải lên: 23/04/2013, 14:23

... frequently used term in the field of microporous materials is “molecular sieves” [5] that refers to a class of porous materials that can distinguish molecules on the basis of size and shape. This chapter ... Robson R., Design and Construction of a New Class of Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D- Linked Molecular Rods. A Reappraisal of the Zn(CN) 2 and Cd(CN) 2 ... MOF- 5 [97,98,109]. A key structural feature of Cu-BTC is the dimeric Cu-Cu (2.628Å) unit. A detailed investigation of sorption properties showed that Cu-BTC may be useable for separation of...

Ngày tải lên: 23/04/2013, 20:25

... possible to obtain a surface finish of Ra about 0.3 àm. Typical applications of HB include finishing of a variety of internal profiles such as prismatic internal profiles, internal gear flanks, ... Hastelloy, Stellite and other exotic materials are clas- sified as hard-turned materials. Machining of Hard Materials 117 In the contact zone, the austenite temperature of the workpiece material is ... speeds of up to 42,000 rpm and finishing laser machining can be very profitable for hard part machining. The elimination of EDM operations and the use of laser shaping result in shortening of the...

Ngày tải lên: 18/10/2013, 03:15

... probably one of the issues that has been at the origin of the interest of many physicists for granular materials [359]. The last point of this subsection will be dedicated to the study of the stress ... horizontal position of the apex of the pile – also, changing the sign of x changes that of the shear σ xz . More generally, the stress state of the jammed grain packing is assumed to be of the form xx = ... properties of granular materials Fig. 14.6 Polar representation of the contact orientation distribution obtained in a numerical simulation of a granular layer prepared by a uniform ‘rain’ of grains [455]....

Ngày tải lên: 01/11/2013, 08:20

... thermodynamics of granular materials Fig. 13.2 An example of two states of a granular system that differ only by the positions of three particles confined to within a region, . The first rigorous theory of ... heap of hot sand will have many of the characteristics of a heap of cold sand) and we can write S = S th + S conf . (13.19) It is interesting to note that confirmation of this ‘thermodynamics’ of ... sketch of the density of granular matter in a vessel after being shaken at amplitude A. Adapted from [172, 173, 356]. Detailed studies of the density of shaken granular systems as a function of the number...

Ngày tải lên: 01/11/2013, 08:20

... ặ 1 ẳ1=5boundaryisoneinwhich1in5ofthegrainboundaryatoms match,asshowninFig.2.8(c). Twinboundariesmayformwithincrystals.Suchboundarieslieacross deformationtwinplanes,asshowninFig.2.8(d).Notethattheatomson eithersideofthetwinplanesaremirrorimages.Stackingfaultsmayalsobe formedwhentheperfectstackinginthecrystallinestackingsequenceis disturbed,Figs2.8(e)and2.8(f).Thesemaybethoughtofastheabsence ofaplaneofatoms(intrinsicstackingfaults)ortheinsertionofrowsof atomsthatdisturbthearrangementofatoms(extrinsicstackingfaults). IntrinsicandextrinsicstackingfaultsareillustratedschematicallyinFigs 2.8(e)and2.8(f),respectively.NotehowtheperfectABCABCstackingof atomsisdisturbedbytheinsertionorabsenceofrowsofatoms. 2.3.4VolumeDefects Volumedefectsareimperfectionssuchasvoids,bubble/gasentrapments, porosity,inclusions,precipitates,andcracks.Theymaybeintroducedintoa solidduringprocessingorfabricationprocesses.Anexampleofvolume defectsispresentedinFig.2.9.ThisshowsMnSinclusionsinanA707 steel.AnotherexampleofavolumedefectispresentedinFig.1.16(d). This ... approximately 0.3–0.5 of the melting temperature in degrees Kelvin. Since the evolution of microstructure is often controlled by diffusion processes, a brief introduction to elementary aspects of diffusion ... picture of nucleation and growth presented above is gen- erally observed in most crystalline metallic materials. However, the rate of nucleation is generally enhanced by the presence of pre-existing...

Ngày tải lên: 23/12/2013, 00:15

... macroscopic level of understanding of structure [Figs 16(a)–(d)]. They are often unaware of the atomic and micro- structural constituents that can affect the mechanical behavior of materials and of the ... types/ classes of materials. Following a brief introduction to materials science and basic strength of materials, the fundamentals of elasticity and plasticity are presented, prior to a discussion of strengthening ... treatment of the fundamen- tals of the mechanical behavior of materials. The text provides a rigorous review of the fundamental mechanics aspects of the mechanical behavior of materials. Shackleford,...

Ngày tải lên: 23/12/2013, 00:15

... stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 4/5 Check of delivery documents The delivery note transferred by the driver is compared with the specification of ... Supply and stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 1/5 Process owner: Hr. Bauer Process purpose and target: Transfer and storage of conformal material ... false storage Environment: Disposal quantity because of false storage PB-Nr: S05 Supply and stock of raw materials Issed by Date of release Version Page Hr. Bauer 00 2/5 flow/process...

Ngày tải lên: 25/01/2014, 00:20

Ngày tải lên: 29/01/2014, 14:39

... gradient probe. All NMR spectra were acquired at 303 K. NMR data were processed using nmrpipe ⁄ nmrdraw [53], and assigned using ansig [54,55]. NMR titration studies The stock solutions of substrates ... upon addition of ATP in the absence of pantoate. An important feature of the NMR study is the fact that a single set of resonances were observed for nPS in the absence or presence of substrates. ... effects of one of the substrates, i.e. pantoate [8,9]. One of the interesting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9]. This sequence of amino...

Ngày tải lên: 16/02/2014, 09:20

... resonance assignments of the 18.5 kDa isoform of murine myelin basic protein (MBP). J Biomol NMR 29, 545–546. 31 Nygaard E, Mendz GL, Moore WJ & Martenson RE (1984) NMR of a peptic peptide ... Thus, comparison of the tertiary structures of this epitope under various conditions is of interest to understand its pharmaco- kinetics. We have initiated solution NMR studies of 18.5 kDa rmMBP ... [7]. There had been several previous, contradictory predic- tions of the kind of secondary structure of this segment of MBP, due to the plethora of experimental conditions, and the SDSL ⁄ EPR experiments...

Ngày tải lên: 19/02/2014, 07:20