small signal modelling in the triode and cutoff regions
Báo cáo khoa học: Small-molecule modulators of zymogen activation in the fibrinolytic and coagulation systems pptx
Ngày tải lên :
06/03/2014, 22:21
... K1, K2 and K4 of plasminogen, the AH site can bind an internal lysine residue in addition to the C-terminal lysine [30], which is a preferred ligand for the lysine-binding site in K1, K2 and K4 ... binding sites for plasminogen The high-affinity lysine-binding sites in K1 and K4 may be involved in this propagation process Thus, plasminogen binding is essential for the fibrinolytic process The ... complestatin are canceled by a lysine analog Thus, the target of complestatin is Glu-plasminogen, and the agent promotes its binding to fibrin and cells via the AH site or the lysine-binding sites...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... provide insight into the receptor specificity of the B2wt internalization motif The resulting data also hint at a receptor specific role of the putative helix in G protein activation and interaction ... of the C-terminal B1wt and B2wt sequences and chimera thereof The C-terminal sequences beginning at transmembrane domain are shown B1wt parts are indicated in filled circles, B2wt portions in ... rhodopsin [29] In the angiotensin II receptor AT1A point mutations in the region of putative helix abolished release of inositol trisphosphates and the GTP-inducible shift in receptor affinity In...
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Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
Ngày tải lên :
30/03/2014, 03:20
... synthesis, protein folding and protein degradation Knockdown of these genes is expected to increase intracellular levels of damaged and denatured proteins Damaged proteins in turn act as a signal to ... protein synthesis [27,28], which likely results in the accumulation of incomplete and aberrantly folded polypeptides in the cytoplasm The majority of the protein homeostasis genes identified in ... new protein synthesis and cotranslational protein folding Damaged proteins function as a signal that activates gpdh-1 expression and glycerol synthesis Glycerol replaces inorganic ions in the cytoplasm...
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Báo cáo khoa học nông nghiệp " The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - MS2 " potx
Ngày tải lên :
21/06/2014, 06:20
... overcome, thereby improving the income and well-being of farming communities in these areas Executive Summary The following report presents information on the initiation of activities for the CARD ... focus of the project at this stage has been the training of DARD officers from Ninh Thuan, Binh Thuan and Lam Dong provinces in goat husbandry and management, in the conduct of surveys and the acquisition ... responsible for the routine management of the CARD initiatives Dr Binh has agreed to organise this Board which will meet in Lam Dong in November 2006, in Binh Thuan in 2007 and in Ninh Thuan in 2008...
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Project Progress Report: The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - MS3 " doc
Ngày tải lên :
21/06/2014, 06:20
... merit) In this way the existing limitations to improving productivity will be overcome, thereby improving the income and well-being of farming communities in these areas The bbb The following report ... categories of farming systems (lowland high rainfall, upland low rainfall and highland high rainfall) have been selected The plan is to develop 27 farms (15 in Ninh Thuan, in Binh Thuan, in Lam Dong) ... Hanoi The local people are mainly Kinh, Cham, Ede and are amongst the poorest in Vietnam (US$45-65 income per annum) The traditional farming systems vary from rice cropping in the river deltas in...
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The development and implementation of new appropriate technologies for improving goat production and increasing small-holder income in the central region of Vietnam - Milestone 9" pot
Ngày tải lên :
21/06/2014, 06:20
... well-being of farming communities in these areas The following report (Milestone 9) is a comprehensive description of the findings from The bbb project activities, including analysis and interpretation ... of farming system surveys carried out in 2006 and 2008, and of the biology and productivity of goats following the introduction of new technologies to farmers in Ninh Thuan, Binh Thuan and Lam ... GRRC in the north This aim is reflected in the project title The improvement and implementation of new appropriate technologies for improving goat production and increasing small- holder income in...
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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc
Ngày tải lên :
14/08/2014, 08:20
... ligand-protein binding Power-law behaviors of ligand-protein binding The number of ligands (N) decays with an increase in the number (L) of (a) domains and (b) folds that bind the ligand and ... release during ligand binding may meet the free energy demand during protein folding It is tempting to examine the conjecture of ligand-induced formation and/ or folding of primordial proteins through ... binding of ligands with primordial proteins would also be a critical step in the origin of life Thus, it is intriguing to explore the chronology of ligand-protein binding and answer the following...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin ... two-hybrid screen and identified CTNNBL1 (beta catenin-like protein 1) as an AID-interacting protein Interestingly, he found that an AID mutant deficient in CTNNBL1 binding retains deamination activity ... asymmetric division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant Numb is critical in determining lineage commitment in the immune system...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
Ngày tải lên :
31/10/2012, 17:11
... temporary dose discontinuation in 3/20 (15%) Forns and colleagues used relatively high-dose interferon/ribavirin therapy in their cohort of 30 patients awaiting transplantation in Spain in an effort to ... low initial dose, with increases every two weeks toward standard target doses Duration of therapy was intended to be 24 weeks in genotypes and and 48 weeks in genotype infection Hematologic inclusion ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin [13, 14] Finally, growing experience with antiviral therapy in this high-risk group...
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Natural botanical products have a long history in the world and are featured in using a complex
Ngày tải lên :
03/11/2012, 09:54
... is therefore possible that CKBM could induce cytokine release including TNF-α in these animals and inhibit tumor growth However, further study is needed to determine how they are induced and the ... compounds including lunasin and lectins that were shown to induce apoptosis in malignant cells [13] As CKBM contains these compounds, this would partially explain why it inhibits tumor growth in the ... through the induction of apoptosis and inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic...
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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works
Ngày tải lên :
07/11/2012, 15:01
... another The grandmother held the floor most of the time from the beginning of the story in her decision where to go, in her introduction of the scenery along the journey While the father, the mother ... character and setting Technique has to with the structuring of the story into the plot so that the writer can convey the theme and the manipulating of the language in order to express the ideas of the ... “Everything That Rises Must Converge.”, however, the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another...
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Development of a Regional Risk Management Framework for APEC Economies for use in the Control and Prevention of Introduced Marine Pests
Ngày tải lên :
28/10/2013, 11:15
... Conclusions, including the results of the November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC and the MRCWG have a role in liaising with ... NACA to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to identify ... Within APEC little is known on the introduction of marine pests Little practical information on measures to prevent introductions Lack of knowledge in what individual countries are doing...
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Radioactive waste in the Barents and Kara Seas - Russian implementation of the global dumping regime
Ngày tải lên :
01/11/2013, 09:20
... nuclear issues in general, the feeling grew in the environmental movement that Yeltsin was increasingly yielding to the demands of the Ministry of Atomic Power and the nuclear-industrial lobby.99 ... nuclear matters, including the Navy and the Ministry of Atomic Power, have consolidated their control over domestic decisionmaking and are themselves becoming increasingly involved in cooperative ... dumping, as these prescriptions figure prominently in the unequivocal argument made in the Yablokov Report on the severity of past dumping and the need to invest more in storage and decontamination...
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Tài liệu EXACT SMALL SAMPLE THEORY IN THE SIMULTANEOUS EQUATIONS MODEL docx
Ngày tải lên :
25/01/2014, 07:20
... guidelines for the design of Monte Carlo experiments (at least in the context of SEMs) by indicating the canonical parameter space which is instrumental in influencing the shape of the relevant small ... underflow and overflow in the computer evaluations of the coefficients in the series and the polynomials themselves To take as a simple example the case of the exact density of the IV estimator in the ... 0(pe3) These considerations led Anderson and Sawa to take LIMLK and a proxy for LIML in analyzing the small sample properties of the latter and in the comparison with 2SLS They found the central...
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Tài liệu NEW ADVANCES IN THE BASIC AND CLINICAL GASTROENTEROLOGY docx
Ngày tải lên :
12/02/2014, 16:20
... cells, single lymphocytes scattered in the lamina propria and intraepithelial lymphocytes spread in the intestinal epithelia The immune system of infants is not fully developed The structures of the ... demonstrated their capacity to stimulate the production of intestinal mucines, their trophic effect on intestinal epithelium, the reestablishment of the intestinal mucosa integrity, the stimulation of the ... approximately the eighty per cent of the immune system is found in the area of the intestinal tract and it is particularly prevalent in the small intestine The intestinal immune system is referred...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf
Ngày tải lên :
14/02/2014, 21:20
... emigrated, and were either residing in our Colonies or in other parts of the world, and the only method I could discover of obtaining information regarding several of viil INTRODUCTION them, was ... health; in others, to the rowers being by nature constitutionally delicate; and in others again, to their having thoroughly overdone it, to their being in boating language "stale." As regards the ... rowing as to be of little or no service in maintaining the theory of rowing being injurious to the health At the same time I have never doubted that his early death, at the age of twenty-nine,...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
Ngày tải lên :
15/02/2014, 13:20
... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered ... heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data validity score as covariates, they ... vaccination of adults and the type of vaccine strain administered precluded the inclusion of these factors as covariates in the random-effects regression model However, these researchers determined...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
Ngày tải lên :
16/02/2014, 15:20
... of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain In the case ... deficient in the AD brain There remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore we will briefly review some of the current thoughts on the role of GIF in AD There ... investigated whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound...
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Tài liệu Trends in the Fees and expenses of Mutual Funds, 2010 pptx
Ngày tải lên :
19/02/2014, 15:20
... inflation by taking the fee breakpoints available in 2010 and multiplying by the Consumer Price Index in December 2000 and dividing by the Consumer Price Index in December 2010 The front-end ... endowments, and other institutional investors investing for their own accounts, rather than on behalf of retail investors Stock Funds The average fees and expenses paid by stock fund investors declined ... paid for investing in bond funds declined by basis point in 2010, to 72 basis points (Figure 2) This reflects a basis-point drop in the annualized cost of load fee payments and no change in the average...
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Tài liệu Trends in the Expenses and Fees of Mutual Funds, 2011 ppt
Ngày tải lên :
19/02/2014, 15:20
... declined in 2011 owing to declines in the expense ratios of individual funds, an increase in the demand for index funds, and a continuing shift by investors in both actively managed and index ... Although growing investor demand for index funds has contributed to the overall decline in fund expense ratios, the average expense ratios incurred by investors in both index and actively managed ... the steep decline in the average expense ratio of money market funds reflects developments stemming from the current low interest rate environment In 2007 and 2008, to stimulate the economy and...
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