small cell lung cancer clinical trials us

... non -small- cell lung cancer: clinical implications. Radiother Oncol 2010, 94:1-11. 27. Chen Y, Guo W, Lu Y, Zou B: Dose-individualized stereotactic body radiotherapy for T1-3N0 non -small cell lung ... non -small- cell lung cancer. Int J Radiat Oncol Biol Phys 2002, 52:382-389. 16. Qiao X, Tullgren O, Lax I, Sirzén F, Lewensohn R: The role of radiotherapy in treatment of stage I non -small cell lung ... for lung cancer varied greatly from institution to institution [10]. The most frequently used schedule was 48 Gy in 4 fractions for both stage IA and IB primary lung cancer and metastatic lung cancer. As...

Ngày tải lên: 09/08/2014, 09:20

... chemotherapy and IMRT [21]. More clinical evidence on using IMRT in treating lung cancer is needed. We started using IMRT to treat lung cancer in 2005, and we evaluated clinical and dosimetric factors ... 0.01). Conclusions: NTCP value and V10 are the useful indicators for predicting SARP in NSCLC patients treated with concurrent chemotherapy and IMRT. Background Lung cancer is the leading cause of cancer- related ... unresectable stage III non -small- cell lung cancer. J Clin Oncol 1999, 17:2692-2699. 3. Komaki R, Seiferheld W, Curran W, Langer C, Lee J, Hauser S, Movasas B, Wasserman T, Russell A, Byhardt R: Sequential...

Ngày tải lên: 09/08/2014, 08:23

... randomized trial of limited-disease small cell lung cancer: the Japan Clinical Oncology Group (JCOG) trial 0202 Naoko Sanuki-Fujimoto †1 , Satoshi Ishikura* †1,2 , Kazushige Hayakawa 2 , Kaoru Kubota 3 , ... committee, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan and 3 JCOG lung cancer ... (2%; 95% CI, 0.4%–6%), respectively. Discussion In clinical trials, patients must receive optimal treatment. Since the 1980s, a number of reports have focused on the relationship between RT compliance...

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... Tisaire JL: Gemcitabine plus docetaxel as first-line chemotherapy in patients with advanced non -small cell lung cancer: a lung cancer Galician group phase II study. Cancer Chemother Pharma- col ... regi- mens and paclitaxel plus gemcitabine in advanced non -small- cell lung cancer: a phase III trial of the European Organiza- tion for Research and Treatment of Cancer Lung Cancer Group – EORTC 08975. ... patients with advanced non small cell lung carcinoma using docetaxel and gemcitabine plus granulocyte-colony stimulating factor. Cancer 2000, 89:516-522. 22. Georgoulias V, Kouroussis C, Androulakis...

Ngày tải lên: 18/06/2014, 15:20

... of detecting EGFR mutations in lung cancer patients. Methods: EGFR mutation status was analyzed by DNA assays, and compared with IHC results in five non -small- cell lung cancer (NSCLC) cell lines and tumor ... Non -small- cell lung cancer harbouring mutations in the EGFR kinase domain. Clin Transl Oncol 2010, 12:75-80. 9. Gazdar AF: Activating and resistance mutations of EGFR in non -small- cell lung cancer: ... of EGFR mutations in non -small- cell lung cancer. Clin Cancer Res 2009, 15:3023-3028. 13. Motoi N, Szoke J, Riely GJ, Seshan VE, Kris MG, Rusch VW, Gerald WL, Travis WD: Lung adenocarcinoma: modification...

Ngày tải lên: 18/06/2014, 16:20

... for clinical- pathological reasons are often divided into two broad categories: small cell lung cancer (SCLC) and non -small cell lung cancer (NSCLC). All major histological types of lung cancer ... act as a risk marker of lung cancer in Taiwan. Cancer 2003, 97:1558-1563. 11. Klein F, Amin Kotb WF, Petersen I: Incidence of human papilloma virus in lung cancer. Lung Cancer 2009, 65:13-18. 12. ... skin, oesophagus, head and neck cancer. HPV has also been speculated to have a role in the pathogenesis of lung cancer. To validate the hypothesis of HPV involvement in small cell lung cancer pathogenesis...

Ngày tải lên: 18/06/2014, 16:20

... marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007, 13:6649-57. 24. World Health Organization: Histological Typing of Lung and Pleural Tumours. ... Persson M, Bremnes RM, Busund LT: Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non -small cell lung cancer. Anticancer Res 2009, 29:4175-83. 28. ... NSCLC histology. Lung Cancer 2010. 31. Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Busund LT, Bremnes RM: Prognostic impact of platelet-derived growth factors in non -small cell lung cancer tumor...

Ngày tải lên: 18/06/2014, 16:20

... Staging of small cell and non -small cell lung cancer. University of Iowa Virtual Hos- pital; 1999. 6. Hopwood P, Stephens RJ: Symptoms at presentation for treat- ment in patients with lung cancer: ... pemetrexed versus docetaxel in patients with non -small cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004, 22:1589-97. 28. Hopwood P, Watkins J, Ellis P, Smith I: Clinical interpretation ... breast cancer. Br J Cancer 2006, 95(6):683-90. 17. Cancer Research UK [http://www.cancerresearchuk.org ] 18. Cancer Help [http://www.cancerhelp.org.uk ] 19. Association for International Cancer...

Ngày tải lên: 18/06/2014, 19:20

... non -small cell lung cancer cell lines. Mol Cancer Res. 2006; 4(8): 521-8. 102. Taguchi F, Solomon B, Gregorc V, et al. Mass spectrometry to classify non -small- cell lung cancer patients for clinical ... cause of cancer death world- wide (1). Lung cancer is generally classified into two histological types, small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC). NSCLC accounts for ... ifosfamide in patients with advanced non -small- cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non -Small Cell Lung Cancer Study Group. J Clin Oncol....

Ngày tải lên: 08/08/2014, 17:20

... chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer Ferdinando Riccardi 1* , Giuseppe Di Lorenzo 1 , Carlo Buonerba 1 , Guglielmo Monaco 2 , Roberto Monaco 3 , Mimma ... Carteni’ 1 Abstract Background: Defining the optimal treatment for patients with inoperable non small cell lung cancer (NSCLC), presenting with metastatic mediastinal lymph nodes, is challenging. Nevertheless, ... few cycles should not automatically discourage to continue treatment. Introduction In non -small cell lung cancer (NSCLC), mediastinal lymphnode involvement comprises a wide spectrum of severity....

Ngày tải lên: 09/08/2014, 03:21

... morphological characteristics of permanent human small cell lung cancer cell lines. J Cancer Res Clin Oncol 1987, 113:31-40. 16. NCCN guidelines for small- cell lung cancer. [http://www.nccn.org/ professionals/physician_gls/f_guidelines.asp]. 17. ... limited-stage small cell lung cancer. [http:// clinicaltrials.gov/ct2/show/NCT00433563]. 27. Three different radiation therapy regimens in treating patients with limited-stage small cell lung cancer ... in limited-stage small cell lung cancer: facts, questions, prospects. Radiother Oncol 2000, 55:1-9. 2. Murray N, Turrisi AT: A review of first-line treatment for small- cell lung cancer. J Thorac...

Ngày tải lên: 09/08/2014, 09:20

... prospective clinical studies are needed. Keywords: Stereotactic Body Rad iotherapy, Oligometastases, Non -Small Cell Lung Cancer Background Non -small cell lung cancer (NSCLC) is the leading cause of cancer ... Access Comparison of outcomes in patients with stage III versus limited stage IV non -small cell lung cancer Praveena Cheruvu 1 , Su K Metcalfe 1 , Justin Metcalfe 1 , Yuhchyau Chen 1 , Paul Okunieff 2 and ... Okunieff 2 and Michael T Milano 1* Abstract Background: Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemic chemotherapy and/or radiotherapy. Recent studies...

Ngày tải lên: 09/08/2014, 09:20

... patients with operable lung cancer. A randomized phase III trial of Radiosurgery Or Surgery for operable Early stage (stage 1A) non -small cell Lung cancer (ROSEL, ClinicalTrials.gov ID = NCT00687986) has ... and 4 stage 1B non -small cell lung cancer patients in order to develop and evaluate the planning guidelines differentiated according to type of dose calculation algorithm used. Patient characteristics and ... Y, Matsushita H, Takeda K, Takahashi C, Britton KR, Jingu K, Takai K, Mitsuya M, Nemoto K, Yamada S: A phase II study on stereotactic body radiotherapy for stage I non -small cell lung cancer. ...

Ngày tải lên: 09/08/2014, 09:22

... energy agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: non -small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys 2008, 72(2):335-342. 6. Therasse P, ... purposes) Radiation Oncology Open Access Research Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non -small cell lung cancer Erik P Sulman, Ritsuko Komaki, Ann ... P, Boersma LJ, Lebesque JV: First results of a phase I/II dose esca- lation trial in non -small cell lung cancer using three-dimen- sional conformal radiotherapy. Radiother Oncol 2003, 66:119-126. 9....

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... [8]. Similar findings were made for non -small- cell lung cancer (NSCLC), where a continuous tumor regression during radiotherapy was observed [9]. This continuous tumor regression during radiotherapy makes ... versus bronchi and vessels was not possible in all patients and these OARs were included into the GTV. This was done because the OARs were too small for manual and automatic segmentation or because ... Wagner TH, Langen KM: Serial megavoltage CT imaging during exter- nal beam radiotherapy for non -small- cell lung cancer: obser- vations on tumor regression during treatment. Int J Radiat Oncol Biol Phys...

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